NO970626L - Fremgangsmåte for å diagnostisere disponering for bryst- og ovariekreft - Google Patents
Fremgangsmåte for å diagnostisere disponering for bryst- og ovariekreftInfo
- Publication number
- NO970626L NO970626L NO970626A NO970626A NO970626L NO 970626 L NO970626 L NO 970626L NO 970626 A NO970626 A NO 970626A NO 970626 A NO970626 A NO 970626A NO 970626 L NO970626 L NO 970626L
- Authority
- NO
- Norway
- Prior art keywords
- ovarian cancer
- breast
- relates
- human
- diagnosis
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 6
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 6
- 206010033128 Ovarian cancer Diseases 0.000 title abstract 6
- 206010061535 Ovarian neoplasm Diseases 0.000 title abstract 6
- 210000000481 breast Anatomy 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 108700040618 BRCA1 Genes Proteins 0.000 abstract 3
- 101150072950 BRCA1 gene Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 3
- 206010069754 Acquired gene mutation Diseases 0.000 abstract 2
- 238000004393 prognosis Methods 0.000 abstract 2
- 230000037439 somatic mutation Effects 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Foreliggende oppfinnelse vedrører generelt området human genetikk. Spesielt vedrøres fremgangsmåter og materialer benyttet til å isolere og detektere et human bryst- og ovariekreft predisponeringsgen (BRCA1), noen mutantalleler av hvilket forårsaker mottagelighet for kreft, særlig bryst- og ovariekreft. Mer spesielt vedrøres kjønnscelle-mutasjoner i BRCA1 genet og-deres bruk i diagnose av predisponering av human bryst- og ovariekreft. Ytterligere vedrører oppfinnelsen somatiske mutasjoner i BRCA1 genet i human bryst- og ovariekreft og deres anvendelse i diagnose og prognose av human bryst- og ovariekreft. 1 tillegg vedrøres somatiske mutasjoner i BRCA1 genet i andre humane kreftformer og deres bruk i diagnose og prognose av humane krefttyper. Oppfinnelsen vedrører også behandling av human kreft som har mutasjoner i BRGA1 genet inkludert genterapi, proteinerstatningsterapi og proteinetteriigninger. Det beskrives videre screening av legemidler for kreftbehandling. Endelig beskrives screening av BRCA1 genet for mutasjoner, som er nyttig for diagnostisering av predisponering av bryst- og ovariekreft.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28922194A | 1994-08-12 | 1994-08-12 | |
US30026694A | 1994-09-02 | 1994-09-02 | |
US30810494A | 1994-09-16 | 1994-09-16 | |
US34882494A | 1994-11-29 | 1994-11-29 | |
US40930595A | 1995-03-24 | 1995-03-24 | |
US48801195A | 1995-06-07 | 1995-06-07 | |
US08/487,002 US5710001A (en) | 1994-08-12 | 1995-06-07 | 17q-linked breast and ovarian cancer susceptibility gene |
US08/483,554 US5747282A (en) | 1994-08-12 | 1995-06-07 | 17Q-linked breast and ovarian cancer susceptibility gene |
PCT/US1995/010220 WO1996005308A1 (en) | 1994-08-12 | 1995-08-11 | Method for diagnosing a predisposition for breast and ovarian cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
NO970626D0 NO970626D0 (no) | 1997-02-11 |
NO970626L true NO970626L (no) | 1997-04-14 |
Family
ID=27575337
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO970626A NO970626L (no) | 1994-08-12 | 1997-02-11 | Fremgangsmåte for å diagnostisere disponering for bryst- og ovariekreft |
NO970625A NO970625L (no) | 1994-08-12 | 1997-02-11 | 17q-koblete bryst- og ovariekreft mottagelighetsgener |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO970625A NO970625L (no) | 1994-08-12 | 1997-02-11 | 17q-koblete bryst- og ovariekreft mottagelighetsgener |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP0699754B2 (no) |
JP (1) | JP3399539B2 (no) |
CN (1) | CN1159829A (no) |
AT (2) | ATE209660T1 (no) |
AU (2) | AU691331B2 (no) |
CA (2) | CA2196795C (no) |
DE (2) | DE69524182T3 (no) |
DK (2) | DK0699754T3 (no) |
ES (2) | ES2154712T5 (no) |
FI (2) | FI970514A (no) |
GR (1) | GR3035631T3 (no) |
NO (2) | NO970626L (no) |
NZ (1) | NZ291624A (no) |
PT (2) | PT699754E (no) |
WO (2) | WO1996005307A2 (no) |
Families Citing this family (68)
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WO1995019369A1 (en) | 1994-01-14 | 1995-07-20 | Vanderbilt University | Method for detection and treatment of breast cancer |
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US6838256B2 (en) | 1996-02-12 | 2005-01-04 | Gene Logic Inc. | Coding sequences of the human BRCA1 gene |
US6130322A (en) * | 1996-02-12 | 2000-10-10 | Gene Logic, Inc. | Coding sequences of the human BRCA1 gene |
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US6951721B2 (en) | 1996-02-12 | 2005-10-04 | Gene Logic Inc. | Method for determining the haplotype of a human BRCA1 gene |
US5891857A (en) * | 1996-02-20 | 1999-04-06 | Vanderbilt University | Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins |
CA2262479A1 (en) | 1996-08-02 | 1998-02-12 | The Wistar Institute Of Anatomy And Biology | Brca1 associated protein (bap-1) and uses therefor |
WO1998012327A2 (en) * | 1996-09-20 | 1998-03-26 | Board Of Regents, The University Of Texas System | Compositions and methods comprising bard1 and other brca1 binding proteins |
CA2273051A1 (en) * | 1996-12-03 | 1998-06-11 | Prasanna Athma | Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus |
US5965377A (en) * | 1997-03-24 | 1999-10-12 | Baystate Medical Center | Method for determining the presence of mutated BRCA protein |
CA2293674A1 (en) * | 1997-06-04 | 1998-12-10 | Egbert Bakker | A diagnostic test kit for determining a predisposition for breast and ovarian cancer, materials and methods for such determination |
EP1003779A1 (en) * | 1997-07-07 | 2000-05-31 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the breast |
US5994096A (en) * | 1997-07-25 | 1999-11-30 | Smithkline Beecham Corporation | Regulator |
US6492109B1 (en) | 1997-09-23 | 2002-12-10 | Gene Logic, Inc. | Susceptibility mutation 6495delGC of BRCA2 |
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US6686163B2 (en) | 1998-05-06 | 2004-02-03 | Gene Logic Inc. | Coding sequence haplotype of the human BRCA1 gene |
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AU2002317247A1 (en) * | 2001-06-13 | 2002-12-23 | Centre National De La Recherche Scientifique (C.N.R.S.) | Brca1/acc alpha molecular complexes, diagnostic and therapeutic applications |
FR2836919B1 (fr) * | 2002-03-05 | 2004-07-09 | Centre Nat Rech Scient | Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques |
FR2826012B1 (fr) * | 2001-06-13 | 2003-09-26 | Centre Nat Rech Scient | Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques |
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1995
- 1995-08-11 WO PCT/US1995/010203 patent/WO1996005307A2/en not_active Application Discontinuation
- 1995-08-11 DK DK95305602T patent/DK0699754T3/da active
- 1995-08-11 ES ES95305602T patent/ES2154712T5/es not_active Expired - Lifetime
- 1995-08-11 AU AU33216/95A patent/AU691331B2/en not_active Expired
- 1995-08-11 EP EP95305602A patent/EP0699754B2/en not_active Expired - Lifetime
- 1995-08-11 AU AU32428/95A patent/AU691958B2/en not_active Expired
- 1995-08-11 PT PT95305602T patent/PT699754E/pt unknown
- 1995-08-11 AT AT95305601T patent/ATE209660T1/de not_active IP Right Cessation
- 1995-08-11 PT PT95305601T patent/PT705902E/pt unknown
- 1995-08-11 EP EP95305601A patent/EP0705902B2/en not_active Expired - Lifetime
- 1995-08-11 WO PCT/US1995/010220 patent/WO1996005308A1/en not_active Application Discontinuation
- 1995-08-11 DK DK95305601T patent/DK0705902T3/da active
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- 1995-08-11 ES ES95305601T patent/ES2164136T5/es not_active Expired - Lifetime
- 1995-08-11 DE DE69524182T patent/DE69524182T3/de not_active Expired - Lifetime
- 1995-08-11 DE DE69519834T patent/DE69519834T3/de not_active Expired - Lifetime
- 1995-08-11 CA CA002196795A patent/CA2196795C/en not_active Expired - Lifetime
- 1995-08-11 CN CN95195311.7A patent/CN1159829A/zh active Pending
- 1995-08-11 CA CA002196790A patent/CA2196790C/en not_active Expired - Lifetime
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1997
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- 1997-02-11 NO NO970626A patent/NO970626L/no not_active Application Discontinuation
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2001
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