ATE194660T1 - Veraendertes gen bei menschlichem colorektalem- krebs - Google Patents

Veraendertes gen bei menschlichem colorektalem- krebs

Info

Publication number
ATE194660T1
ATE194660T1 AT92905276T AT92905276T ATE194660T1 AT E194660 T1 ATE194660 T1 AT E194660T1 AT 92905276 T AT92905276 T AT 92905276T AT 92905276 T AT92905276 T AT 92905276T AT E194660 T1 ATE194660 T1 AT E194660T1
Authority
AT
Austria
Prior art keywords
mcc
colorectal cancer
human colorectal
altered gene
human
Prior art date
Application number
AT92905276T
Other languages
English (en)
Inventor
Bert Vogelstein
Kenneth W Kinzler
Raymond L White
Yusuke Nakamura
Original Assignee
Univ Johns Hopkins
Univ Utah
Japan Found Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Univ Utah, Japan Found Cancer filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE194660T1 publication Critical patent/ATE194660T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92905276T 1991-03-13 1992-01-16 Veraendertes gen bei menschlichem colorektalem- krebs ATE194660T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/670,611 US5330892A (en) 1991-03-13 1991-03-13 MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
PCT/US1992/000377 WO1992016656A1 (en) 1991-03-13 1992-01-16 Gene mutated in colorectal cancer of humans

Publications (1)

Publication Number Publication Date
ATE194660T1 true ATE194660T1 (de) 2000-07-15

Family

ID=24691103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92905276T ATE194660T1 (de) 1991-03-13 1992-01-16 Veraendertes gen bei menschlichem colorektalem- krebs

Country Status (11)

Country Link
US (5) US5330892A (de)
EP (1) EP0580596B1 (de)
JP (1) JP3501802B2 (de)
AT (1) ATE194660T1 (de)
AU (1) AU664834B2 (de)
CA (1) CA2105876A1 (de)
DE (1) DE69231245T2 (de)
DK (1) DK0580596T3 (de)
ES (1) ES2148171T3 (de)
GR (1) GR3034446T3 (de)
WO (1) WO1992016656A1 (de)

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US5330892A (en) * 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
EP0672181B1 (de) 1992-04-01 2003-11-05 The Johns Hopkins University School Of Medicine Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
US7326778B1 (en) * 1993-05-05 2008-02-05 The John Hopkins University Mutator gene and hereditary non-polyposis colorectal cancer
WO1994028161A1 (en) * 1993-05-26 1994-12-08 The Johns Hopkins University Antibodies specific for dcc gene product
US5962220A (en) * 1993-10-26 1999-10-05 Thomas Jefferson University Compositions that specifically bind to colorectal cells and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
DE4431174A1 (de) * 1994-09-01 1996-03-07 Deutsches Krebsforsch Nachweisverfahren für tumorspezifische mRNA
US5891629A (en) * 1995-09-28 1999-04-06 Ambion, Inc. Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids
US5670325A (en) * 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US6242212B1 (en) * 1996-02-09 2001-06-05 Thomas Jefferson University Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins
US5858673A (en) * 1996-06-24 1999-01-12 Charlotte-Mecklenburg Hospital Authority Method for detecting prostate cells
US5928870A (en) * 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6020137A (en) * 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6146828A (en) * 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US20020064792A1 (en) * 1997-11-13 2002-05-30 Lincoln Stephen E. Database for storage and analysis of full-length sequences
US6897018B1 (en) * 1998-02-25 2005-05-24 The United States Of America As Represented By The Department Of Health And Human Services DLC-1 gene deleted in cancers
WO2000005376A1 (en) * 1998-07-24 2000-02-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pb 39, a gene dysregulated in prostate cancer, and uses thereof
US7226731B1 (en) 1998-07-24 2007-06-05 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services PB 39, a gene dysregulated in prostate cancer, and uses thereof
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
EP1155147B1 (de) 1999-02-25 2006-06-14 EXACT Sciences Corporation Verfahren zur erhaltung der dns-integrität
JP4794052B2 (ja) 1999-04-09 2011-10-12 ジェンザイム・コーポレーション 癌の指標である核酸を検出するための方法
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US7368233B2 (en) * 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
ATE452989T1 (de) 2000-03-27 2010-01-15 Univ Jefferson Zusammensetzungen und methoden zur identifizierung von krebszellen
WO2002016605A1 (en) * 2000-08-25 2002-02-28 Fujirebio Inc. Method of protecting personal information
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
WO2005047881A2 (en) * 2003-11-05 2005-05-26 Exact Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
US20070243531A1 (en) * 2004-01-23 2007-10-18 Maija Kohonen-Corish Methods of Diagnosing Colorectal Cancer and Reagents Therefor
WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
US7981607B2 (en) * 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
WO2007044071A2 (en) * 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
EP3080298B1 (de) 2013-12-11 2018-10-31 AccuraGen Holdings Limited Verfahren für den nachweis seltener sequenzvarianten
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
HK1259101A1 (zh) 2015-10-09 2019-11-22 Accuragen Holdings Limited 用於富集扩增产物的方法及组合物
EP3383994A4 (de) 2015-12-03 2019-08-28 Accuragen Holdings Limited Verfahren und zusammensetzungen zum formen von ligationsprodukten
EP3458586B1 (de) 2016-05-16 2022-12-28 Accuragen Holdings Limited Verfahren zur verbesserten sequenzierung durch strangidentifizierung
JP6966052B2 (ja) 2016-08-15 2021-11-10 アキュラーゲン ホールディングス リミテッド 稀な配列変異体を検出するための組成物および方法
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
US12049665B2 (en) 2018-06-12 2024-07-30 Accuragen Holdings Limited Methods and compositions for forming ligation products
CN115963268B (zh) * 2023-02-14 2023-09-19 浙江大学 一种用于结直肠癌早期诊断的血浆分泌蛋白组合及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625169B2 (en) * 1987-03-23 1992-07-02 Imperial Chemical Industries Plc Molecular markers
EP0440744B1 (de) * 1988-10-31 1997-12-10 The Regents Of The University Of California Erzeugnisse und verfahren zur regelung der suppression von neoplastischen phenotypen
US5352775A (en) * 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US5330892A (en) * 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors

Also Published As

Publication number Publication date
DE69231245D1 (de) 2000-08-17
DE69231245T2 (de) 2001-02-01
EP0580596A1 (de) 1994-02-02
WO1992016656A1 (en) 1992-10-01
DK0580596T3 (da) 2000-10-30
US5576422A (en) 1996-11-19
US5330892A (en) 1994-07-19
ES2148171T3 (es) 2000-10-16
AU1330292A (en) 1992-10-21
CA2105876A1 (en) 1992-09-14
US5693536A (en) 1997-12-02
US5571905A (en) 1996-11-05
EP0580596B1 (de) 2000-07-12
GR3034446T3 (en) 2000-12-29
AU664834B2 (en) 1995-12-07
JP3501802B2 (ja) 2004-03-02
US5830676A (en) 1998-11-03
JPH06509701A (ja) 1994-11-02

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee