DE3884529D1 - Leader-anteile zur produktion von rekombinanten proteinen. - Google Patents
Leader-anteile zur produktion von rekombinanten proteinen.Info
- Publication number
- DE3884529D1 DE3884529D1 DE88902750T DE3884529T DE3884529D1 DE 3884529 D1 DE3884529 D1 DE 3884529D1 DE 88902750 T DE88902750 T DE 88902750T DE 3884529 T DE3884529 T DE 3884529T DE 3884529 D1 DE3884529 D1 DE 3884529D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- recombinant proteins
- leader
- shares
- leader shares
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2850087A | 1987-03-20 | 1987-03-20 | |
PCT/US1988/000729 WO1988007086A1 (en) | 1987-03-20 | 1988-03-04 | Leader sequences for the production of recombinant proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3884529D1 true DE3884529D1 (de) | 1993-11-04 |
DE3884529T2 DE3884529T2 (de) | 1994-04-28 |
Family
ID=21843794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE88902750T Expired - Fee Related DE3884529T2 (de) | 1987-03-20 | 1988-03-04 | Leader-anteile zur produktion von rekombinanten proteinen. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0305481B1 (de) |
JP (1) | JP2535066B2 (de) |
AU (1) | AU601273B2 (de) |
CA (1) | CA1334943C (de) |
DE (1) | DE3884529T2 (de) |
WO (1) | WO1988007086A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
US6025165A (en) * | 1991-11-25 | 2000-02-15 | Enzon, Inc. | Methods for producing multivalent antigen-binding proteins |
EP1170300A1 (de) * | 1992-07-13 | 2002-01-09 | Bionebraska, Inc. | Verfahren zur Modifizierung rekombinanter Polypeptide |
US5656456A (en) * | 1992-07-13 | 1997-08-12 | Bionebraska, Inc. | Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof |
WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
DE4336810A1 (de) * | 1993-10-28 | 1995-05-18 | Basf Ag | Verfahren zur rekombinanten Herstellung von Proteinen in Hefe |
AU4415796A (en) * | 1994-12-07 | 1996-06-26 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
WO1996017942A1 (en) * | 1994-12-07 | 1996-06-13 | Bionebraska, Inc. | Production of peptides using recombinant fusion protein constructs |
EP0963435B1 (de) | 1997-01-08 | 2008-05-28 | Invitrogen Corporation | Verfahren zur herstellung von proteinen |
KR100620554B1 (ko) | 2004-06-05 | 2006-09-06 | 한국생명공학연구원 | Tag-72에 대한 인간화 항체 |
WO2008042495A2 (en) | 2006-07-21 | 2008-04-10 | Life Technologies Corporation | Sharply resolving labeled protein molecular weight standards |
US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
KR101338517B1 (ko) | 2011-04-18 | 2013-12-10 | 연세대학교 산학협력단 | 인간 간-카르복실에스터라제 1을 특이적으로 인식하는 단일클론 항체, 상기 항체를 생산하는 하이브리도마 세포주 및 이의 용도 |
US9115182B2 (en) | 2011-06-21 | 2015-08-25 | E I Du Pont De Nemours And Company | Cysteine cross-linked structural peptides |
CN104812773B (zh) | 2012-07-20 | 2018-04-06 | 庆熙大学校产学协力团 | 表位标记用抗体、杂交瘤细胞株以及其用途 |
CN105636976A (zh) | 2012-07-20 | 2016-06-01 | 庆熙大学校产学协力团 | 新型肽标签以及其用途 |
KR101453462B1 (ko) | 2013-05-16 | 2014-10-23 | 앱클론(주) | Her2에 특이적으로 결합하는 항체 |
KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
EP3783031B1 (de) | 2014-12-03 | 2023-08-02 | Aimed Bio Inc. | Antikörper gegen neuropilin 1 und verwendung davon |
KR102462811B1 (ko) | 2015-04-27 | 2022-11-04 | 에이비온 주식회사 | 항체에 덴드론이 접합된 면역접합체 및 이의 용도 |
KR101896882B1 (ko) | 2015-11-30 | 2018-09-11 | 앱클론(주) | Vegfr2에 특이적으로 결합하는 항체 |
KR101887977B1 (ko) | 2016-02-15 | 2018-08-14 | 사회복지법인 삼성생명공익재단 | EGFRvIII (Epidermal Growth Factor Receptor Variant III)에 대한 항체 및 이의 용도 |
JP2019520086A (ja) | 2016-05-27 | 2019-07-18 | オラム・セラピューティクス・インコーポレイテッド | 細胞質浸透抗体およびその用途 |
AU2017273169B2 (en) | 2016-06-03 | 2020-07-30 | Aimed Bio Inc. | Method for screening antibody using patient-derived tumor spheroids |
WO2017209553A2 (ko) | 2016-06-03 | 2017-12-07 | 사회복지법인 삼성생명공익재단 | 환자 유래 세포를 이용한 항체 스크리닝 방법 |
WO2017209554A2 (ko) | 2016-06-03 | 2017-12-07 | 사회복지법인 삼성생명공익재단 | 항-nrp1 항체 스크리닝 방법 |
KR101993893B1 (ko) | 2016-06-03 | 2019-07-01 | 사회복지법인 삼성생명공익재단 | 항-nrp1 항체 스크리닝 방법 |
US10919966B2 (en) | 2016-08-05 | 2021-02-16 | Y-Biologics Inc. | Antibody to programmed death-ligand 1 (PD-L1) and use thereof |
WO2018026249A1 (ko) | 2016-08-05 | 2018-02-08 | 주식회사 와이바이오로직스 | 프로그램화된 세포 사멸 단백질 리간드-1 (pd-l1)에 대한 항체 및 이의 용도 |
BR112019002258A2 (pt) | 2016-08-05 | 2019-05-14 | Y-Biologics Inc. | anticorpo que se liga a pd-1 ou fragmento de ligação ao antígeno do anticorpo, método para produzir o mesmo e composição para prevenir ou tratar câncer |
KR101757346B1 (ko) | 2017-03-27 | 2017-07-26 | 아주대학교산학협력단 | 항-emap ii 항체 및 이의 용도 |
KR101970327B1 (ko) | 2017-04-13 | 2019-04-18 | 고려대학교 산학협력단 | 검출 신호의 자가 증폭 원리를 이용한 정확, 신속, 편리한 단일 단계 질병 진단 방법 |
KR102078292B1 (ko) | 2017-05-30 | 2020-02-19 | 주식회사 종근당 | 신규한 항 c-Met 항체 및 이의 용도 |
KR102125032B1 (ko) | 2017-09-08 | 2020-06-19 | 주식회사 와이바이오로직스 | 인간 dlk1에 대한 항체 및 이의 용도 |
KR102281405B1 (ko) | 2017-10-20 | 2021-07-26 | 주식회사 파멥신 | 항-vista 항체 및 이의 용도 |
KR102311838B1 (ko) | 2017-12-27 | 2021-10-14 | 주식회사 파멥신 | 항-pd-l1 항체 및 이의 용도 |
KR102275930B1 (ko) | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
EP3783026A4 (de) | 2018-04-18 | 2021-08-11 | AbClon Inc. | Schaltermolekül und umschaltbarer chimärer antigenrezeptor |
CA3096533C (en) | 2018-04-27 | 2023-08-29 | Aimed Bio Inc. | Magnetic-based biopanning method through attachment of magnetic bead to cell |
KR102115300B1 (ko) | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법 |
KR20210043623A (ko) | 2018-08-10 | 2021-04-21 | 주식회사 유틸렉스 | Hla-dr에 결합하는 키메라 항원 수용체 및 car-t 세포 |
KR102353568B1 (ko) | 2018-11-14 | 2022-01-20 | 주식회사 헬릭스미스 | 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편 |
WO2020180121A1 (ko) | 2019-03-06 | 2020-09-10 | 주식회사 레고켐 바이오사이언스 | 인간 dlk1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
KR102502287B1 (ko) | 2020-04-17 | 2023-02-22 | 앱클론(주) | 항-her2 어피바디 및 이를 스위치 분자로 이용하는 스위처블 키메라 항원 수용체 |
CN115667310A (zh) | 2020-06-01 | 2023-01-31 | 创新生物有限公司 | Cd22特异性抗体及其用途 |
WO2021251564A1 (ko) | 2020-06-09 | 2021-12-16 | 국민대학교산학협력단 | Grp94에 특이적으로 결합하는 항체 또는 그의 항원 결합 단편 및 이들의 용도 |
KR20220080375A (ko) | 2020-12-07 | 2022-06-14 | (주)이노베이션바이오 | Cd47에 특이적인 항체 및 이의 용도 |
US20240141061A1 (en) | 2021-01-12 | 2024-05-02 | Sg Medical Inc | Novel antibody against cd55 and use thereof |
JP2024514890A (ja) | 2021-04-20 | 2024-04-03 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | 向上した癌細胞死滅効能を有する非対称抗体 |
WO2023277281A1 (ko) | 2021-06-30 | 2023-01-05 | (주)이노베이션바이오 | Cd47에 특이적인 인간화 항체 및 이를 포함하는 cd47 관련 질환의 예방 또는 치료용 약학적 조성물 |
KR20230066257A (ko) | 2021-11-05 | 2023-05-15 | 서울대학교병원 | 리지스틴 특이적 항체 및 이의 용도 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0305500B1 (de) * | 1987-03-20 | 1994-11-09 | Creative Biomolecules, Inc. | Verfahren zur reinigung von rekombinanten polypeptiden |
-
1988
- 1988-03-04 AU AU14824/88A patent/AU601273B2/en not_active Ceased
- 1988-03-04 EP EP88902750A patent/EP0305481B1/de not_active Expired - Lifetime
- 1988-03-04 DE DE88902750T patent/DE3884529T2/de not_active Expired - Fee Related
- 1988-03-04 JP JP63502689A patent/JP2535066B2/ja not_active Expired - Lifetime
- 1988-03-04 WO PCT/US1988/000729 patent/WO1988007086A1/en active IP Right Grant
- 1988-03-18 CA CA000561914A patent/CA1334943C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2535066B2 (ja) | 1996-09-18 |
AU1482488A (en) | 1988-10-10 |
EP0305481A1 (de) | 1989-03-08 |
EP0305481B1 (de) | 1993-09-29 |
DE3884529T2 (de) | 1994-04-28 |
JPH01503117A (ja) | 1989-10-26 |
CA1334943C (en) | 1995-03-28 |
AU601273B2 (en) | 1990-09-06 |
WO1988007086A1 (en) | 1988-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |