MX9708401A - Genes reguladores de la cromatina. - Google Patents

Genes reguladores de la cromatina.

Info

Publication number
MX9708401A
MX9708401A MX9708401A MX9708401A MX9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A MX 9708401 A MX9708401 A MX 9708401A
Authority
MX
Mexico
Prior art keywords
chromatin
regulator genes
genes
deregulation
regulator
Prior art date
Application number
MX9708401A
Other languages
English (en)
Other versions
MXPA97008401A (es
Inventor
Thomas Jenuwein
Gotz Laible
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MXPA97008401A publication Critical patent/MXPA97008401A/es
Publication of MX9708401A publication Critical patent/MX9708401A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invencion se relaciona con la desregulacion de los genes reguladores de la cromatina, los cuales tienen un domino SET, tal desregulacion es de importancia en ciertas condiciones del cáncer. Esos genes, en particular los dominios SET como tales, pueden usarse en el diagnostico y terapia de tales condiciones.
MX9708401A 1995-05-10 1996-05-02 Genes reguladores de la cromatina. MX9708401A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19516776.7 1995-05-10
DE19516776A DE19516776A1 (de) 1995-05-10 1995-05-10 Chromatin-Regulatorgene
PCT/EP1996/001818 WO1996035784A2 (de) 1995-05-10 1996-05-02 Chromatin-regulatorgene

Publications (2)

Publication Number Publication Date
MXPA97008401A MXPA97008401A (es) 1998-02-01
MX9708401A true MX9708401A (es) 1998-02-28

Family

ID=7761318

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708401A MX9708401A (es) 1995-05-10 1996-05-02 Genes reguladores de la cromatina.

Country Status (11)

Country Link
US (2) US6689583B1 (es)
EP (1) EP0827537B1 (es)
JP (1) JP4295824B2 (es)
AT (1) ATE404667T1 (es)
CA (1) CA2220442C (es)
DE (2) DE19516776A1 (es)
DK (1) DK0827537T3 (es)
ES (1) ES2313726T3 (es)
MX (1) MX9708401A (es)
PT (1) PT827537E (es)
WO (1) WO1996035784A2 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
US6239327B1 (en) * 1998-04-16 2001-05-29 Cold Spring Harbor Laboratory Seed specific polycomb group gene and methods of use for same
BR0009471A (pt) * 1999-03-11 2002-12-17 Genesis Res & Dev Corp Ltd Composições e processos para modificação de transcrição de gene
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US20020039776A1 (en) 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
AU2002211624A1 (en) * 2000-10-10 2002-04-22 Genencor International, Inc. Information rich libraries
US7264964B2 (en) 2001-06-22 2007-09-04 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
US20040053848A1 (en) * 2001-08-23 2004-03-18 Allis C. David Antibodies specific for methylated lysines in histones
AU2002359916A1 (en) * 2001-12-27 2003-07-15 Takeda Chemical Industries, Ltd. Preventives/remedies for cancer
GB0228900D0 (en) * 2002-12-11 2003-01-15 Ml Lab Plc Cancer Immunotherapy
WO2004058969A1 (ja) * 2002-12-24 2004-07-15 Takeda Pharmaceutical Company Limited がんの予防・治療剤
JPWO2005054467A1 (ja) * 2003-12-03 2007-12-06 中外製薬株式会社 哺乳類βアクチンプロモーターを利用した発現系
JP2005170799A (ja) * 2003-12-08 2005-06-30 Univ Kurume ｚｅｓｔｅホモログ２のエンハンサーのＨＬＡ−Ａ２４結合ペプチド
JP5160885B2 (ja) * 2004-06-01 2013-03-13 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 再構成ヒストンメチルトランスフェラーゼ複合体及びそのモジュレーターの識別方法
JP2009528050A (ja) * 2006-02-27 2009-08-06 イムジェン カンパニー リミテッド Ｂｍｉ−１を用いた星状細胞の神経幹細胞への脱分化
US8574832B2 (en) * 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
US20130195843A1 (en) * 2010-06-23 2013-08-01 British Columbia Cancer Agency Branch Biomarkers for Non-Hodgkin Lymphomas and Uses Thereof
US8895245B2 (en) * 2010-09-10 2014-11-25 Epizyme, Inc. Inhibitors of human EZH2 and methods of use thereof
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
EP2621942A4 (en) 2010-09-29 2015-01-21 Gen Hospital Corp MEANS FOR PROVIDING CONTROLS AND STANDARDS FOR IMMUNE PRECIPITATION ASSAYS
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
EP4190777A1 (en) 2012-04-13 2023-06-07 Epizyme, Inc. Hbr salt form for ezh2 inhibition
CA2888021A1 (en) 2012-10-15 2014-04-24 Epizyme, Inc. Substituted n-((2-oxo-1,2-dihydropyridin-3-yl)-methyl)-benzamide compounds and their use in the treatment of ezh2-mediated disorders
CA2905070A1 (en) 2013-03-14 2014-09-25 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
CN103215352B (zh) * 2013-03-29 2015-03-11 中国医学科学院血液病医院（血液学研究所） 一种检测setd2基因突变的试剂盒
MY179802A (en) 2013-10-16 2020-11-16 Eisai R&D Man Co Ltd Hydrochloride salt form for ezh2 inhibition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
EP0956032A4 (en) 1996-12-20 2002-09-04 Univ Texas PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
US5972608A (en) 1997-08-27 1999-10-26 University Of Massachusetts Assays and reagents for chromatin remodeling enzymes and their modulators
EP1029547A1 (en) 1999-02-15 2000-08-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Pharmaceutically active compounds and method for identifying same
US20020039776A1 (en) 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
US6555329B2 (en) 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US20020164620A1 (en) 2001-01-19 2002-11-07 Boehringer Ingelheim International Gmbh Method for identifying compounds modulating sister chromatid separation
EP1227160A1 (en) 2001-01-19 2002-07-31 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Compounds modulating sister chromatid separation and method for identifying same
CN1678735A (zh) 2001-05-04 2005-10-05 佛罗里达大学研究基金会有限公司 来源于细菌的丙酮酸脱羧酶(pdc)基因的克隆和测序及其用途

Also Published As

Publication number Publication date
JP2001505402A (ja) 2001-04-24
CA2220442C (en) 2011-07-12
PT827537E (pt) 2008-10-09
WO1996035784A3 (de) 1996-12-27
ATE404667T1 (de) 2008-08-15
DK0827537T3 (da) 2008-12-01
ES2313726T3 (es) 2009-03-01
WO1996035784A2 (de) 1996-11-14
DE59611481D1 (en) 2008-09-25
US20050089880A1 (en) 2005-04-28
JP4295824B2 (ja) 2009-07-15
EP0827537B1 (de) 2008-08-13
US6689583B1 (en) 2004-02-10
US7252968B2 (en) 2007-08-07
EP0827537A2 (de) 1998-03-11
CA2220442A1 (en) 1996-11-14
DE19516776A1 (de) 1996-11-14

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