BR9812948A - Derivado de 1,2-benzoisotiazol 2-substituìdo, e, uso do composto - Google Patents
Derivado de 1,2-benzoisotiazol 2-substituìdo, e, uso do compostoInfo
- Publication number
- BR9812948A BR9812948A BR9812948-1A BR9812948A BR9812948A BR 9812948 A BR9812948 A BR 9812948A BR 9812948 A BR9812948 A BR 9812948A BR 9812948 A BR9812948 A BR 9812948A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- branched
- unbranched
- phenyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
"DERIVADO DE 1,2-BENZOISOTIAZOL 2-SUBSTITUìDO, E, USO DO COMPOSTO" A invenção está relacionada a derivados de 1,2-benzoisotiazol 2-substituído com a fórmula (I) na qual R^ 1^ e R^ 2^ representam alquila (C~ 1-6~), independentemente um do outro; A representa alquileno (C~ 1-10~) ramificada ou não ramificada ou alquileno (C~ 2-10~) de cadeia linear ou ramificada que compreende pelo menos um grupo Z o qual é selecionado de O, S, NR^ 7^, ciclopropila, CHOH, uma dupla ou tripla ligação; B representa 4-piperidina, 4-tetrahidro-1,2,3,6-piridina, 4-piperazina e os correspondentes compostos em anel aumentados com um grupo metileno, sendo que um átomo de N de B proporciona a união com A; Ar representa fenila o qual é opcionalmente substituído por alquila (C~ 1-6~) ramificada ou não ramificada, O-alquila (C~ 1-6~) ramificada ou não ramificada, OH, F, Cl, Br, I, trifluorometila, NR^ 5^R^ 6^, CO~ 2~R^ 7^, ciano ou fenila, tetralina, indano, aromáticos altamente condensados tais como naftaleno opcionalmente substituído por alquila (C~ 1-4~) ou O-alquila (C~ 1-4~); antraceno ou aromáticos de 5 ou 6 membros heterocíclicos com 1 ou 2 heteroátomos os quais são selecionados independentemente um do outro de O e N e que pode ser ainda anelado com outros radicais aromáticos tais como quinolina, isoquinolina, ftalazina, indol e quinazolina e que pode ele próprio ser substituído novamente com fenila; e R^ 3^ e R^ 4^ que possuem os significados apresentados na descrição. A invenção está relacionada ainda à produção dos derivados da invenção e ao seu uso como antagonistas de serotonina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19746612A DE19746612A1 (de) | 1997-10-22 | 1997-10-22 | 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung |
| PCT/EP1998/006300 WO1999020616A1 (de) | 1997-10-22 | 1998-10-05 | 2-substituierte 1,2-benzisothiazol-derivate und ihre verwendung als serotonin-antagonisten (5-ht1a, 5-ht1b und 5-ht1d) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812948A true BR9812948A (pt) | 2000-08-08 |
Family
ID=7846266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812948-1A BR9812948A (pt) | 1997-10-22 | 1998-10-05 | Derivado de 1,2-benzoisotiazol 2-substituìdo, e, uso do composto |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6346622B1 (pt) |
| EP (1) | EP1034170A1 (pt) |
| JP (1) | JP2001520224A (pt) |
| KR (1) | KR20010031297A (pt) |
| CN (1) | CN1277607A (pt) |
| AR (1) | AR016968A1 (pt) |
| AU (1) | AU748613B2 (pt) |
| BG (1) | BG104332A (pt) |
| BR (1) | BR9812948A (pt) |
| CA (1) | CA2307199A1 (pt) |
| CO (1) | CO4980863A1 (pt) |
| DE (1) | DE19746612A1 (pt) |
| HR (1) | HRP980555A2 (pt) |
| HU (1) | HUP0003758A3 (pt) |
| IL (1) | IL135256A0 (pt) |
| NO (1) | NO20001937D0 (pt) |
| NZ (1) | NZ503604A (pt) |
| PL (1) | PL340033A1 (pt) |
| SK (1) | SK4572000A3 (pt) |
| TR (1) | TR200001080T2 (pt) |
| TW (1) | TW517052B (pt) |
| WO (1) | WO1999020616A1 (pt) |
| ZA (1) | ZA989571B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
| PL375981A1 (en) * | 2002-09-17 | 2005-12-12 | Warner-Lambert Company Llc | Heterocyclic substituted piperazines for the treatment of schizophrenia |
| US20040127501A1 (en) * | 2002-09-24 | 2004-07-01 | Zhengming Chen | Therapeutic agents useful for treating pain |
| EP1560488B1 (en) | 2002-11-05 | 2010-09-01 | Glaxo Group Limited | Antibacterial agents |
| KR100472988B1 (ko) | 2002-11-27 | 2005-03-10 | 씨제이 주식회사 | 조직감, 취반성 및 안전성이 우수한 발아 현미의 제조방법및 이로부터 얻은 발아 현미 |
| CN101151249B (zh) * | 2005-03-31 | 2011-04-06 | 辉瑞产品公司 | 环戊吡啶及四氢喹啉衍生物 |
| ES2964383T3 (es) * | 2008-12-11 | 2024-04-05 | Viiv Healthcare Co | Procesos e intermedios para inhibidores de la integrasa del VIH de carbamoilpiridona |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT43600A (en) | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
| DE3620643A1 (de) * | 1985-06-22 | 1987-01-22 | Sandoz Ag | Thiazole, ihre herstellung und verwendung |
| FR2662696A2 (fr) | 1989-12-13 | 1991-12-06 | Rhone Poulenc Sante | Antagonistes de la serotonine, leur preparation et medicaments les contenant. |
| FR2675800A1 (fr) * | 1991-04-26 | 1992-10-30 | Rhone Poulenc Rorer Sa | Derives heterocycliques antiserotonines leur preparation et les medicaments les contenant. |
| JPH0912562A (ja) * | 1995-06-22 | 1997-01-14 | Suntory Ltd | 置換ベンゾチアジン誘導体 |
-
1997
- 1997-10-22 DE DE19746612A patent/DE19746612A1/de not_active Withdrawn
-
1998
- 1998-10-05 HU HU0003758A patent/HUP0003758A3/hu unknown
- 1998-10-05 NZ NZ503604A patent/NZ503604A/en unknown
- 1998-10-05 SK SK457-2000A patent/SK4572000A3/sk unknown
- 1998-10-05 KR KR1020007004286A patent/KR20010031297A/ko not_active Application Discontinuation
- 1998-10-05 PL PL98340033A patent/PL340033A1/xx unknown
- 1998-10-05 CN CN98810529A patent/CN1277607A/zh active Pending
- 1998-10-05 WO PCT/EP1998/006300 patent/WO1999020616A1/de not_active Application Discontinuation
- 1998-10-05 CA CA002307199A patent/CA2307199A1/en not_active Abandoned
- 1998-10-05 JP JP2000516958A patent/JP2001520224A/ja active Pending
- 1998-10-05 TR TR2000/01080T patent/TR200001080T2/xx unknown
- 1998-10-05 BR BR9812948-1A patent/BR9812948A/pt not_active IP Right Cessation
- 1998-10-05 AU AU11497/99A patent/AU748613B2/en not_active Ceased
- 1998-10-05 EP EP98954330A patent/EP1034170A1/en not_active Withdrawn
- 1998-10-05 IL IL13525698A patent/IL135256A0/xx unknown
- 1998-10-05 US US09/529,828 patent/US6346622B1/en not_active Expired - Lifetime
- 1998-10-20 TW TW087117331A patent/TW517052B/zh active
- 1998-10-20 CO CO98060934A patent/CO4980863A1/es unknown
- 1998-10-21 ZA ZA9809571A patent/ZA989571B/xx unknown
- 1998-10-21 HR HR19746612.5A patent/HRP980555A2/hr not_active Application Discontinuation
- 1998-10-21 AR ARP980105243A patent/AR016968A1/es not_active Application Discontinuation
-
2000
- 2000-04-11 BG BG104332A patent/BG104332A/xx unknown
- 2000-04-13 NO NO20001937A patent/NO20001937D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003758A1 (hu) | 2001-10-28 |
| HRP980555A2 (en) | 1999-08-31 |
| HUP0003758A3 (en) | 2001-12-28 |
| AU748613B2 (en) | 2002-06-06 |
| NZ503604A (en) | 2002-03-01 |
| IL135256A0 (en) | 2001-05-20 |
| SK4572000A3 (en) | 2000-10-09 |
| TR200001080T2 (tr) | 2001-01-22 |
| WO1999020616A1 (de) | 1999-04-29 |
| JP2001520224A (ja) | 2001-10-30 |
| AR016968A1 (es) | 2001-08-01 |
| CA2307199A1 (en) | 1999-04-29 |
| CO4980863A1 (es) | 2000-11-27 |
| TW517052B (en) | 2003-01-11 |
| KR20010031297A (ko) | 2001-04-16 |
| BG104332A (en) | 2001-02-28 |
| CN1277607A (zh) | 2000-12-20 |
| ZA989571B (en) | 2000-04-25 |
| EP1034170A1 (en) | 2000-09-13 |
| PL340033A1 (en) | 2001-01-15 |
| NO20001937L (no) | 2000-04-13 |
| DE19746612A1 (de) | 1999-04-29 |
| US6346622B1 (en) | 2002-02-12 |
| NO20001937D0 (no) | 2000-04-13 |
| AU1149799A (en) | 1999-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A E 8A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |