FR2904558B1 - "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees" - Google Patents

"composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"

Info

Publication number
FR2904558B1
FR2904558B1 FR0607016A FR0607016A FR2904558B1 FR 2904558 B1 FR2904558 B1 FR 2904558B1 FR 0607016 A FR0607016 A FR 0607016A FR 0607016 A FR0607016 A FR 0607016A FR 2904558 B1 FR2904558 B1 FR 2904558B1
Authority
FR
France
Prior art keywords
majorityally
glycannic
biantennae
bisialylated
fucosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0607016A
Other languages
English (en)
Other versions
FR2904558A1 (fr
Inventor
Abdessatar Sami Chtourou
Emmanuel Nony
Nicolas Bihoreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LFB SA
Original Assignee
LFB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2904558(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by LFB SA filed Critical LFB SA
Priority to FR0607016A priority Critical patent/FR2904558B1/fr
Priority to CN201310341768.0A priority patent/CN103397011B/zh
Priority to CA2658800A priority patent/CA2658800C/fr
Priority to CNA2007800279681A priority patent/CN101495133A/zh
Priority to PCT/FR2007/001324 priority patent/WO2008015339A2/fr
Priority to CA2876621A priority patent/CA2876621A1/fr
Priority to JP2009522304A priority patent/JP5653619B2/ja
Priority to BRPI0715420-8A priority patent/BRPI0715420A2/pt
Priority to EP07823378A priority patent/EP2049150A2/fr
Priority to US12/374,269 priority patent/US20090239788A1/en
Priority to KR1020097001954A priority patent/KR101233630B1/ko
Priority to AU2007280330A priority patent/AU2007280330B2/en
Priority to ARP070103379A priority patent/AR062162A1/es
Priority to TW096128233A priority patent/TWI391400B/zh
Publication of FR2904558A1 publication Critical patent/FR2904558A1/fr
Publication of FR2904558B1 publication Critical patent/FR2904558B1/fr
Application granted granted Critical
Priority to IL196379A priority patent/IL196379A/en
Priority to US13/705,948 priority patent/US20130189244A1/en
Priority to JP2014234766A priority patent/JP2015042678A/ja
Priority to ARP150104084A priority patent/AR103027A2/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FR0607016A 2006-08-01 2006-08-01 "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees" Expired - Fee Related FR2904558B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR0607016A FR2904558B1 (fr) 2006-08-01 2006-08-01 "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
KR1020097001954A KR101233630B1 (ko) 2006-08-01 2007-07-31 바이안테너리 비아시알릴화 및 비푸코실화된 형태의 다수의글리칸을 가지는 재조합 또는 형질전환 인자 ⅶ 화합물
CA2658800A CA2658800C (fr) 2006-08-01 2007-07-31 Composition de facteur vii recombinant ou transgenique comportant une majorite de formes glycanniques, biantennees, bisialylees et non fucosylees
CNA2007800279681A CN101495133A (zh) 2006-08-01 2007-07-31 大部分为二天线、二唾液酸和非岩藻糖基化聚糖结构的重组或转基因因子ⅶ合成物
PCT/FR2007/001324 WO2008015339A2 (fr) 2006-08-01 2007-07-31 Composition de facteur vii recombinant
CA2876621A CA2876621A1 (fr) 2006-08-01 2007-07-31 Composition de facteur vii recombinant ou transgenique comportant une majorite de formes glycanniques, biantennees, bisialylees et non fucosylees
JP2009522304A JP5653619B2 (ja) 2006-08-01 2007-07-31 遺伝子組み換えあるいは形質転換ｆｖｉｉ組成物およびその組成物を有効成分とする医薬
BRPI0715420-8A BRPI0715420A2 (pt) 2006-08-01 2007-07-31 fator recombinante ou transgÊnico vii contendo uma maior parte de formas de glicano, formas biantenÁrias, bissialiladas e nço fucosiladas
EP07823378A EP2049150A2 (fr) 2006-08-01 2007-07-31 Composition de facteur vii recombinant
US12/374,269 US20090239788A1 (en) 2006-08-01 2007-07-31 Recombinant or transgenic factor vii compound having a majority of glycan, biantennary, bisialylated and non-fucosylated forms
CN201310341768.0A CN103397011B (zh) 2006-08-01 2007-07-31 大部分为二天线、二唾液酸和非岩藻糖基化聚糖结构的重组或转基因因子vii合成物
AU2007280330A AU2007280330B2 (en) 2006-08-01 2007-07-31 Recombinant Factor VII composition
ARP070103379A AR062162A1 (es) 2006-08-01 2007-08-01 Una composicion del factor vii recombinante o transgenico que exhibe principalmente formas de glicano no fucosilado bisialilado y biantenario
TW096128233A TWI391400B (zh) 2006-08-01 2007-08-01 多數顯示雙觸、雙唾液酸化及無海藻糖化聚醣形式之基因轉殖第vii因子之組成物
IL196379A IL196379A (en) 2006-08-01 2009-01-07 Process for Preparing a Recombinant or Transgenic Factor Factor Composition with Most Glycan, Biantenary, Bisyaltic and Non-Focosylated Forms
US13/705,948 US20130189244A1 (en) 2006-08-01 2012-12-05 Recombinant or transgenic factor vii compound having a majority of glycan, biantennary, bisialylated and non-fucosylated forms
JP2014234766A JP2015042678A (ja) 2006-08-01 2014-11-19 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換ｆｖｉｉの組成物
ARP150104084A AR103027A2 (es) 2006-08-01 2015-12-15 Una composición del factor vii (fvii) transgénico, un proceso para prepararla, y una composición farmacéutica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0607016A FR2904558B1 (fr) 2006-08-01 2006-08-01 "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"

Publications (2)

Publication Number Publication Date
FR2904558A1 FR2904558A1 (fr) 2008-02-08
FR2904558B1 true FR2904558B1 (fr) 2008-10-17

Family

ID=37903443

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0607016A Expired - Fee Related FR2904558B1 (fr) 2006-08-01 2006-08-01 "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"

Country Status (13)

Country Link
US (2) US20090239788A1 (fr)
EP (1) EP2049150A2 (fr)
JP (2) JP5653619B2 (fr)
KR (1) KR101233630B1 (fr)
CN (2) CN101495133A (fr)
AR (2) AR062162A1 (fr)
AU (1) AU2007280330B2 (fr)
BR (1) BRPI0715420A2 (fr)
CA (2) CA2876621A1 (fr)
FR (1) FR2904558B1 (fr)
IL (1) IL196379A (fr)
TW (1) TWI391400B (fr)
WO (1) WO2008015339A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275432A1 (fr) 2003-12-01 2011-01-19 Novo Nordisk Health Care AG Nanofiltration des solutions du facteur VII pour enlever des virus
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
FR2915398B1 (fr) * 2007-04-25 2012-12-28 Lab Francais Du Fractionnement "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse"
EP2271206A1 (fr) * 2008-03-25 2011-01-12 Bioprotein Technologies Sa Lapins transgeniques producteurs de facteur vii humain
FR2933496B1 (fr) * 2008-07-02 2012-10-05 Lfb Biotechnologies Procede de mesure du taux de facteur vii active dans un echantillon
WO2013017555A1 (fr) 2011-08-01 2013-02-07 Lfb-Biotechnologies Compositions de facteur vii ayant une glycosylation spécifique pour une demi-vie régulée
EP2554161A1 (fr) 2011-08-02 2013-02-06 LFB Biotechnologies Composition pharmaceutique comprenant factor VII encapsulé dans des micelles
WO2013114164A1 (fr) * 2012-01-30 2013-08-08 Dr. Reddy's Laboratories Limited Procédé d'obtention d'une composition glycoprotéique ayant une concentration accrue d'afucosylation
WO2014140927A2 (fr) * 2013-02-13 2014-09-18 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Protéines à glycosylation modifiée et leurs procédés de production
ES2755181T3 (es) 2013-02-13 2020-04-21 Lab Francais Du Fractionnement Anticuerpos anti-TNF-alfa altamente galactosilados y usos de los mismos
SG11201704351WA (en) * 2014-12-01 2017-06-29 Amgen Inc Process for manipulating the level of glycan content of a glycoprotein

Family Cites Families (22)

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US4229342A (en) * 1977-05-18 1980-10-21 Rhone-Poulenc Industries Process for extracting proteins from milk using silica and anion exchange resins
NL8204923A (nl) * 1982-12-21 1984-07-16 Stichting Nl I Zuivelonderzoek Werkwijze voor het bereiden van een precipitaat van caseine en wei-eiwit alsmede aldus bereid precipitaat.
DE122007000007I1 (de) * 1986-04-09 2007-05-16 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
FR2632524B1 (fr) * 1988-06-09 1992-03-13 Fondation Nale Transfusion San Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament
DE4028800A1 (de) * 1990-09-11 1992-03-12 Behringwerke Ag Gentechnische sialylierung von glykoproteinen
US6984772B1 (en) * 1994-02-18 2006-01-10 Virginia Tech Intellectual Properties, Inc. Transgenic non-human mammals producing fibrinogen in their milk
FR2684999A1 (fr) * 1991-12-16 1993-06-18 Aquitaine Dev Transf Sanguine Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.
US5827690A (en) * 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
GB9408717D0 (en) * 1994-05-03 1994-06-22 Biotech & Biolog Scien Res DNA sequences
US5880327A (en) * 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
DK1015622T3 (da) * 1997-01-16 2004-08-02 Neose Technologies Inc Praktisk sialylering in vitro af rekombinante glycoproteiner
US5880237A (en) * 1997-01-31 1999-03-09 Nalco Chemical Company Preparation and utility of water-soluble polymers having pendant derivatized amide, ester or ether functionalities as ceramics dispersants and binders
US6238894B1 (en) * 1998-11-04 2001-05-29 Diane Taylor α1,2 fucosyltransferase
US6183803B1 (en) * 1999-06-11 2001-02-06 Biosante Pharmaceuticals, Inc. Method for processing milk
US7067713B2 (en) * 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
WO2001058935A2 (fr) * 2000-02-11 2001-08-16 Maxygen Aps MOLECULES DE TYPE FACTEUR VII OU VIIa
HUP0301245A3 (en) * 2000-10-02 2005-12-28 Novo Nordisk Healthcare Ag Tmethod for the production of vitamin k-dependent proteins
MXPA04012496A (es) * 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
ES2363205T3 (es) * 2002-06-21 2011-07-26 Novo Nordisk Health Care Ag Glicoformas del factor vii pegilado.
FR2841747B1 (fr) * 2002-07-02 2004-08-20 Cie Laitiere Europeenne Isolat de proteines de lait et procede pour sa preparation
EP1664291B1 (fr) * 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Polypeptides du facteur vii de coagulation
AU2005260004A1 (en) * 2004-06-25 2006-01-12 Altor Bioscience Corporation Production of tissue factor in plants

Also Published As

Publication number Publication date
AU2007280330A1 (en) 2008-02-07
AR103027A2 (es) 2017-04-12
IL196379A0 (en) 2011-08-01
KR20090040892A (ko) 2009-04-27
US20090239788A1 (en) 2009-09-24
CA2876621A1 (fr) 2008-02-07
TWI391400B (zh) 2013-04-01
CN103397011B (zh) 2016-10-05
FR2904558A1 (fr) 2008-02-08
CA2658800A1 (fr) 2008-02-07
US20130189244A1 (en) 2013-07-25
CN101495133A (zh) 2009-07-29
CN103397011A (zh) 2013-11-20
CA2658800C (fr) 2015-03-31
BRPI0715420A2 (pt) 2013-07-02
WO2008015339A2 (fr) 2008-02-07
KR101233630B1 (ko) 2013-02-18
JP5653619B2 (ja) 2015-01-14
IL196379A (en) 2016-04-21
AR062162A1 (es) 2008-10-22
JP2015042678A (ja) 2015-03-05
EP2049150A2 (fr) 2009-04-22
TW200825102A (en) 2008-06-16
JP2009545575A (ja) 2009-12-24
AU2007280330B2 (en) 2011-11-10
WO2008015339A3 (fr) 2008-04-17

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Legal Events

Date Code Title Description
TP Transmission of property
AS Court action brought to claim ownership of the patent
PLFP Fee payment

Year of fee payment: 11

JU Final juridical decision affecting the ownership or exploitation of an industrial property right

Effective date: 20171207

ST Notification of lapse

Effective date: 20180430