KR20220035941A - Parp1 억제제 - Google Patents
Parp1 억제제Info
- Publication number
- KR20220035941A KR20220035941A KR1020227005427A KR20227005427A KR20220035941A KR 20220035941 A KR20220035941 A KR 20220035941A KR 1020227005427 A KR1020227005427 A KR 1020227005427A KR 20227005427 A KR20227005427 A KR 20227005427A KR 20220035941 A KR20220035941 A KR 20220035941A
- Authority
- KR
- South Korea
- Prior art keywords
- parp1 inhibitor
- parp1
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962876065P | 2019-07-19 | 2019-07-19 | |
| PCT/EP2020/070306 WO2021013735A1 (en) | 2019-07-19 | 2020-07-17 | Parp1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220035941A true KR20220035941A (ko) | 2022-03-22 |
Family
ID=71728735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227005427A KR20220035941A (ko) | 2019-07-19 | 2020-07-17 | Parp1 억제제 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11325906B2 (ko) |
| EP (1) | EP3999506A1 (ko) |
| JP (1) | JP2022541483A (ko) |
| KR (1) | KR20220035941A (ko) |
| CN (1) | CN114144413A (ko) |
| AR (1) | AR119424A1 (ko) |
| AU (1) | AU2020318599B2 (ko) |
| BR (1) | BR112022000534A2 (ko) |
| CA (1) | CA3145644A1 (ko) |
| CL (1) | CL2022000110A1 (ko) |
| CO (1) | CO2022001590A2 (ko) |
| CR (1) | CR20220070A (ko) |
| DO (1) | DOP2022000006A (ko) |
| EC (1) | ECSP22012826A (ko) |
| IL (1) | IL289534A (ko) |
| JO (1) | JOP20220008A1 (ko) |
| MX (1) | MX2022000711A (ko) |
| PE (1) | PE20221339A1 (ko) |
| UY (1) | UY38793A (ko) |
| WO (1) | WO2021013735A1 (ko) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11826430B2 (en) | 2019-05-14 | 2023-11-28 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| EP4058464A1 (en) | 2019-11-13 | 2022-09-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| TW202228693A (zh) * | 2020-10-08 | 2022-08-01 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之組合療法 |
| CA3195117A1 (en) | 2020-10-09 | 2022-04-14 | Jerome Thomas Mettetal Ii | Combination of antibody-drug conjugate and parp1 selective inhibitor |
| US11834458B2 (en) | 2021-03-23 | 2023-12-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| CA3216373A1 (en) * | 2021-04-19 | 2022-10-27 | Lynnie TRZOSS | Parp1 inhibitors and uses thereof |
| KR20230175225A (ko) * | 2021-04-22 | 2023-12-29 | 위겐 바이오메더슨 테크널러지 (상하이) 컴퍼니 리미티드 | 피페라진 구조를 포함하는 파프 억제제, 그의 제조 방법 및 그의 약제학적 용도 |
| WO2022222965A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| CN116710433A (zh) * | 2021-04-23 | 2023-09-05 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| CN115232154A (zh) * | 2021-04-23 | 2022-10-25 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| WO2022222995A1 (zh) * | 2021-04-23 | 2022-10-27 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| JP2024516024A (ja) * | 2021-05-03 | 2024-04-11 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
| AU2022276986A1 (en) * | 2021-05-18 | 2023-11-30 | Onconic Therapeutics Inc. | Parp inhibitor-resistant cancer therapeutic agent |
| AU2022280845A1 (en) | 2021-05-24 | 2023-12-14 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Nitrogen-containing heterocyclic compound, preparation method therefor, and application thereof in medicines |
| WO2022261777A1 (en) * | 2021-06-16 | 2022-12-22 | Repare Therapeutics Inc. | Use of atr inhibitors in combination with parp inhibitors for treating cancer |
| WO2022271547A1 (en) | 2021-06-21 | 2022-12-29 | Tesaro, Inc. | Combination treatment of cancer with a parp inhibitor and a lipophilic statin |
| WO2023036285A1 (zh) * | 2021-09-09 | 2023-03-16 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
| WO2023046149A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 喹喔啉类化合物及其医药用途 |
| WO2023051716A1 (zh) * | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 杂芳基衍生物parp抑制剂及其用途 |
| WO2023051807A1 (zh) | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 双环衍生物parp抑制剂及其用途 |
| WO2023051812A1 (zh) | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 含氮杂环衍生物parp抑制剂及其用途 |
| US20230159525A1 (en) | 2021-10-01 | 2023-05-25 | Xinthera, Inc. | Azetidine and pyrrolidine parp1 inhibitors and uses thereof |
| WO2023061406A1 (zh) * | 2021-10-12 | 2023-04-20 | 微境生物医药科技(上海)有限公司 | 含三并环结构的parp抑制剂、及其制备方法和医药用途 |
| TW202322811A (zh) * | 2021-10-22 | 2023-06-16 | 大陸商海思科醫藥集團股份有限公司 | Parp-1降解劑及其用途 |
| TW202329936A (zh) | 2021-11-18 | 2023-08-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物與parp1選擇性抑制劑之組合 |
| WO2023088408A1 (zh) * | 2021-11-19 | 2023-05-25 | 成都百裕制药股份有限公司 | 选择性parp1抑制剂及其应用 |
| WO2023096915A1 (en) * | 2021-11-24 | 2023-06-01 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023109521A1 (zh) * | 2021-12-17 | 2023-06-22 | 凯复(苏州)生物医药有限公司 | Parp抑制剂、包含其的药物组合物及其用途 |
| WO2023118085A1 (en) * | 2021-12-21 | 2023-06-29 | Astrazeneca Ab | Methods of treating brain tumours and neuroblastomas |
| WO2023122140A1 (en) * | 2021-12-22 | 2023-06-29 | Synnovation Therapeutics, Inc. | Parp1 inhibitors |
| WO2023133413A1 (en) * | 2022-01-07 | 2023-07-13 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023134647A1 (zh) * | 2022-01-13 | 2023-07-20 | 优领医药科技(香港)有限公司 | 含哌嗪并环类衍生物、其药学上可接受的盐及其制备方法和应用 |
| WO2023138541A1 (zh) * | 2022-01-20 | 2023-07-27 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| WO2023141290A1 (en) | 2022-01-21 | 2023-07-27 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| WO2023146957A1 (en) * | 2022-01-27 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| WO2023146960A1 (en) * | 2022-01-28 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| WO2023165501A1 (zh) * | 2022-03-01 | 2023-09-07 | 杭州领业医药科技有限公司 | Azd5305的晶型及其制备方法和用途 |
| WO2023178035A1 (en) * | 2022-03-14 | 2023-09-21 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2023194530A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Combination therapy for treating cancer |
| WO2023194525A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Combination therapy for treating cancer |
| WO2023194528A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Combination therapy for treating cancer |
| WO2023201338A1 (en) | 2022-04-15 | 2023-10-19 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a parp inhibitor |
| WO2023207284A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Piperazine derivatives as parp1 inhibitiors |
| WO2023207283A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Compounds as parp1 inhibitiors |
| EP4355749A1 (en) | 2022-04-28 | 2024-04-24 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| WO2023217045A1 (zh) * | 2022-05-07 | 2023-11-16 | 南京明德新药研发有限公司 | 选择性抑制parp1的氟代喹喔啉酮衍生物 |
| WO2023227052A1 (zh) * | 2022-05-25 | 2023-11-30 | 西藏海思科制药有限公司 | 双环衍生物parp抑制剂及其用途 |
| WO2023242302A1 (en) | 2022-06-15 | 2023-12-21 | Astrazeneca Ab | Combination therapy for treating cancer |
| WO2024012572A1 (zh) * | 2022-07-14 | 2024-01-18 | 西藏海思科制药有限公司 | 一种杂芳基衍生物的药物组合物及其在医药上的应用 |
| CN115919859B (zh) * | 2022-07-14 | 2024-01-05 | 四川海思科制药有限公司 | 一种杂芳基衍生物的药物组合物及其在医药上的应用 |
| CN115232129B (zh) * | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
| WO2024041605A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
| WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
| WO2024041643A1 (zh) * | 2022-08-25 | 2024-02-29 | 江苏恒瑞医药股份有限公司 | 稠合三环类化合物、其制备方法及其在医药上的应用 |
| WO2024046420A1 (zh) * | 2022-08-31 | 2024-03-07 | 江苏恒瑞医药股份有限公司 | 稠合二环类化合物、其制备方法及其在医药上的应用 |
| CN117658983A (zh) * | 2022-09-01 | 2024-03-08 | 浙江文达医药科技有限公司 | 选择性parp1抑制剂 |
| WO2024067691A1 (zh) * | 2022-09-30 | 2024-04-04 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| WO2024067694A1 (zh) * | 2022-09-30 | 2024-04-04 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| WO2024077137A1 (en) * | 2022-10-06 | 2024-04-11 | Xinthera, Inc. | Crystalline forms of a parp1 inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE198623T1 (de) | 1994-08-12 | 2001-01-15 | Myriad Genetics Inc | Verfahren zum nachweis von prädisposition von ovarial- und brustkrebs |
| JP2002503943A (ja) | 1994-08-12 | 2002-02-05 | ミリアド・ジェネティックス・インコーポレイテッド | １７ｑ−連鎖乳癌および卵巣癌感受性遺伝子におけるイン・ビボ突然変異および多形性 |
| AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| EP1633724B1 (en) | 2003-03-12 | 2011-05-04 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| WO2005054201A1 (en) | 2003-11-20 | 2005-06-16 | Janssen Pharmaceutica N.V. | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| EA010488B1 (ru) | 2003-12-05 | 2008-10-30 | Янссен Фармацевтика Н.В. | 6-замещённые 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли (адф-рибоза) полимеразы |
| WO2005058843A1 (en) | 2003-12-10 | 2005-06-30 | Janssen Pharmaceutica N.V. | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| EP1791827A1 (en) | 2004-08-26 | 2007-06-06 | Kudos Pharmaceuticals Limited | 4-heteroarylmethyl substituted phthalazinone derivatives |
| ES2381446T3 (es) | 2007-03-08 | 2012-05-28 | Janssen Pharmaceutica, N.V. | Derivado de quinolinona como inhibidores de PARP y TANK |
| PL2215075T3 (pl) | 2007-10-26 | 2014-04-30 | Janssen Pharmaceutica Nv | Pochodne chinolinonu jako inhibitory PARP |
| UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
| EP2389379A1 (en) * | 2009-01-23 | 2011-11-30 | Takeda Pharmaceutical Company Limited | Poly (ADP-Ribose) Polymerase (PARP) Inhibitors |
| US8541417B2 (en) * | 2009-07-30 | 2013-09-24 | Takeda Pharmaceutical Company Limited | Poly (ADP-ribose) polymerase (PARP) inhibitors |
| AU2016276806B9 (en) * | 2015-06-09 | 2019-02-21 | Onconic Therapeutics Inc. | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
-
2020
- 2020-07-17 CA CA3145644A patent/CA3145644A1/en active Pending
- 2020-07-17 WO PCT/EP2020/070306 patent/WO2021013735A1/en active Application Filing
- 2020-07-17 EP EP20743121.4A patent/EP3999506A1/en active Pending
- 2020-07-17 CN CN202080051330.7A patent/CN114144413A/zh active Pending
- 2020-07-17 UY UY0001038793A patent/UY38793A/es unknown
- 2020-07-17 BR BR112022000534A patent/BR112022000534A2/pt unknown
- 2020-07-17 JP JP2022502556A patent/JP2022541483A/ja active Pending
- 2020-07-17 AR ARP200102008A patent/AR119424A1/es unknown
- 2020-07-17 MX MX2022000711A patent/MX2022000711A/es unknown
- 2020-07-17 JO JOP/2022/0008A patent/JOP20220008A1/ar unknown
- 2020-07-17 CR CR20220070A patent/CR20220070A/es unknown
- 2020-07-17 AU AU2020318599A patent/AU2020318599B2/en active Active
- 2020-07-17 US US16/931,792 patent/US11325906B2/en active Active
- 2020-07-17 KR KR1020227005427A patent/KR20220035941A/ko unknown
- 2020-07-17 PE PE2022000086A patent/PE20221339A1/es unknown
-
2021
- 2021-12-31 IL IL289534A patent/IL289534A/en unknown
-
2022
- 2022-01-17 CL CL2022000110A patent/CL2022000110A1/es unknown
- 2022-01-17 DO DO2022000006A patent/DOP2022000006A/es unknown
- 2022-02-16 CO CONC2022/0001590A patent/CO2022001590A2/es unknown
- 2022-02-17 EC ECSENADI202212826A patent/ECSP22012826A/es unknown
- 2022-04-07 US US17/715,463 patent/US20220227768A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CL2022000110A1 (es) | 2022-09-20 |
| WO2021013735A1 (en) | 2021-01-28 |
| PE20221339A1 (es) | 2022-09-13 |
| AR119424A1 (es) | 2021-12-15 |
| US11325906B2 (en) | 2022-05-10 |
| JP2022541483A (ja) | 2022-09-26 |
| MX2022000711A (es) | 2022-02-23 |
| US20210040084A1 (en) | 2021-02-11 |
| ECSP22012826A (es) | 2022-03-31 |
| EP3999506A1 (en) | 2022-05-25 |
| BR112022000534A2 (pt) | 2022-05-10 |
| IL289534A (en) | 2022-03-01 |
| JOP20220008A1 (ar) | 2023-01-30 |
| CA3145644A1 (en) | 2021-01-28 |
| DOP2022000006A (es) | 2022-03-15 |
| CN114144413A (zh) | 2022-03-04 |
| AU2020318599B2 (en) | 2023-09-07 |
| US20220227768A1 (en) | 2022-07-21 |
| CR20220070A (es) | 2022-03-21 |
| UY38793A (es) | 2021-02-26 |
| TW202116750A (zh) | 2021-05-01 |
| AU2020318599A1 (en) | 2022-03-10 |
| CO2022001590A2 (es) | 2022-03-18 |
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| ES1243687Y (es) | Salmorejo | |
| IT201900020430A1 (it) | Espositore | |
| DE202019004111U8 (de) | Weichenstellvorichtung | |
| TH190914S (th) | ขันโตก | |
| TH190910S (th) | ขันโตก | |
| TH190911S (th) | ขันโตก | |
| DK3786413T3 (da) | Rullejalousi | |
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| UA40636S (uk) | Мотоблок | |
| UA40530S (uk) | Електропила ланцюгова | |
| UA40531S (uk) | Електропила ланцюгова | |
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