DE3585657D1 - Gegenseitige trennung von proteinen. - Google Patents

Gegenseitige trennung von proteinen.

Info

Publication number
DE3585657D1
DE3585657D1 DE8585306559A DE3585657A DE3585657D1 DE 3585657 D1 DE3585657 D1 DE 3585657D1 DE 8585306559 A DE8585306559 A DE 8585306559A DE 3585657 A DE3585657 A DE 3585657A DE 3585657 D1 DE3585657 D1 DE 3585657D1
Authority
DE
Germany
Prior art keywords
proteins
mutual separation
mutual
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585306559A
Other languages
English (en)
Other versions
DE3585657A1 (de
Inventor
Koichi Kato
Takao Yamada
Kenji Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000460 external-priority patent/WO1986002068A1/ja
Priority claimed from PCT/JP1985/000274 external-priority patent/WO1986007063A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3585657D1 publication Critical patent/DE3585657D1/de
Publication of DE3585657A1 publication Critical patent/DE3585657A1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C07K1/28—Isoelectric focusing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8585306559A 1984-09-26 1985-09-16 Gegenseitige trennung von proteinen. Expired - Lifetime DE3585657D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1984/000460 WO1986002068A1 (en) 1984-09-26 1984-09-26 Mutual separation of proteins
PCT/JP1985/000274 WO1986007063A1 (en) 1985-05-21 1985-05-21 Mutual separation of proteins

Publications (2)

Publication Number Publication Date
DE3585657D1 true DE3585657D1 (de) 1992-04-23
DE3585657A1 DE3585657A1 (de) 1992-04-23

Family

ID=26425064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585306559A Expired - Lifetime DE3585657D1 (de) 1984-09-26 1985-09-16 Gegenseitige trennung von proteinen.

Country Status (8)

Country Link
EP (1) EP0176299B1 (de)
JP (1) JPH0694476B2 (de)
KR (1) KR860002526A (de)
AU (1) AU599575B2 (de)
DE (1) DE3585657D1 (de)
DK (1) DK431485A (de)
IL (1) IL76360A0 (de)
NZ (1) NZ213615A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
CN86104525A (zh) * 1985-07-31 1987-02-25 武田药品工业株式会社 人类白细胞介素-2的分析方法和试剂
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
WO1989003840A1 (en) * 1987-10-23 1989-05-05 Schering Corporation Method of purifying protein
US5451662A (en) * 1987-10-23 1995-09-19 Schering Corporation Method of purifying protein
US5250296A (en) * 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
DE60230491D1 (de) 2001-03-29 2009-02-05 Schering Corp Als ccr5-antagonisten verwendbare aryloxim-piperazine
WO2004085406A1 (en) 2003-03-24 2004-10-07 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
WO2007045573A1 (en) 2005-10-19 2007-04-26 F. Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
MX2009001198A (es) 2006-08-16 2009-02-11 Hoffmann La Roche Inhibidores no nucleosidicos de la transcriptasa inversa.
WO2008071587A2 (en) 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
ES2542153T3 (es) 2007-05-30 2015-07-31 F. Hoffmann-La Roche Ag Inhibidores no nucleósidos de la transcriptasa inversa
KR101610607B1 (ko) 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
AU2010294192A1 (en) 2009-09-10 2012-04-05 Lonza Biologics Plc Method and system for polypeptide purification

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
NZ195980A (en) * 1980-01-08 1984-10-19 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing leukocyte interferon-like polypeptides;pharmaceutical and veterinary compositions
CH657141A5 (de) 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Ｉｌ‐２をコードする新規伝令ｒｎａの製造法
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
EP0091539B2 (de) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Das Polypeptid Interleukin-2 kodierendes Gen, rekombinante, dieses Gen enthaltende DNA, diese rekombinante DNA aufweisende Zelllinien und Verfahren zur Herstellung von Interleukin-2 unter Verwendung der genannten Zellen
ATE37564T1 (de) * 1982-04-20 1988-10-15 Sloan Kettering Inst Cancer Reinigung von interleukin-2.
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
IL90047A (en) 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
JPS59116231A (ja) * 1982-12-13 1984-07-05 スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ 抗−インタ−ロイキン−２単クロ−ン抗体
ZA841395B (en) * 1983-03-03 1984-10-31 Hoffmann La Roche Purification of interferon
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
WO1985000606A1 (en) * 1983-07-19 1985-02-14 Takeda Chemical Industries, Ltd. Human il-2 and process for its preparation
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
JPS60126088A (ja) 1983-12-13 1985-07-05 Takeda Chem Ind Ltd 新規ｄνａおよびその用途
JPS60172999A (ja) * 1983-12-20 1985-09-06 Suntory Ltd 新規な塩基性ポリペプチドおよびその製造法
DK174501B1 (da) * 1983-12-23 2003-04-28 Hoffmann La Roche Fremgangsmåde til fremstilling af interleukin-2
DE122004000009I1 (de) * 1984-08-16 2004-11-18 Savient Pharmaceuticals Inc Methode zur Herstellung von menschlichen Wachstumshormonen.

Also Published As

Publication number Publication date
EP0176299A2 (de) 1986-04-02
JPH0694476B2 (ja) 1994-11-24
DK431485A (da) 1986-03-27
AU599575B2 (en) 1990-07-26
NZ213615A (en) 1989-08-29
IL76360A0 (en) 1986-01-31
EP0176299A3 (en) 1987-07-15
DK431485D0 (da) 1985-09-24
KR860002526A (ko) 1986-04-26
AU4749685A (en) 1986-04-10
JPS6178799A (ja) 1986-04-22
EP0176299B1 (de) 1992-03-18
DE3585657A1 (de) 1992-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee