EA199900349A1 - Каталитическая субъединица теломеразы человека - Google Patents

Каталитическая субъединица теломеразы человека

Info

Publication number
EA199900349A1
EA199900349A1 EA199900349A EA199900349A EA199900349A1 EA 199900349 A1 EA199900349 A1 EA 199900349A1 EA 199900349 A EA199900349 A EA 199900349A EA 199900349 A EA199900349 A EA 199900349A EA 199900349 A1 EA199900349 A1 EA 199900349A1
Authority
EA
Eurasian Patent Office
Prior art keywords
human telomerase
unit
human
catalytic sub
present
Prior art date
Application number
EA199900349A
Other languages
English (en)
Inventor
Томас Р. Кеч
Йоахим Лингнер
Тору Накамура
Карен Б. Чэпмен
Грегг Б. Морин
Келвин Б. Харли
Уилльям Х. Эндрюз
Original Assignee
Джерон Корпорейшн
Юниверсити Текнолоджи Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27575511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900349(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/851,843 external-priority patent/US6093809A/en
Priority claimed from US08/854,050 external-priority patent/US6261836B1/en
Priority claimed from US08/912,951 external-priority patent/US6475789B1/en
Application filed by Джерон Корпорейшн, Юниверсити Текнолоджи Корпорейшн filed Critical Джерон Корпорейшн
Publication of EA199900349A1 publication Critical patent/EA199900349A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1276RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07049RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/15Nucleic acids forming more than 2 strands, e.g. TFOs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/828Cancer

Abstract

В настоящем изобретении созданы композиции и способы, имеющие отношение к обратной транскриптазе теломеразы человека (hTRT), к каталитической субъединице теломеразы человека. Полинуклеотиды и полипептиды настоящего изобретения пригодны для диагноза, прогноза и лечения заболеваний человека, для изменения пролиферативной способности клеток и организмов и для идентификации и скринирования соединений и терапий, пригодных для лечения таких заболеваний, как раковые заболевания.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900349A 1996-10-01 1997-10-01 Каталитическая субъединица теломеразы человека EA199900349A1 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US72464396A 1996-10-01 1996-10-01
US84441997A 1997-04-18 1997-04-18
US84601797A 1997-04-25 1997-04-25
US08/851,843 US6093809A (en) 1996-10-01 1997-05-06 Telomerase
US08/854,050 US6261836B1 (en) 1996-10-01 1997-05-09 Telomerase
US91550397A 1997-08-14 1997-08-14
US91131297A 1997-08-14 1997-08-14
US08/912,951 US6475789B1 (en) 1996-10-01 1997-08-14 Human telomerase catalytic subunit: diagnostic and therapeutic methods
PCT/US1997/017885 WO1998014593A2 (en) 1996-10-01 1997-10-01 Human telomerase catalytic subunit

Publications (1)

Publication Number Publication Date
EA199900349A1 true EA199900349A1 (ru) 2000-06-26

Family

ID=27575511

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199900355A EA199900355A1 (ru) 1996-10-01 1997-10-01 Теломераза обратная тринскриптаза
EA199900349A EA199900349A1 (ru) 1996-10-01 1997-10-01 Каталитическая субъединица теломеразы человека

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199900355A EA199900355A1 (ru) 1996-10-01 1997-10-01 Теломераза обратная тринскриптаза

Country Status (21)

Country Link
US (4) US6166178A (ru)
EP (6) EP0954585B1 (ru)
JP (7) JP2001523947A (ru)
KR (2) KR20000048820A (ru)
CN (3) CN102021153B (ru)
AT (3) ATE245194T1 (ru)
AU (2) AU734089B2 (ru)
BR (3) BR9711844A (ru)
CA (3) CA2645721C (ru)
DE (5) DE19743497A1 (ru)
EA (2) EA199900355A1 (ru)
ES (1) ES2205132T5 (ru)
FI (1) FI990655A0 (ru)
FR (1) FR2757177A1 (ru)
GB (2) GB2317891C (ru)
HK (1) HK1156967A1 (ru)
IL (2) IL129222A0 (ru)
NO (2) NO319982B1 (ru)
NZ (1) NZ334709A (ru)
SG (1) SG94355A1 (ru)
WO (2) WO1998014593A2 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2581800C2 (ru) * 2010-02-16 2016-04-20 Ультимовакс Ас Полипептиды

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
US6517834B1 (en) * 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
ATE219151T1 (de) 1995-11-16 2002-06-15 Michael W Dahm Verfahren zur quantifizierung von tumorzellen in einer körperflüssigkeit und dazu geeignete testkits
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6607898B1 (en) 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6444650B1 (en) * 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6261836B1 (en) * 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
EP0954585B1 (en) 1996-10-01 2009-11-25 Geron Corporation Human telomerase reverse transcriptase promoter
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
EP0942991A2 (en) * 1996-11-26 1999-09-22 Baylor College Of Medicine Identification of inhibitors that prevent access of telomerase to chromosomal terminus
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US20050013825A1 (en) * 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
EP0990037A2 (de) * 1997-06-20 2000-04-05 Bayer Ag Humane katalytische telomerase-untereinheit und deren diagnostische und therapeutische verwendung
EP1571215A3 (en) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
KR100581990B1 (ko) * 1997-07-01 2006-05-23 캄비아 바이오시스템즈 엘엘씨 척추 동물 텔로머라제 유전자 및 단백질과 이의 용도
US7378244B2 (en) * 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (en) * 1997-11-26 1999-06-03 Geron Corporation Mouse telomerase reverse transcriptase
DE19757984A1 (de) * 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
DE19804372A1 (de) 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
US6639057B1 (en) 1998-03-26 2003-10-28 Kyowa Hakko Kogyo Co., Ltd. Monoclonal antibody against human telomerase catalytic subunit
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US20030105315A1 (en) * 1998-04-09 2003-06-05 Metagen Pharmaceuticals Gmbh Human nucleic acid sequences from ovarian tumor tissue
US7030211B1 (en) 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000025813A1 (en) 1998-10-29 2000-05-11 Dana-Farber Cancer Institute CANCER IMMUNOTHERAPHY AND DIAGNOSIS USING UNIVERSAL TUMOR ASSOCIATED ANTIGENS, INCLUDING hTERT
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
WO2000043501A2 (de) * 1999-01-22 2000-07-27 Humboldt-Universität Zu Berlin Universitätsklinikum Charite GEGEN DIE KATALYTISCHE UNTEREINHEIT DER HUMANEN TELOMERASE (hTERT) GERICHTETE RIBOZYME
EP1147181B1 (en) * 1999-02-04 2004-05-12 Geron Corporation Replicative virus driven by the promoter for telomerase reverse transcriptase for use in treating cancer
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (en) 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
CA2368967A1 (en) * 1999-04-09 2000-10-19 Biomira, Inc. Telomerase-specific cancer vaccine
US6358739B1 (en) * 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
DE19916929A1 (de) 1999-04-15 2000-10-19 Bayer Ag Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
CA2382521C (en) 1999-09-10 2009-08-25 Sergei Gryaznov Oligonucleotide n3'.fwdarw.p5' thiophosphoramidates: their synthesis and use
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
WO2001036971A1 (fr) * 1999-11-16 2001-05-25 Kyowa Hakko Kogyo Co., Ltd. Methode de recherche de substance d'inhibition de liaison entre des sous-unites de telomerase
GB9927353D0 (en) * 1999-11-19 2000-01-19 Cantab Pharma Res Virus preparation and use
US6664046B1 (en) * 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
KR20010096991A (ko) * 2000-04-19 2001-11-08 임정빈 텔로머레이즈의 프로모터에 특정하게 결합하는더블유티이1 절편, 그 유전자, 발현벡터 및 그것을 이용한세포성장 억제 방법
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
IT1318504B1 (it) * 2000-05-08 2003-08-27 Talent Srl Metodo e apparecchiatura per la diagnosi precoce di tumori vescicalisu campioni di urina.
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US6492171B2 (en) * 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
US7078491B1 (en) 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6713055B2 (en) 2000-11-27 2004-03-30 Geron Corporation Glycosyltransferase vectors for treating cancer
AU2002226076A1 (en) * 2000-12-14 2002-06-24 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Telomerase immortalized human liver cell lines
US6906237B2 (en) * 2001-02-27 2005-06-14 G. Scott Herron Vivo assay for anti angiogenic compounds
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US7262174B2 (en) * 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
GB0112342D0 (en) * 2001-05-21 2001-07-11 Norsk Hydro As Polypeptides
US7291499B2 (en) 2001-07-16 2007-11-06 Fuyuki Ishikawa Transformed cell, method of screening anti-aging agent and anti-aging agent
US7150989B2 (en) * 2001-08-10 2006-12-19 Cornell Research Foundation, Inc. Telomerase immortalized neural progenitor cells
AUPR769701A0 (en) * 2001-09-14 2001-10-11 Li, He Telomerase inhibitory peptides and uses thereof
EP1440085B8 (de) * 2001-10-18 2010-08-04 Medicyte GmbH Transiente immortalisierung von zellen durch onkogenproteine oder telomerproteine
CA2478681A1 (en) * 2001-10-22 2003-05-01 University Of Rochester Telomerase interference
WO2003038076A1 (fr) * 2001-10-31 2003-05-08 Renomedix Institute Inc. Cellules mesenchymateuses immortalisees et leur utilisation
CA2470539C (en) * 2001-12-07 2011-10-04 Geron Corporation Islet cells from human embryonic stem cells
US20030153082A1 (en) 2001-12-07 2003-08-14 The John P. Robarts Research Institute Hematopoietic cells from human embryonic stem cells
DE10163130B4 (de) * 2001-12-20 2009-05-14 Cyto Tools Gmbh Apoptotisch wirksame Peptide und diese umfassende pharmazeutische Zusammensetzungen
WO2003054545A1 (fr) * 2001-12-21 2003-07-03 Mitsubishi Kagaku Iatron, Inc. Procede permettant de detecter un anticorps anti-telomerase
GB0200929D0 (en) * 2002-01-16 2002-03-06 Univ Glasgow Tissue rejection
ATE548461T1 (de) * 2002-01-18 2012-03-15 Morphotek Inc Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
US20030175961A1 (en) * 2002-02-26 2003-09-18 Herron G. Scott Immortal micorvascular endothelial cells and uses thereof
US20050106729A1 (en) * 2002-05-03 2005-05-19 Mark Irvin Rosenblatt Gene transfer methods and compositions
EP1513865A4 (en) * 2002-05-28 2006-05-03 Univ Minnesota CRISP POLYPEPTIDES AS PREVENTIONAL AND INHIBITORS OF SPERM CAPACITATION
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
CA2488924A1 (en) * 2002-06-18 2003-12-24 Zymogenetics, Inc. Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
AU2003290689A1 (en) 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
WO2004099385A2 (en) * 2003-04-30 2004-11-18 Duke University Telomere elongation
KR101465515B1 (ko) 2003-06-23 2014-11-26 텔로머레이스 엑티베이션 사이언시즈, 인코퍼레이티드 텔로머라제 활성을 증가시키기 위한 조성물 및 방법
EP1664098A1 (en) * 2003-09-12 2006-06-07 Reneuron Limited Immortalisation of mammalian cells and therapeutic applications of said cells
EP1522858A1 (en) * 2003-10-10 2005-04-13 Jean-Christophe Roegel Methods for selecting compounds using antibodies with activity as agonist, antagonist or allosteric modulators
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
DE602005025106D1 (de) 2004-05-11 2011-01-13 Axiogenesis Ag Methoden zur medikamentenaufspürung auf der basis von in vitro differenzierten zellen
EP1781337A4 (en) * 2004-08-05 2010-06-23 Univ Leland Stanford Junior METHODS AND COMPOSITIONS FOR CELL ACTIVATION
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
JP2006242618A (ja) * 2005-03-01 2006-09-14 Univ Of Tokyo 組織fish法によるテロメア量を指標とした癌の診断
JP4635196B2 (ja) * 2005-03-04 2011-02-16 国立大学法人広島大学 遺伝子導入細胞、及びそれを用いたテロメラーゼ誘導物質の検出方法
RU2007137122A (ru) * 2005-03-09 2009-04-20 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем (Us) НОВЫЙ ПРОМОТОР hTMC И ВЕКТОРЫ ДЛЯ ОПУХОЛЕСЕЛЕКТИВНОЙ И ВЫСОКОЭФФЕКТИВНОЙ ЭКСПРЕССИИ ТЕРАПЕВТИЧЕСКИХ ПРОТИВОРАКОВЫХ ГЕНОВ
EP1886138A4 (en) * 2005-05-11 2009-04-15 Genetic Technologies Ltd PROCESS FOR ENRICHING FETTAL CELLS
EP1748067A1 (en) * 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
ES2672205T3 (es) 2005-12-21 2018-06-13 Université Catholique de Louvain Células madre hepáticas aisladas
WO2007149182A2 (en) 2006-06-19 2007-12-27 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2008002285A1 (en) * 2006-06-26 2008-01-03 Science Applications International Corporation Igy antibodies to human telomerase reverse transcriptase
US20080131442A1 (en) * 2006-06-26 2008-06-05 Science Applications International Corporation IgY antibodies to human telomerase reverse transcriptase
AU2013203229C1 (en) * 2006-07-28 2015-10-29 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
CN105132439A (zh) 2006-07-28 2015-12-09 宾夕法尼亚大学托管会 改进的疫苗及其使用方法
ES2376010T3 (es) * 2006-10-12 2012-03-08 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Prote�?na de fusión de transcriptasa inversa de la telomerasa, nucleótidos que la codifican y usos de la misma.
EP2088864B1 (en) 2006-11-03 2017-08-16 The Board of Trustees of the Leland Stanford Junior University Selective immunodepletion of endogenous stem cell niche for engraftment
EP1994942A1 (en) * 2007-05-25 2008-11-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions comprising telomerase, and uses thereof
ES2751997T3 (es) 2008-01-14 2020-04-02 Conventus Orthopaedics Inc Aparato de reparación de fracturas
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
US20110014161A1 (en) * 2009-07-09 2011-01-20 Xiaozhen Wang Cardiac Tissue-Derived Cells
US20110178520A1 (en) 2010-01-15 2011-07-21 Kyle Taylor Rotary-rigid orthopaedic rod
CN102821707B (zh) 2010-01-20 2016-02-03 康文图斯整形外科公司 用于骨接近和骨腔准备的装置及方法
US9249452B2 (en) * 2010-02-26 2016-02-02 Zhu Zhen Pirot Method of detecting and assaying telomerase activity of telomerase bound by anti-telomerase antibodies
CN105361942B (zh) 2010-03-08 2018-01-09 康文图斯整形外科公司 用于固定骨植入物的装置及方法
AU2011236653B2 (en) 2010-04-08 2016-10-27 The University Court Of The University Of Edinburgh Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
WO2012026309A1 (ja) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 抗pad4抗体医薬の創成
CN102093980B (zh) * 2010-12-10 2013-04-17 梁伟国 永生化人椎间盘髓核细胞体系的制备方法
US8420617B2 (en) * 2011-03-11 2013-04-16 Biocell Laboratories Multiantivirus compound, composition and method for treatment of virus diseases
CN102676518B (zh) * 2012-02-27 2013-09-18 华侨大学 一种新型抗肿瘤amiRNA序列及其应用
EP2639299A1 (en) 2012-03-16 2013-09-18 Invectys Universal cancer peptides derived from telomerase
US9730984B2 (en) * 2012-05-11 2017-08-15 Gemvax & Kael Co., Ltd. Composition for preventing or treating rheumatoid arthritis
KR20210025132A (ko) * 2012-05-11 2021-03-08 주식회사 젬백스앤카엘 항염증 활성을 갖는 펩티드 및 이를 포함하는 조성물
US10900072B2 (en) * 2012-06-27 2021-01-26 Rutgers, The State University Of New Jersey Rapid assays for T-cell activation by RNA measurements using flow cytometry
US20150125438A1 (en) * 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
CN110028554B (zh) * 2012-09-19 2023-04-07 珍白斯凯尔有限公司 细胞穿透性肽、包含该肽的缀合物、及包含该缀合物的组合物
ES2802253T3 (es) * 2012-09-19 2021-01-18 Gemvax & Kael Co Ltd Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado
KR102038487B1 (ko) 2012-09-19 2019-10-30 주식회사 젬백스앤카엘 텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물
KR102166542B1 (ko) 2012-09-28 2020-10-16 주식회사 젬백스앤카엘 줄기세포 검출을 위한 텔로머라제 유래 펩티드 및 조영물질의 컨쥬게이트 및 이를 포함하는 조영제
KR102093093B1 (ko) 2012-12-13 2020-03-25 주식회사 젬백스앤카엘 피부 노화 개선용 조성물
KR102106756B1 (ko) 2012-12-13 2020-05-06 주식회사 젬백스앤카엘 자외선에 의한 피부 손상 예방 또는 치료용 조성물
AU2014218667A1 (en) 2013-02-22 2015-10-08 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods, and kits relating to telomere extension
US10138488B2 (en) 2013-03-28 2018-11-27 Invectys Cancer vaccine for dogs
US9931387B2 (en) 2013-03-28 2018-04-03 Invectys Cancer vaccine for cats
MX2015017103A (es) 2013-06-11 2016-11-07 Harvard College Celulas beta derivadas de células madre ( sc-beta ) y composiciones y métodos para generarlas.
CN106061509B (zh) 2013-10-28 2022-04-08 英韦克泰斯公司 编码端粒酶的dna疫苗
JP6601915B2 (ja) 2013-10-28 2019-11-06 アンヴェクティ 皮膚細胞への電気的遺伝子導入
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
AU2014362251B2 (en) 2013-12-12 2019-10-10 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
KR102166549B1 (ko) 2014-01-10 2020-10-16 주식회사 젬백스앤카엘 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트
SI3656869T1 (sl) 2014-08-26 2021-03-31 The Board Of Trustees Of The Leland Stanford Junior University Vsaditev matičnih celic s kombinacijo sredstva, ki cilja matične celice in modulacija imunoregulatornega signaliziranja
EP3370764A4 (en) 2015-11-05 2019-07-17 The Regents of The University of California CELLS MARKED BY LIPID CONJUGATES AND METHODS OF USING THE SAME
AU2017208848A1 (en) 2016-01-19 2018-07-12 Pfizer Inc. Cancer vaccines
CN110312527A (zh) 2017-01-30 2019-10-08 小利兰·斯坦福大学托管委员会 用于干细胞移植的非基因毒性预处理方案
US10631881B2 (en) 2017-03-09 2020-04-28 Flower Orthopedics Corporation Plating depth gauge and countersink instrument
US11351246B2 (en) 2017-05-09 2022-06-07 Invectys SAS Recombinant measles vaccine expressing hTERT
WO2019010252A2 (en) 2017-07-04 2019-01-10 Conventus Orthopaedics, Inc. APPARATUS AND METHODS FOR TREATING BONES
US11786557B2 (en) 2017-10-02 2023-10-17 Fred Hutchinson Cancer Center Luteinizing hormone receptor binding agents and luteinizing hormone agonists to identify, expand, ablate and modify stem cells
CN108715863B (zh) * 2018-05-30 2020-09-11 吉林大学 一种肿瘤靶向性载体pcTERT及其构建方法及其应用
CN110827920B (zh) * 2018-08-14 2022-11-22 武汉华大医学检验所有限公司 测序数据分析方法和设备及高通量测序方法
CN112930404A (zh) * 2018-09-05 2021-06-08 瑞德库尔有限责任公司 用于治疗剂分析的方法和系统
AU2019333905A1 (en) * 2018-09-06 2021-03-04 The Board Of Regents Of The University Of Texas System Telomerase holoenzyme complex and methods of use thereof
CN109545039A (zh) * 2019-01-15 2019-03-29 苏州大学 一种核孔复合体结构模型教具及其使用方法
CA3145681A1 (en) 2019-07-05 2021-01-14 Case Western Reserve University Priming media and methods for stem cell culture and therapy
JP2021151979A (ja) * 2020-03-24 2021-09-30 均 石井 再生医療薬
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
JP2022151412A (ja) * 2021-03-23 2022-10-07 均 石井 脳卒中治療薬
CN113355303B (zh) * 2021-06-07 2023-06-16 中元汇吉生物技术股份有限公司 一种m-mlv逆转录酶突变体及其应用
WO2023141534A1 (en) * 2022-01-19 2023-07-27 Northwestern University Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy
CN114920802B (zh) * 2022-05-16 2023-05-23 中国地质大学(武汉) 调节端粒酶限速蛋白运动的多肽探针及其复合物和方法
CN116364195B (zh) * 2023-05-10 2023-10-13 浙大城市学院 一种基于预训练模型的微生物遗传序列表型预测方法

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US912629A (en) 1908-08-29 1909-02-16 Conrad L Stueber Foundation-top for pipe-carriers.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4254082A (en) 1978-06-12 1981-03-03 Miles Laboratories, Inc. Specific binding-adsorbent assay test means
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
JPS57502090A (ru) 1980-07-18 1982-11-25
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US5055556A (en) 1981-10-06 1991-10-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Fluorescent conjugates for analysis of molecules and cells
JPS58215453A (ja) 1982-06-09 1983-12-14 Toray Silicone Co Ltd 室温硬化後塗装可能なオルガノポリシロキサン組成物
FR2542494B1 (fr) 1983-03-08 1985-08-16 Sevylor International Combinaison protectrice, utilisable notamment en atmosphere irradiee
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
US4889806A (en) 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US5017478A (en) 1987-07-16 1991-05-21 Berlex Laboratories, Inc. Transfected cells containing plasmids having genes oriented in opposing directions and methods of using
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5075227A (en) * 1989-03-07 1991-12-24 Zymogenetics, Inc. Directional cloning
JPH02307059A (ja) 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
AU647741B2 (en) 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
DE69027683T2 (de) 1989-12-01 1997-02-13 Pharming Bv Herstellung rekombinanter polypeptide durch rinder und transgene methoden
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
DE69034135T3 (de) 1989-12-22 2012-08-23 Laboratoires Serono S.A. DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen
EP0466874A1 (fr) 1990-02-09 1992-01-22 Asulab S.A. Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
AU7979491A (en) 1990-05-03 1991-11-27 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
SE468913B (sv) 1990-05-16 1993-04-05 Igesto Ab Saekerhetskrok
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
KR100198659B1 (ko) 1996-05-16 1999-06-15 구본준 메모리 셀, 메모리 장치 및 그의 제조 방법
JP2904583B2 (ja) 1991-10-11 1999-06-14 プロメガ・コーポレーション 真核無細胞抽出物中での転写と翻訳の共役
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
AU687736B2 (en) 1992-05-11 1998-03-05 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting viral replication
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US5645986A (en) 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5648215A (en) 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5639613A (en) 1992-05-13 1997-06-17 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
EP0654077A4 (en) 1992-07-17 1996-03-13 Ribozyme Pharm Inc PROCESS AND REAGENT FOR THE TREATMENT OF DISEASES IN ANIMALS.
US6107062A (en) 1992-07-30 2000-08-22 Inpax, Inc. Antisense viruses and antisense-ribozyme viruses
GB2273932A (en) 1992-11-24 1994-07-06 Stiefel Laboratories Stable oligonucleotides
WO1994012629A1 (en) 1992-12-02 1994-06-09 Baylor College Of Medicine Episomal vectors for gene therapy
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
AU680459B2 (en) 1992-12-03 1997-07-31 Genzyme Corporation Gene therapy for cystic fibrosis
JPH08508636A (ja) 1993-01-27 1996-09-17 オンコール インコーポレーテッド 核酸配列の増幅
US6140087A (en) 1993-06-24 2000-10-31 Advec, Inc. Adenovirus vectors for gene therapy
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
US6120764A (en) 1993-06-24 2000-09-19 Advec, Inc. Adenoviruses for control of gene expression
WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
HUT78054A (hu) * 1994-07-07 1999-07-28 Geron Corporation Emlőseredetű telomeráz RNS-összetevője
US5597697A (en) 1994-09-30 1997-01-28 Diamond; Paul Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases
US5698686A (en) 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
JPH10513343A (ja) * 1994-12-19 1998-12-22 コールド スプリング ハーバー ラボラトリー テロメラーゼの蛋白質成分
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
WO1997015687A1 (en) 1995-06-07 1997-05-01 Geron Corporation Telomerase activity assays
EP0832190A1 (en) 1995-06-07 1998-04-01 Cold Spring Harbor Laboratory Essential oligonucleotides of vertebrate telomerase
US5722998A (en) 1995-06-07 1998-03-03 Intermedics, Inc. Apparatus and method for the control of an implantable medical device
US5968506A (en) 1995-08-04 1999-10-19 Geron Corporation Purified telomerase
US6517834B1 (en) 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
DE69524247T2 (de) 1995-08-04 2002-08-08 Ibm Stempel für lithographie-verfahren
JPH09154575A (ja) 1995-10-04 1997-06-17 Soosei:Kk テロメラーゼ
JPH09164575A (ja) 1995-12-13 1997-06-24 Japan Steel Works Ltd:The 流れ模様を有する樹脂板の製造方法およびその装置
US6015710A (en) 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US5747317A (en) 1996-07-08 1998-05-05 Tularik Inc. Human telomerase RNA interacting protein gene
US5770422A (en) 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
US5724021A (en) 1996-07-09 1998-03-03 Stephen C. Perrone Self-contained, programmable, time interval alarm reminder device for eyedrop medication administration and a means for affixing such to eyedrop/medication container
WO1998007838A1 (fr) 1996-08-21 1998-02-26 Mitsubishi Chemical Corporation Proteine de telomerase d'animaux superieurs et gene codant pour elle
WO1998008938A1 (en) 1996-08-28 1998-03-05 Shonen Yoshida Proteins having telomerase activity
DE19638482A1 (de) 1996-09-20 1998-04-02 Bosch Gmbh Robert Verfahren zur Auswahl einer Sendefrequenz
US6767719B1 (en) 1997-11-26 2004-07-27 Geron Corporation Mouse telomerase reverse transcriptase
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
EP0954585B1 (en) 1996-10-01 2009-11-25 Geron Corporation Human telomerase reverse transcriptase promoter
US5890326A (en) 1996-11-06 1999-04-06 Hill-Rom, Inc. Head wall for a hospital room
US7390891B1 (en) * 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
US5919656A (en) 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
EP0942991A2 (en) 1996-11-26 1999-09-22 Baylor College Of Medicine Identification of inhibitors that prevent access of telomerase to chromosomal terminus
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
ES2208895T3 (es) * 1997-04-04 2004-06-16 Geron Corporation Telomerasa purificada.
US6485789B1 (en) 1997-04-14 2002-11-26 3M Innovative Properties Company Fluorochemical composition containing a condensation product of a fluorochemical polyether and a poly-isocyanate to impart stain release properties to a substrate
US20050013825A1 (en) 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US6201830B1 (en) 1997-06-11 2001-03-13 Texas Instruments Incorporated Low computation idle transmission method for DSL modems
EP0990037A2 (de) * 1997-06-20 2000-04-05 Bayer Ag Humane katalytische telomerase-untereinheit und deren diagnostische und therapeutische verwendung
KR100581990B1 (ko) 1997-07-01 2006-05-23 캄비아 바이오시스템즈 엘엘씨 척추 동물 텔로머라제 유전자 및 단백질과 이의 용도
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (en) 1997-11-26 1999-06-03 Geron Corporation Mouse telomerase reverse transcriptase
DE19757984A1 (de) 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
US6608188B1 (en) 1998-01-08 2003-08-19 Chugai Seiyaku Kabushiki Kaisha CRT-1 gene having reverse transcriptase motif
GB9801902D0 (en) 1998-01-29 1998-03-25 Cancer Res Campaign Tech A gene promoter
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
JP2002509716A (ja) 1998-03-31 2002-04-02 ユニバーシティ テクノロジー コーポレイション テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物
CA2331378A1 (en) 1998-06-12 1999-12-16 Sloan-Kettering Institute For Cancer Research Vaccination strategy to prevent and treat cancers
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
EP1147181B1 (en) 1999-02-04 2004-05-12 Geron Corporation Replicative virus driven by the promoter for telomerase reverse transcriptase for use in treating cancer
CA2368967A1 (en) 1999-04-09 2000-10-19 Biomira, Inc. Telomerase-specific cancer vaccine
WO2000073420A2 (en) 1999-06-02 2000-12-07 Whitehead Institute For Biomedical Research Creation of human tumorigenic cells and uses therefor
US6354941B2 (en) 1999-11-03 2002-03-12 516 Holdings Electronic system for a game of chance
CA2399816A1 (en) 2000-02-15 2001-08-23 Regents Of The University Of California A universal vaccine and method for treating cancer employing telomerase reverse transcriptase
US7262174B2 (en) 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
JP2002348474A (ja) 2001-05-23 2002-12-04 Dow Corning Toray Silicone Co Ltd ポリオルガノシロキサンマイクロエマルジョン組成物および化粧料原料
US20030143228A1 (en) 2001-10-29 2003-07-31 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-II restricted tumor-associated antigen
US7294708B2 (en) 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
KR100705868B1 (ko) 2003-05-06 2007-04-10 후지 덴키 디바이스 테크놀로지 가부시키가이샤 반도체 장치 및 그 제조 방법

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2581800C2 (ru) * 2010-02-16 2016-04-20 Ультимовакс Ас Полипептиды
US9657068B2 (en) 2010-02-16 2017-05-23 Ultimovacs As Telomerase polypeptide vaccine for treating cancer
US10383928B2 (en) 2010-02-16 2019-08-20 Ultimovacs As Telomerase polypeptide vaccine for treating cancer
US11529403B2 (en) 2010-02-16 2022-12-20 Ultimovacs As Telomerase polypeptide vaccine for treating cancer

Also Published As

Publication number Publication date
US6166178A (en) 2000-12-26
DE69739497D1 (de) 2009-08-27
GB2317891A (en) 1998-04-08
IL129103A0 (en) 2000-02-17
CA2266752A1 (en) 1998-04-09
EP0841396B2 (en) 2012-04-11
DE69739675D1 (de) 2010-01-07
NO20053120L (no) 1998-04-02
EP1783139B1 (en) 2009-07-15
GB2321642B (en) 2000-02-09
CN1291231A (zh) 2001-04-11
BR9712254A (pt) 2000-01-18
WO1998014592A2 (en) 1998-04-09
NO991588D0 (no) 1999-03-31
CN102021153A (zh) 2011-04-20
GB2321642B8 (en) 2006-08-22
JPH11253177A (ja) 1999-09-21
CN1291231B (zh) 2010-06-02
ES2205132T3 (es) 2004-05-01
JP4070331B2 (ja) 2008-04-02
ATE449851T1 (de) 2009-12-15
AU4803697A (en) 1998-04-24
GB2317891B (en) 1998-08-19
DE19743497A1 (de) 1998-08-20
DE69723531D1 (de) 2003-08-21
EP1783139A3 (en) 2007-05-23
EP1333094B1 (en) 2012-04-04
EP0954585A2 (en) 1999-11-10
US20090269739A1 (en) 2009-10-29
HK1156967A1 (zh) 2012-06-22
EP0841396A1 (en) 1998-05-13
CN1254376A (zh) 2000-05-24
EA199900355A1 (ru) 2000-08-28
DE69723531T3 (de) 2012-09-06
CA2645721C (en) 2015-05-12
FR2757177A1 (fr) 1998-06-19
GB9804859D0 (en) 1998-04-29
KR100530483B1 (ko) 2006-01-09
ATE552341T1 (de) 2012-04-15
CA2645721A1 (en) 1998-04-09
US8222392B2 (en) 2012-07-17
GB9720890D0 (en) 1997-12-03
WO1998014592A3 (en) 1999-04-01
EP1333094A3 (en) 2005-02-09
NO319982B1 (no) 2005-10-10
KR20000048839A (ko) 2000-07-25
NO332085B1 (no) 2012-06-18
JP2001510985A (ja) 2001-08-07
NO20053120D0 (no) 2005-06-24
WO1998014593A9 (en) 1999-05-14
JP2009040779A (ja) 2009-02-26
EP0841396B1 (en) 2003-07-16
AU4807397A (en) 1998-04-24
EP0932686A2 (en) 1999-08-04
DE69723531T2 (de) 2004-05-27
WO1998014593A3 (en) 1999-02-18
FI990655A (fi) 1999-03-24
BR9711844A (pt) 2000-01-18
SG94355A1 (en) 2003-02-18
JP2001523947A (ja) 2001-11-27
JP3869092B2 (ja) 2007-01-17
DE841396T1 (de) 1998-09-24
CN102021153B (zh) 2016-05-25
WO1998014593A2 (en) 1998-04-09
JP2001081042A (ja) 2001-03-27
NZ334709A (en) 2001-06-29
EP1783139A2 (en) 2007-05-09
ES2205132T5 (es) 2012-06-18
JPH11313689A (ja) 1999-11-16
JP4852576B2 (ja) 2012-01-11
NO991588L (no) 1999-05-31
GB2317891C (en) 2015-06-24
EP1333094A2 (en) 2003-08-06
BRPI9712254B1 (pt) 2019-01-15
CA2267664C (en) 2013-06-11
EP0954585B1 (en) 2009-11-25
FI990655A0 (fi) 1999-03-24
KR20000048820A (ko) 2000-07-25
EP2213740A1 (en) 2010-08-04
US7517971B1 (en) 2009-04-14
AU734089B2 (en) 2001-06-07
JPH10234384A (ja) 1998-09-08
CA2267664A1 (en) 1998-04-09
GB2321642A (en) 1998-08-05
ATE245194T1 (de) 2003-08-15
EP1783139B8 (en) 2009-09-23
IL129222A0 (en) 2000-02-17
US6617110B1 (en) 2003-09-09

Similar Documents

Publication Publication Date Title
EA199900349A1 (ru) Каталитическая субъединица теломеразы человека
TR199901971T2 (xx) Bir resept�re ba�lanan peptidler ve bile�ikler.
DE60136099D1 (de) Zusammensetzungen zur behandlung und diagnose von eierstockkrebs
PT991421E (pt) Deteccao e modulacao das iap e naip para o diagnostico e tratamento de doenca proliferativa
NZ512247A (en) Compositions and methods for therapy and diagnosis of ovarian cancer
AR006250A1 (es) Compuestos y metodos para la inmunoterapia e inmunodiagnostico del cancer prostatico
NO20002979D0 (no) Undersøkelse av human papillomavirus-relatert sykdom
DE60039752D1 (de) Herstellung tetravalenter antikörper
ES2148171T3 (es) Gen mutado en cancer colorrectal de humanos.
BR9807734A (pt) Composto para imunodiagnose de câncer de próstata e métodos para o uso dos memos
RU2001104349A (ru) Композиции и способы для терапии и диагностики рака предстательной железы
EA199800692A1 (ru) Изолируемые смеси из семян eugenia jambolana lamarck, способы их получения, способ получения оксамата натрия, лекарственные средства для профилактики и лечения диабета и применение указанных смесей, их компонентов и оксамата натрия для получения этих лекарственных средств
WO2001018046A3 (en) Ovarian tumor sequences and methods of use therefor
WO2004047757A3 (en) Diagnosing and treating hematopoietic cancers
DE69942637D1 (de) Zusammensetzungen und verfahren für die therapie und diagnose von ovariumkrebs
WO1999064869A3 (en) Back pain diagnosis and apparatus for use therein
ATE542900T1 (de) Icbp90-polypeptide, polypeptidfragmente davon, die dafür kodierenden polynukleotide, und ihre verwendung zur behandlung und diagnose von krebs
BR1100558A (pt) famìlia de anticorpos modificados, com elevada afinidade, para tratamento de cáncer.
WO2000056351A3 (en) Combination use of gemcitabine and tumor suppressor gene therapy in the treatment of neoplasms