BR0115580A - Derivados de 3-aroilindol e a utilizaçao dos mesmos como agonistas dos receptores cb2 - Google Patents
Derivados de 3-aroilindol e a utilizaçao dos mesmos como agonistas dos receptores cb2Info
- Publication number
- BR0115580A BR0115580A BR0115580-6A BR0115580A BR0115580A BR 0115580 A BR0115580 A BR 0115580A BR 0115580 A BR0115580 A BR 0115580A BR 0115580 A BR0115580 A BR 0115580A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor agonists
- derivatives
- aroylindole
- compounds
- aroilindol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Obesity (AREA)
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Abstract
"DERIVADOS DE 3-AROILINDOL E A UTILIZAçãO DOS MESMOS COMO AGONISTAS DOS RECEPTORES CB2". Derivados de 3-aroilindol e a utilização dos mesmos como agonistas dos receptores CB~ 2~. A presente invenção refere-se aos compostos de fórmula: (I) assim como a respectiva preparação e as composições farmacêuticas que os contêm. Esses compostos são agonistas dos receptores aos canabinóides CB~ 2~.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0015158A FR2816938B1 (fr) | 2000-11-22 | 2000-11-22 | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
PCT/FR2001/003665 WO2002042269A1 (fr) | 2000-11-22 | 2001-11-21 | Derives de 3-aroylindole et leur utilisation en tant qu'agonistes des recepteurs cb2 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0115580A true BR0115580A (pt) | 2003-09-09 |
Family
ID=8856819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0115580-6A BR0115580A (pt) | 2000-11-22 | 2001-11-21 | Derivados de 3-aroilindol e a utilizaçao dos mesmos como agonistas dos receptores cb2 |
Country Status (32)
Country | Link |
---|---|
US (1) | US6995184B2 (pt) |
EP (1) | EP1339679B1 (pt) |
JP (1) | JP4264258B2 (pt) |
KR (1) | KR20030048161A (pt) |
CN (1) | CN1234688C (pt) |
AR (1) | AR033594A1 (pt) |
AT (1) | ATE301638T1 (pt) |
AU (1) | AU2002222001A1 (pt) |
BG (1) | BG107827A (pt) |
BR (1) | BR0115580A (pt) |
CA (1) | CA2427444A1 (pt) |
CZ (1) | CZ20031392A3 (pt) |
DE (1) | DE60112607T2 (pt) |
DK (1) | DK1339679T3 (pt) |
DZ (1) | DZ3443A1 (pt) |
EA (1) | EA005854B1 (pt) |
EE (1) | EE200300244A (pt) |
ES (1) | ES2247201T3 (pt) |
FR (1) | FR2816938B1 (pt) |
HR (1) | HRP20030417A2 (pt) |
HU (1) | HUP0400561A2 (pt) |
IL (1) | IL155634A0 (pt) |
IS (1) | IS6802A (pt) |
MA (1) | MA26959A1 (pt) |
MX (1) | MXPA03004549A (pt) |
NO (1) | NO20031952L (pt) |
NZ (1) | NZ525609A (pt) |
PL (1) | PL362276A1 (pt) |
SK (1) | SK6042003A3 (pt) |
TW (1) | TWI224592B (pt) |
WO (1) | WO2002042269A1 (pt) |
ZA (1) | ZA200303728B (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200407110A (en) * | 2001-11-23 | 2004-05-16 | Astrazeneca Ab | New use for the treatment of gastroesophageal reflux disease |
JP2006517194A (ja) | 2002-06-06 | 2006-07-20 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム | 骨成長を調節するための方法、組成物および製造物 |
JP4667867B2 (ja) | 2002-08-02 | 2011-04-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換フロ[2,3−b]ピリジン誘導体 |
FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
FR2847899B1 (fr) | 2002-11-29 | 2006-04-28 | Sanofi Synthelabo | Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique |
FR2854633B1 (fr) * | 2003-05-07 | 2005-06-24 | Sanofi Synthelabo | Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique |
FR2856684B1 (fr) * | 2003-06-26 | 2008-04-11 | Sanofi Synthelabo | Derives de diphenylpyridine, leur preparation et leur application en therapeutique |
FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
CA2571679A1 (en) * | 2004-06-22 | 2005-12-29 | Pharmos Limited | Use of cb2 receptors agonists for the treatment of huntington's disease |
EA011307B1 (ru) | 2004-07-12 | 2009-02-27 | Кадила Хелзкэр Лимитед | Трициклические производные пиразола в качестве модуляторов каннабиноидного рецептора |
US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
EP1819338A4 (en) * | 2004-11-22 | 2009-11-04 | Threshold Pharmaceuticals Inc | ANTICANCER TUBULIN-BINDING AGENTS AND THEIR PRODUCTS |
JP4922946B2 (ja) * | 2004-12-21 | 2012-04-25 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての3−シクロアルキルカルボニルインドール類 |
FR2893615B1 (fr) * | 2005-11-18 | 2008-03-07 | Sanofi Aventis Sa | Derives de 3-acylindole, leur preparation et leur application en therapeutique |
US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
CA2647598A1 (en) | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
GB0702862D0 (en) * | 2007-02-14 | 2007-03-28 | Univ Aberdeen | Therapeutic compounds |
CN101765594A (zh) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
FR2915199B1 (fr) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique. |
US8735434B2 (en) | 2007-05-18 | 2014-05-27 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US9193713B2 (en) * | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
FR2933697B1 (fr) * | 2008-07-11 | 2010-08-13 | Sanofi Aventis | Derives de 1-benzyl-cinnolin-4-(1h)-one substitues, leur preparation et leur application en therapeutique |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US8188135B2 (en) | 2008-09-16 | 2012-05-29 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
FR2941696B1 (fr) | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
FR2945533B1 (fr) | 2009-05-12 | 2011-05-27 | Sanofi Aventis | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
US20120277296A1 (en) | 2009-07-23 | 2012-11-01 | Sophie Lotersztajn | Selective CB2 Receptor Agonists for Use in the Prevention or Treatment of Alcoholic Liver Disease |
FR2950055A1 (fr) | 2009-09-17 | 2011-03-18 | Sanofi Aventis | Derives de 3-amino-cinnolin-4(1h)-one substitues, leur preparation et leur application en therapeutique |
WO2011100359A1 (en) * | 2010-02-09 | 2011-08-18 | Ironwood Pharmaceuticals, Inc. | Cannabinoid agonists |
FR2983859B1 (fr) | 2011-12-12 | 2014-01-17 | Sanofi Sa | Derives de 1,3,5-triazine-2-amine, leur preparation et leur application en diagnostique et en therapeutique |
CN105899948A (zh) * | 2013-11-28 | 2016-08-24 | 联邦科学技术研究组织 | 检测疟原虫感染的方法 |
CN108794379A (zh) * | 2017-04-26 | 2018-11-13 | 华东师范大学 | 1h-吲哚-2-甲酰胺衍生物及其制备方法和应用 |
WO2022128050A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammation and pain |
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US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
EP1223929B1 (en) * | 1999-10-18 | 2006-08-23 | The University Of Connecticut | Cannabimimetic indole derivatives |
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