DE69534907D1 - Transgene schweine, die den menschlichen blutgerinnungsfaktor viii exprimieren - Google Patents

Transgene schweine, die den menschlichen blutgerinnungsfaktor viii exprimieren

Info

Publication number
DE69534907D1
DE69534907D1 DE69534907T DE69534907T DE69534907D1 DE 69534907 D1 DE69534907 D1 DE 69534907D1 DE 69534907 T DE69534907 T DE 69534907T DE 69534907 T DE69534907 T DE 69534907T DE 69534907 D1 DE69534907 D1 DE 69534907D1
Authority
DE
Germany
Prior art keywords
milk
promoter
factor viii
animal
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69534907T
Other languages
English (en)
Other versions
DE69534907T2 (de
Inventor
Henryk Lubron
N Drohan
H Velander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American National Red Cross
Virginia Tech Intellectual Properties Inc
Original Assignee
American National Red Cross
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American National Red Cross, Virginia Tech Intellectual Properties Inc filed Critical American National Red Cross
Publication of DE69534907D1 publication Critical patent/DE69534907D1/de
Application granted granted Critical
Publication of DE69534907T2 publication Critical patent/DE69534907T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
DE69534907T 1994-09-21 1995-09-21 Transgene schweine, die den menschlichen blutgerinnungsfaktor viii exprimieren Expired - Lifetime DE69534907T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US308518 1981-10-05
US08/308,518 US5880327A (en) 1994-09-21 1994-09-21 Transgenic mammals expressing human coagulation factor VIII
PCT/US1995/011781 WO1996009377A1 (en) 1994-09-21 1995-09-21 Transgenic animals expressing human coagulation factor viii and von willebrand factor

Publications (2)

Publication Number Publication Date
DE69534907D1 true DE69534907D1 (de) 2006-05-18
DE69534907T2 DE69534907T2 (de) 2007-03-15

Family

ID=23194291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534907T Expired - Lifetime DE69534907T2 (de) 1994-09-21 1995-09-21 Transgene schweine, die den menschlichen blutgerinnungsfaktor viii exprimieren

Country Status (8)

Country Link
US (2) US5880327A (de)
EP (2) EP1739170A3 (de)
JP (2) JPH10506013A (de)
AT (1) ATE321785T1 (de)
CA (1) CA2200610C (de)
DE (1) DE69534907T2 (de)
ES (1) ES2262143T3 (de)
WO (1) WO1996009377A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518482B2 (en) 1994-09-13 2003-02-11 American National Red Cross Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor
US5880327A (en) * 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
US6613958B1 (en) 1997-12-19 2003-09-02 Wyeth Transgenic mouse model for degeneration of type II collagen in joints
GB9807464D0 (en) * 1998-04-07 1998-06-10 Pharming Bv Purification of human acid µ-glucosidase
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
US7030289B2 (en) 1998-11-19 2006-04-18 Ppl Therapeutics (Scotland) Ltd Stabilization of milk from transgenic animals
AU765315B2 (en) * 1998-11-19 2003-09-18 Pharming Intellectual Property Bv Stabilisation of milk from transgenic animals
US7208576B2 (en) 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
CA2354638C (en) * 1999-01-06 2013-03-19 Atlantic Biopharmaceuticals, Inc. Expression of secreted human alpha-fetoprotein in transgenic animals
US6183803B1 (en) 1999-06-11 2001-02-06 Biosante Pharmaceuticals, Inc. Method for processing milk
AU6913600A (en) * 1999-08-19 2001-03-13 Us Transgenics, Inc. Transgenic prothrombin and related thrombin precursors and transgenics, methods,compositions, uses and the like relating thereto
KR20020073127A (ko) * 1999-09-17 2002-09-19 겐자임 트랜스제닉스 코포레이션 형질전환에 의하여 생성된 융합 단백질
WO2001022810A2 (en) * 1999-09-28 2001-04-05 Us Transgenics, Inc. Transgenic animals expressing von willebrand factor (vwf) and vwf-related polypeptides
WO2001027303A1 (en) * 1999-10-12 2001-04-19 The University Of North Carolina At Chapel Hill Adeno-associated virus vectors encoding factor viii and methods of using the same
US20030129745A1 (en) * 1999-10-28 2003-07-10 Robl James M. Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
AU782067B2 (en) 1999-12-20 2005-06-30 Immunex Corporation TWEAK receptor
US20030046716A1 (en) * 2000-06-19 2003-03-06 Yann Echelard Transgenically produced platelet derived growth factor
US20020073441A1 (en) 2000-12-13 2002-06-13 Ross Brian D. Compositions and methods for detecting proteolytic activity
WO2002072023A2 (en) * 2001-03-12 2002-09-19 Progenetics Llc Production of high levels of transgenic factor viii with engineered stability, and its therapeutic uses
US7220718B2 (en) * 2001-08-03 2007-05-22 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oral treatment of hemophilia
EP1585386A4 (de) * 2002-02-20 2009-09-02 American Integrated Biolog Inc Rekombinante produktion im speichel
US20040117862A1 (en) * 2002-03-11 2004-06-17 Cooper Julian D. Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EP1497418B1 (de) 2002-04-19 2012-10-17 Verenium Corporation Phospholipasen, diese codierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung
EP3023498B1 (de) 2003-03-06 2018-11-28 BASF Enzymes LLC Amylasen, nukleinsäuren zur codierung davon und verfahren zur herstellung und verwendung davon
MX295545B (es) 2003-03-07 2012-02-03 Diversa Corp Hidrolasas, acidos nucleicos que las codifican, y metodos para hacerlas y usarlas.
US7592434B2 (en) 2003-04-04 2009-09-22 Verenium Corporation Pectate lyases, nucleic encoding them and methods for making and using them
US7514593B2 (en) 2003-05-30 2009-04-07 The University Of North Carolina At Chapel Hill Animal model for chronic obstructive pulmonary disease and cystic fibrosis
EP2404931A1 (de) 2003-07-02 2012-01-11 Verenium Corporation Glucanasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung
CA2535526C (en) 2003-08-11 2015-09-29 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
EP1699469B1 (de) * 2003-12-03 2010-04-07 University of Rochester Rekombinanter faktor viii mit erhöhter spezifischer aktivität
US7667089B2 (en) * 2004-04-09 2010-02-23 National Chung Hsing University Transgenic mammal secreting B-domain deleted human FVII in its milk
AU2005264938B2 (en) 2004-06-16 2011-11-24 Verenium Corporation Compositions and methods for enzymatic decolorization of chlorophyll
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101227A (ko) 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
AU2005282380A1 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
WO2006099207A2 (en) 2005-03-10 2006-09-21 Diversa Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
NZ594810A (en) 2005-03-15 2012-12-21 Verenium Corp Cellulases, nucleic acids encoding them and methods for making and using them
US20070061899A1 (en) * 2005-04-13 2007-03-15 The Trustees Of Columbia University In The City Of New York Transgenic mammal with constitutive, tissue-specific cytokine expression and use as a cancer model
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
WO2007092314A2 (en) 2006-02-02 2007-08-16 Verenium Corporation Esterases and related nucleic acids and methods
DK2450439T3 (da) 2006-02-10 2014-02-10 Verenium Corp Cellulosenedbrydende enzymer, nucleinsyrer, der koder for dem, og fremgangsmåder til at fremstille og benytte dem
EP2548955A1 (de) 2006-02-14 2013-01-23 Verenium Corporation Xylanasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung
EP2112227B1 (de) 2006-03-07 2013-05-15 Cargill, Incorporated Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung
KR101588539B1 (ko) 2006-03-07 2016-01-25 바스프 엔자임스 엘엘씨 알돌라제, 이것을 코딩하는 핵산과 그 제조 방법 및 사용 방법
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
FR2904558B1 (fr) * 2006-08-01 2008-10-17 Lab Francais Du Fractionnement "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
BRPI0714876B1 (pt) 2006-08-04 2022-04-19 Verenium Corporation Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos
CN113789316A (zh) 2006-09-21 2021-12-14 巴斯夫酶有限责任公司 肌醇六磷酸酶、编码它们的核酸及制备和使用它们的方法
WO2008036863A2 (en) 2006-09-21 2008-03-27 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
CA2673525C (en) 2006-12-21 2017-12-05 Verenium Corporation Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them
FR2910786B1 (fr) * 2006-12-29 2017-08-11 Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) "procede d'extraction d'une proteine presente dans du lait"
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
FR2920024B1 (fr) * 2007-08-14 2012-12-14 Lfb Biotechnologies Procede de purification ou de detection d'une proteine cible
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
WO2009045627A2 (en) 2007-10-03 2009-04-09 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
CA2739011A1 (en) * 2007-10-29 2009-05-07 The Regents Of The University Of California Osteoarthritis gene therapy
WO2009058446A1 (en) * 2007-11-01 2009-05-07 University Of Rochester Recombinant factor viii having increased stability
JP5624891B2 (ja) * 2007-12-31 2014-11-12 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ ヒト血液凝固因子を発現するトランスジェニック非ヒト動物
JP5563990B2 (ja) 2008-01-03 2014-07-30 ヴェレニウム コーポレイション トランスフェラーゼおよびオキシドレダクターゼ、それらをコードする核酸並びにそれらを製造および使用する方法
US8541220B2 (en) 2008-01-03 2013-09-24 Verenium Corporation Isomerases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
EP2326720B1 (de) 2008-09-15 2018-03-21 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zur regulierung einer zellosmolarität
FR2940655B1 (fr) 2008-12-31 2011-02-18 Lfb Biotechnologies Peptides isoles de facteur vii de lapin.
FR2942231B1 (fr) 2009-02-19 2015-03-20 Lfb Biotechnologies Acides nucleiques se liant specifiquement au facteur vii/viia humain, et utilisations
FR2942232B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre
CN102459303B (zh) 2009-05-21 2016-06-29 巴斯夫酶有限责任公司 肌醇六磷酸酶、编码它们的核酸及制备和使用它们的方法
FR2948664B1 (fr) 2009-07-31 2013-11-01 Lfb Biotechnologies Procede pour la purification de proteines de la coagulation a domaine gla
FR2948665B1 (fr) 2009-07-31 2011-09-23 Lfb Biotechnologies Procede pour la purification de proteines de la coagulation a domaine gla actives
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
FR2983212A1 (fr) 2011-11-28 2013-05-31 Lfb Biotechnologies Aptameres anti-fh, procede pour leur obtention et utilisations
FR3011250A1 (fr) 2013-09-30 2015-04-03 Lab Francais Du Fractionnement Acides nucleiques se liant specifiquement au facteur ix/ixa humain, et utilisations
CN104313052A (zh) * 2014-10-29 2015-01-28 上海滔滔转基因工程股份有限公司 一种利用vWF稳定表达人凝血因子VIII的乳腺特异共表达载体
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
JP2023500896A (ja) 2019-11-05 2023-01-11 ヴァーシティ ブラッド リサーチ インスティテュート ファウンデーション， インコーポレイテッド 胎児／新生児同種抗体血小板減少症のマウスモデル

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
WO1986006745A1 (en) * 1985-05-16 1986-11-20 Meloy Laboratories, Inc. MOLECULAR CLONING OF cDNA FOR HUMAN FACTOR VIIIR (VON WILLEBRAND FACTOR)
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
US5366894A (en) * 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
GB8826446D0 (en) * 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
CA2351200A1 (en) * 1989-12-01 1991-06-13 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
US5288846A (en) * 1990-10-19 1994-02-22 The General Hospital Corporation Cell specific gene regulators
FR2677652B1 (fr) * 1991-06-12 2005-05-27 Agronomique Inst Nat Rech Procede de preparation d'une proteine d'interet dans le lait d'un animal transgenique, produit obtenu et cellule eucaryote utilisee.
US5880327A (en) * 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor

Also Published As

Publication number Publication date
US6255554B1 (en) 2001-07-03
EP0807170A1 (de) 1997-11-19
ES2262143T3 (es) 2006-11-16
EP1739170A3 (de) 2007-03-07
WO1996009377A1 (en) 1996-03-28
CA2200610A1 (en) 1996-03-28
EP0807170B1 (de) 2006-03-29
JPH10506013A (ja) 1998-06-16
DE69534907T2 (de) 2007-03-15
JP2010017184A (ja) 2010-01-28
US5880327A (en) 1999-03-09
ATE321785T1 (de) 2006-04-15
EP1739170A2 (de) 2007-01-03
CA2200610C (en) 2010-11-23

Similar Documents

Publication Publication Date Title
DE69534907D1 (de) Transgene schweine, die den menschlichen blutgerinnungsfaktor viii exprimieren
Shani et al. Expression of human serum albumin in the milk of transgenic mice
DK8892D0 (da) Humant proteingen
US6111165A (en) Production of human recombinant collagen in the milk of transgenic animals
DE3752130T2 (de) Herstellung von peptiden
US5959171A (en) Method for the production of biologically active polypeptides in a mammal's
CA2099562A1 (en) Expression of active human protein c in mammary tissue of transgenic animals
DE69027683T2 (de) Herstellung rekombinanter polypeptide durch rinder und transgene methoden
NL300257I2 (nl) Transgene dieren die gewenste eiwitten in de melk afscheiden.
ATE455552T1 (de) Expression des active human factor ix im brustdrüsengewebe transgener tiere
EP0597010A4 (en) Transgenic protein production.
FI882707A (fi) Foerfarande och preparat foer hoejning av proteinhalten i mjoelk.
US7667089B2 (en) Transgenic mammal secreting B-domain deleted human FVII in its milk
MXPA03008209A (es) Produccion de altos niveles del factor viii transgenico con estabilidad disenada, y sus usos terapeuticos.
Kim et al. Cloning of human genomic lactoferrin sequence and expression in the mammary glands of transgenic animals
Pursel 19 Genetic Modification of Production Traits in Farm Animals
Whitelaw et al. Animal bioreactors.
HUP9903094A2 (hu) IgE-kötő domént és HSA komponenst tartalmazó fúziós polipeptidek valamint diagnosztikai és terápiás alkalmazásuk

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803