ATE239722T1 - Benzofurylpiperazine als serotonin-agonisten - Google Patents
Benzofurylpiperazine als serotonin-agonistenInfo
- Publication number
- ATE239722T1 ATE239722T1 AT00948746T AT00948746T ATE239722T1 AT E239722 T1 ATE239722 T1 AT E239722T1 AT 00948746 T AT00948746 T AT 00948746T AT 00948746 T AT00948746 T AT 00948746T AT E239722 T1 ATE239722 T1 AT E239722T1
- Authority
- AT
- Austria
- Prior art keywords
- benzofurylpiperazine
- serotonin agonists
- serotonin
- agonists
- benzofurans
- Prior art date
Links
- LFWCEWLQBGZAGG-UHFFFAOYSA-N 1-(1-benzofuran-2-yl)piperazine Chemical compound C1CNCCN1C1=CC2=CC=CC=C2O1 LFWCEWLQBGZAGG-UHFFFAOYSA-N 0.000 title 1
- 239000000952 serotonin receptor agonist Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000862 serotonergic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14628799P | 1999-07-29 | 1999-07-29 | |
| US17216999P | 1999-12-17 | 1999-12-17 | |
| PCT/US2000/019545 WO2001009123A1 (en) | 1999-07-29 | 2000-07-21 | Benzofurylpiperazine serotonin agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239722T1 true ATE239722T1 (de) | 2003-05-15 |
Family
ID=26843756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948746T ATE239722T1 (de) | 1999-07-29 | 2000-07-21 | Benzofurylpiperazine als serotonin-agonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6638936B1 (de) |
| EP (1) | EP1204658B1 (de) |
| JP (1) | JP2003506370A (de) |
| AT (1) | ATE239722T1 (de) |
| AU (1) | AU6220300A (de) |
| CA (1) | CA2380531A1 (de) |
| DE (1) | DE60002583T2 (de) |
| DK (1) | DK1204658T3 (de) |
| ES (1) | ES2198329T3 (de) |
| PT (1) | PT1204658E (de) |
| WO (1) | WO2001009123A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60004066T2 (de) * | 1999-07-29 | 2004-04-15 | Eli Lilly And Co., Indianapolis | Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten |
| EP1337518B1 (de) | 2000-11-20 | 2009-06-17 | Biovitrum AB (publ) | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| DK1408976T5 (da) * | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
| BR0311970A (pt) | 2002-06-19 | 2005-03-29 | Biovitrum Ab | Novos compostos, seu uso e preparação |
| US8685924B2 (en) | 2004-08-25 | 2014-04-01 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| EP2018863B9 (de) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Kondensierte, heterocyclische Verbindung und ihre Verwendung |
| WO2008052086A1 (en) * | 2006-10-24 | 2008-05-02 | Wyeth | Benzodioxane derivatives and uses thereof |
| EP2789338A3 (de) | 2007-11-15 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Kondensiertes Pyridinderivat und seine Verwendung |
| US20120253036A1 (en) | 2009-12-11 | 2012-10-04 | Yukinori Nagakura | Agent for treating fibromyalgia |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| CN112773898A (zh) * | 2019-11-11 | 2021-05-11 | 广州华真医药科技有限公司 | 磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006524A1 (de) * | 1978-06-22 | 1980-01-09 | Ciba-Geigy Ag | Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen |
| DE3586794T2 (de) * | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| EP0724580A1 (de) * | 1993-10-19 | 1996-08-07 | Smithkline Beecham Plc | Benzamilid-derivate als 5ht-1d-rezeptor antagonisten |
| US5698766A (en) * | 1995-04-05 | 1997-12-16 | The Regents Of The University Of California | Transgenic animal model for testing drugs for treating eating disorders and epilepsy |
| GB9517559D0 (en) | 1995-08-26 | 1995-10-25 | Smithkline Beecham Plc | Novel compounds |
| ES2271967T3 (es) | 1996-03-29 | 2007-04-16 | Duphar International Research B.V | Compuestos de piperazina y piperidina. |
| US6132538A (en) | 1998-07-30 | 2000-10-17 | Autoliv Development Ab | High gas yield generant compositions |
| GB0012165D0 (en) | 2000-05-20 | 2000-07-12 | Team Consulting Ltd | Portable device with consistent power output |
-
2000
- 2000-07-21 DE DE60002583T patent/DE60002583T2/de not_active Expired - Fee Related
- 2000-07-21 DK DK00948746T patent/DK1204658T3/da active
- 2000-07-21 EP EP00948746A patent/EP1204658B1/de not_active Expired - Lifetime
- 2000-07-21 PT PT00948746T patent/PT1204658E/pt unknown
- 2000-07-21 CA CA002380531A patent/CA2380531A1/en not_active Abandoned
- 2000-07-21 WO PCT/US2000/019545 patent/WO2001009123A1/en not_active Ceased
- 2000-07-21 US US10/031,310 patent/US6638936B1/en not_active Expired - Fee Related
- 2000-07-21 JP JP2001514326A patent/JP2003506370A/ja not_active Withdrawn
- 2000-07-21 ES ES00948746T patent/ES2198329T3/es not_active Expired - Lifetime
- 2000-07-21 AT AT00948746T patent/ATE239722T1/de not_active IP Right Cessation
- 2000-07-21 AU AU62203/00A patent/AU6220300A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002583T2 (de) | 2004-03-25 |
| JP2003506370A (ja) | 2003-02-18 |
| PT1204658E (pt) | 2003-08-29 |
| DK1204658T3 (da) | 2003-09-01 |
| CA2380531A1 (en) | 2001-02-08 |
| EP1204658B1 (de) | 2003-05-07 |
| ES2198329T3 (es) | 2004-02-01 |
| US6638936B1 (en) | 2003-10-28 |
| DE60002583D1 (de) | 2003-06-12 |
| WO2001009123A1 (en) | 2001-02-08 |
| AU6220300A (en) | 2001-02-19 |
| EP1204658A1 (de) | 2002-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1204658 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |