ATE199746T1 - Geerbte und somatische mutationen des apc-gens bei menschlichem colorectal-krebs - Google Patents
Geerbte und somatische mutationen des apc-gens bei menschlichem colorectal-krebsInfo
- Publication number
- ATE199746T1 ATE199746T1 AT92906080T AT92906080T ATE199746T1 AT E199746 T1 ATE199746 T1 AT E199746T1 AT 92906080 T AT92906080 T AT 92906080T AT 92906080 T AT92906080 T AT 92906080T AT E199746 T1 ATE199746 T1 AT E199746T1
- Authority
- AT
- Austria
- Prior art keywords
- apc
- colorectal cancer
- inheritable
- somatic mutations
- human colorectal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100963A GB9100963D0 (en) | 1991-01-16 | 1991-01-16 | Nucleic acid |
| US07/741,940 US5352775A (en) | 1991-01-16 | 1991-08-08 | APC gene and nucleic acid probes derived therefrom |
| PCT/US1992/000376 WO1992013103A1 (en) | 1991-01-16 | 1992-01-16 | Inherited and somatic mutations of apc gene in colorectal cancer of humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199746T1 true ATE199746T1 (de) | 2001-03-15 |
Family
ID=26298271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92906080T ATE199746T1 (de) | 1991-01-16 | 1992-01-16 | Geerbte und somatische mutationen des apc-gens bei menschlichem colorectal-krebs |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0569527B1 (de) |
| AT (1) | ATE199746T1 (de) |
| AU (1) | AU1366992A (de) |
| CA (1) | CA2100472C (de) |
| DE (1) | DE69231734T2 (de) |
| DK (1) | DK0569527T3 (de) |
| ES (1) | ES2158847T3 (de) |
| GR (1) | GR3036047T3 (de) |
| WO (1) | WO1992013103A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994021814A1 (en) * | 1993-03-19 | 1994-09-29 | The Johns Hopkins University | Antibodies and assays for determining mutations in the apc gene |
| US6025127A (en) * | 1994-01-14 | 2000-02-15 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection in histologic tissue |
| DE4431174A1 (de) * | 1994-09-01 | 1996-03-07 | Deutsches Krebsforsch | Nachweisverfahren für tumorspezifische mRNA |
| EP0929661A4 (de) * | 1995-11-15 | 2000-01-12 | Univ Utah | Neuartiges verfahren der kultivierung menschlicher epithelzellenzur identifizierung von therapeutika und diagnostika gegen krebs |
| US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US5733732A (en) * | 1996-01-03 | 1998-03-31 | University Of Iowa Research Foundation | Methods for detecting primary adhalinopathy |
| US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US5952178A (en) * | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US5879890A (en) * | 1997-01-31 | 1999-03-09 | The Johns Hopkins University | APC mutation associated with familial colorectal cancer in Ashkenazi jews |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US6818404B2 (en) | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
| DE19848665A1 (de) * | 1998-10-22 | 2000-04-27 | Bayer Ag | Ein automatisierbarer Schnelltest zum direkten Nachweis der APC Resistenz Mutation mit spezifischen Primern und Probes |
| US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| DE19933237A1 (de) * | 1999-07-15 | 2001-01-18 | Max Planck Gesellschaft | Verfahren zur Bestimmung der Proliferationsaktivität von Zellen |
| US6271257B1 (en) * | 2000-04-17 | 2001-08-07 | Hormos Nutraceutical Oy Ltd. | Decreasing the intracellular level of β-catenin by administering hydroxymatairesinol |
| WO2002028432A2 (en) * | 2000-10-04 | 2002-04-11 | Ca*Tx, Inc. | Stem cell-based methods for preventing and treating tumor |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| EP2543740A3 (de) * | 2006-08-11 | 2013-03-27 | Johns Hopkins University | Konsenskodierende Sequenzen von menschlichem Kolorektalkrebs |
| DE102011008050A1 (de) * | 2011-01-07 | 2012-07-12 | Universitätsklinikum Schleswig-Holstein | Verfahren zur Diagnose der familiären adenomatösen Polyposis (FAP) |
| BR112013033122A2 (pt) | 2011-06-30 | 2017-01-24 | Nanoholdings Llc | método e aparelho para detectar radiação infravermelha com ganho |
| US10767222B2 (en) | 2013-12-11 | 2020-09-08 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| CN114807323A (zh) | 2015-10-09 | 2022-07-29 | 安可济控股有限公司 | 用于富集扩增产物的方法及组合物 |
| EP3458586B1 (de) | 2016-05-16 | 2022-12-28 | Accuragen Holdings Limited | Verfahren zur verbesserten sequenzierung durch strangidentifizierung |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| US12049665B2 (en) | 2018-06-12 | 2024-07-30 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| CN114539379B (zh) * | 2022-03-03 | 2024-06-07 | 山东省滨州畜牧兽医研究院 | Aqp1突变型基因、蛋白、细胞系及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719061D0 (en) * | 1987-08-12 | 1987-09-16 | Imp Cancer Research Fund Paten | Probe |
| AU638954B2 (en) * | 1988-10-31 | 1993-07-15 | Regents Of The University Of California, The | Products and methods for controlling the suppression of the neoplastic phenotype |
-
1992
- 1992-01-16 DE DE69231734T patent/DE69231734T2/de not_active Expired - Lifetime
- 1992-01-16 WO PCT/US1992/000376 patent/WO1992013103A1/en active IP Right Grant
- 1992-01-16 ES ES92906080T patent/ES2158847T3/es not_active Expired - Lifetime
- 1992-01-16 EP EP92906080A patent/EP0569527B1/de not_active Expired - Lifetime
- 1992-01-16 AU AU13669/92A patent/AU1366992A/en not_active Abandoned
- 1992-01-16 CA CA002100472A patent/CA2100472C/en not_active Expired - Lifetime
- 1992-01-16 DK DK92906080T patent/DK0569527T3/da active
- 1992-01-16 AT AT92906080T patent/ATE199746T1/de not_active IP Right Cessation
-
2001
- 2001-06-14 GR GR20010400861T patent/GR3036047T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3036047T3 (en) | 2001-09-28 |
| DE69231734D1 (de) | 2001-04-19 |
| DK0569527T3 (da) | 2001-07-16 |
| CA2100472C (en) | 2009-04-07 |
| EP0569527A1 (de) | 1993-11-18 |
| DE69231734T2 (de) | 2001-09-20 |
| WO1992013103A1 (en) | 1992-08-06 |
| AU1366992A (en) | 1992-08-27 |
| ES2158847T3 (es) | 2001-09-16 |
| EP0569527B1 (de) | 2001-03-14 |
| CA2100472A1 (en) | 1992-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |