HK1069827A1 - Pyranones useful as atm inhibitors. - Google Patents

Pyranones useful as atm inhibitors.

Info

Publication number
HK1069827A1
HK1069827A1 HK05103310A HK05103310A HK1069827A1 HK 1069827 A1 HK1069827 A1 HK 1069827A1 HK 05103310 A HK05103310 A HK 05103310A HK 05103310 A HK05103310 A HK 05103310A HK 1069827 A1 HK1069827 A1 HK 1069827A1
Authority
HK
Hong Kong
Prior art keywords
atm inhibitors
pyranones
useful
pyranones useful
sulfonamino
Prior art date
Application number
HK05103310A
Other languages
English (en)
Inventor
Graeme Cameron Murray Smith
Niall Morrison Barr Martin
Stephen Philip Jackson
Mark James O'connor
Alan Yin Kai Lau
Xiao-Ling Fan Cockcroft
Ian Timothy Williams Matthews
Keith Allan Menear
Laurent Jean Martin Rigoreau
Marc Geoffrey Hummersone
Roger John Griffin
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of HK1069827A1 publication Critical patent/HK1069827A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK05103310A 2002-02-25 2005-04-19 Pyranones useful as atm inhibitors. HK1069827A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0204350.3A GB0204350D0 (en) 2002-02-25 2002-02-25 ATM inhibitors
US39588402P 2002-07-15 2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en) 2002-02-25 2003-02-24 Pyranones useful as atm inhibitors

Publications (1)

Publication Number Publication Date
HK1069827A1 true HK1069827A1 (en) 2005-06-03

Family

ID=27758841

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05103310A HK1069827A1 (en) 2002-02-25 2005-04-19 Pyranones useful as atm inhibitors.

Country Status (20)

Country Link
EP (2) EP2174939A1 (el)
JP (1) JP2005521689A (el)
CN (1) CN100358891C (el)
AT (1) ATE451365T1 (el)
AU (1) AU2003209990B8 (el)
BR (1) BR0307944A (el)
CA (1) CA2473100A1 (el)
CY (1) CY1109835T1 (el)
DE (1) DE60330442D1 (el)
DK (1) DK1485377T5 (el)
ES (1) ES2336206T3 (el)
GB (1) GB2401606B (el)
HK (1) HK1069827A1 (el)
MX (1) MXPA04007809A (el)
NO (1) NO329806B1 (el)
NZ (1) NZ534821A (el)
PL (1) PL370074A1 (el)
PT (1) PT1485377E (el)
SI (1) SI1485377T1 (el)
WO (1) WO2003070726A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
EP1501822B1 (en) 2002-04-30 2010-12-15 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en) 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
WO2004097426A2 (en) * 2003-05-01 2004-11-11 Kudos Pharmaceuticals Limited Methods and means for the treatment of disorders associated with cellular senescence
CA2534300A1 (en) 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
CN102107008B (zh) 2003-12-01 2013-04-03 库多斯药物有限公司 用于治疗癌症的dna损伤修复抑制剂
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
UA88329C2 (en) 2004-09-20 2009-10-12 Кудос Фармасьютикалз Лимитед Dna-pk inhibitors
JP2008529995A (ja) * 2005-02-09 2008-08-07 クドス ファーマシューティカルズ リミテッド Ａｔｍ阻害剤
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
TW200745094A (en) * 2005-08-31 2007-12-16 Kudos Pharm Ltd ATM inhibitor
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
MX2010002749A (es) 2007-09-14 2010-06-25 Astrazeneca Ab Derivados de ftalazinona.
UA106878C2 (uk) 2008-10-07 2014-10-27 Астразенека Юк Лімітед Фармацевтична композиція, що містить 4-[3-(4-циклопропанкарбонілпіперазин-1-карбоніл)-4-фторбензил]-2н-фталазин-1-он або його сіль, або сольват, у твердій дисперсії з матричним полімером коповідоном
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
EP2724156B1 (en) 2011-06-27 2017-08-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
JP6074043B2 (ja) * 2013-08-29 2017-02-01 富士フイルム株式会社 新規なモルホリン誘導体またはその塩
US20230256110A1 (en) 2020-06-24 2023-08-17 Astrazeneca Uk Limited Combination of antibody-drug conjugate and atm inhibitor
CN112094210A (zh) * 2020-09-24 2020-12-18 江苏扬农化工股份有限公司 一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0331250B1 (en) * 1988-03-02 1994-04-13 Merck & Co. Inc. Antihypercholesterolemic agents
EP0489877B1 (en) * 1990-06-29 1995-09-20 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
WO1997043434A1 (fr) * 1996-05-14 1997-11-20 Snow Brand Milk Products Co., Ltd. Nouvelle substance active sur le plan physiologique et son procede de preparation
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
CN1205198C (zh) * 1997-09-26 2005-06-08 东丽株式会社 环酮衍生物及其医药用途
AU756965B2 (en) * 1998-03-12 2003-01-30 Microbial Chemistry Research Foundation Benzofurylpyrone derivatives

Also Published As

Publication number Publication date
GB2401606B (en) 2005-08-31
NZ534821A (en) 2006-07-28
PL370074A1 (en) 2005-05-16
SI1485377T1 (sl) 2010-04-30
NO329806B1 (no) 2010-12-20
DK1485377T5 (da) 2010-12-06
EP1485377B9 (en) 2010-10-06
GB0419534D0 (en) 2004-10-06
PT1485377E (pt) 2010-03-12
DK1485377T3 (da) 2010-04-19
CN100358891C (zh) 2008-01-02
CN1639154A (zh) 2005-07-13
AU2003209990B2 (en) 2008-10-09
AU2003209990B8 (en) 2008-10-30
GB2401606A (en) 2004-11-17
BR0307944A (pt) 2005-02-01
CA2473100A1 (en) 2003-08-28
AU2003209990A1 (en) 2003-09-09
JP2005521689A (ja) 2005-07-21
MXPA04007809A (es) 2004-10-15
EP1485377B8 (en) 2010-02-24
ATE451365T1 (de) 2009-12-15
EP1485377B1 (en) 2009-12-09
WO2003070726A1 (en) 2003-08-28
NO20044063L (no) 2004-09-24
DE60330442D1 (de) 2010-01-21
EP2174939A1 (en) 2010-04-14
ES2336206T9 (es) 2011-03-24
CY1109835T1 (el) 2014-09-10
ES2336206T3 (es) 2010-04-09
EP1485377A1 (en) 2004-12-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110224