JPS57118570A - Novel 3-phenyl-4-quinazolone derivative - Google Patents

Novel 3-phenyl-4-quinazolone derivative

Info

Publication number
JPS57118570A
JPS57118570A JP390481A JP390481A JPS57118570A JP S57118570 A JPS57118570 A JP S57118570A JP 390481 A JP390481 A JP 390481A JP 390481 A JP390481 A JP 390481A JP S57118570 A JPS57118570 A JP S57118570A
Authority
JP
Japan
Prior art keywords
positions
formula
alkyl
quinazolone
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP390481A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Soyao Moriguchi
Hisashi Ebisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP390481A priority Critical patent/JPS57118570A/en
Priority to AU79172/82A priority patent/AU543928B2/en
Priority to US06/337,454 priority patent/US4451467A/en
Priority to ES508765A priority patent/ES8304097A1/en
Priority to CA000394290A priority patent/CA1167442A/en
Priority to DE8282100273T priority patent/DE3264802D1/en
Priority to EP82100273A priority patent/EP0056637B1/en
Publication of JPS57118570A publication Critical patent/JPS57118570A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 4-quinazolone derivative shown by the formulaI(R1 and R3 are lower alkyl; R2 is alkoxycarbonyl, R1WR3 are linked in this order to 5 and 6 positions, 6 and 7 positions, or 7 and 8 positions, respectively; R4 is H, halogen, alkyl, CF3, or NO2; R5 and R6 are H or alkyl; with the proviso that when R1WR3 are linked to 6, 7, and 8 positions, and R4 and R5 are H, R6 is not alkyl).
EXAMPLE: 3-( o-Chlorophenyl )-6-ethoxycarbonyl-5, 7-dimethyl-2-( N-methylcarbamoyloxymethyl)-4(3H)-quinazolone.
USE: A vasoldilator, blood stream improver, hypotensor, or arteriosclerosis alleviating agent.
PROCESS: For example, a 2-hydroxymethyl-4-quinazolone derivative shown by the formula II is reacted with an isocyanate shown by the formula II is reacted with an isocyanate shown by the formula R5NCO (when R6 in the formulaIis H) or a carbamine derivative shown by the formula III, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP390481A 1981-01-16 1981-01-16 Novel 3-phenyl-4-quinazolone derivative Pending JPS57118570A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP390481A JPS57118570A (en) 1981-01-16 1981-01-16 Novel 3-phenyl-4-quinazolone derivative
AU79172/82A AU543928B2 (en) 1981-01-16 1982-01-04 4(311)-quinazolinone derivatives
US06/337,454 US4451467A (en) 1981-01-16 1982-01-06 4(3H)-Quinazolinone derivatives, process for production thereof, and pharmaceutical compositions comprising said compounds
ES508765A ES8304097A1 (en) 1981-01-16 1982-01-15 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds.
CA000394290A CA1167442A (en) 1981-01-16 1982-01-15 4(3h)-quinazolinone derivatives, process for production thereof, and pharmaceutical compositions comprising said compounds
DE8282100273T DE3264802D1 (en) 1981-01-16 1982-01-15 4(3h)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds
EP82100273A EP0056637B1 (en) 1981-01-16 1982-01-15 4(3h)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP390481A JPS57118570A (en) 1981-01-16 1981-01-16 Novel 3-phenyl-4-quinazolone derivative

Publications (1)

Publication Number Publication Date
JPS57118570A true JPS57118570A (en) 1982-07-23

Family

ID=11570174

Family Applications (1)

Application Number Title Priority Date Filing Date
JP390481A Pending JPS57118570A (en) 1981-01-16 1981-01-16 Novel 3-phenyl-4-quinazolone derivative

Country Status (1)

Country Link
JP (1) JPS57118570A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative
JP2009149658A (en) * 2002-02-06 2009-07-09 Novartis Ag Quinazolinone derivatives and their use as cb agonists
JP4994552B2 (en) * 1999-09-16 2012-08-08 キュリス，インコーポレイテッド Hedgehog signaling pathway mediators, compositions and related uses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4994552B2 (en) * 1999-09-16 2012-08-08 キュリス，インコーポレイテッド Hedgehog signaling pathway mediators, compositions and related uses
JP2009149658A (en) * 2002-02-06 2009-07-09 Novartis Ag Quinazolinone derivatives and their use as cb agonists
JP2008156358A (en) * 2004-02-13 2008-07-10 Banyu Pharmaceut Co Ltd Fused ring 4-oxopyrimidine derivative

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