MX9708401A - Genes reguladores de la cromatina. - Google Patents

Genes reguladores de la cromatina.

Info

Publication number
MX9708401A
MX9708401A MX9708401A MX9708401A MX9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A
Authority
MX
Mexico
Prior art keywords
chromatin
regulator genes
genes
deregulation
regulator
Prior art date
Application number
MX9708401A
Other languages
English (en)
Other versions
MXPA97008401A (es
Inventor
Thomas Jenuwein
Gotz Laible
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MXPA97008401A publication Critical patent/MXPA97008401A/es
Publication of MX9708401A publication Critical patent/MX9708401A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invencion se relaciona con la desregulacion de los genes reguladores de la cromatina, los cuales tienen un domino SET, tal desregulacion es de importancia en ciertas condiciones del cáncer. Esos genes, en particular los dominios SET como tales, pueden usarse en el diagnostico y terapia de tales condiciones.
MX9708401A 1995-05-10 1996-05-02 Genes reguladores de la cromatina. MX9708401A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19516776A DE19516776A1 (de) 1995-05-10 1995-05-10 Chromatin-Regulatorgene
DE19516776.7 1995-05-10
PCT/EP1996/001818 WO1996035784A2 (de) 1995-05-10 1996-05-02 Chromatin-regulatorgene

Publications (2)

Publication Number Publication Date
MXPA97008401A MXPA97008401A (es) 1998-02-01
MX9708401A true MX9708401A (es) 1998-02-28

Family

ID=7761318

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708401A MX9708401A (es) 1995-05-10 1996-05-02 Genes reguladores de la cromatina.

Country Status (11)

Country Link
US (2) US6689583B1 (es)
EP (1) EP0827537B1 (es)
JP (1) JP4295824B2 (es)
AT (1) ATE404667T1 (es)
CA (1) CA2220442C (es)
DE (2) DE19516776A1 (es)
DK (1) DK0827537T3 (es)
ES (1) ES2313726T3 (es)
MX (1) MX9708401A (es)
PT (1) PT827537E (es)
WO (1) WO1996035784A2 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
US6239327B1 (en) 1998-04-16 2001-05-29 Cold Spring Harbor Laboratory Seed specific polycomb group gene and methods of use for same
ATE441717T1 (de) 1999-03-11 2009-09-15 Arborgen Llc Zusammensetzungen und verfahren zur veränderung der gentranskription
US20020039776A1 (en) 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US20020155460A1 (en) * 2000-10-10 2002-10-24 Genencor International Inc. Information rich libraries
US7264964B2 (en) 2001-06-22 2007-09-04 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
US20040053848A1 (en) * 2001-08-23 2004-03-18 Allis C. David Antibodies specific for methylated lysines in histones
CA2471385A1 (en) * 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Preventives/remedies for cancer
GB0228900D0 (en) * 2002-12-11 2003-01-15 Ml Lab Plc Cancer Immunotherapy
US20060104981A1 (en) * 2002-12-24 2006-05-18 Yuichi Hikichi Prophylactic/therapeutic agent for cancer
CA2548185A1 (en) 2003-12-03 2005-06-16 Chugai Seiyaku Kabushiki Kaisha Expression systems using mammalian .beta.-actin promoter
JP2005170799A (ja) * 2003-12-08 2005-06-30 Univ Kurume ｚｅｓｔｅホモログ２のエンハンサーのＨＬＡ−Ａ２４結合ペプチド
DE602005017781D1 (de) * 2004-06-01 2009-12-31 Univ North Carolina Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür
JP2009528050A (ja) * 2006-02-27 2009-08-06 イムジェン カンパニー リミテッド Ｂｍｉ−１を用いた星状細胞の神経幹細胞への脱分化
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
US20130195843A1 (en) * 2010-06-23 2013-08-01 British Columbia Cancer Agency Branch Biomarkers for Non-Hodgkin Lymphomas and Uses Thereof
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
HUE028977T2 (en) * 2010-09-10 2017-02-28 Epizyme Inc A method for determining the suitability of human EZH2 inhibitors during treatment
WO2012050963A2 (en) 2010-09-29 2012-04-19 The General Hospital Corporation D/B/A Massachusetts General Hospital Agents providing controls and standards for immuno-precipitation assays
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
DK3628670T3 (da) 2012-04-13 2022-12-05 Epizyme Inc Saltform til ezh2-hæmning
CN110041250A (zh) 2012-10-15 2019-07-23 Epizyme股份有限公司 经取代的苯化合物
EP2968565A2 (en) 2013-03-14 2016-01-20 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
CN103215352B (zh) * 2013-03-29 2015-03-11 中国医学科学院血液病医院（血液学研究所） 一种检测setd2基因突变的试剂盒
MX2016004703A (es) 2013-10-16 2017-02-28 Epizyme Inc Forma salina de hidrocloruro para la inhibicion de ezh2.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
WO1998027994A1 (en) 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Proteins and compositions for modulating mitosis
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
US5972608A (en) * 1997-08-27 1999-10-26 University Of Massachusetts Assays and reagents for chromatin remodeling enzymes and their modulators
EP1029547A1 (en) 1999-02-15 2000-08-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Pharmaceutically active compounds and method for identifying same
US20020039776A1 (en) * 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US20020164620A1 (en) * 2001-01-19 2002-11-07 Boehringer Ingelheim International Gmbh Method for identifying compounds modulating sister chromatid separation
EP1227160A1 (en) 2001-01-19 2002-07-31 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Compounds modulating sister chromatid separation and method for identifying same
CN1678735A (zh) * 2001-05-04 2005-10-05 佛罗里达大学研究基金会有限公司 来源于细菌的丙酮酸脱羧酶(pdc)基因的克隆和测序及其用途

Also Published As

Publication number Publication date
DK0827537T3 (da) 2008-12-01
CA2220442C (en) 2011-07-12
ATE404667T1 (de) 2008-08-15
DE19516776A1 (de) 1996-11-14
CA2220442A1 (en) 1996-11-14
PT827537E (pt) 2008-10-09
WO1996035784A2 (de) 1996-11-14
DE59611481D1 (en) 2008-09-25
US7252968B2 (en) 2007-08-07
EP0827537B1 (de) 2008-08-13
WO1996035784A3 (de) 1996-12-27
JP2001505402A (ja) 2001-04-24
US20050089880A1 (en) 2005-04-28
EP0827537A2 (de) 1998-03-11
US6689583B1 (en) 2004-02-10
ES2313726T3 (es) 2009-03-01
JP4295824B2 (ja) 2009-07-15

Similar Documents

Publication Publication Date Title
MX9708401A (es) Genes reguladores de la cromatina.
IL147017A0 (en) TREATING PROSTATE CANCER WITH ANTI-ErbB2 ANTIBODIES
AU7736300A (en) Therapeutic treatment of androgen receptor driven conditions
HUP9902068A3 (en) Methods and compositions for the diagnosis and treatment of cancer
SI1187632T1 (sl) Zdravljenje z anti-ErbB2 protitelesi
BG104356A (en) Compounds based on azabenzimidazole for the modulation of serin/treonin protein kinase function
DE69703294T2 (de) Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
NO20004803L (no) Smilagening og anzurogenin for behandling av Alzheimers sykdom
AU1378499A (en) Methods for treating prostate tumors using radioactive compositions
GR970300016T1 (en) Lactobacillus strains of human origin, their compositions and uses thereof
AU2386201A (en) Substituted sapogenins and their use
CA2301032A1 (en) A method of preventing or treating estrogen-dependent diseases and disorders
AU2291097A (en) Novel phenanthridines substituted in the 6 position
IL187254A (en) ANTISENSE NUCLEOTIDES, COMPOSITIONS COMPRISING THEREOF AND THEIR USE IN MODULATING ACTIVATION OF NF-kB
HK1050860A1 (en) Nordihydroguaiaretic derivatives for use in treatment of tumors
UA66793C2 (uk) Лептин як стримувач швидкого збільшення пухлини клітини
ATE239509T1 (de) Konjugate zur behandlung von prostatakrebs
HUP0104688A2 (hu) Összetételek és eljárások a rákbetegség és a rákbetegséggel kapcsolódó csontveszteség megelőzéséhez és kezeléséhez
BR9808606A (pt) Materiais e métodos para tratamento de doenças com ribozimas
BG102250A (en) The use of marigold-extracted glycosides for the treatment of psoriasis
AU2821295A (en) Compositions and methods for the treatment of tumors
GB9923078D0 (en) Sapogenin derivatives and their use
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
NZ320259A (en) Deodorizing preparations containing cationic biopolymers, aluminium hydrochlorate and esterase inhibitors
MX9700624A (es) Azolidinonas de imidazopiridina.