YU72000A - Kompleks platine, njegovo dobijanje i terapeutska primena - Google Patents
Kompleks platine, njegovo dobijanje i terapeutska primenaInfo
- Publication number
- YU72000A YU72000A YU72000A YU72000A YU72000A YU 72000 A YU72000 A YU 72000A YU 72000 A YU72000 A YU 72000A YU 72000 A YU72000 A YU 72000A YU 72000 A YU72000 A YU 72000A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- complex
- carbon atoms
- platinum complex
- disclosed
- preparation
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title abstract 6
- 229910052697 platinum Inorganic materials 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Opisan kompleks platine opste formule (I) gde X predstavlja atomhalogena, i A predstavlja grupu -NH2R, gde R je triciklicna ugljovodonicna grupa koja sadrzi od 10 do 14 atoma ugljenika, koja moze da bude po izboru supstituisana na triciklicnom prstenu pomocu jedne ili dva alkil grupa koje sadrze od 1 do 4 atoma ugljenika, i dalje inkluzioni kompleks gornjeg kompleksa platine sa ß- ili γ-ciklodekstrinom koji moze po izboru da bude supstituisan sa hidroksialkil grupom koja sadrzi od 1 do 6 atoma ugljenika. Takodje, je opisan postupak za dobijanje kompleksa formule (I) koji obuhvata reagovanje rastvora amin-trihalogenplatinatne (II) alkalno metalne soli u polarnom organskom rastvaracu ili u vodi sa primarnim aminom formule R-NH2, gde R je triciklicna hidrogemska grupa koja sadrzi od 10 do 14 atoma ugljenika koja moze po izboru da bude supstituisana na triciklicnom prstenu sa jednom ili dve alkil grupe koje sadrze od jedan do cetiri atoma ugljenika, na temperaturi od 0 do 100°C kao i postupak za proizvodnju gornjeg inkluzionog kompleksa. Oba opisana kompleksa mogu da budu koriscena kao deo farmaceutskog preparata u terapiji onkoloskih obolenja.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ19981627A CZ288406B6 (en) | 1998-05-27 | 1998-05-27 | Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU72000A true YU72000A (sh) | 2002-10-18 |
| RS49739B RS49739B (sr) | 2008-04-04 |
Family
ID=5463561
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6350737B1 (sh) |
| EP (1) | EP1082329B1 (sh) |
| JP (1) | JP3647748B2 (sh) |
| CN (1) | CN1124278C (sh) |
| AU (1) | AU741381B2 (sh) |
| BG (1) | BG64598B1 (sh) |
| BR (1) | BR9910668A (sh) |
| CA (1) | CA2331464C (sh) |
| CZ (1) | CZ288406B6 (sh) |
| DE (1) | DE69905714T2 (sh) |
| ES (1) | ES2194457T3 (sh) |
| HR (1) | HRP20000792B1 (sh) |
| HU (1) | HU228940B1 (sh) |
| IL (1) | IL139528A (sh) |
| NO (1) | NO328940B1 (sh) |
| PL (1) | PL191131B1 (sh) |
| RS (1) | RS49739B (sh) |
| RU (1) | RU2203901C2 (sh) |
| SK (1) | SK284398B6 (sh) |
| UA (1) | UA56314C2 (sh) |
| WO (1) | WO1999061450A1 (sh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102312A1 (en) * | 2004-04-27 | 2005-11-03 | Mayne Pharma Limited | Concentrated oxaliplatin solutions |
| CA2584493A1 (en) | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Kinase inhibitors for treating cancers |
| JP2008506463A (ja) * | 2004-07-14 | 2008-03-06 | ゲーペーツェー ビオテック アーゲー | 可変投与量パッケージシステム |
| CZ2004964A3 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
| CZ300120B6 (cs) * | 2006-06-20 | 2009-02-11 | Pliva - Lachema A. S. | Farmaceutická kompozice pro injekcní podání |
| US20120238488A1 (en) | 2009-09-08 | 2012-09-20 | Konstantinos Alevizopoulos | Compounds and methods for treating neoplasia |
| PL3127544T3 (pl) * | 2014-04-04 | 2022-01-03 | Taiho Pharmaceutical Co., Ltd. | Lek przeciwnowotworowy zawierający przeciwnowotworowy kompleks platyny i wzmacniacz działania przeciwnowotworowego |
| CN104922688A (zh) * | 2015-02-10 | 2015-09-23 | 昆明贵研药业有限公司 | 奥沙利铂的环糊精复合物及制备方法 |
| CN104984356A (zh) * | 2015-05-14 | 2015-10-21 | 昆明贵研药业有限公司 | 赛特铂的环糊精复合物及制备方法 |
| RU2613513C2 (ru) * | 2015-07-17 | 2017-03-16 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Способ получения комплексов платины (IV) с аминонитроксильными радикалами |
| RU2726826C2 (ru) * | 2016-12-27 | 2020-07-15 | Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") | Композиция на основе аминонитроксильного комплекса платины и доксорубицина и способ лечения опухолей |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2060615B (en) * | 1979-08-23 | 1983-06-22 | Johnson Matthey Co Ltd | Platinum-amine complexes |
| US4902797A (en) * | 1986-12-18 | 1990-02-20 | Shionogi & Co., Ltd. | Ammine-alicyclic amine-platinum complexes and antitumor agents |
| US5225207A (en) * | 1989-03-17 | 1993-07-06 | Laboratoire Roger Bellon | Complexes derived from platinum, their preparation and the pharmaceutical compositions which contain them |
| GB9105037D0 (en) * | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
-
1998
- 1998-05-27 CZ CZ19981627A patent/CZ288406B6/cs not_active IP Right Cessation
-
1999
- 1999-05-24 UA UA2000116683A patent/UA56314C2/uk unknown
- 1999-05-24 US US09/700,513 patent/US6350737B1/en not_active Expired - Fee Related
- 1999-05-24 CN CN99806647A patent/CN1124278C/zh not_active Expired - Fee Related
- 1999-05-24 HU HU0201762A patent/HU228940B1/hu not_active IP Right Cessation
- 1999-05-24 IL IL13952899A patent/IL139528A/en not_active IP Right Cessation
- 1999-05-24 JP JP2000550854A patent/JP3647748B2/ja not_active Expired - Fee Related
- 1999-05-24 BR BR9910668-0A patent/BR9910668A/pt not_active Application Discontinuation
- 1999-05-24 DE DE69905714T patent/DE69905714T2/de not_active Expired - Lifetime
- 1999-05-24 PL PL344345A patent/PL191131B1/pl not_active IP Right Cessation
- 1999-05-24 WO PCT/CZ1999/000014 patent/WO1999061450A1/en active IP Right Grant
- 1999-05-24 CA CA002331464A patent/CA2331464C/en not_active Expired - Fee Related
- 1999-05-24 RU RU2000128647/04A patent/RU2203901C2/ru not_active IP Right Cessation
- 1999-05-24 RS YUP-720/00A patent/RS49739B/sr unknown
- 1999-05-24 ES ES99920540T patent/ES2194457T3/es not_active Expired - Lifetime
- 1999-05-24 SK SK1774-2000A patent/SK284398B6/sk not_active IP Right Cessation
- 1999-05-24 AU AU38092/99A patent/AU741381B2/en not_active Ceased
- 1999-05-24 EP EP99920540A patent/EP1082329B1/en not_active Expired - Lifetime
-
2000
- 2000-11-17 HR HR20000792A patent/HRP20000792B1/xx not_active IP Right Cessation
- 2000-11-21 BG BG104971A patent/BG64598B1/bg unknown
- 2000-11-23 NO NO20005919A patent/NO328940B1/no not_active IP Right Cessation
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