ES2158847T3 - Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre. - Google Patents
Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre.Info
- Publication number
- ES2158847T3 ES2158847T3 ES92906080T ES92906080T ES2158847T3 ES 2158847 T3 ES2158847 T3 ES 2158847T3 ES 92906080 T ES92906080 T ES 92906080T ES 92906080 T ES92906080 T ES 92906080T ES 2158847 T3 ES2158847 T3 ES 2158847T3
- Authority
- ES
- Spain
- Prior art keywords
- apc
- colorectal cancer
- gen
- injured
- man
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PRESENTA UN GEN HUMANO DENOMINADO APC. SE PRESENTAN LOS METODOS Y KITS PARA VALORAR LAS MUTACIONES DEL GEN APC EN LOS TEJIDOS HUMANOS Y EN MUESTRAS CORPORALES. LAS MUTACIONES DEL APC TIENEN LUGAR EN PACIENTES CON POLIPOSIS ADENOMATOSA HEREDITARIA ASI COMO EN PACIENTES CON CANCER COLORECTAL ESPORADICO. EL APC SE EXPRESA EN LA MAYORIA DE LOS TEJIDOS NORMALES. ESTOS RESULTADOS HACEN PENSAR QUE EL APC ES UN SUPRESOR DE TUMORES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919100963A GB9100963D0 (en) | 1991-01-16 | 1991-01-16 | Nucleic acid |
US07/741,940 US5352775A (en) | 1991-01-16 | 1991-08-08 | APC gene and nucleic acid probes derived therefrom |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2158847T3 true ES2158847T3 (es) | 2001-09-16 |
Family
ID=26298271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92906080T Expired - Lifetime ES2158847T3 (es) | 1991-01-16 | 1992-01-16 | Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0569527B1 (es) |
AT (1) | ATE199746T1 (es) |
AU (1) | AU1366992A (es) |
CA (1) | CA2100472C (es) |
DE (1) | DE69231734T2 (es) |
DK (1) | DK0569527T3 (es) |
ES (1) | ES2158847T3 (es) |
GR (1) | GR3036047T3 (es) |
WO (1) | WO1992013103A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0689606A1 (en) * | 1993-03-19 | 1996-01-03 | The Johns Hopkins University | ANTIBODIES AND ASSAYS FOR DETERMINING MUTATIONS IN THE $i(APC) GENE |
US6025127A (en) * | 1994-01-14 | 2000-02-15 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection in histologic tissue |
DE4431174A1 (de) * | 1994-09-01 | 1996-03-07 | Deutsches Krebsforsch | Nachweisverfahren für tumorspezifische mRNA |
WO1997018296A1 (en) * | 1995-11-15 | 1997-05-22 | University Of Utah | Novel method of culturing human epithelial cells for the identification of cancer therapeutics and diagnostics |
US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
US5733732A (en) * | 1996-01-03 | 1998-03-31 | University Of Iowa Research Foundation | Methods for detecting primary adhalinopathy |
US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
US5879890A (en) * | 1997-01-31 | 1999-03-09 | The Johns Hopkins University | APC mutation associated with familial colorectal cancer in Ashkenazi jews |
US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
US6818404B2 (en) | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
DE19848665A1 (de) * | 1998-10-22 | 2000-04-27 | Bayer Ag | Ein automatisierbarer Schnelltest zum direkten Nachweis der APC Resistenz Mutation mit spezifischen Primern und Probes |
US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
DE19933237A1 (de) * | 1999-07-15 | 2001-01-18 | Max Planck Gesellschaft | Verfahren zur Bestimmung der Proliferationsaktivität von Zellen |
US6271257B1 (en) * | 2000-04-17 | 2001-08-07 | Hormos Nutraceutical Oy Ltd. | Decreasing the intracellular level of β-catenin by administering hydroxymatairesinol |
US20020061289A1 (en) * | 2000-10-04 | 2002-05-23 | Boman Bruce M. | Stem cell-based methods for preventing and treating tumor |
WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
WO2007044071A2 (en) | 2005-04-21 | 2007-04-19 | Exact Sciences Corporation | Analysis of heterogeneous nucleic acid samples |
EP2069535B1 (en) * | 2006-08-11 | 2013-04-10 | Johns Hopkins University | Consensus coding sequences of human breast and colorectal cancers |
DE102011008050A1 (de) * | 2011-01-07 | 2012-07-12 | Universitätsklinikum Schleswig-Holstein | Verfahren zur Diagnose der familiären adenomatösen Polyposis (FAP) |
CN103733355B (zh) | 2011-06-30 | 2017-02-08 | 佛罗里达大学研究基金会有限公司 | 用于检测红外辐射的带有增益的方法和设备 |
US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
JP6435334B2 (ja) | 2013-12-11 | 2018-12-05 | アキュラジェン ホールディングス リミテッド | 稀な配列変異体を検出するための組成物および方法 |
AU2016334233B2 (en) | 2015-10-09 | 2023-01-05 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
WO2017201102A1 (en) | 2016-05-16 | 2017-11-23 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
CA3033749A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
US12049665B2 (en) | 2018-06-12 | 2024-07-30 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
CN114539379B (zh) * | 2022-03-03 | 2024-06-07 | 山东省滨州畜牧兽医研究院 | Aqp1突变型基因、蛋白、细胞系及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8719061D0 (en) * | 1987-08-12 | 1987-09-16 | Imp Cancer Research Fund Paten | Probe |
EP0440744B1 (en) * | 1988-10-31 | 1997-12-10 | The Regents Of The University Of California | Products and methods for controlling the suppression of the neoplastic phenotype |
-
1992
- 1992-01-16 WO PCT/US1992/000376 patent/WO1992013103A1/en active IP Right Grant
- 1992-01-16 CA CA002100472A patent/CA2100472C/en not_active Expired - Lifetime
- 1992-01-16 ES ES92906080T patent/ES2158847T3/es not_active Expired - Lifetime
- 1992-01-16 AT AT92906080T patent/ATE199746T1/de not_active IP Right Cessation
- 1992-01-16 DE DE69231734T patent/DE69231734T2/de not_active Expired - Lifetime
- 1992-01-16 DK DK92906080T patent/DK0569527T3/da active
- 1992-01-16 AU AU13669/92A patent/AU1366992A/en not_active Abandoned
- 1992-01-16 EP EP92906080A patent/EP0569527B1/en not_active Expired - Lifetime
-
2001
- 2001-06-14 GR GR20010400861T patent/GR3036047T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2100472A1 (en) | 1992-07-17 |
GR3036047T3 (en) | 2001-09-28 |
DK0569527T3 (da) | 2001-07-16 |
AU1366992A (en) | 1992-08-27 |
EP0569527A1 (en) | 1993-11-18 |
DE69231734T2 (de) | 2001-09-20 |
ATE199746T1 (de) | 2001-03-15 |
DE69231734D1 (de) | 2001-04-19 |
CA2100472C (en) | 2009-04-07 |
EP0569527B1 (en) | 2001-03-14 |
WO1992013103A1 (en) | 1992-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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