ATE198623T1 - Verfahren zum nachweis von prädisposition von ovarial- und brustkrebs - Google Patents
Verfahren zum nachweis von prädisposition von ovarial- und brustkrebsInfo
- Publication number
- ATE198623T1 ATE198623T1 AT95305602T AT95305602T ATE198623T1 AT E198623 T1 ATE198623 T1 AT E198623T1 AT 95305602 T AT95305602 T AT 95305602T AT 95305602 T AT95305602 T AT 95305602T AT E198623 T1 ATE198623 T1 AT E198623T1
- Authority
- AT
- Austria
- Prior art keywords
- ovarian cancer
- relates
- breast
- human
- diagnosis
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 6
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 206010033128 Ovarian cancer Diseases 0.000 abstract 5
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 5
- 210000000481 breast Anatomy 0.000 abstract 5
- 108700040618 BRCA1 Genes Proteins 0.000 abstract 3
- 101150072950 BRCA1 gene Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 3
- 206010069754 Acquired gene mutation Diseases 0.000 abstract 2
- 238000004393 prognosis Methods 0.000 abstract 2
- 230000037439 somatic mutation Effects 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28922194A | 1994-08-12 | 1994-08-12 | |
| US30026694A | 1994-09-02 | 1994-09-02 | |
| US30810494A | 1994-09-09 | 1994-09-09 | |
| US34882494A | 1994-11-29 | 1994-11-29 | |
| US40930595A | 1995-03-24 | 1995-03-24 | |
| US48801195A | 1995-06-07 | 1995-06-07 | |
| US08/483,554 US5747282A (en) | 1994-08-12 | 1995-06-07 | 17Q-linked breast and ovarian cancer susceptibility gene |
| US08/487,002 US5710001A (en) | 1994-08-12 | 1995-06-07 | 17q-linked breast and ovarian cancer susceptibility gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198623T1 true ATE198623T1 (de) | 2001-01-15 |
Family
ID=27575337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95305601T ATE209660T1 (de) | 1994-08-12 | 1995-08-11 | 17q-verbundenes ovarial- und brustkrebs empfindlichkeitsgen |
| AT95305602T ATE198623T1 (de) | 1994-08-12 | 1995-08-11 | Verfahren zum nachweis von prädisposition von ovarial- und brustkrebs |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95305601T ATE209660T1 (de) | 1994-08-12 | 1995-08-11 | 17q-verbundenes ovarial- und brustkrebs empfindlichkeitsgen |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP0699754B2 (de) |
| JP (1) | JP3399539B2 (de) |
| CN (1) | CN1159829A (de) |
| AT (2) | ATE209660T1 (de) |
| AU (2) | AU691331B2 (de) |
| CA (2) | CA2196795C (de) |
| DE (2) | DE69519834T3 (de) |
| DK (2) | DK0705902T3 (de) |
| ES (2) | ES2164136T5 (de) |
| FI (2) | FI970514A7 (de) |
| GR (1) | GR3035631T3 (de) |
| NO (2) | NO970625L (de) |
| NZ (1) | NZ291624A (de) |
| PT (2) | PT699754E (de) |
| WO (2) | WO1996005307A2 (de) |
Families Citing this family (74)
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|---|---|---|---|---|
| WO1995019369A1 (en) | 1994-01-14 | 1995-07-20 | Vanderbilt University | Method for detection and treatment of breast cancer |
| US6403303B1 (en) | 1996-05-14 | 2002-06-11 | Visible Genetics Inc. | Method and reagents for testing for mutations in the BRCA1 gene |
| US6083698A (en) * | 1995-09-25 | 2000-07-04 | Oncormed, Inc. | Cancer susceptibility mutations of BRCA1 |
| US6951721B2 (en) | 1996-02-12 | 2005-10-04 | Gene Logic Inc. | Method for determining the haplotype of a human BRCA1 gene |
| US6838256B2 (en) | 1996-02-12 | 2005-01-04 | Gene Logic Inc. | Coding sequences of the human BRCA1 gene |
| US6130322A (en) * | 1996-02-12 | 2000-10-10 | Gene Logic, Inc. | Coding sequences of the human BRCA1 gene |
| US5654155A (en) * | 1996-02-12 | 1997-08-05 | Oncormed, Inc. | Consensus sequence of the human BRCA1 gene |
| US5891857A (en) * | 1996-02-20 | 1999-04-06 | Vanderbilt University | Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins |
| EP0950189A4 (de) | 1996-08-02 | 2000-06-07 | Wistar Inst | Brca1-assoziiertes protein (bap-1) und anwenudngen dafür |
| WO1998012327A2 (en) * | 1996-09-20 | 1998-03-26 | Board Of Regents, The University Of Texas System | Compositions and methods comprising bard1 and other brca1 binding proteins |
| WO1998025125A2 (en) * | 1996-12-03 | 1998-06-11 | Swift Michael R | Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus |
| US5965377A (en) * | 1997-03-24 | 1999-10-12 | Baystate Medical Center | Method for determining the presence of mutated BRCA protein |
| WO1998055650A1 (en) * | 1997-06-04 | 1998-12-10 | Rijksuniversiteit Te Leiden | A diagnostic test kit for determining a predisposition for breast and ovarian cancer, materials and methods for such determination |
| CA2292843A1 (en) * | 1997-07-07 | 1999-01-21 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
| US5994096A (en) * | 1997-07-25 | 1999-11-30 | Smithkline Beecham Corporation | Regulator |
| US6492109B1 (en) | 1997-09-23 | 2002-12-10 | Gene Logic, Inc. | Susceptibility mutation 6495delGC of BRCA2 |
| US6177410B1 (en) | 1997-12-05 | 2001-01-23 | Vanderbilt University | Therapeutic methods for prostate cancer |
| US6686163B2 (en) | 1998-05-06 | 2004-02-03 | Gene Logic Inc. | Coding sequence haplotype of the human BRCA1 gene |
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| AU2002258518A1 (en) * | 2001-03-14 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| FR2826012B1 (fr) * | 2001-06-13 | 2003-09-26 | Centre Nat Rech Scient | Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques |
| EP1430081A2 (de) * | 2001-06-13 | 2004-06-23 | Centre National De La Recherche Scientifique (Cnrs) | Molekuläre komplexe brca1/acc alpha, diagnostische und therapeutische verwendungen |
| FR2836919B1 (fr) * | 2002-03-05 | 2004-07-09 | Centre Nat Rech Scient | Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques |
| AU2003229953A1 (en) | 2002-04-30 | 2003-11-17 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| WO2005053662A1 (en) | 2003-12-01 | 2005-06-16 | Kudos Pharmaceuticals Limited | Dna damage repair inhibitors for treatment of cancer |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| CN101037690B (zh) * | 2006-03-16 | 2011-07-20 | 国家人口计生委科学技术研究所 | 具有新的单核苷酸多态性的brca1基因变体和其编码的蛋白质变体 |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| CN103424541B (zh) | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
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| UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| EP2805945B1 (de) | 2007-01-10 | 2019-04-03 | MSD Italia S.r.l. | Amidsubstituierte Indazole als Poly-(ADP-Ribose)-Polymerase (PARP)-Hemmer |
| GB0716532D0 (en) | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| JP2010539149A (ja) | 2007-09-14 | 2010-12-16 | アストラゼネカ アクチボラグ | フタラジノン誘導体 |
| JP5593229B2 (ja) | 2007-10-17 | 2014-09-17 | クドス ファーマシューティカルズ リミテッド | 4−[3−(4−シクロプロパンカルボニル−ピペラジン−1−カルボニル)−4−フルオロ−ベンジル]−2h−フタラジン−1−オン |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| EP2767537B1 (de) | 2008-08-06 | 2017-04-12 | Medivation Technologies, Inc. | Dihydropyridophthalazinonhemmer der Poly(ADP-Ribose)Polymerase (PARP) |
| EP2324127B1 (de) | 2008-08-10 | 2015-01-21 | Kuakini Medical Center | Verfahren zur verwendung von foxo3a-polymorphismen und haplotypen zur prognose und förderung von gesundem altern und langlebigkeit |
| ES2598178T5 (es) | 2008-10-07 | 2023-12-26 | Kudos Pharm Ltd | Formulación farmacéutica 514 |
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| AU2010221721A1 (en) * | 2009-02-06 | 2011-08-18 | Yale University | A SNP marker of breast and ovarian cancer risk |
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| KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| CN105525009B (zh) * | 2016-01-26 | 2018-10-16 | 绍兴华因生物科技有限公司 | 检测杂合性brca1/2基因缺失的方法及所用引物 |
| CN112566666A (zh) | 2018-05-14 | 2021-03-26 | 努瓦申生物公司 | 靶向抗癌核激素受体的化合物 |
| JP2022532342A (ja) | 2019-05-14 | 2022-07-14 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
| TWI837403B (zh) | 2019-07-19 | 2024-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
| CN113388680B (zh) * | 2020-03-14 | 2023-07-04 | 复旦大学附属妇产科医院 | 上皮性卵巢癌靶点ret及其在诊断和治疗中的作用 |
| KR102262529B1 (ko) * | 2020-06-15 | 2021-06-09 | 연세대학교 산학협력단 | Brca 변이성 난소암에 대한 진단 방법 및 이를 이용한 키트 |
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| CN119212702A (zh) | 2022-04-07 | 2024-12-27 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的组合疗法 |
| AU2023290506A1 (en) | 2022-06-15 | 2025-01-23 | Astrazeneca Ab | Combination therapy for treating cancer |
| TW202412859A (zh) | 2022-07-28 | 2024-04-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及雙特異性檢查點抑制劑之組合 |
| TW202440169A (zh) | 2022-11-30 | 2024-10-16 | 日商第一三共股份有限公司 | 抗體-藥物結合物與dnmt抑制劑之組合 |
| WO2025088496A1 (en) | 2023-10-24 | 2025-05-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and anti-pd-1/tim-3 bispecific binding protein |
| TW202535479A (zh) | 2023-12-05 | 2025-09-16 | 英商阿斯特捷利康英國股份有限公司 | 抗體藥物結合物與血腦屏障穿透性parp1選擇性抑制劑之組合 |
| TW202545525A (zh) | 2024-01-19 | 2025-12-01 | 瑞典商阿斯特捷利康公司 | 包含azd5305之藥物組成物 |
| WO2026052764A1 (en) | 2024-09-06 | 2026-03-12 | Astrazeneca Uk Limited | A scoring method for an anti-trop2 antibody drug conjugate therapy |
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| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| WO1994000764A1 (en) * | 1992-06-26 | 1994-01-06 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES | The met proto-oncogene and a method for predicting breast cancer progression |
| WO1995019369A1 (en) * | 1994-01-14 | 1995-07-20 | Vanderbilt University | Method for detection and treatment of breast cancer |
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1995
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- 1995-08-11 JP JP50751696A patent/JP3399539B2/ja not_active Expired - Lifetime
- 1995-08-11 DK DK95305601T patent/DK0705902T3/da active
- 1995-08-11 AU AU33216/95A patent/AU691331B2/en not_active Expired
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- 1995-08-11 CA CA002196790A patent/CA2196790C/en not_active Expired - Lifetime
- 1995-08-11 PT PT95305602T patent/PT699754E/pt unknown
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- 1995-08-11 NZ NZ291624A patent/NZ291624A/en not_active IP Right Cessation
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- 1995-08-11 CN CN95195311.7A patent/CN1159829A/zh active Pending
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1997
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