ATE201445T1 - Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgens - Google Patents
Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgensInfo
- Publication number
- ATE201445T1 ATE201445T1 AT95305605T AT95305605T ATE201445T1 AT E201445 T1 ATE201445 T1 AT E201445T1 AT 95305605 T AT95305605 T AT 95305605T AT 95305605 T AT95305605 T AT 95305605T AT E201445 T1 ATE201445 T1 AT E201445T1
- Authority
- AT
- Austria
- Prior art keywords
- ovarian cancer
- mutations
- ovarial
- breast
- breast cancer
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 6
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 6
- 230000035772 mutation Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000035945 sensitivity Effects 0.000 title 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 5
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 5
- 210000000481 breast Anatomy 0.000 abstract 5
- 108700040618 BRCA1 Genes Proteins 0.000 abstract 2
- 101150072950 BRCA1 gene Proteins 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 2
- 206010069754 Acquired gene mutation Diseases 0.000 abstract 1
- 108700028369 Alleles Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000037439 somatic mutation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28922194A | 1994-08-12 | 1994-08-12 | |
US30026694A | 1994-09-02 | 1994-09-02 | |
US30810494A | 1994-09-16 | 1994-09-16 | |
US34882494A | 1994-11-29 | 1994-11-29 | |
US40930595A | 1995-03-24 | 1995-03-24 | |
US08/480,784 US5693473A (en) | 1994-08-12 | 1995-06-07 | Linked breast and ovarian cancer susceptibility gene |
US08/483,553 US5709999A (en) | 1994-08-12 | 1995-06-07 | Linked breast and ovarian cancer susceptibility gene |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE201445T1 true ATE201445T1 (de) | 2001-06-15 |
Family
ID=27569596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95305605T ATE201445T1 (de) | 1994-08-12 | 1995-08-11 | Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgens |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0705903B2 (de) |
JP (1) | JP2002503943A (de) |
CN (1) | CN1172502A (de) |
AT (1) | ATE201445T1 (de) |
AU (1) | AU686004B2 (de) |
CA (1) | CA2196797C (de) |
DE (1) | DE69521002T3 (de) |
DK (1) | DK0705903T3 (de) |
ES (1) | ES2158048T5 (de) |
FI (1) | FI970513A (de) |
GR (1) | GR3036322T3 (de) |
MX (1) | MX9701075A (de) |
NO (1) | NO970624L (de) |
NZ (1) | NZ291621A (de) |
PT (1) | PT705903E (de) |
WO (1) | WO1996005306A2 (de) |
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WO1995019369A1 (en) | 1994-01-14 | 1995-07-20 | Vanderbilt University | Method for detection and treatment of breast cancer |
AU707348B2 (en) * | 1995-01-17 | 1999-07-08 | Vanderbilt University | Method for detection and treatment of breast cancer |
US5654155A (en) * | 1996-02-12 | 1997-08-05 | Oncormed, Inc. | Consensus sequence of the human BRCA1 gene |
US6951721B2 (en) | 1996-02-12 | 2005-10-04 | Gene Logic Inc. | Method for determining the haplotype of a human BRCA1 gene |
US6838256B2 (en) * | 1996-02-12 | 2005-01-04 | Gene Logic Inc. | Coding sequences of the human BRCA1 gene |
US5891857A (en) * | 1996-02-20 | 1999-04-06 | Vanderbilt University | Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characterized BRCA1 and BRCA2 proteins |
WO1998012327A2 (en) * | 1996-09-20 | 1998-03-26 | Board Of Regents, The University Of Texas System | Compositions and methods comprising bard1 and other brca1 binding proteins |
WO1998031801A1 (en) | 1997-01-21 | 1998-07-23 | Human Genome Sciences, Inc. | I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and cd-95 induced apoptosis |
US5965377A (en) * | 1997-03-24 | 1999-10-12 | Baystate Medical Center | Method for determining the presence of mutated BRCA protein |
AU754748B2 (en) | 1997-06-04 | 2002-11-21 | Rijksuniversiteit Te Leiden | A diagnostic test kit for determining a predisposition for breast and ovarian cancer, materials and methods for such determination |
US6492109B1 (en) | 1997-09-23 | 2002-12-10 | Gene Logic, Inc. | Susceptibility mutation 6495delGC of BRCA2 |
EP1038026B1 (de) | 1997-11-06 | 2005-01-12 | Oklahoma Medical Research Foundation | Diagnostisches assay zur krebsanfälligkeit |
US6177410B1 (en) | 1997-12-05 | 2001-01-23 | Vanderbilt University | Therapeutic methods for prostate cancer |
US6686163B2 (en) | 1998-05-06 | 2004-02-03 | Gene Logic Inc. | Coding sequence haplotype of the human BRCA1 gene |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
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EP2371392B1 (de) | 2002-05-02 | 2015-07-08 | Wyeth Holdings LLC | Calicheamicin-Derivat-Trägerkonjugate |
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US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
SG150548A1 (en) | 2003-12-01 | 2009-03-30 | Kudos Pharm Ltd | Dna damage repair inhibitors for treatment of cancer |
GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
KR101138862B1 (ko) | 2005-02-14 | 2012-05-14 | 삼성전자주식회사 | 단일염기 다형을 포함하는 유방암과 관련된 폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단 키트 및 그를이용한 유방암 진단 방법 |
KR101206028B1 (ko) | 2005-03-05 | 2012-11-28 | 삼성전자주식회사 | 유방암 특이적 다형성 서열을 이용한 유방암의 진단방법,유방암 특이적인 폴리뉴클레오티드 및 상기 폴리뉴클레오티드가 고정되어 있는 마이크로어레이 |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
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EA020783B1 (ru) | 2008-10-07 | 2015-01-30 | Астразенека Юк Лимитед | Фармацевтическая композиция, содержащая 4-[3-(4-циклопропанкарбонилпиперазин-1-карбонил)-4-фторбензил]-2н-фталазин-1-он и коповидон |
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AR079774A1 (es) | 2009-07-15 | 2012-02-22 | Astrazeneca Ab | Compuesto de ftalazinona como forma cristalina c , composicion farmaceutica y usos del mismo |
KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
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CN109897852A (zh) * | 2018-07-25 | 2019-06-18 | 广州普世利华科技有限公司 | 基于C2c2的肿瘤相关突变基因的gRNA、检测方法、检测试剂盒 |
CN113811333B (zh) | 2019-05-14 | 2024-03-12 | 诺维逊生物股份有限公司 | 靶向抗癌核激素受体的化合物 |
JOP20220008A1 (ar) | 2019-07-19 | 2023-01-30 | Astrazeneca Ab | مثبطات parp1 |
TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
CN113388680B (zh) * | 2020-03-14 | 2023-07-04 | 复旦大学附属妇产科医院 | 上皮性卵巢癌靶点ret及其在诊断和治疗中的作用 |
US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
BR112023006337A2 (pt) | 2020-10-09 | 2023-05-09 | Astrazeneca Uk Ltd | Produto farmacêutico, uso de um conjugado anticorpo anti-her2-fármaco ou um inibidor seletivo de parp1, e, método de tratamento do câncer |
US11834458B2 (en) | 2021-03-23 | 2023-12-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
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KR20240130087A (ko) | 2021-12-28 | 2024-08-28 | 아스트라제네카 유케이 리미티드 | 항체-약물 접합체와 atr 저해제의 조합 |
TW202333800A (zh) | 2021-12-28 | 2023-09-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及rasg12c抑制劑之組合 |
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WO2023194530A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Combination therapy for treating cancer |
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WO2023242302A1 (en) | 2022-06-15 | 2023-12-21 | Astrazeneca Ab | Combination therapy for treating cancer |
WO2024023750A1 (en) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
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WO2024199668A1 (en) | 2023-03-31 | 2024-10-03 | Astrazeneca Ab | Dosing regiment of azd5305 |
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AU707348B2 (en) * | 1995-01-17 | 1999-07-08 | Vanderbilt University | Method for detection and treatment of breast cancer |
-
1995
- 1995-08-11 MX MX9701075A patent/MX9701075A/es unknown
- 1995-08-11 AT AT95305605T patent/ATE201445T1/de not_active IP Right Cessation
- 1995-08-11 WO PCT/US1995/010202 patent/WO1996005306A2/en not_active Application Discontinuation
- 1995-08-11 CA CA002196797A patent/CA2196797C/en not_active Expired - Lifetime
- 1995-08-11 PT PT95305605T patent/PT705903E/pt unknown
- 1995-08-11 AU AU33212/95A patent/AU686004B2/en not_active Expired
- 1995-08-11 NZ NZ291621A patent/NZ291621A/en not_active IP Right Cessation
- 1995-08-11 DK DK95305605T patent/DK0705903T3/da active
- 1995-08-11 JP JP50750796A patent/JP2002503943A/ja active Pending
- 1995-08-11 EP EP95305605A patent/EP0705903B2/de not_active Expired - Lifetime
- 1995-08-11 DE DE69521002T patent/DE69521002T3/de not_active Expired - Lifetime
- 1995-08-11 CN CN95195413.XA patent/CN1172502A/zh active Pending
- 1995-08-11 ES ES95305605T patent/ES2158048T5/es not_active Expired - Lifetime
-
1997
- 1997-02-07 FI FI970513A patent/FI970513A/fi unknown
- 1997-02-11 NO NO970624A patent/NO970624L/no not_active Application Discontinuation
-
2001
- 2001-08-06 GR GR20010401173T patent/GR3036322T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI970513A0 (fi) | 1997-02-07 |
NO970624D0 (no) | 1997-02-11 |
CA2196797C (en) | 2000-10-10 |
DE69521002T2 (de) | 2001-11-15 |
EP0705903A1 (de) | 1996-04-10 |
JP2002503943A (ja) | 2002-02-05 |
GR3036322T3 (en) | 2001-11-30 |
NO970624L (no) | 1997-04-14 |
WO1996005306A3 (en) | 1996-03-14 |
AU3321295A (en) | 1996-03-07 |
PT705903E (pt) | 2001-11-30 |
AU686004B2 (en) | 1998-01-29 |
DK0705903T3 (da) | 2001-08-27 |
FI970513A (fi) | 1997-04-07 |
WO1996005306A2 (en) | 1996-02-22 |
MX9701075A (es) | 1998-03-31 |
NZ291621A (en) | 1998-09-24 |
DE69521002D1 (de) | 2001-06-28 |
EP0705903B2 (de) | 2009-08-12 |
ES2158048T5 (es) | 2009-11-04 |
EP0705903B1 (de) | 2001-05-23 |
DE69521002T3 (de) | 2010-02-25 |
CA2196797A1 (en) | 1996-02-22 |
CN1172502A (zh) | 1998-02-04 |
ES2158048T3 (es) | 2001-09-01 |
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UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |