DK0827537T3 - Chromatin-regulator-gener - Google Patents

Chromatin-regulator-gener

Info

Publication number
DK0827537T3
DK0827537T3 DK96914165T DK96914165T DK0827537T3 DK 0827537 T3 DK0827537 T3 DK 0827537T3 DK 96914165 T DK96914165 T DK 96914165T DK 96914165 T DK96914165 T DK 96914165T DK 0827537 T3 DK0827537 T3 DK 0827537T3
Authority
DK
Denmark
Prior art keywords
regulator genes
chromatin regulator
genes
chromatin
deregulation
Prior art date
Application number
DK96914165T
Other languages
English (en)
Inventor
Thomas Jenuwein
Goetz Laible
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK0827537T3 publication Critical patent/DK0827537T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK96914165T 1995-05-10 1996-05-02 Chromatin-regulator-gener DK0827537T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19516776A DE19516776A1 (de) 1995-05-10 1995-05-10 Chromatin-Regulatorgene
PCT/EP1996/001818 WO1996035784A2 (de) 1995-05-10 1996-05-02 Chromatin-regulatorgene

Publications (1)

Publication Number Publication Date
DK0827537T3 true DK0827537T3 (da) 2008-12-01

Family

ID=7761318

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96914165T DK0827537T3 (da) 1995-05-10 1996-05-02 Chromatin-regulator-gener

Country Status (11)

Country Link
US (2) US6689583B1 (da)
EP (1) EP0827537B1 (da)
JP (1) JP4295824B2 (da)
AT (1) ATE404667T1 (da)
CA (1) CA2220442C (da)
DE (2) DE19516776A1 (da)
DK (1) DK0827537T3 (da)
ES (1) ES2313726T3 (da)
MX (1) MX9708401A (da)
PT (1) PT827537E (da)
WO (1) WO1996035784A2 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
US6239327B1 (en) 1998-04-16 2001-05-29 Cold Spring Harbor Laboratory Seed specific polycomb group gene and methods of use for same
CA2366479A1 (en) * 1999-03-11 2000-09-14 Genesis Research And Development Corporation Ltd. Compositions and methods for the modification of gene transcription
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
US20020039776A1 (en) 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
WO2002031745A1 (en) * 2000-10-10 2002-04-18 Genencor International, Inc. Information rich libraries
WO2003000715A1 (en) 2001-06-22 2003-01-03 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
US20040053848A1 (en) * 2001-08-23 2004-03-18 Allis C. David Antibodies specific for methylated lysines in histones
WO2003055506A1 (fr) * 2001-12-27 2003-07-10 Takeda Chemical Industries, Ltd. Medicaments pour la prevention et le traitement du cancer
GB0228900D0 (en) * 2002-12-11 2003-01-15 Ml Lab Plc Cancer Immunotherapy
WO2004058969A1 (ja) * 2002-12-24 2004-07-15 Takeda Pharmaceutical Company Limited がんの予防・治療剤
CN1914320A (zh) 2003-12-03 2007-02-14 中外制药株式会社 利用哺乳类β肌动蛋白启动子的表达体系
JP2005170799A (ja) * 2003-12-08 2005-06-30 Univ Kurume zesteホモログ2のエンハンサーのHLA−A24結合ペプチド
JP5160885B2 (ja) * 2004-06-01 2013-03-13 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 再構成ヒストンメチルトランスフェラーゼ複合体及びそのモジュレーターの識別方法
WO2007097494A1 (en) * 2006-02-27 2007-08-30 Imgen Co., Ltd. De-differentiation of astrocytes into neural stem cell using bmi-1
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
US20130195843A1 (en) * 2010-06-23 2013-08-01 British Columbia Cancer Agency Branch Biomarkers for Non-Hodgkin Lymphomas and Uses Thereof
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
US9175331B2 (en) * 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
KR102373074B1 (ko) 2010-09-10 2022-03-11 에피자임, 인코포레이티드 인간 ezh2의 억제제 및 이의 사용 방법
WO2012050963A2 (en) 2010-09-29 2012-04-19 The General Hospital Corporation D/B/A Massachusetts General Hospital Agents providing controls and standards for immuno-precipitation assays
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
RU2658911C2 (ru) 2012-04-13 2018-06-26 Эпизайм, Инк. Солевая форма ингибитора гистон-метилтрансферазы ezh2 человека
US10092572B2 (en) 2012-10-15 2018-10-09 Epizyme, Inc. Substituted benzene compounds
RU2015139054A (ru) 2013-03-14 2017-04-19 Дженентек, Инк. Способы лечения рака и профилактики лекарственной резистентности рака
CN103215352B (zh) * 2013-03-29 2015-03-11 中国医学科学院血液病医院(血液学研究所) 一种检测setd2基因突变的试剂盒
EA038869B1 (ru) 2013-10-16 2021-10-29 Эпизим, Инк. Кристаллические формы гидрохлорида n-((4,6-диметил-2-оксо-1,2-дигидропиридин-3-ил)метил)-5-(этил(тетрагидро-2h-пиран-4-ил)амино)-4-метил-4'-(морфолинометил)-[1,1'-бифенил]-3-карбоксамида, фармацевтические композиции на их основе и способы их применения

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486623A (en) 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
EP0956032A4 (en) 1996-12-20 2002-09-04 Univ Texas PROTEINS AND COMPOSITIONS FOR MODULATING MITOSIS
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
US5972608A (en) * 1997-08-27 1999-10-26 University Of Massachusetts Assays and reagents for chromatin remodeling enzymes and their modulators
EP1029547A1 (en) 1999-02-15 2000-08-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Pharmaceutically active compounds and method for identifying same
US20020039776A1 (en) * 2000-06-09 2002-04-04 Thomas Jenuwein Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
US6555329B2 (en) * 2000-06-09 2003-04-29 Boehringer Ingelheim International Gmbh Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
EP1227160A1 (en) 2001-01-19 2002-07-31 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Compounds modulating sister chromatid separation and method for identifying same
US20020164620A1 (en) * 2001-01-19 2002-11-07 Boehringer Ingelheim International Gmbh Method for identifying compounds modulating sister chromatid separation
KR100708794B1 (ko) * 2001-05-04 2007-04-18 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. 박테리아로부터 유래한 피루베이트 데카르복실라제(pdc) 유전자의 클로닝 및 서열분석, 및 그의 용도

Also Published As

Publication number Publication date
DE59611481D1 (en) 2008-09-25
CA2220442C (en) 2011-07-12
PT827537E (pt) 2008-10-09
ATE404667T1 (de) 2008-08-15
US6689583B1 (en) 2004-02-10
US20050089880A1 (en) 2005-04-28
CA2220442A1 (en) 1996-11-14
JP2001505402A (ja) 2001-04-24
JP4295824B2 (ja) 2009-07-15
DE19516776A1 (de) 1996-11-14
WO1996035784A3 (de) 1996-12-27
US7252968B2 (en) 2007-08-07
EP0827537B1 (de) 2008-08-13
ES2313726T3 (es) 2009-03-01
MX9708401A (es) 1998-02-28
EP0827537A2 (de) 1998-03-11
WO1996035784A2 (de) 1996-11-14

Similar Documents

Publication Publication Date Title
DK0827537T3 (da) Chromatin-regulator-gener
TR200102499T2 (tr) Neoplazi tedavisinde bir kombinasyon terapisi olarak bir siklooksijenaz-2 inhibitörü ve bir veya daha fazla antineoplastik ajan kullanma yöntemi
MX9700534A (es) Uso de droloxifeno y sus sales farmaceuticamente aceptables en la preparacion de remedios para tratar las enfermedades de prostata, endometriosis y obesidad.
ATE301457T1 (de) Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
TR199701056T1 (xx) Farnesil-protein transferaz enzimi inhibit�rleri.
BR9805544C1 (pt) Uso de um composto.
EP0840608A4 (en) TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES
DE69518919T2 (de) Autoantikörper enthaltende zusammensetzung für tumorbehandlung und -vorbeugung
ATE196844T1 (de) Zusammensetzungen die konjugate von cis- docosahexaenoic-säure und taxotere enthalten
TR200000756T2 (tr) Davranış bozukluğu tedavisi.
PT1149092E (pt) 4- e 5-alciniloxindois e 4- e 5-alceniloxindois
ATE239509T1 (de) Konjugate zur behandlung von prostatakrebs
HUP0104688A2 (hu) Összetételek és eljárások a rákbetegség és a rákbetegséggel kapcsolódó csontveszteség megelőzéséhez és kezeléséhez
DK0876346T3 (da) Antimalariaaktive quinolinderivater
DE60037813D1 (de) Antworten auf hypoxia modifizieren
MX9201643A (es) Agentes contra tumores y anti-psoriasicos.
TR199802704T2 (xx) H�V tedavisinde Vx478, Zidov�din, FTC ve/veya 3TC i�eren kombinasyonlar�n kullan�m�.
NO981019L (no) Deodoriserende preparater inneholdende kationiske biopolymerer, aluminiumklorhydrat og esteraseinhibitorer
DE69723580D1 (de) Impfstoff gegen metastasierenden kolorektalkrebs.
AU1278600A (en) Novel therapeutic application of nicergoline
NO20005548D0 (no) Mykobakterieinhibitorer
DE59409704D1 (de) In den menschlichen körper einführbares instrument
MX9601031A (es) Composicion farmaceutica para el tratamiento y prevencion del cancer de prostata.
DE69838686D1 (de) Tripeptidylpeptidaseinhibitoren
TR199802703T2 (xx) HIV tedavisinde Vx478, Zidov�din, ve/veya 1592U89 i�eren kombinasyonlar�n kullan�m�.