ES8304097A1 - Un procedimiento para la obtencion de un compuesto de 4(3h- quinazolinona). - Google Patents
Un procedimiento para la obtencion de un compuesto de 4(3h- quinazolinona).Info
- Publication number
- ES8304097A1 ES8304097A1 ES508765A ES508765A ES8304097A1 ES 8304097 A1 ES8304097 A1 ES 8304097A1 ES 508765 A ES508765 A ES 508765A ES 508765 A ES508765 A ES 508765A ES 8304097 A1 ES8304097 A1 ES 8304097A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- production
- pharmaceutical compositions
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- QMNUDYFKZYBWQX-UHFFFAOYSA-N 1H-quinazolin-4-one Chemical class C1=CC=C2C(=O)N=CNC2=C1 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4(3H)-QUINAZOLINONA Y DE SUS SALES DE ADICION, DE FORMULA (I), EN LA QUE R Y R SON ALCOHILO INFERIOR; R ES ALCOXICARBONILO INFERIOR; R ES HIDROGENO O ALCOHILO INFERIOR; Z Y Z SON OXIGENO O AZUFRE Y R Y Q PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R NC=Z , EN LAS QUE TODOS LOS SIMBOLOS TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA AMINA TERCIARIA COMO CATALIZADOR, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS ENFERMEDADES HIPERTENSIVAS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP390481A JPS57118570A (en) | 1981-01-16 | 1981-01-16 | Novel 3-phenyl-4-quinazolone derivative |
| JP12137981A JPS5823678A (ja) | 1981-08-04 | 1981-08-04 | 新規な３−フエニル−４−キナゾロン誘導体 |
| JP14630181A JPS5849370A (ja) | 1981-09-18 | 1981-09-18 | 新規な３−フエニル−４−キナゾロン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8304097A1 true ES8304097A1 (es) | 1983-02-16 |
| ES508765A0 ES508765A0 (es) | 1983-02-16 |
Family
ID=27276029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508765A Granted ES508765A0 (es) | 1981-01-16 | 1982-01-15 | Un procedimiento para la obtencion de un compuesto de 4(3h- quinazolinona). |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4451467A (es) |
| EP (1) | EP0056637B1 (es) |
| AU (1) | AU543928B2 (es) |
| CA (1) | CA1167442A (es) |
| DE (1) | DE3264802D1 (es) |
| ES (1) | ES508765A0 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599336A (en) * | 1983-08-08 | 1986-07-08 | Hoffmann-La Roche Inc. | Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide |
| US5017567A (en) * | 1983-11-25 | 1991-05-21 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
| US4906635A (en) * | 1983-11-25 | 1990-03-06 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
| US4778795A (en) * | 1983-11-25 | 1988-10-18 | Schering Corporation | Carboxyalkyl dipeptides as antiglaucoma agents |
| US4757075A (en) * | 1986-10-14 | 1988-07-12 | Merrell Dow Pharmaceuticals Inc. | Tetrazolylquinazolinones as anti-hyperuricemic agents |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| CZ295565B6 (cs) | 1996-05-15 | 2005-08-17 | Pfizer Inc. | 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi |
| EP1216234B1 (en) * | 1999-09-16 | 2004-12-29 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| BR0015110A (pt) * | 1999-10-27 | 2002-07-02 | Cytokinetics Inc | Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos |
| US7671200B2 (en) | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6753428B2 (en) | 2001-11-20 | 2004-06-22 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| TW200306839A (en) * | 2002-02-06 | 2003-12-01 | Novartis Ag | Quinazolinone derivatives and their use as CB agonists |
| AU2007202781B2 (en) * | 2002-02-06 | 2010-09-09 | Novartis Ag | Quinazolinone derivatives and their use as CB agonists |
| WO2003070701A2 (en) | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Syntheses of quinazolinones |
| AU2003270015A1 (en) | 2002-05-09 | 2003-12-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2003094839A2 (en) | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
| JP2005536475A (ja) | 2002-05-23 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
| EP1556357A4 (en) | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP1537089A4 (en) | 2002-07-23 | 2008-04-16 | Cytokinetics Inc | CONNECTIONS, COMPOSITIONS AND PROCEDURES |
| EP1558083A4 (en) | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| JP2007513154A (ja) | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| CA2555824C (en) * | 2004-02-13 | 2011-06-07 | Banyu Pharmaceutical Co., Ltd. | Fused-ring 4-oxopyrimidine derivative |
| GB0413618D0 (en) * | 2004-06-17 | 2004-07-21 | Novartis Ag | Organic compounds |
| KR20100024494A (ko) | 2007-06-22 | 2010-03-05 | 아르퀼 인코포레이티드 | 퀴나졸리논 화합물 및 이의 사용 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5442991B2 (es) * | 1972-06-12 | 1979-12-17 | ||
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| NZ192392A (en) * | 1978-12-19 | 1983-02-15 | M Ishikawa | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
-
1982
- 1982-01-04 AU AU79172/82A patent/AU543928B2/en not_active Ceased
- 1982-01-06 US US06/337,454 patent/US4451467A/en not_active Expired - Fee Related
- 1982-01-15 DE DE8282100273T patent/DE3264802D1/de not_active Expired
- 1982-01-15 ES ES508765A patent/ES508765A0/es active Granted
- 1982-01-15 CA CA000394290A patent/CA1167442A/en not_active Expired
- 1982-01-15 EP EP82100273A patent/EP0056637B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU7917282A (en) | 1982-07-22 |
| DE3264802D1 (en) | 1985-08-29 |
| EP0056637A1 (en) | 1982-07-28 |
| US4451467A (en) | 1984-05-29 |
| AU543928B2 (en) | 1985-05-09 |
| EP0056637B1 (en) | 1985-07-24 |
| CA1167442A (en) | 1984-05-15 |
| ES508765A0 (es) | 1983-02-16 |
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