DE69027683T2 - Herstellung rekombinanter polypeptide durch rinder und transgene methoden - Google Patents
Herstellung rekombinanter polypeptide durch rinder und transgene methodenInfo
- Publication number
- DE69027683T2 DE69027683T2 DE69027683T DE69027683T DE69027683T2 DE 69027683 T2 DE69027683 T2 DE 69027683T2 DE 69027683 T DE69027683 T DE 69027683T DE 69027683 T DE69027683 T DE 69027683T DE 69027683 T2 DE69027683 T2 DE 69027683T2
- Authority
- DE
- Germany
- Prior art keywords
- production
- cattle
- recombinant polypeptides
- milk
- transgenic methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44474589A | 1989-12-01 | 1989-12-01 | |
PCT/US1990/006874 WO1991008216A1 (en) | 1989-12-01 | 1990-11-30 | Production of recombinant polypeptides by bovine species and transgenic methods |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69027683D1 DE69027683D1 (de) | 1996-08-08 |
DE69027683T2 true DE69027683T2 (de) | 1997-02-13 |
Family
ID=23766173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69027683T Revoked DE69027683T2 (de) | 1989-12-01 | 1990-11-30 | Herstellung rekombinanter polypeptide durch rinder und transgene methoden |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0737746A3 (de) |
AT (1) | ATE140027T1 (de) |
AU (1) | AU656720B2 (de) |
CA (2) | CA2075206C (de) |
DE (1) | DE69027683T2 (de) |
DK (1) | DK0502976T3 (de) |
ES (1) | ES2090299T3 (de) |
FI (1) | FI923485A (de) |
GR (1) | GR3021239T3 (de) |
MC (1) | MC2211A1 (de) |
NO (1) | NO922996L (de) |
OA (1) | OA09669A (de) |
RU (1) | RU2095414C1 (de) |
WO (1) | WO1991008216A1 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL94183A (en) | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
US6262336B1 (en) | 1991-01-11 | 2001-07-17 | American Red Cross | Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter |
US5831141A (en) * | 1991-01-11 | 1998-11-03 | United States Of America As Represented By The Department Of Health And Human Services | Expression of a heterologous polypeptide in mammary tissue of transgenic non-human mammals using a long whey acidic protein promoter |
CA2110404A1 (en) * | 1991-05-31 | 1992-12-10 | Christina Teng | Human lactoferrin |
DK0555435T3 (da) * | 1991-08-13 | 2000-04-25 | Wisconsin Milk Marketing Board | DNA-sekvens, der koder bovint alfa-lactalbumin, og fremgangsmåder til anvendelse |
WO1993004171A1 (en) * | 1991-08-19 | 1993-03-04 | Symbicom Aktiebolag | Human beta-casein, process for producing it and use thereof |
DK8892D0 (da) | 1992-01-23 | 1992-01-23 | Symbicom Ab | Humant proteingen |
EP0652889A4 (de) * | 1992-06-15 | 1997-05-07 | Gene Pharming Europ Bv | Herstellung von rekombinantpolypeptiden durch runderarten und transgene verfahren. |
US5667839A (en) * | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
US5856178A (en) * | 1993-08-30 | 1999-01-05 | Utah State University | DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same |
US5827690A (en) * | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
WO1995022258A2 (en) * | 1994-02-16 | 1995-08-24 | Pharming Bv | Isolation of lactoferrin from milk |
US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
US5750176A (en) * | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
WO1995024494A1 (en) * | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Humanized milk |
US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
GB9414651D0 (en) * | 1994-07-20 | 1994-09-07 | Gene Pharming Europ Bv | Separation of human serum albumin |
US6518482B2 (en) | 1994-09-13 | 2003-02-11 | American National Red Cross | Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor |
US5880327A (en) * | 1994-09-21 | 1999-03-09 | American National Red Cross | Transgenic mammals expressing human coagulation factor VIII |
US6268487B1 (en) | 1996-05-13 | 2001-07-31 | Genzyme Transgenics Corporation | Purification of biologically active peptides from milk |
US7696404B2 (en) | 1996-08-19 | 2010-04-13 | Advanced Cell Technology, Inc. | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions |
SG94355A1 (en) | 1996-10-01 | 2003-02-18 | Geron Corp | Human telomerase catalytic subunit |
JP2001522230A (ja) | 1997-02-14 | 2001-11-13 | アメリカン・レツド・クロス | トランスジェニック動物乳房組織における活性ヒト第▲ix▼因子の発現 |
AU744445B2 (en) | 1997-04-24 | 2002-02-21 | University Of Washington | Targeted gene modification by parvoviral vectors |
KR20010031210A (ko) | 1997-10-20 | 2001-04-16 | 추후보정 | 세포계내의 mRNA량 및 단백질 발현을 증가시키는 방법및 변형 핵산 서열 |
US7157615B2 (en) | 1998-03-17 | 2007-01-02 | Nexia Biotechnologies, Inc. | Production of biofilaments in transgenic animals |
PT2020438T (pt) | 1998-12-07 | 2018-07-13 | Genzyme Corp | Tratamento da doença de pompe |
DE10026998A1 (de) * | 2000-05-31 | 2001-12-13 | Fresenius Kabi De Gmbh | Verfahren zur Herstellung einer kosmetischen Zusammensetzung, die humanes Serum Albumin umfasst, welches aus transgenen nicht-menschlichen Säugern erhalten wurde |
US20040133930A1 (en) | 2002-03-11 | 2004-07-08 | Cooper Julian D. | Production of high levels of transgenic factor ix without gene rescue, and its therapeutic uses |
NZ529767A (en) * | 2001-06-13 | 2005-10-28 | Taurus Hsa Llc | Purification of human serum albumin |
US6867189B2 (en) | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
PT1523496E (pt) | 2002-07-18 | 2011-09-29 | Merus B V | Produção de misturas de anticorpos de forma recombinante |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
CA2554054C (en) | 2004-01-20 | 2013-06-04 | Merus B.V. | Mixtures of binding proteins |
US8933209B2 (en) | 2006-04-26 | 2015-01-13 | Abbvie Inc. | Dep2 and its uses in major depressive disorder and other related disorders |
DE102007014742A1 (de) | 2007-03-23 | 2008-09-25 | Evonik Degussa Gmbh | Isoformen der Schweineleber Esterase |
EP2285400B1 (de) | 2008-05-02 | 2015-10-28 | Laboratoire Français du Fractionnement et des Biotechnologies | Behandlung von blutungen mit fibrinogen geringer halbwertszeit |
DE102009007272A1 (de) | 2009-02-03 | 2010-08-05 | Evocatal Gmbh | Alkoholdehydrogenase aus Gluconobacter oxydans und deren Verwendung |
PL3095871T3 (pl) | 2010-02-08 | 2019-10-31 | Regeneron Pharma | Mysz zawierająca wspólny łańcuch lekki |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
WO2012122512A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
HUE055276T2 (hu) | 2011-08-05 | 2021-11-29 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
JP6393255B2 (ja) | 2012-04-20 | 2018-09-19 | メルス ナムローゼ フェンノートシャップ | ヘテロ二量体のIgG様分子を生産する方法、ヘテロ二量体のIgG様分子、ヘテロ二量体の抗体、組み換え宿主細胞、医薬組成物、宿主細胞を作成する方法、および培養物 |
CN105308068A (zh) | 2013-02-13 | 2016-02-03 | 法国化学与生物科技实验室 | 高度半乳糖基化的抗TNF-α抗体及其用途 |
TW201446962A (zh) | 2013-02-13 | 2014-12-16 | Lab Francais Du Fractionnement | 具有修飾的糖化作用之蛋白質及其製造方法 |
KR20210088756A (ko) | 2014-03-21 | 2021-07-14 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
WO2016149678A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
RU2644663C2 (ru) * | 2015-11-12 | 2018-02-13 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Генетическая конструкция рБТШ70 для экспрессии основного человеческого стресс белка в молоке трансгенных животных |
WO2020028617A1 (en) * | 2018-08-01 | 2020-02-06 | University Of Georgia Research Foundation, Inc. | Compositions and methods for improving embryo development |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
JP2874751B2 (ja) * | 1986-04-09 | 1999-03-24 | ジェンザイム・コーポレーション | 希望する蛋白質をミルク中へ分泌する遺伝子移植動物 |
AU7879987A (en) * | 1986-08-28 | 1988-03-24 | Immunex Corp. | Expression of heterologous proteins by transgenic lactating mammals |
EP0365591A4 (en) * | 1987-06-16 | 1992-01-22 | Edison Animal Biotechnology Center | Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase |
US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5082779A (en) * | 1987-08-06 | 1992-01-21 | Edison Animal Biotechnology Center/Ohio University | Method of directing transgenic expression in animals using a prolactin promoter |
WO1989005864A1 (en) * | 1987-12-15 | 1989-06-29 | The Trustees Of Princeton University | Transgenic testing systems for mutagens and carcinogens |
GB8826446D0 (en) * | 1988-11-11 | 1988-12-14 | Agricultural & Food Res | Peptide production |
JPH02261386A (ja) * | 1989-03-31 | 1990-10-24 | Kyowa Hakko Kogyo Co Ltd | 組換えベクター |
AU649407B2 (en) * | 1989-09-21 | 1994-05-26 | Infigen, Inc. | Enhanced gene expression in response to lactation signals |
JPH04365487A (ja) * | 1990-04-11 | 1992-12-17 | Consortium Elektrochem Ind Gmbh | 組換dna−構造体、組換ベクター、トランスゲン動物の乳からの蛋白質の取得法、トランスゲン動物の製法及びトランスゲン動物の乳 |
WO1992022670A1 (en) * | 1991-06-12 | 1992-12-23 | Genpharm International, Inc. | Early detection of transgenic embryos |
-
1990
- 1990-11-30 ES ES91901026T patent/ES2090299T3/es not_active Expired - Lifetime
- 1990-11-30 EP EP95203326A patent/EP0737746A3/de not_active Withdrawn
- 1990-11-30 DE DE69027683T patent/DE69027683T2/de not_active Revoked
- 1990-11-30 RU SU905052392A patent/RU2095414C1/ru active
- 1990-11-30 AU AU69608/91A patent/AU656720B2/en not_active Expired
- 1990-11-30 WO PCT/US1990/006874 patent/WO1991008216A1/en not_active Application Discontinuation
- 1990-11-30 CA CA002075206A patent/CA2075206C/en not_active Expired - Lifetime
- 1990-11-30 EP EP91901026A patent/EP0502976B1/de not_active Revoked
- 1990-11-30 MC MC906874A patent/MC2211A1/xx unknown
- 1990-11-30 AT AT91901026T patent/ATE140027T1/de not_active IP Right Cessation
- 1990-11-30 DK DK91901026.4T patent/DK0502976T3/da active
- 1990-11-30 CA CA002351200A patent/CA2351200A1/en not_active Abandoned
-
1992
- 1992-07-29 NO NO92922996A patent/NO922996L/no unknown
- 1992-07-31 FI FI923485A patent/FI923485A/fi not_active Application Discontinuation
- 1992-08-28 OA OA60265A patent/OA09669A/en unknown
-
1996
- 1996-10-03 GR GR960402588T patent/GR3021239T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU656720B2 (en) | 1995-02-16 |
NO922996D0 (no) | 1992-07-29 |
ES2090299T3 (es) | 1996-10-16 |
NO922996L (no) | 1992-07-29 |
RU2095414C1 (ru) | 1997-11-10 |
ATE140027T1 (de) | 1996-07-15 |
MC2211A1 (fr) | 1992-11-26 |
OA09669A (en) | 1993-05-15 |
EP0502976A4 (en) | 1993-09-29 |
CA2075206C (en) | 2006-05-23 |
GR3021239T3 (en) | 1997-01-31 |
FI923485A0 (fi) | 1992-07-31 |
AU6960891A (en) | 1991-06-26 |
DK0502976T3 (da) | 1996-11-11 |
CA2351200A1 (en) | 1991-06-13 |
WO1991008216A1 (en) | 1991-06-13 |
EP0502976B1 (de) | 1996-07-03 |
FI923485A (fi) | 1992-07-31 |
CA2075206A1 (en) | 1991-06-02 |
EP0737746A3 (de) | 1996-10-23 |
EP0737746A2 (de) | 1996-10-16 |
EP0502976A1 (de) | 1992-09-16 |
DE69027683D1 (de) | 1996-08-08 |
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