ES2164136T3 - Gen de susceptibilidad al cancer de mama y de ovarios asociado a 17q. - Google Patents

Gen de susceptibilidad al cancer de mama y de ovarios asociado a 17q.

Info

Publication number
ES2164136T3
ES2164136T3 ES95305601T ES95305601T ES2164136T3 ES 2164136 T3 ES2164136 T3 ES 2164136T3 ES 95305601 T ES95305601 T ES 95305601T ES 95305601 T ES95305601 T ES 95305601T ES 2164136 T3 ES2164136 T3 ES 2164136T3
Authority
ES
Spain
Prior art keywords
cancer
breast
human
invention refers
brca1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95305601T
Other languages
English (en)
Other versions
ES2164136T5 (es
Inventor
Mark H Skolnick
David E Goldgar
Yoshio Miki
Jeff Swensen
Alexander Kamb
Keith D Harshman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myriad Genetics Inc
University of Utah Research Foundation Inc
United States Department of Health and Human Services
Original Assignee
Myriad Genetics Inc
University of Utah Research Foundation Inc
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27575337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164136(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/483,554 external-priority patent/US5747282A/en
Priority claimed from US08/487,002 external-priority patent/US5710001A/en
Application filed by Myriad Genetics Inc, University of Utah Research Foundation Inc, United States Department of Health and Human Services filed Critical Myriad Genetics Inc
Application granted granted Critical
Publication of ES2164136T3 publication Critical patent/ES2164136T3/es
Publication of ES2164136T5 publication Critical patent/ES2164136T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE GENERALMENTE AL CAMPO DE LA GENETICA HUMANA. ESPECIFICAMENTE LA PRESENTE INVENCION SE REFIERE A METODOS Y MATERIALES UTILIZADOS PARA AISLAR Y DETECTAR UN GEN HUMANO DE PREDISPOSICION AL CANCER DE OVARIOS Y MAMA (BRCA1), ALGUNOS ALELOS MUTANTES QUE CAUSAN LA SUSCEPTIBILIDAD AL CANCER, EN PARTICULAR CANCER DE MAMA Y OVARIOS. MAS ESPECIFICAMENTE, LA INVENCION SE REFIERE A MUTACIONES DE LA LINEA GERMINAL EN EL GEN BRCA1 Y SU USO EN LA DIAGNOSIS DE LA PREDISPOSICION AL CANCER DE OVARIOS Y MAMA. LA PRESENTE INVENCION SE REFIERE ADEMAS A MUTACIONES SOMATICAS EN EL GEN BRCA1 EN EL CANCER DE OVARIOS Y DE MAMA HUMANO Y SU USO EN LA DIAGNOSIS Y PROGNOSIS DE DICHO CANCER. ADICIONALMENTE, LA INVENCION SE REFIERE A MUTACIONES SOMATICAS EN EL GEN BRCA1 EN OTROS CANCERES HUMANOS Y SU USO EN LA DIAGNOSIS Y PROGNOSIS DE CANCERES HUMANOS. LA INVENCION TAMBIEN SE REFIERE A LA TERAPIA DE CANCERES HUMANOS QUE TIENEN UNA MURATION EN EL GEN BRCA1, INCLUYENDO TERAPIA GENETICA, TERAPIA DE SUSTITUCION PROTEINA Y MIMETICAS DE PROTEINA. LA INVENCION SE REFIERE ADEMAS AL ESTUDIO DE MEDICAMENTOS PARA EL CANCER. FINALMENTE, LA INVENCION TAMBIEN SE REFIERE AL ESTUDIO DEL GEN BRCA1 PARA MUTACIONES QUE SON UTILES PARA LA DIAGNOSIS DE LA PREDISPOSICION AL CANCER DE MAMA Y OVARIOS.
ES95305601T 1994-08-12 1995-08-11 Sondas de acidos nucleicos que copmrenden un fragmento del gen de susceptibilidad al cancer de mama y ovarios asociado a 17q. Expired - Lifetime ES2164136T5 (es)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US28922194A 1994-08-12 1994-08-12
US289221 1994-08-12
US30026694A 1994-09-02 1994-09-02
US300266 1994-09-02
US30810494A 1994-09-16 1994-09-16
US308104 1994-09-16
US34882494A 1994-11-29 1994-11-29
US348824 1994-11-29
US40930595A 1995-03-24 1995-03-24
US409305 1995-03-24
US48801195A 1995-06-07 1995-06-07
US08/483,554 US5747282A (en) 1994-08-12 1995-06-07 17Q-linked breast and ovarian cancer susceptibility gene
US488011 1995-06-07
US08/487,002 US5710001A (en) 1994-08-12 1995-06-07 17q-linked breast and ovarian cancer susceptibility gene
US483554 1995-06-07
US487002 1995-06-07

Publications (2)

Publication Number Publication Date
ES2164136T3 true ES2164136T3 (es) 2002-02-16
ES2164136T5 ES2164136T5 (es) 2009-02-16

Family

ID=27575337

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95305602T Expired - Lifetime ES2154712T5 (es) 1994-08-12 1995-08-11 Metodo para diagnosticar la predisposicion al cancer de mama y de ovarios.
ES95305601T Expired - Lifetime ES2164136T5 (es) 1994-08-12 1995-08-11 Sondas de acidos nucleicos que copmrenden un fragmento del gen de susceptibilidad al cancer de mama y ovarios asociado a 17q.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95305602T Expired - Lifetime ES2154712T5 (es) 1994-08-12 1995-08-11 Metodo para diagnosticar la predisposicion al cancer de mama y de ovarios.

Country Status (15)

Country Link
EP (2) EP0699754B2 (es)
JP (1) JP3399539B2 (es)
CN (1) CN1159829A (es)
AT (2) ATE198623T1 (es)
AU (2) AU691331B2 (es)
CA (2) CA2196790C (es)
DE (2) DE69519834T3 (es)
DK (2) DK0699754T3 (es)
ES (2) ES2154712T5 (es)
FI (2) FI970515A7 (es)
GR (1) GR3035631T3 (es)
NO (2) NO970625L (es)
NZ (1) NZ291624A (es)
PT (2) PT699754E (es)
WO (2) WO1996005308A1 (es)

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AU3242895A (en) 1996-03-07
ES2164136T5 (es) 2009-02-16
EP0699754B1 (en) 2001-01-10
NO970626L (no) 1997-04-14
FI970514A7 (fi) 1997-04-07
GR3035631T3 (en) 2001-06-29
WO1996005308A1 (en) 1996-02-22
WO1996005307A3 (en) 1996-03-14
CA2196790C (en) 2000-10-10
DE69519834T3 (de) 2010-04-01
CA2196795A1 (en) 1996-02-22
ES2154712T5 (es) 2009-12-14
DE69524182T3 (de) 2009-07-09
WO1996005307A2 (en) 1996-02-22
FI970515A7 (fi) 1997-04-07
DE69524182T2 (de) 2002-05-29
AU691958B2 (en) 1998-05-28
CN1159829A (zh) 1997-09-17
DK0705902T3 (da) 2002-03-11
PT699754E (pt) 2001-04-30
JP3399539B2 (ja) 2003-04-21
DE69524182D1 (de) 2002-01-10
FI970515A0 (fi) 1997-02-07
NO970625L (no) 1997-04-14
CA2196795C (en) 2001-04-03
EP0705902B1 (en) 2001-11-28
ATE209660T1 (de) 2001-12-15
ATE198623T1 (de) 2001-01-15
NO970625D0 (no) 1997-02-11
EP0699754B2 (en) 2009-08-12
NZ291624A (en) 1998-07-28
DE69519834D1 (de) 2001-02-15
EP0699754A1 (en) 1996-03-06
FI970514A0 (fi) 1997-02-07
NO970626D0 (no) 1997-02-11
CA2196790A1 (en) 1996-02-22
DK0699754T3 (da) 2001-02-26
PT705902E (pt) 2002-05-31
EP0705902B2 (en) 2008-08-06
EP0705902A1 (en) 1996-04-10
AU691331B2 (en) 1998-05-14
AU3321695A (en) 1996-03-07
DE69519834T2 (de) 2001-04-26
JP2002502227A (ja) 2002-01-22
ES2154712T3 (es) 2001-04-16

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