ES8606382A1 - Un procedimiento para preparar un derivado de uridina 2'-desoxi-5-sustituido - Google Patents
Un procedimiento para preparar un derivado de uridina 2'-desoxi-5-sustituidoInfo
- Publication number
- ES8606382A1 ES8606382A1 ES532716A ES532716A ES8606382A1 ES 8606382 A1 ES8606382 A1 ES 8606382A1 ES 532716 A ES532716 A ES 532716A ES 532716 A ES532716 A ES 532716A ES 8606382 A1 ES8606382 A1 ES 8606382A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- preparing
- group
- deoxy
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE URIDINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA II CON OTRO DE FORMULA RX, PARA OBTENER DERIVADOS DE URIDINA DE FORMULA I, EN DONDE R ES UN GRUPO ALQUILO DE 1 A 10 ATOMOS DE CARBONO, GRUPO ALQUENILO DE 2 A 6 ATOMOS DE CARBONO, GRUPO BENCILO, GRUPO ARALQUILO O ALCOXI DE 1 A 4 ATOMOS DE CARBONO, GRUPO NITRO O ALQUILO DE 1 A 3 ATOMOS DE CARBONO Y X ES UN ATOMO DE CLORO, BROMO O YODO. SIENDO RK1 GRUPO BENZOILO O TETRAHIDROFURANILO, RK2 ES FLUOR O TRIFLUORMETILO, Y R3, R4 ES HIDROGENO Y EL OTRO ES ANALOGO AL SUSTITUYENTE R. APLICACION COMO AGENTE ANTITUMORAL.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58091190A JPS59216899A (ja) | 1983-05-23 | 1983-05-23 | 2′―デオキシ―5―トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤 |
JP58170149A JPS6061593A (ja) | 1983-09-14 | 1983-09-14 | 2’−デオキシ−5−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤 |
JP58170147A JPS6061591A (ja) | 1983-09-14 | 1983-09-14 | 2′―デオキシ―5―フルオロウリジン誘導体及びそれを含む抗腫瘍剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532716A0 ES532716A0 (es) | 1986-04-01 |
ES8606382A1 true ES8606382A1 (es) | 1986-04-01 |
Family
ID=27306680
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532716A Expired ES8606382A1 (es) | 1983-05-23 | 1984-05-23 | Un procedimiento para preparar un derivado de uridina 2'-desoxi-5-sustituido |
ES85546062A Expired ES8606381A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina. |
ES546061A Expired ES8607982A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina |
ES546060A Expired ES8706715A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES85546062A Expired ES8606381A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina. |
ES546061A Expired ES8607982A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina |
ES546060A Expired ES8706715A1 (es) | 1983-05-23 | 1985-08-09 | Un procedimiento para preparar un derivado de uridina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4886877A (es) |
EP (1) | EP0129984B1 (es) |
KR (1) | KR860001865B1 (es) |
AU (1) | AU548712B2 (es) |
CA (1) | CA1227794A (es) |
DE (1) | DE3469533D1 (es) |
ES (4) | ES8606382A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250673A (en) * | 1983-05-23 | 1993-10-05 | Taiho Pharmaceutical Company, Ltd. | 2'-deoxy-5-substituted uridine derivatives |
DE3588036T2 (de) * | 1984-10-30 | 1995-11-16 | Otsuka Pharma Co Ltd | 5-Fluoruracilderivate. |
US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
DE3685315D1 (de) * | 1985-07-22 | 1992-06-17 | Teijin Ltd | Antivirus-heilmittel. |
DE3786834T2 (de) * | 1986-04-30 | 1994-03-03 | Otsuka Pharma Co Ltd | 5-Fluoro-Uracil-Derivate. |
DK363987A (da) * | 1986-08-08 | 1988-02-09 | Hoffmann La Roche | Pyrimidinderivater |
AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
EP0517262A1 (en) * | 1991-06-07 | 1992-12-09 | MITSUI TOATSU CHEMICALS, Inc. | Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same |
NO934399L (no) * | 1992-12-07 | 1994-06-08 | Mitsui Toatsu Chemicals | Tioesterderivater av 3'-O-propargyl-trifluortymidin, fremgangsmåte for fremstilling samt anvendelse av slike |
JP4110347B2 (ja) * | 1999-11-05 | 2008-07-02 | 大鵬薬品工業株式会社 | 抗hiv剤 |
US20050131224A1 (en) * | 2003-12-15 | 2005-06-16 | Cti Pet Systems, Inc. | Method for preparing radiolabeled thymidine |
US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658672A1 (de) * | 1976-12-23 | 1978-06-29 | Robugen Gmbh | Neue nucleosid-verbindungen und verfahren zu ihrer herstellung |
US4210638A (en) * | 1978-03-17 | 1980-07-01 | Pcr, Inc. | Antiviral composition and method of treating virus diseases |
GB2016921B (en) * | 1978-03-27 | 1982-08-18 | Taiho Pharmaceutical Co Ltd | Anti cancer compositions containing uracil derivatives |
JPS5924999B2 (ja) * | 1978-06-10 | 1984-06-13 | 富山化学工業株式会社 | 新規な5−フルオロ−2′−デオキシ−β−ウリジン誘導体の製造法 |
DE3105111A1 (de) * | 1980-02-15 | 1981-12-24 | Funai Yakuhin Kogyo K.K., Osaka | "2 -desoxy-3',5-di-o-alkylcarbonyl-5-fluoruridin-derivate, verfahren zu ihrer herstellung, ihre verwendung zur behandlung von tumoren und antitumormittel" |
JP3834939B2 (ja) * | 1997-06-12 | 2006-10-18 | 松下電工株式会社 | 照明装置 |
-
1984
- 1984-05-22 EP EP84303476A patent/EP0129984B1/en not_active Expired
- 1984-05-22 CA CA000454814A patent/CA1227794A/en not_active Expired
- 1984-05-22 AU AU28467/84A patent/AU548712B2/en not_active Ceased
- 1984-05-22 DE DE8484303476T patent/DE3469533D1/de not_active Expired
- 1984-05-22 KR KR1019840002789A patent/KR860001865B1/ko not_active IP Right Cessation
- 1984-05-23 ES ES532716A patent/ES8606382A1/es not_active Expired
-
1985
- 1985-08-09 ES ES85546062A patent/ES8606381A1/es not_active Expired
- 1985-08-09 ES ES546061A patent/ES8607982A1/es not_active Expired
- 1985-08-09 ES ES546060A patent/ES8706715A1/es not_active Expired
-
1988
- 1988-02-26 US US07/163,237 patent/US4886877A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES546062A0 (es) | 1986-04-01 |
DE3469533D1 (en) | 1988-04-07 |
EP0129984B1 (en) | 1988-03-02 |
ES532716A0 (es) | 1986-04-01 |
ES546060A0 (es) | 1987-06-16 |
KR840009104A (ko) | 1984-12-24 |
ES546061A0 (es) | 1986-06-01 |
US4886877A (en) | 1989-12-12 |
KR860001865B1 (ko) | 1986-10-24 |
ES8606381A1 (es) | 1986-04-01 |
ES8706715A1 (es) | 1987-06-16 |
CA1227794A (en) | 1987-10-06 |
AU548712B2 (en) | 1986-01-02 |
EP0129984A1 (en) | 1985-01-02 |
AU2846784A (en) | 1984-11-29 |
ES8607982A1 (es) | 1986-06-01 |
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