ES2148171T3 - Gen mutado en cancer colorrectal de humanos. - Google Patents
Gen mutado en cancer colorrectal de humanos.Info
- Publication number
- ES2148171T3 ES2148171T3 ES92905276T ES92905276T ES2148171T3 ES 2148171 T3 ES2148171 T3 ES 2148171T3 ES 92905276 T ES92905276 T ES 92905276T ES 92905276 T ES92905276 T ES 92905276T ES 2148171 T3 ES2148171 T3 ES 2148171T3
- Authority
- ES
- Spain
- Prior art keywords
- mcc
- humans
- colorectal cancer
- mutated gene
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE DESCUBRE UN NUEVO GEN HUMANO DENOMINADO MCC. SE PROVEEN METODOS Y EQUIPOS PARA DETERMINAR MUTACIONES DEL GEN MCC EN TEJIDOS HUMANOS Y MUESTRAS CORPORALES. EN CELULAS DE TUMOR HUMANO SE OBSERVAN RECOMPOSICION INTEGRA Y MUTACIONES PUNTUALES. MCC SE EXPRESA EN LA MAYORIA DE LOS TEJIDOS NORMALES. ESTOS RESULTADOS SUGIEREN QUE MCC ES UN SUPRESOR DE TUMOR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/670,611 US5330892A (en) | 1991-03-13 | 1991-03-13 | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2148171T3 true ES2148171T3 (es) | 2000-10-16 |
Family
ID=24691103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92905276T Expired - Lifetime ES2148171T3 (es) | 1991-03-13 | 1992-01-16 | Gen mutado en cancer colorrectal de humanos. |
Country Status (11)
Country | Link |
---|---|
US (5) | US5330892A (es) |
EP (1) | EP0580596B1 (es) |
JP (1) | JP3501802B2 (es) |
AT (1) | ATE194660T1 (es) |
AU (1) | AU664834B2 (es) |
CA (1) | CA2105876A1 (es) |
DE (1) | DE69231245T2 (es) |
DK (1) | DK0580596T3 (es) |
ES (1) | ES2148171T3 (es) |
GR (1) | GR3034446T3 (es) |
WO (1) | WO1992016656A1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
JP3633932B2 (ja) | 1992-04-01 | 2005-03-30 | ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン | 糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬 |
US7326778B1 (en) * | 1993-05-05 | 2008-02-05 | The John Hopkins University | Mutator gene and hereditary non-polyposis colorectal cancer |
EP0700446A1 (en) * | 1993-05-26 | 1996-03-13 | The Johns Hopkins University | Antibodies specific for dcc gene product |
US5962220A (en) * | 1993-10-26 | 1999-10-05 | Thomas Jefferson University | Compositions that specifically bind to colorectal cells and methods of using the same |
US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
US7097839B1 (en) * | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
DE4431174A1 (de) * | 1994-09-01 | 1996-03-07 | Deutsches Krebsforsch | Nachweisverfahren für tumorspezifische mRNA |
US5891629A (en) * | 1995-09-28 | 1999-04-06 | Ambion, Inc. | Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids |
US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
US6242212B1 (en) * | 1996-02-09 | 2001-06-05 | Thomas Jefferson University | Fragile histidine triad (FHIT) nucleic acids and methods of producing FHIT proteins |
US5858673A (en) * | 1996-06-24 | 1999-01-12 | Charlotte-Mecklenburg Hospital Authority | Method for detecting prostate cells |
US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6146828A (en) * | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
US6020137A (en) * | 1996-08-14 | 2000-02-01 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
US6120995A (en) * | 1997-08-07 | 2000-09-19 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
US7135333B1 (en) | 1997-08-07 | 2006-11-14 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
US20020064792A1 (en) * | 1997-11-13 | 2002-05-30 | Lincoln Stephen E. | Database for storage and analysis of full-length sequences |
US6897018B1 (en) | 1998-02-25 | 2005-05-24 | The United States Of America As Represented By The Department Of Health And Human Services | DLC-1 gene deleted in cancers |
US7226731B1 (en) | 1998-07-24 | 2007-06-05 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | PB 39, a gene dysregulated in prostate cancer, and uses thereof |
AU5128799A (en) * | 1998-07-24 | 2000-02-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Pb 39, a gene dysregulated in prostate cancer, and uses thereof |
US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
ES2269102T3 (es) | 1999-02-25 | 2007-04-01 | Exact Sciences Corporation | Procedimientos para conservar la integridad del adn. |
DE60029092T2 (de) | 1999-04-09 | 2007-02-01 | Exact Sciences Corp., Marlborough | Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen |
US6586177B1 (en) * | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
US7368233B2 (en) * | 1999-12-07 | 2008-05-06 | Exact Sciences Corporation | Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm |
US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
CA2404428A1 (en) * | 2000-03-27 | 2001-10-04 | Thomas Jefferson University | High specificity marker detection |
US7923205B2 (en) * | 2000-08-25 | 2011-04-12 | Toshikazu Shiba | Method for protecting personal information |
US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
US7776524B2 (en) * | 2002-02-15 | 2010-08-17 | Genzyme Corporation | Methods for analysis of molecular events |
US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
CA2586515A1 (en) * | 2003-11-05 | 2005-05-26 | Exact Sciences Corporation | Repetitive reversed-field affinity electrophoresis and uses therefor |
WO2005071404A1 (en) * | 2004-01-23 | 2005-08-04 | Garvan Institute Of Medical Research | Methods of diagnosing colorectal cancer and reagents therefor |
WO2005111244A2 (en) * | 2004-05-10 | 2005-11-24 | Exact Sciences Corporation | Methods for detecting a mutant nucleic acid |
US20080124714A1 (en) * | 2004-05-14 | 2008-05-29 | Exact Sciences Corporation | Method for Stabilizing Biological Samples for Nucleic Acid Analysis |
WO2006026654A2 (en) * | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
WO2007044071A2 (en) * | 2005-04-21 | 2007-04-19 | Exact Sciences Corporation | Analysis of heterogeneous nucleic acid samples |
US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
SG11201604737VA (en) | 2013-12-11 | 2016-07-28 | Accuragen Inc | Compositions and methods for detecting rare sequence variants |
KR20180055905A (ko) | 2015-10-09 | 2018-05-25 | 아큐라젠 홀딩스 리미티드 | 증폭 산물의 농축을 위한 방법 및 조성물 |
CA3024630A1 (en) | 2016-05-16 | 2017-11-23 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
CN109844133A (zh) | 2016-08-15 | 2019-06-04 | 安可济控股有限公司 | 检测罕见序列变体的组合物和方法 |
US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
CN115963268B (zh) * | 2023-02-14 | 2023-09-19 | 浙江大学 | 一种用于结直肠癌早期诊断的血浆分泌蛋白组合及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU625169B2 (en) * | 1987-03-23 | 1992-07-02 | Imperial Chemical Industries Plc | Molecular markers |
JPH03505675A (ja) * | 1988-10-31 | 1991-12-12 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア | 新生表現型の抑制を制御する産生体及び方法 |
US5352775A (en) * | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
US5411860A (en) * | 1992-04-07 | 1995-05-02 | The Johns Hopkins University | Amplification of human MDM2 gene in human tumors |
-
1991
- 1991-03-13 US US07/670,611 patent/US5330892A/en not_active Expired - Lifetime
-
1992
- 1992-01-16 AU AU13302/92A patent/AU664834B2/en not_active Ceased
- 1992-01-16 DK DK92905276T patent/DK0580596T3/da active
- 1992-01-16 AT AT92905276T patent/ATE194660T1/de not_active IP Right Cessation
- 1992-01-16 EP EP92905276A patent/EP0580596B1/en not_active Expired - Lifetime
- 1992-01-16 DE DE69231245T patent/DE69231245T2/de not_active Expired - Fee Related
- 1992-01-16 JP JP50475792A patent/JP3501802B2/ja not_active Expired - Lifetime
- 1992-01-16 ES ES92905276T patent/ES2148171T3/es not_active Expired - Lifetime
- 1992-01-16 WO PCT/US1992/000377 patent/WO1992016656A1/en active IP Right Grant
- 1992-01-16 CA CA002105876A patent/CA2105876A1/en not_active Abandoned
-
1994
- 1994-03-31 US US08/220,674 patent/US5571905A/en not_active Expired - Lifetime
-
1995
- 1995-05-19 US US08/446,549 patent/US5693536A/en not_active Expired - Lifetime
- 1995-05-19 US US08/446,550 patent/US5830676A/en not_active Expired - Lifetime
- 1995-05-19 US US08/445,186 patent/US5576422A/en not_active Expired - Lifetime
-
2000
- 2000-09-20 GR GR20000402138T patent/GR3034446T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5571905A (en) | 1996-11-05 |
EP0580596A1 (en) | 1994-02-02 |
AU1330292A (en) | 1992-10-21 |
GR3034446T3 (en) | 2000-12-29 |
JP3501802B2 (ja) | 2004-03-02 |
US5576422A (en) | 1996-11-19 |
CA2105876A1 (en) | 1992-09-14 |
EP0580596B1 (en) | 2000-07-12 |
DK0580596T3 (da) | 2000-10-30 |
ATE194660T1 (de) | 2000-07-15 |
DE69231245T2 (de) | 2001-02-01 |
JPH06509701A (ja) | 1994-11-02 |
US5830676A (en) | 1998-11-03 |
DE69231245D1 (de) | 2000-08-17 |
US5330892A (en) | 1994-07-19 |
US5693536A (en) | 1997-12-02 |
WO1992016656A1 (en) | 1992-10-01 |
AU664834B2 (en) | 1995-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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