ES2090299T3 - Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos. - Google Patents

Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos.

Info

Publication number
ES2090299T3
ES2090299T3 ES91901026T ES91901026T ES2090299T3 ES 2090299 T3 ES2090299 T3 ES 2090299T3 ES 91901026 T ES91901026 T ES 91901026T ES 91901026 T ES91901026 T ES 91901026T ES 2090299 T3 ES2090299 T3 ES 2090299T3
Authority
ES
Spain
Prior art keywords
production
bovine species
recombinant polypeptides
transgenic methods
milk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901026T
Other languages
English (en)
Inventor
Herbert L Heyneker
Herman A Deboer
Rein Strijker
Gerard Plantenburg
Sang He Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharming BV
Original Assignee
Pharming BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23766173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2090299(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharming BV filed Critical Pharming BV
Application granted granted Critical
Publication of ES2090299T3 publication Critical patent/ES2090299T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732—Casein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN TRANSGEN PARA PRODUCIR POLIPEPTIDOS RECOMBINANTES EN LA LECHE DE ESPECIES BOVINAS TRANSGENICAS COMPRENDE, AL MENOS, UNA SECUENCIA DE REGULACION DE EXPRESION, CODIFICANDO UNA SECUENCIA DE ADN SECRETORA UNA SEÑAL SECRETORA QUE ES FUNCIONAL EN CELULAS SECRETORAS DE LOS MAMIFEROS DE ESPECIES BOVINAS Y UNA SECUENCIA DE ADN RECOMBINANTE CODIFICANDO LOS POLIPEPTIDOS RECOMBINANTES. UN METODO PARA LA PRODUCCION DE ESPECIES BOVINAS TRANSGENICAS COMPRENDE EL INTRODUCIR EL TRANSGEN ANTERIOR EN UNA CELULA BLANCO EMBRIONARIA DE UNA ESPECIE BOVINA, AL TRANSPLANTAR LA CELULA BLANCO EMBRIONARIA TRANSGENICA ALLI FORMADA A UN PADRE BOVINO RECEPTOR E IDENTIFICAR, AL MENOS, UN DESCENDIENTE HEMBRA CAPAZ DE PRODUCIR EL POLIPEPTIDO RECOMBINANTE EN SU LECHE. LA INVENCION INCLUYE TAMBIEN ESPECIES BOVINAS TRANSGENICAS CAPACES DE PRODUCIR POLIPEPTIDOS RECOMBINANTES EN LA LECHE TRANSGENICA ASI COMO LA LECHE DE DICHAS ESPECIES BOVINAS TRANSGENICAS Y FORMULACIONES ALIMENTICIAS CONTENIENDO UNO O MAS POLIPEPTIDOS RECOMBINANTES. UN METODO PARA LA PRODUCCION DE MAMIFEROS NO HUMANOS TRANSGENICOS TENIENDO UN FENOTIPO DESEABLE, COMPRENDE EL DESNATURALIZAR PRIMERO UN TRANSGEN SEGUIDO DE LA INTRODUCCION EN OVOCITOS FERTILIZADOS. A CONTINUACION, SE CULTIVAN LOS OVOCITOS PARA FORMAR EMBRIONES DE PREIMPLANTACION. DESPUES, SE EXTRAE, AL MENOS, UNA CELULA DE CADA UNO DE LOS EMBRIONES PREIMPLANTADOS Y EL ADN DIGERIDO CON UNA ENDONUCLEASA CAPAZ DE HENDIR EL TRANSGEN DESNATURALIZADO, PERO INCAPAZ DE HENDIR LA FORMA NO DESNATURALIZADA DEL TRANSGEN.
ES91901026T 1989-12-01 1990-11-30 Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos. Expired - Lifetime ES2090299T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44474589A 1989-12-01 1989-12-01

Publications (1)

Publication Number Publication Date
ES2090299T3 true ES2090299T3 (es) 1996-10-16

Family

ID=23766173

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901026T Expired - Lifetime ES2090299T3 (es) 1989-12-01 1990-11-30 Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos.

Country Status (14)

Country Link
EP (2) EP0502976B1 (es)
AT (1) ATE140027T1 (es)
AU (1) AU656720B2 (es)
CA (2) CA2075206C (es)
DE (1) DE69027683T2 (es)
DK (1) DK0502976T3 (es)
ES (1) ES2090299T3 (es)
FI (1) FI923485A (es)
GR (1) GR3021239T3 (es)
MC (1) MC2211A1 (es)
NO (1) NO922996D0 (es)
OA (1) OA09669A (es)
RU (1) RU2095414C1 (es)
WO (1) WO1991008216A1 (es)

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Also Published As

Publication number Publication date
DK0502976T3 (da) 1996-11-11
EP0502976B1 (en) 1996-07-03
EP0502976A4 (en) 1993-09-29
EP0737746A3 (en) 1996-10-23
FI923485A0 (fi) 1992-07-31
CA2351200A1 (en) 1991-06-13
CA2075206A1 (en) 1991-06-02
AU6960891A (en) 1991-06-26
NO922996L (no) 1992-07-29
MC2211A1 (fr) 1992-11-26
NO922996D0 (no) 1992-07-29
EP0737746A2 (en) 1996-10-16
DE69027683T2 (de) 1997-02-13
WO1991008216A1 (en) 1991-06-13
DE69027683D1 (de) 1996-08-08
RU2095414C1 (ru) 1997-11-10
AU656720B2 (en) 1995-02-16
GR3021239T3 (en) 1997-01-31
CA2075206C (en) 2006-05-23
OA09669A (en) 1993-05-15
ATE140027T1 (de) 1996-07-15
FI923485A (fi) 1992-07-31
EP0502976A1 (en) 1992-09-16

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