ES8607982A1 - Un procedimiento para preparar un derivado de uridina - Google Patents

Un procedimiento para preparar un derivado de uridina

Info

Publication number
ES8607982A1
ES8607982A1 ES546061A ES546061A ES8607982A1 ES 8607982 A1 ES8607982 A1 ES 8607982A1 ES 546061 A ES546061 A ES 546061A ES 546061 A ES546061 A ES 546061A ES 8607982 A1 ES8607982 A1 ES 8607982A1
Authority
ES
Spain
Prior art keywords
same
deoxy
preparing
novel
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546061A
Other languages
English (en)
Other versions
ES546061A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58091190A external-priority patent/JPS59216899A/ja
Priority claimed from JP58170149A external-priority patent/JPS6061593A/ja
Priority claimed from JP58170147A external-priority patent/JPS6061591A/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES546061A0 publication Critical patent/ES546061A0/es
Publication of ES8607982A1 publication Critical patent/ES8607982A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE URIDINA, DE FORMULA (I), EN LA QUE R2 ES UN ATOMO DE FLUOR O GRUPO TRIFLUORMETILO; R5 ES UN GRUPO TETRAHIDROFURANILO; Y R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON 2-CLOROTETRAHIDROFURANO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, TAL COMO DIMETILFORMAMIDA O DIMETILACETAMIDA, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE C50JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTITUMORALES.
ES546061A 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina Expired ES8607982A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58091190A JPS59216899A (ja) 1983-05-23 1983-05-23 ２′―デオキシ―５―トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
JP58170149A JPS6061593A (ja) 1983-09-14 1983-09-14 ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
JP58170147A JPS6061591A (ja) 1983-09-14 1983-09-14 ２′―デオキシ―５―フルオロウリジン誘導体及びそれを含む抗腫瘍剤

Publications (2)

Publication Number Publication Date
ES546061A0 ES546061A0 (es) 1986-06-01
ES8607982A1 true ES8607982A1 (es) 1986-06-01

Family

ID=27306680

Family Applications (4)

Application Number Title Priority Date Filing Date
ES532716A Expired ES8606382A1 (es) 1983-05-23 1984-05-23 Un procedimiento para preparar un derivado de uridina 2'-desoxi-5-sustituido
ES546060A Expired ES8706715A1 (es) 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina.
ES546061A Expired ES8607982A1 (es) 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina
ES85546062A Expired ES8606381A1 (es) 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES532716A Expired ES8606382A1 (es) 1983-05-23 1984-05-23 Un procedimiento para preparar un derivado de uridina 2'-desoxi-5-sustituido
ES546060A Expired ES8706715A1 (es) 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES85546062A Expired ES8606381A1 (es) 1983-05-23 1985-08-09 Un procedimiento para preparar un derivado de uridina.

Country Status (7)

Country Link
US (1) US4886877A (es)
EP (1) EP0129984B1 (es)
KR (1) KR860001865B1 (es)
AU (1) AU548712B2 (es)
CA (1) CA1227794A (es)
DE (1) DE3469533D1 (es)
ES (4) ES8606382A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250673A (en) * 1983-05-23 1993-10-05 Taiho Pharmaceutical Company, Ltd. 2'-deoxy-5-substituted uridine derivatives
DE3583726D1 (de) * 1984-10-30 1991-09-12 Otsuka Pharma Co Ltd 5-fluoruracilderivate.
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
US4868162A (en) * 1985-07-22 1989-09-19 Teijin Limited Antiviral agent
DE3786834T2 (de) * 1986-04-30 1994-03-03 Otsuka Pharma Co Ltd 5-Fluoro-Uracil-Derivate.
DK363987A (da) * 1986-08-08 1988-02-09 Hoffmann La Roche Pyrimidinderivater
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
KR950004900B1 (ko) * 1991-06-07 1995-05-15 미쯔이 도오아쯔 가가쿠 가부시기가이샤 트리플루오로티미딘 유도체, 그 제조 방법 및 그것을 유효 성분으로 하는 제암제
FI935444A (fi) * 1992-12-07 1994-06-08 Mitsui Toatsu Chemicals 3'-O-propargyyli-trifluoritymidiinin tioesterijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö syövänvastaisena aineena
JP4110347B2 (ja) * 1999-11-05 2008-07-02 大鵬薬品工業株式会社 抗ｈｉｖ剤
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
US4210638A (en) * 1978-03-17 1980-07-01 Pcr, Inc. Antiviral composition and method of treating virus diseases
GB2016921B (en) * 1978-03-27 1982-08-18 Taiho Pharmaceutical Co Ltd Anti cancer compositions containing uracil derivatives
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
JP3834939B2 (ja) * 1997-06-12 2006-10-18 松下電工株式会社 照明装置

Also Published As

Publication number Publication date
ES546062A0 (es) 1986-04-01
ES8606382A1 (es) 1986-04-01
AU2846784A (en) 1984-11-29
EP0129984A1 (en) 1985-01-02
ES546061A0 (es) 1986-06-01
KR860001865B1 (ko) 1986-10-24
DE3469533D1 (en) 1988-04-07
AU548712B2 (en) 1986-01-02
ES546060A0 (es) 1987-06-16
ES8706715A1 (es) 1987-06-16
KR840009104A (ko) 1984-12-24
ES8606381A1 (es) 1986-04-01
EP0129984B1 (en) 1988-03-02
CA1227794A (en) 1987-10-06
US4886877A (en) 1989-12-12
ES532716A0 (es) 1986-04-01

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