NO991588L - Human telomerase katalytisk subenhet - Google Patents

Human telomerase katalytisk subenhet

Info

Publication number
NO991588L
NO991588L NO991588A NO991588A NO991588L NO 991588 L NO991588 L NO 991588L NO 991588 A NO991588 A NO 991588A NO 991588 A NO991588 A NO 991588A NO 991588 L NO991588 L NO 991588L
Authority
NO
Norway
Prior art keywords
human telomerase
catalytic subunit
telomerase catalytic
human
treatment
Prior art date
Application number
NO991588A
Other languages
English (en)
Other versions
NO319982B1 (no
NO991588D0 (no
Inventor
Thomas R Cech
Joachim Lingner
Toru Nakamura
Karen B Chapman
Gregg B Morin
Calvin B Harley
William H Andrews
Original Assignee
Geron Corp
Univ Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27575511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO991588(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/851,843 external-priority patent/US6093809A/en
Priority claimed from US08/854,050 external-priority patent/US6261836B1/en
Priority claimed from US08/912,951 external-priority patent/US6475789B1/en
Application filed by Geron Corp, Univ Technology Corp filed Critical Geron Corp
Publication of NO991588D0 publication Critical patent/NO991588D0/no
Publication of NO991588L publication Critical patent/NO991588L/no
Publication of NO319982B1 publication Critical patent/NO319982B1/no

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
NO19991588A 1996-10-01 1999-03-31 Human telomerase katalytisk subenhet NO319982B1 (no)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US72464396A 1996-10-01 1996-10-01
US84441997A 1997-04-18 1997-04-18
US84601797A 1997-04-25 1997-04-25
US08/851,843 US6093809A (en) 1996-10-01 1997-05-06 Telomerase
US08/854,050 US6261836B1 (en) 1996-10-01 1997-05-09 Telomerase
US91131297A 1997-08-14 1997-08-14
US91550397A 1997-08-14 1997-08-14
US08/912,951 US6475789B1 (en) 1996-10-01 1997-08-14 Human telomerase catalytic subunit: diagnostic and therapeutic methods
PCT/US1997/017885 WO1998014593A2 (en) 1996-10-01 1997-10-01 Human telomerase catalytic subunit

Publications (3)

Publication Number Publication Date
NO991588D0 NO991588D0 (no) 1999-03-31
NO991588L true NO991588L (no) 1999-05-31
NO319982B1 NO319982B1 (no) 2005-10-10

Family

ID=27575511

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19991588A NO319982B1 (no) 1996-10-01 1999-03-31 Human telomerase katalytisk subenhet
NO20053120A NO332085B1 (no) 1996-10-01 2005-06-24 Immunogent peptid av hTRT samt fragment derav, sammensetning, isolert eller rekombinant polynukleotid, vektor og farmasoytisk sammensetning.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20053120A NO332085B1 (no) 1996-10-01 2005-06-24 Immunogent peptid av hTRT samt fragment derav, sammensetning, isolert eller rekombinant polynukleotid, vektor og farmasoytisk sammensetning.

Country Status (21)

Country Link
US (4) US6166178A (no)
EP (6) EP1333094B1 (no)
JP (7) JP2001510985A (no)
KR (2) KR20000048820A (no)
CN (3) CN102021153B (no)
AT (3) ATE552341T1 (no)
AU (2) AU4803697A (no)
BR (3) BRPI9712254B1 (no)
CA (3) CA2645721C (no)
DE (5) DE19743497A1 (no)
EA (2) EA199900349A1 (no)
ES (1) ES2205132T5 (no)
FI (1) FI990655A (no)
FR (1) FR2757177A1 (no)
GB (2) GB2321642B8 (no)
HK (1) HK1156967A1 (no)
IL (2) IL129222A0 (no)
NO (2) NO319982B1 (no)
NZ (1) NZ334709A (no)
SG (1) SG94355A1 (no)
WO (2) WO1998014593A2 (no)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US6517834B1 (en) * 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
CN1202206A (zh) 1995-11-16 1998-12-16 M·W·达姆 用于定量测定体液中肿瘤细胞的方法和适于此方法的试验试剂盒
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6607898B1 (en) 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6444650B1 (en) * 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
JP2001510985A (ja) * 1996-10-01 2001-08-07 ジェロン コーポレイション ヒトテロメラーゼ触媒性サブユニット
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
KR20000057258A (ko) * 1996-11-26 2000-09-15 크로커 사무엘 에스 염색체 말단으로 텔로머라제가 접근하는 것을 방지하는 억제제의 확인
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US20050013825A1 (en) * 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
CA2294646A1 (en) * 1997-06-20 1998-12-30 Bayer Aktiengesellschaft Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
CN1270634A (zh) * 1997-07-01 2000-10-18 卡姆比亚生物系统有限责任公司 脊椎动物端粒酶基因和蛋白质及其用途
EP1571215A3 (en) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
AU1606999A (en) * 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
DE19757984A1 (de) * 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
DE19804372A1 (de) * 1998-02-04 1999-08-05 Michael W Dr Dr Dahm Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits
EP0990701A4 (en) * 1998-03-26 2001-12-12 Kyowa Hakko Kogyo Kk MONOCLONAL ANTIBODIES AGAINST A CATALYTIC SUBUNIT OF HUMAN TELOMERASE
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US20030105315A1 (en) * 1998-04-09 2003-06-05 Metagen Pharmaceuticals Gmbh Human nucleic acid sequences from ovarian tumor tissue
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000025813A1 (en) 1998-10-29 2000-05-11 Dana-Farber Cancer Institute CANCER IMMUNOTHERAPHY AND DIAGNOSIS USING UNIVERSAL TUMOR ASSOCIATED ANTIGENS, INCLUDING hTERT
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
EP1149161A2 (de) * 1999-01-22 2001-10-31 Humboldt-Universität zu Berlin Universitätsklinikum Charite; GEGEN DIE KATALYTISCHE UNTEREINHEIT DER HUMANEN TELOMERASE (hTERT) GERICHTETE RIBOZYME
DK1147181T3 (da) * 1999-02-04 2004-09-20 Geron Corp Telomerase revers transkriptase transskriptionelle regulatoriske sekvenser
US7314926B1 (en) 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1171612A2 (en) * 1999-04-09 2002-01-16 Biomira, Inc. Telomerase-specific cancer vaccine
US6358739B1 (en) * 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
DE19916929A1 (de) * 1999-04-15 2000-10-19 Bayer Ag Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
CA2382521C (en) 1999-09-10 2009-08-25 Sergei Gryaznov Oligonucleotide n3'.fwdarw.p5' thiophosphoramidates: their synthesis and use
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
AU1309101A (en) * 1999-11-16 2001-05-30 Kyowa Hakko Kogyo Co. Ltd. Method of searching for substance inhibiting binding between telomerase subunits
GB9927353D0 (en) * 1999-11-19 2000-01-19 Cantab Pharma Res Virus preparation and use
US6664046B1 (en) * 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
KR20010096991A (ko) * 2000-04-19 2001-11-08 임정빈 텔로머레이즈의 프로모터에 특정하게 결합하는더블유티이1 절편, 그 유전자, 발현벡터 및 그것을 이용한세포성장 억제 방법
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
IT1318504B1 (it) * 2000-05-08 2003-08-27 Talent Srl Metodo e apparecchiatura per la diagnosi precoce di tumori vescicalisu campioni di urina.
US6492171B2 (en) 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
US7078491B1 (en) 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6713055B2 (en) 2000-11-27 2004-03-30 Geron Corporation Glycosyltransferase vectors for treating cancer
AU2002226076A1 (en) * 2000-12-14 2002-06-24 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Telomerase immortalized human liver cell lines
US6906237B2 (en) * 2001-02-27 2005-06-14 G. Scott Herron Vivo assay for anti angiogenic compounds
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US7262174B2 (en) * 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
GB0112342D0 (en) * 2001-05-21 2001-07-11 Norsk Hydro As Polypeptides
CA2454873C (en) * 2001-07-16 2013-10-01 Fuyuki Ishikawa Novel transformed cell, method for screening anti-aging agent, and anti-aging agent
WO2003014320A2 (en) * 2001-08-10 2003-02-20 Cornell Research Foundation, Inc. Telomerase immortalized human neutral stem cells and phenotypically-restricted progenitor cells
AUPR769701A0 (en) * 2001-09-14 2001-10-11 Li, He Telomerase inhibitory peptides and uses thereof
ATE464316T1 (de) * 2001-10-18 2010-04-15 Heart Biosystems Gmbh Transiente immortalisierung von zellen durch onkogenproteine oder telomerproteine
WO2003035667A2 (en) * 2001-10-22 2003-05-01 University Of Rochester Telomerase interference
JPWO2003038076A1 (ja) * 2001-10-31 2005-02-24 株式会社レノメディクス研究所 不死化間葉系細胞及びその利用
EP1463803B1 (en) 2001-12-07 2018-02-14 Asterias Biotherapeutics, Inc. Hematopoietic cells from human embryonic stem cells
KR101089591B1 (ko) 2001-12-07 2011-12-05 제론 코포레이션 인간 배아 줄기세포 유래의 섬세포
DE10163130B4 (de) * 2001-12-20 2009-05-14 Cyto Tools Gmbh Apoptotisch wirksame Peptide und diese umfassende pharmazeutische Zusammensetzungen
AU2002357613A1 (en) * 2001-12-21 2003-07-09 Shuichi Kaneko Method of detecting antitelomerase antibody
GB0200929D0 (en) * 2002-01-16 2002-03-06 Univ Glasgow Tissue rejection
US7638334B2 (en) * 2002-01-18 2009-12-29 Morphotek, Inc. Method for generating engineered cells by homologously recombining segments having increased degeneracy
US20030175961A1 (en) * 2002-02-26 2003-09-18 Herron G. Scott Immortal micorvascular endothelial cells and uses thereof
US20050106729A1 (en) * 2002-05-03 2005-05-19 Mark Irvin Rosenblatt Gene transfer methods and compositions
EP1513865A4 (en) * 2002-05-28 2006-05-03 Univ Minnesota CRISP POLYPEPTIDES AS PREVENTIONAL AND INHIBITORS OF SPERM CAPACITATION
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
EP1513929A4 (en) * 2002-06-18 2006-04-19 Zymogenetics Inc HYBRID VECTOR WITH A CYTOMEGALOVIRUS ENHANCER AND PROMOTER OF MYELOPROLIFERATIVE SARCOMA VIRUS
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
KR20050093761A (ko) 2002-11-08 2005-09-23 헤마테크, 엘엘씨 프리온 단백질 활성이 감소된 트랜스제닉 유제동물 및 그의용도
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
WO2004099385A2 (en) * 2003-04-30 2004-11-18 Duke University Telomere elongation
ZA200509846B (en) 2003-06-23 2007-04-25 Geron Corp Compositions and methods for increasing telomerase activity
CA2536655A1 (en) * 2003-09-12 2005-03-24 Reneuron Limited Immortalisation of mammalian cells and therapeutic applications of said cells
EP1522858A1 (en) * 2003-10-10 2005-04-13 Jean-Christophe Roegel Methods for selecting compounds using antibodies with activity as agonist, antagonist or allosteric modulators
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
WO2005104835A2 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
DK3070174T3 (da) 2004-05-11 2020-01-27 Ncardia Ag Opsporing af lægemidler på grundlag af in vitro-differentierede celler
EP1781337A4 (en) * 2004-08-05 2010-06-23 Univ Leland Stanford Junior METHODS AND COMPOSITIONS FOR CELL ACTIVATION
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
JP2006242618A (ja) * 2005-03-01 2006-09-14 Univ Of Tokyo 組織ｆｉｓｈ法によるテロメア量を指標とした癌の診断
JP4635196B2 (ja) * 2005-03-04 2011-02-16 国立大学法人広島大学 遺伝子導入細胞、及びそれを用いたテロメラーゼ誘導物質の検出方法
CA2601187A1 (en) * 2005-03-09 2006-09-14 Board Of Regents, The University Of Texas System Novel htmc promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes
EP1886138A4 (en) * 2005-05-11 2009-04-15 Genetic Technologies Ltd PROCESS FOR ENRICHING FETTAL CELLS
EP1748067A1 (en) * 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
JP5250423B2 (ja) 2005-12-21 2013-07-31 ユニヴァルシテ カソリック デ ルーバン 単離肝幹細胞
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US20080131442A1 (en) * 2006-06-26 2008-06-05 Science Applications International Corporation IgY antibodies to human telomerase reverse transcriptase
WO2008002285A1 (en) * 2006-06-26 2008-01-03 Science Applications International Corporation Igy antibodies to human telomerase reverse transcriptase
AU2013203229C1 (en) * 2006-07-28 2015-10-29 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
EP2594576B1 (en) 2006-07-28 2015-07-01 The Trustees of The University of Pennsylvania Improved HIV vaccines
CN101522706B (zh) * 2006-10-12 2013-09-04 P.安杰莱蒂分子生物学研究所 端粒酶逆转录酶融合蛋白、编码它的核苷酸以及其用途
EP3960764A1 (en) 2006-11-03 2022-03-02 The Board of Trustees of the Leland Stanford Junior University Selective immunodepletion of endogenous stem cell niche for engraftment
EP1994942A1 (en) * 2007-05-25 2008-11-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions comprising telomerase, and uses thereof
CN105213010A (zh) 2008-01-14 2016-01-06 康文图斯整形外科公司 用于骨折修补的装置和方法
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
SG175282A1 (en) 2009-04-21 2011-11-28 Genetic Technologies Ltd Methods for obtaining fetal genetic material
US20110014161A1 (en) * 2009-07-09 2011-01-20 Xiaozhen Wang Cardiac Tissue-Derived Cells
EP2523614A4 (en) 2010-01-15 2017-02-15 Conventus Orthopaedics, Inc. Rotary-rigid orthopaedic rod
CA2823873A1 (en) 2010-01-20 2011-07-28 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
RS59462B1 (sr) 2010-02-16 2019-11-29 Ultimovacs As Polipeptidi
WO2011106671A1 (en) * 2010-02-26 2011-09-01 Geron Corporation Assay for telomerase activity
EP2544608A4 (en) 2010-03-08 2017-02-22 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
JP5926240B2 (ja) 2010-04-08 2016-05-25 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｃｏｕｒｔ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｅｄｉｎｂｕｒｇｈ 軟骨形成性始原細胞、細胞の派生のためのプロトコールおよびその使用
WO2012026309A1 (ja) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 抗ｐａｄ４抗体医薬の創成
CN102093980B (zh) * 2010-12-10 2013-04-17 梁伟国 永生化人椎间盘髓核细胞体系的制备方法
US8420617B2 (en) * 2011-03-11 2013-04-16 Biocell Laboratories Multiantivirus compound, composition and method for treatment of virus diseases
CN102676518B (zh) * 2012-02-27 2013-09-18 华侨大学 一种新型抗肿瘤amiRNA序列及其应用
EP2639299A1 (en) 2012-03-16 2013-09-18 Invectys Universal cancer peptides derived from telomerase
JP6267190B2 (ja) * 2012-05-11 2018-01-24 ジェムバックス アンド カエル カンパニー，リミティド 悪液質の予防用または治療用組成物
JP6466833B2 (ja) * 2012-05-11 2019-02-06 ジェムバックス アンド カエル カンパニー，リミティド 抗炎症活性を有するペプチド、及びそれを含む組成物
AU2013280416B2 (en) * 2012-06-27 2017-06-15 Rutgers, The State University Of New Jersey Rapid assays for T-cell activation by RNA measurements using flow cytometry
US20150125438A1 (en) * 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
KR102038487B1 (ko) 2012-09-19 2019-10-30 주식회사 젬백스앤카엘 텔로머라제 펩티드를 포함하는 항균 또는 항진균용 조성물
JP6510410B2 (ja) * 2012-09-19 2019-05-08 ジェムバックス アンド カエル カンパニー，リミティド 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物
TWI655287B (zh) * 2012-09-19 2019-04-01 韓商傑姆維克斯＆凱爾有限公司 穿膜胜肽以及包含該胜肽之共軛物及組成物（三）
KR102166542B1 (ko) 2012-09-28 2020-10-16 주식회사 젬백스앤카엘 줄기세포 검출을 위한 텔로머라제 유래 펩티드 및 조영물질의 컨쥬게이트 및 이를 포함하는 조영제
KR102093093B1 (ko) 2012-12-13 2020-03-25 주식회사 젬백스앤카엘 피부 노화 개선용 조성물
KR102106756B1 (ko) 2012-12-13 2020-05-06 주식회사 젬백스앤카엘 자외선에 의한 피부 손상 예방 또는 치료용 조성물
CA2902237C (en) 2013-02-22 2024-02-13 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods, and kits relating to telomere extension
EP2978444B1 (en) 2013-03-28 2018-12-05 Invectys A cancer vaccine for dogs
AU2014242915B2 (en) 2013-03-28 2018-08-09 Invectys A cancer vaccine for cats
US20170029778A1 (en) 2013-06-11 2017-02-02 President And Fellows Of Harvard College Sc-beta cells and compositions and methods for generating the same
US10183065B2 (en) 2013-10-28 2019-01-22 Invectys Telomerase encoding DNA vaccine
AU2014343808B2 (en) 2013-10-28 2020-03-05 Centre National De La Recherche Scientifique Gene electrotransfer into skin cells
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
CA2969316A1 (en) 2013-12-12 2015-06-18 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
KR102166549B1 (ko) 2014-01-10 2020-10-16 주식회사 젬백스앤카엘 혈뇌장벽 투과성 펩티드 및 이를 포함하는 컨쥬게이트
FI3186395T4 (fi) 2014-08-26 2023-05-25 Kantasolujen siirto kantasoluihin kohdistuvan aineen ja immunoregulatorisen signaloinnin modulaation yhdistelmällä
US20190209697A1 (en) 2015-11-05 2019-07-11 The Regents Of The University Of California Cells labelled with lipid conjugates and methods of use thereof
SI3405212T1 (sl) 2016-01-19 2020-09-30 Pfizer Inc. Cepiva proti raku
EP3573629A4 (en) 2017-01-30 2020-10-14 The Board of Trustees of the Leland Stanford Junior University NON-GENOTOXIC CONDITIONING REGIME FOR STEM CELL TRANSPLANTATION
US10631881B2 (en) 2017-03-09 2020-04-28 Flower Orthopedics Corporation Plating depth gauge and countersink instrument
US11351246B2 (en) 2017-05-09 2022-06-07 Invectys SAS Recombinant measles vaccine expressing hTERT
US10918426B2 (en) 2017-07-04 2021-02-16 Conventus Orthopaedics, Inc. Apparatus and methods for treatment of a bone
WO2019070740A2 (en) 2017-10-02 2019-04-11 Fred Hutchinson Cancer Research Center LUTENING HORMONE RECEPTOR BINDING AGENTS AND LUTINISING HORMONE AGONISTS FOR IDENTIFICATION, MULTIPLICATION, REMOVAL AND MODIFICATION OF PRIMITIVE STEM CELL POPULATIONS
CN108715863B (zh) * 2018-05-30 2020-09-11 吉林大学 一种肿瘤靶向性载体pcTERT及其构建方法及其应用
CN110827920B (zh) * 2018-08-14 2022-11-22 武汉华大医学检验所有限公司 测序数据分析方法和设备及高通量测序方法
SG11202102255VA (en) * 2018-09-05 2021-04-29 Readcoor Llc Methods and systems for therapeutic agent analysis
KR20210057024A (ko) * 2018-09-06 2021-05-20 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 텔로머라제 완전효소 복합체 및 이의 사용 방법
CN109545039A (zh) * 2019-01-15 2019-03-29 苏州大学 一种核孔复合体结构模型教具及其使用方法
JP2022539249A (ja) 2019-07-05 2022-09-07 ケース ウェスタン リザーブ ユニバーシティ 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法
JP2021151979A (ja) * 2020-03-24 2021-09-30 均 石井 再生医療薬
CN112063601B (zh) * 2020-09-22 2023-06-02 浙江愈方生物科技有限公司 一种灭活性端粒酶、具有其的腺病毒和人造mRNA及应用
JP2022151412A (ja) * 2021-03-23 2022-10-07 均 石井 脳卒中治療薬
CN113355303B (zh) * 2021-06-07 2023-06-16 中元汇吉生物技术股份有限公司 一种m-mlv逆转录酶突变体及其应用
WO2023141534A1 (en) * 2022-01-19 2023-07-27 Northwestern University Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy
CN114920802B (zh) * 2022-05-16 2023-05-23 中国地质大学（武汉） 调节端粒酶限速蛋白运动的多肽探针及其复合物和方法
CN116364195B (zh) * 2023-05-10 2023-10-13 浙大城市学院 一种基于预训练模型的微生物遗传序列表型预测方法

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US912629A (en) 1908-08-29 1909-02-16 Conrad L Stueber Foundation-top for pipe-carriers.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4254082A (en) 1978-06-12 1981-03-03 Miles Laboratories, Inc. Specific binding-adsorbent assay test means
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
JPS57502090A (no) 1980-07-18 1982-11-25
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US5055556A (en) 1981-10-06 1991-10-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Fluorescent conjugates for analysis of molecules and cells
JPS58215453A (ja) 1982-06-09 1983-12-14 Toray Silicone Co Ltd 室温硬化後塗装可能なオルガノポリシロキサン組成物
FR2542494B1 (fr) 1983-03-08 1985-08-16 Sevylor International Combinaison protectrice, utilisable notamment en atmosphere irradiee
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
GB8612087D0 (en) 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
US4889806A (en) 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US5017478A (en) 1987-07-16 1991-05-21 Berlex Laboratories, Inc. Transfected cells containing plasmids having genes oriented in opposing directions and methods of using
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5093245A (en) 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5075227A (en) * 1989-03-07 1991-12-24 Zymogenetics, Inc. Directional cloning
JPH02307059A (ja) 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5437994A (en) 1989-06-15 1995-08-01 Regents Of The University Of Michigan Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
EP0502976B1 (en) 1989-12-01 1996-07-03 Pharming B.V. Production of recombinant polypeptides by bovine species and transgenic methods
AU647741B2 (en) 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
ATE264916T1 (de) 1989-12-22 2004-05-15 Applied Research Systems Dns-konstrukten zur aktivierung und veränderung der expression von endogenen genen
EP0466874A1 (fr) 1990-02-09 1992-01-22 Asulab S.A. Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
AU7979491A (en) 1990-05-03 1991-11-27 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
SE468913B (sv) 1990-05-16 1993-04-05 Igesto Ab Saekerhetskrok
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
KR100198659B1 (ko) 1996-05-16 1999-06-15 구본준 메모리 셀, 메모리 장치 및 그의 제조 방법
DE69216385T2 (de) 1991-10-11 1997-06-12 Promega Corp Gekoppelte transkription und translation in zellfreien eukaryoten-extrakten
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
EP0642589A4 (en) 1992-05-11 1997-05-21 Ribozyme Pharm Inc METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5639613A (en) 1992-05-13 1997-06-17 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5645986A (en) 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5648215A (en) 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
US6107062A (en) 1992-07-30 2000-08-22 Inpax, Inc. Antisense viruses and antisense-ribozyme viruses
GB2273932A (en) 1992-11-24 1994-07-06 Stiefel Laboratories Stable oligonucleotides
WO1994012629A1 (en) 1992-12-02 1994-06-09 Baylor College Of Medicine Episomal vectors for gene therapy
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
JPH08508636A (ja) 1993-01-27 1996-09-17 オンコール インコーポレーテッド 核酸配列の増幅
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
US6140087A (en) 1993-06-24 2000-10-31 Advec, Inc. Adenovirus vectors for gene therapy
US6120764A (en) 1993-06-24 2000-09-19 Advec, Inc. Adenoviruses for control of gene expression
WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
RO117328B1 (ro) * 1994-07-07 2002-01-30 Geron Corp Componenta rna a telomerazei de mamifere, plasmida recombinanta, de exprimare a acesteia, si metoda pentru detectarea prezentei unei stari neoplazice
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5597697A (en) 1994-09-30 1997-01-28 Diamond; Paul Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases
US5698686A (en) * 1994-10-20 1997-12-16 Arch Development Corporation Yeast telomerase compositions
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
EP0799315A2 (en) 1994-12-19 1997-10-08 Cold Spring Harbor Laboratory Telomerase protein component
US5741677A (en) 1995-06-07 1998-04-21 Geron Corporation Methods for measuring telomere length
US5722998A (en) 1995-06-07 1998-03-03 Intermedics, Inc. Apparatus and method for the control of an implantable medical device
JPH11507839A (ja) 1995-06-07 1999-07-13 ジェロン コーポレイション テロメラーゼ活性検定
JPH11507818A (ja) 1995-06-07 1999-07-13 コールド・スプリング・ハーバー・ラボラトリー 脊椎動物テロメラーゼの必須オリゴヌクレオチド
US6545133B1 (en) 1995-08-04 2003-04-08 Geron Corporation Methods for purifying telomerase
DE69524247T2 (de) 1995-08-04 2002-08-08 Ibm Stempel für lithographie-verfahren
US5968506A (en) 1995-08-04 1999-10-19 Geron Corporation Purified telomerase
US6517834B1 (en) 1995-08-04 2003-02-11 Geron Corporation Purified telomerase
JPH09154575A (ja) 1995-10-04 1997-06-17 Soosei:Kk テロメラーゼ
JPH09164575A (ja) 1995-12-13 1997-06-24 Japan Steel Works Ltd:The 流れ模様を有する樹脂板の製造方法およびその装置
US6015710A (en) 1996-04-09 2000-01-18 The University Of Texas System Modulation of mammalian telomerase by peptide nucleic acids
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US5770422A (en) * 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
US5747317A (en) 1996-07-08 1998-05-05 Tularik Inc. Human telomerase RNA interacting protein gene
US5724021A (en) 1996-07-09 1998-03-03 Stephen C. Perrone Self-contained, programmable, time interval alarm reminder device for eyedrop medication administration and a means for affixing such to eyedrop/medication container
WO1998007838A1 (fr) 1996-08-21 1998-02-26 Mitsubishi Chemical Corporation Proteine de telomerase d'animaux superieurs et gene codant pour elle
AU4030697A (en) 1996-08-28 1998-03-19 Shonen Yoshida Proteins having telomerase activity
DE19638482A1 (de) 1996-09-20 1998-04-02 Bosch Gmbh Robert Verfahren zur Auswahl einer Sendefrequenz
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
JP2001510985A (ja) 1996-10-01 2001-08-07 ジェロン コーポレイション ヒトテロメラーゼ触媒性サブユニット
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6767719B1 (en) 1997-11-26 2004-07-27 Geron Corporation Mouse telomerase reverse transcriptase
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US5890326A (en) 1996-11-06 1999-04-06 Hill-Rom, Inc. Head wall for a hospital room
US5919656A (en) 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
KR20000057258A (ko) 1996-11-26 2000-09-15 크로커 사무엘 에스 염색체 말단으로 텔로머라제가 접근하는 것을 방지하는 억제제의 확인
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
EP0981627B1 (en) * 1997-04-04 2003-09-17 Geron Corporation Purified telomerase
US6485789B1 (en) 1997-04-14 2002-11-26 3M Innovative Properties Company Fluorochemical composition containing a condensation product of a fluorochemical polyether and a poly-isocyanate to impart stain release properties to a substrate
US7622549B2 (en) * 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US20050013825A1 (en) 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US6201830B1 (en) 1997-06-11 2001-03-13 Texas Instruments Incorporated Low computation idle transmission method for DSL modems
CA2294646A1 (en) * 1997-06-20 1998-12-30 Bayer Aktiengesellschaft Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
CN1270634A (zh) 1997-07-01 2000-10-18 卡姆比亚生物系统有限责任公司 脊椎动物端粒酶基因和蛋白质及其用途
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
AU1606999A (en) 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
DE19757984A1 (de) 1997-12-24 1999-07-01 Bayer Ag Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung
US6608188B1 (en) 1998-01-08 2003-08-19 Chugai Seiyaku Kabushiki Kaisha CRT-1 gene having reverse transcriptase motif
GB9801902D0 (en) 1998-01-29 1998-03-25 Cancer Res Campaign Tech A gene promoter
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
WO1999063945A2 (en) 1998-06-12 1999-12-16 Sloan-Kettering Institute For Cancer Research Vaccination strategy to prevent and treat cancers
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
DK1147181T3 (da) 1999-02-04 2004-09-20 Geron Corp Telomerase revers transkriptase transskriptionelle regulatoriske sekvenser
EP1171612A2 (en) 1999-04-09 2002-01-16 Biomira, Inc. Telomerase-specific cancer vaccine
WO2000073420A2 (en) 1999-06-02 2000-12-07 Whitehead Institute For Biomedical Research Creation of human tumorigenic cells and uses therefor
US6354941B2 (en) 1999-11-03 2002-03-12 516 Holdings Electronic system for a game of chance
US7388071B2 (en) 2000-02-15 2008-06-17 The Regents Of The University Of California Composition and method for inducing and enhancing a telomerase reverse transcriptase-reactive cytotoxic T lymphocyte response
US7262174B2 (en) 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
JP2002348474A (ja) 2001-05-23 2002-12-04 Dow Corning Toray Silicone Co Ltd ポリオルガノシロキサンマイクロエマルジョン組成物および化粧料原料
US20030143228A1 (en) 2001-10-29 2003-07-31 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-II restricted tumor-associated antigen
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
KR100705868B1 (ko) 2003-05-06 2007-04-10 후지 덴키 디바이스 테크놀로지 가부시키가이샤 반도체 장치 및 그 제조 방법

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