ES2164136T3 - Gen de susceptibilidad al cancer de mama y de ovarios asociado a 17q. - Google Patents

Gen de susceptibilidad al cancer de mama y de ovarios asociado a 17q.

Info

Publication number
ES2164136T3
ES2164136T3 ES95305601T ES95305601T ES2164136T3 ES 2164136 T3 ES2164136 T3 ES 2164136T3 ES 95305601 T ES95305601 T ES 95305601T ES 95305601 T ES95305601 T ES 95305601T ES 2164136 T3 ES2164136 T3 ES 2164136T3
Authority
ES
Spain
Prior art keywords
cancer
breast
human
invention refers
brca1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95305601T
Other languages
English (en)
Other versions
ES2164136T5 (es
Inventor
Mark H Skolnick
David E Goldgar
Yoshio Miki
Jeff Swensen
Alexander Kamb
Keith D Harshman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myriad Genetics Inc
University of Utah Research Foundation Inc
US Department of Health and Human Services
Original Assignee
Myriad Genetics Inc
University of Utah Research Foundation Inc
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27575337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164136(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/483,554 external-priority patent/US5747282A/en
Priority claimed from US08/487,002 external-priority patent/US5710001A/en
Application filed by Myriad Genetics Inc, University of Utah Research Foundation Inc, US Department of Health and Human Services filed Critical Myriad Genetics Inc
Publication of ES2164136T3 publication Critical patent/ES2164136T3/es
Application granted granted Critical
Publication of ES2164136T5 publication Critical patent/ES2164136T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE GENERALMENTE AL CAMPO DE LA GENETICA HUMANA. ESPECIFICAMENTE LA PRESENTE INVENCION SE REFIERE A METODOS Y MATERIALES UTILIZADOS PARA AISLAR Y DETECTAR UN GEN HUMANO DE PREDISPOSICION AL CANCER DE OVARIOS Y MAMA (BRCA1), ALGUNOS ALELOS MUTANTES QUE CAUSAN LA SUSCEPTIBILIDAD AL CANCER, EN PARTICULAR CANCER DE MAMA Y OVARIOS. MAS ESPECIFICAMENTE, LA INVENCION SE REFIERE A MUTACIONES DE LA LINEA GERMINAL EN EL GEN BRCA1 Y SU USO EN LA DIAGNOSIS DE LA PREDISPOSICION AL CANCER DE OVARIOS Y MAMA. LA PRESENTE INVENCION SE REFIERE ADEMAS A MUTACIONES SOMATICAS EN EL GEN BRCA1 EN EL CANCER DE OVARIOS Y DE MAMA HUMANO Y SU USO EN LA DIAGNOSIS Y PROGNOSIS DE DICHO CANCER. ADICIONALMENTE, LA INVENCION SE REFIERE A MUTACIONES SOMATICAS EN EL GEN BRCA1 EN OTROS CANCERES HUMANOS Y SU USO EN LA DIAGNOSIS Y PROGNOSIS DE CANCERES HUMANOS. LA INVENCION TAMBIEN SE REFIERE A LA TERAPIA DE CANCERES HUMANOS QUE TIENEN UNA MURATION EN EL GEN BRCA1, INCLUYENDO TERAPIA GENETICA, TERAPIA DE SUSTITUCION PROTEINA Y MIMETICAS DE PROTEINA. LA INVENCION SE REFIERE ADEMAS AL ESTUDIO DE MEDICAMENTOS PARA EL CANCER. FINALMENTE, LA INVENCION TAMBIEN SE REFIERE AL ESTUDIO DEL GEN BRCA1 PARA MUTACIONES QUE SON UTILES PARA LA DIAGNOSIS DE LA PREDISPOSICION AL CANCER DE MAMA Y OVARIOS.
ES95305601T 1994-08-12 1995-08-11 Sondas de acidos nucleicos que copmrenden un fragmento del gen de susceptibilidad al cancer de mama y ovarios asociado a 17q. Expired - Lifetime ES2164136T5 (es)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US28922194A 1994-08-12 1994-08-12
US289221 1994-08-12
US30026694A 1994-09-02 1994-09-02
US300266 1994-09-02
US30810494A 1994-09-16 1994-09-16
US308104 1994-09-16
US34882494A 1994-11-29 1994-11-29
US348824 1994-11-29
US40930595A 1995-03-24 1995-03-24
US409305 1995-03-24
US48801195A 1995-06-07 1995-06-07
US08/483,554 US5747282A (en) 1994-08-12 1995-06-07 17Q-linked breast and ovarian cancer susceptibility gene
US483554 1995-06-07
US488011 1995-06-07
US08/487,002 US5710001A (en) 1994-08-12 1995-06-07 17q-linked breast and ovarian cancer susceptibility gene
US487002 1995-06-07

Publications (2)

Publication Number Publication Date
ES2164136T3 true ES2164136T3 (es) 2002-02-16
ES2164136T5 ES2164136T5 (es) 2009-02-16

Family

ID=27575337

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95305602T Expired - Lifetime ES2154712T5 (es) 1994-08-12 1995-08-11 Metodo para diagnosticar la predisposicion al cancer de mama y de ovarios.
ES95305601T Expired - Lifetime ES2164136T5 (es) 1994-08-12 1995-08-11 Sondas de acidos nucleicos que copmrenden un fragmento del gen de susceptibilidad al cancer de mama y ovarios asociado a 17q.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES95305602T Expired - Lifetime ES2154712T5 (es) 1994-08-12 1995-08-11 Metodo para diagnosticar la predisposicion al cancer de mama y de ovarios.

Country Status (15)

Country Link
EP (2) EP0699754B2 (es)
JP (1) JP3399539B2 (es)
CN (1) CN1159829A (es)
AT (2) ATE209660T1 (es)
AU (2) AU691958B2 (es)
CA (2) CA2196795C (es)
DE (2) DE69519834T3 (es)
DK (2) DK0699754T3 (es)
ES (2) ES2154712T5 (es)
FI (2) FI970514A7 (es)
GR (1) GR3035631T3 (es)
NO (2) NO970625L (es)
NZ (1) NZ291624A (es)
PT (2) PT705902E (es)
WO (2) WO1996005307A2 (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019369A1 (en) 1994-01-14 1995-07-20 Vanderbilt University Method for detection and treatment of breast cancer
US6403303B1 (en) * 1996-05-14 2002-06-11 Visible Genetics Inc. Method and reagents for testing for mutations in the BRCA1 gene
US6083698A (en) * 1995-09-25 2000-07-04 Oncormed, Inc. Cancer susceptibility mutations of BRCA1
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
US6838256B2 (en) 1996-02-12 2005-01-04 Gene Logic Inc. Coding sequences of the human BRCA1 gene
US6951721B2 (en) 1996-02-12 2005-10-04 Gene Logic Inc. Method for determining the haplotype of a human BRCA1 gene
US6130322A (en) * 1996-02-12 2000-10-10 Gene Logic, Inc. Coding sequences of the human BRCA1 gene
US5891857A (en) * 1996-02-20 1999-04-06 Vanderbilt University Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins
AU728352B2 (en) 1996-08-02 2001-01-04 Wistar Institute Of Anatomy And Biology, The BRCA1 associated protein (BAP-1) and uses therefor
AU4586697A (en) * 1996-09-20 1998-04-14 Board Of Regents, The University Of Texas System Compositions and methods comprising bard1 and other brca1 binding proteins
WO1998025125A2 (en) * 1996-12-03 1998-06-11 Swift Michael R Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus
US5965377A (en) * 1997-03-24 1999-10-12 Baystate Medical Center Method for determining the presence of mutated BRCA protein
EP0983389A1 (en) * 1997-06-04 2000-03-08 Rijksuniversiteit te Leiden A diagnostic test kit for determining a predisposition for breast and ovarian cancer, materials and methods for such determination
EP1003779A1 (en) * 1997-07-07 2000-05-31 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
US5994096A (en) * 1997-07-25 1999-11-30 Smithkline Beecham Corporation Regulator
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
US6177410B1 (en) 1997-12-05 2001-01-23 Vanderbilt University Therapeutic methods for prostate cancer
US6686163B2 (en) 1998-05-06 2004-02-03 Gene Logic Inc. Coding sequence haplotype of the human BRCA1 gene
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
AU2002258518A1 (en) * 2001-03-14 2002-09-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
EP1430081A2 (fr) * 2001-06-13 2004-06-23 Centre National De La Recherche Scientifique (Cnrs) Complexes moleculaires brca1/acc alpha, applications diagnostiques et therapeutiques
FR2826012B1 (fr) * 2001-06-13 2003-09-26 Centre Nat Rech Scient Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques
FR2836919B1 (fr) * 2002-03-05 2004-07-09 Centre Nat Rech Scient Complexes moleculaires brca1/accalpha, applications diagnostiques et therapeutiques
ES2357057T3 (es) 2002-04-30 2011-04-15 Kudos Pharmaceuticals Limited Derivados de ftalazinona.
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
DK2305221T3 (en) 2003-12-01 2015-08-24 Kudos Pharm Ltd DNA damage repair inhibitors for the treatment of cancer
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
CN101037690B (zh) * 2006-03-16 2011-07-20 国家人口计生委科学技术研究所 具有新的单核苷酸多态性的brca1基因变体和其编码的蛋白质变体
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
EP2032980A4 (en) 2006-05-18 2012-01-04 Molecular Profiling Inst Inc SYSTEM AND METHOD FOR DETERMINING INDIVIDUALIZED MEDICAL USE AGAINST A SICKNESS STATE
EP2032140A1 (en) 2006-05-31 2009-03-11 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
TWI404716B (zh) 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
EP3536690A1 (en) 2007-01-10 2019-09-11 MSD Italia S.r.l. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
KR20100059950A (ko) 2007-09-14 2010-06-04 아스트라제네카 아베 프탈라지논 유도체
RU2487868C2 (ru) 2007-10-17 2013-07-20 Кудос Фармасеутикалс Лимитед 4-[3-(4-циклопропанкарбонил-пиперазин-1-карбонил)-4-фтор-бензил]-2н-фталазин-1-он
AR070221A1 (es) 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
WO2010017055A2 (en) 2008-08-06 2010-02-11 Lead Therapeutics, Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)
NZ592719A (en) 2008-10-07 2012-09-28 Astrazeneca Uk Ltd PHARMACEUTICAL FORMULATION 514 comprising 4-[3-( 4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
EP2393939B1 (en) * 2009-02-06 2014-09-17 Yale University A snp marker of breast and ovarian cancer risk
US20110015393A1 (en) 2009-07-15 2011-01-20 Astrazeneca Ab Phthalazinone compound
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
US9469876B2 (en) 2010-04-06 2016-10-18 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for metastatic prostate cancer
CN105525009B (zh) * 2016-01-26 2018-10-16 绍兴华因生物科技有限公司 检测杂合性brca1/2基因缺失的方法及所用引物
WO2019222272A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2020232119A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN114144413B (zh) 2019-07-19 2024-08-16 阿斯利康(瑞典)有限公司 Parp1抑制剂
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN113388680B (zh) * 2020-03-14 2023-07-04 复旦大学附属妇产科医院 上皮性卵巢癌靶点ret及其在诊断和治疗中的作用
KR102262529B1 (ko) * 2020-06-15 2021-06-09 연세대학교 산학협력단 Brca 변이성 난소암에 대한 진단 방법 및 이를 이용한 키트
US11795158B2 (en) 2020-06-25 2023-10-24 Astrazeneca Ab Chemical compounds
TW202222350A (zh) 2020-10-09 2022-06-16 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及parp1選擇性抑制劑之組合
EP4313991A1 (en) 2021-03-23 2024-02-07 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
IL308104A (en) 2021-05-03 2023-12-01 Nuvation Bio Inc Nuclear hormone receptor-targeted compounds against cancer
US20240366584A1 (en) 2021-06-21 2024-11-07 Tesaro, Inc. Combination treatment of cancer with a parp inhibitor and a lipophilic statin
WO2023089527A1 (en) 2021-11-18 2023-05-25 Astrazeneca Uk Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
CA3242082A1 (en) 2021-12-21 2023-06-29 Astrazeneca Ab Methods of treating brain tumours and neuroblastomas
TW202339805A (zh) 2021-12-28 2023-10-16 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及atr抑制劑之組合
JP2025503511A (ja) 2021-12-28 2025-02-04 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲート及びｒａｓｇ１２ｃ阻害剤の組み合わせ
EP4493933A1 (en) 2022-03-16 2025-01-22 AstraZeneca UK Limited A scoring method for an anti-trop2 antibody-drug conjugate therapy
EP4504180A1 (en) 2022-04-07 2025-02-12 Astrazeneca AB Combination therapy for treating cancer
US20250213556A1 (en) 2022-04-07 2025-07-03 Astrazeneca Ab Combination therapy for treating cancer
CA3254950A1 (en) 2022-04-07 2023-10-12 Astrazeneca Ab Polytherapy for the treatment of cancer
IL317573A (en) 2022-06-15 2025-02-01 Astrazeneca Ab Combination therapy for cancer treatment
CA3262449A1 (en) 2022-07-28 2024-02-01 Astrazeneca Uk Ltd COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A BISPECIFIC CHECKPOINT INHIBITOR
WO2024116094A1 (en) 2022-11-30 2024-06-06 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugates and dnmt inhibitors
TW202523359A (zh) 2023-10-24 2025-06-16 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物與抗pd-1/tim-3雙特異性結合蛋白質之組合
TW202535479A (zh) 2023-12-05 2025-09-16 英商阿斯特捷利康英國股份有限公司 抗體藥物結合物與血腦屏障穿透性ｐａｒｐ１選擇性抑制劑之組合
WO2025153668A1 (en) 2024-01-19 2025-07-24 Astrazeneca Ab Pharmaceutical compositions comprising azd5305

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
CA1188246A (en) 1981-08-31 1985-06-04 Jerry L. Gregory Immobilized microbe recycle apparatus
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
IE61148B1 (en) 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
US5362623A (en) * 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
ATE164629T1 (de) * 1990-01-04 1998-04-15 Univ Johns Hopkins In menschlichen kolorektalkarzinomen fehlendes gen
AU8221191A (en) * 1990-06-27 1992-01-23 Princeton University Probes for detecting mutant p53
AU1236092A (en) * 1991-01-04 1992-08-17 Baylor College Of Medicine Tumor susceptible non-human animals
IL103059A0 (en) 1991-09-30 1993-02-21 Boehringer Ingelheim Int Conjugates for introducing nucleic acid into higher eucaryotic cells
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
AU4645293A (en) * 1992-06-26 1994-01-24 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The The met proto-oncogene and a method for predicting breast cancer progression
WO1995019369A1 (en) * 1994-01-14 1995-07-20 Vanderbilt University Method for detection and treatment of breast cancer

Also Published As

Publication number Publication date
PT705902E (pt) 2002-05-31
EP0699754A1 (en) 1996-03-06
ES2154712T3 (es) 2001-04-16
WO1996005308A1 (en) 1996-02-22
GR3035631T3 (en) 2001-06-29
DE69519834T3 (de) 2010-04-01
NO970626D0 (no) 1997-02-11
AU691331B2 (en) 1998-05-14
AU3321695A (en) 1996-03-07
CA2196790A1 (en) 1996-02-22
FI970515A7 (fi) 1997-04-07
WO1996005307A2 (en) 1996-02-22
DE69519834D1 (de) 2001-02-15
DK0699754T3 (da) 2001-02-26
CN1159829A (zh) 1997-09-17
CA2196795A1 (en) 1996-02-22
NO970626L (no) 1997-04-14
DE69519834T2 (de) 2001-04-26
JP3399539B2 (ja) 2003-04-21
ATE198623T1 (de) 2001-01-15
ES2154712T5 (es) 2009-12-14
PT699754E (pt) 2001-04-30
EP0705902B1 (en) 2001-11-28
CA2196790C (en) 2000-10-10
FI970514A0 (fi) 1997-02-07
JP2002502227A (ja) 2002-01-22
NO970625D0 (no) 1997-02-11
ES2164136T5 (es) 2009-02-16
DE69524182D1 (de) 2002-01-10
EP0699754B1 (en) 2001-01-10
CA2196795C (en) 2001-04-03
WO1996005307A3 (en) 1996-03-14
EP0705902A1 (en) 1996-04-10
FI970514A7 (fi) 1997-04-07
DE69524182T3 (de) 2009-07-09
DE69524182T2 (de) 2002-05-29
AU691958B2 (en) 1998-05-28
ATE209660T1 (de) 2001-12-15
FI970515A0 (fi) 1997-02-07
NO970625L (no) 1997-04-14
EP0699754B2 (en) 2009-08-12
NZ291624A (en) 1998-07-28
DK0705902T3 (da) 2002-03-11
EP0705902B2 (en) 2008-08-06
AU3242895A (en) 1996-03-07

Similar Documents

Publication Publication Date Title
ES2164136T3 (es) Gen de susceptibilidad al cancer de mama y de ovarios asociado a 17q.
ES2158048T3 (es) Mutaciones del gen ligado al cromosoma 17q, de susceptibilidad al cancer de mama y de ovario.
ES2190466T3 (es) Gen brca2 de susceptibilidad al cancer de mama ligado al cromosoma 13.
NO982785D0 (no) Kromosom 13-koblet brystkreftmottagelighetsgen
Ford et al. Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence
TR199902053T2 (xx) Prostat kanserinin immunoterapisine y�nelik bile�ikler ve bunlar�n kullan�lmas�na matuf metodlar.
CY1111863T1 (el) Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων
ES2158847T3 (es) Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre.
DE69717664D1 (de) Protein e25a, methoden zu dessen herstellung und anwendung
TR199800270T1 (xx) Kanser hastal�klar�n�n ilerlemesini �nlemede flukonazol kullan�m�.
WO2002088750A3 (en) Proteins, genes and their use for diagnosis and treatment of breast cancer
WO2001071357A3 (en) Diagnosis and treatment of breast cancer
DE69935782D1 (de) Brustkrebsresistenzprotein (bcrp) und für dieses kodierende dna
Zachariah et al. Brain metastasis from primary small cell carcinoma of the prostate
WO2002016939A3 (en) Methods of diagnosis of cancer and screening for cancer modulators
MX9701074A (es) Gen de susceptibilidad al cancer de pecho y ovario enlazado con 17q.
MXPA03005004A (es) Metodos de diagnostico de cancer colorrectal y/o cancer de pecho, composiciones, y metodos para rastrear moduladores de cancer colorrectal y/o cancer de pecho.
Park et al. 1018-CD97 IS A CRITICAL REGULATOR OF ACUTE MYELOID LEUKEMIA STEM CELL FUNCTION
GUVEN et al. Protection of melatonin on beta cell toxicity induced by doxorubicin though MAPK/NF-kB signaling.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 705902

Country of ref document: ES