PE20131143A1 - Nuevas aminopirazoloquinazolinas - Google Patents

Nuevas aminopirazoloquinazolinas

Info

Publication number
PE20131143A1
PE20131143A1 PE2013000125A PE2013000125A PE20131143A1 PE 20131143 A1 PE20131143 A1 PE 20131143A1 PE 2013000125 A PE2013000125 A PE 2013000125A PE 2013000125 A PE2013000125 A PE 2013000125A PE 20131143 A1 PE20131143 A1 PE 20131143A1
Authority
PE
Peru
Prior art keywords
alkyl
aminopyrazoloquinazolines
new
dihydropirazolo
pyrazole
Prior art date
Application number
PE2013000125A
Other languages
English (en)
Inventor
Matthias Treu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43037625&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131143(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20131143A1 publication Critical patent/PE20131143A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Abstract

SE REFIERE A NUEVAS AMINOPIRAZOLOQUINAZOLINAS DE FORMULA (I) DONDE R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6 ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C10, ENTRE OTROS; R3 ES (II) , (III) DONDE A ES UN ARILO C6-C10 Y HETEROARILO C5-C12; B ES UN HETEROARILO NO AROMATICO C5-C7 CON AL MENOS UN HETEROATOMO SELECCIONADO DEL GRUPO N, S Y O, R4 Y R5 ESTAN SELECCIONADOS DEL GRUPO Ra y Rb, Ra ES UN ALQUILO C1-C6, ALQUENILO C2-C6 ENTRE OTROS; Rb ES HALOGENO, -CN, -NO2 ENTRE OTROS; m es 0,1,2,y3; n ES 0 Y 1; X ES -CH2- Y -CH2-CH2- ENTRE OTROS. SON COMPUESTOS PREFERIDOS (5S)-N-[1-(2-METOXIETIL) PIRAZOL-3-IL]-5,8-DIMETIL-9-FENIL-5,6-DIHIDROPIRAZOLO[3,4-H]-QUINAZOLIN-2-AMINA, N-[1-(2-DIMETILAMINOETIL)PIRAZOL-3-IL]-5,8-DIMETIL-9-FENIL-5,6-DIHIDROPIRAZOLO[3,4-H]-QUINAZOLIN-2-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA FORMULACION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE CARCINOMAS BRONQUIALES NO MICROCITICOS Y CARCINOMAS HEPATOCITICOS.
PE2013000125A 2010-07-23 2011-07-22 Nuevas aminopirazoloquinazolinas PE20131143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10170683 2010-07-23

Publications (1)

Publication Number Publication Date
PE20131143A1 true PE20131143A1 (es) 2013-10-23

Family

ID=43037625

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000125A PE20131143A1 (es) 2010-07-23 2011-07-22 Nuevas aminopirazoloquinazolinas

Country Status (22)

Country Link
US (1) US8735386B2 (es)
EP (1) EP2595987B1 (es)
JP (1) JP5991974B2 (es)
KR (1) KR20130132394A (es)
CN (1) CN103097388A (es)
AP (1) AP2012006640A0 (es)
AR (1) AR082850A1 (es)
AU (1) AU2011281504A1 (es)
BR (1) BR112013000107A2 (es)
CA (1) CA2803467A1 (es)
CL (1) CL2012003745A1 (es)
CO (1) CO6670575A2 (es)
EA (1) EA201201661A1 (es)
EC (1) ECSP13012448A (es)
GE (1) GEP20156289B (es)
MA (1) MA34389B1 (es)
MX (1) MX2013000821A (es)
PE (1) PE20131143A1 (es)
SG (1) SG187548A1 (es)
TW (1) TW201217380A (es)
UY (1) UY33526A (es)
WO (1) WO2012010704A1 (es)

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US9150578B2 (en) 2012-01-23 2015-10-06 Boehringer Ingelheim International Gmbh 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
DK3546461T3 (da) * 2013-11-15 2021-09-13 Oncoceutics Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, salts thereof and methods of using the same in combination therapy
MX2017009841A (es) 2015-01-30 2018-02-09 Oncoceutics Inc 7-bencil-4-(2-metilbencilo) -2,4,6,7,8,9-hexahidroimidazo [1,2-a] pirido [3,4-e] pirimidin-5 (1h) -ona, analogos y sales del mismo y su uso en terapia.
US10414769B2 (en) 2015-05-13 2019-09-17 Boehringer Ingelheim International Gmbh 5,8-dimethyl-9-phenyl-5,8-dihydro-6H-pyrazolo[3,4-h]quinazolin-2-yl)-(1H-pyrazol-3-yl)-amines as IGF-1R/IR inhibitors
US11168088B2 (en) 2016-11-11 2021-11-09 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
WO2018214961A1 (zh) * 2017-05-26 2018-11-29 江苏新元素医药科技有限公司 促尿酸排泄的urat1抑制剂
CN107383019B (zh) * 2017-07-28 2019-10-15 江苏艾凡生物医药有限公司 吡唑并[4,3-h]喹唑啉类化合物及其用途
WO2019206154A1 (zh) 2018-04-24 2019-10-31 上海海雁医药科技有限公司 Cdk4/6抑制剂及其药学上可接受的盐和多晶型物及其应用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020160321A1 (en) * 2019-01-30 2020-08-06 Yale University Compounds, compositions, and methods for treating fibrosis
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
CU24679B1 (es) * 2019-03-07 2023-09-07 BioNTech SE Proceso para la preparación de una imidazoquinolina sustituida
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
KR20220003557A (ko) * 2019-04-19 2022-01-10 파운트 바이오 인코포레이티드 피부 내에서의 활성제의 전달 및 보유
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
MX2022001940A (es) 2019-08-14 2022-05-10 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2.
PE20221905A1 (es) 2019-10-11 2022-12-23 Incyte Corp Aminas biciclicas como inhibidoras de la cdk2
BR112022024729A2 (pt) 2020-06-05 2023-02-28 Kinnate Biopharma Inc Inibidores de quinases do receptor do fator de crescimento de fibroblastos
CN111960974A (zh) * 2020-08-28 2020-11-20 山东潍坊润丰化工股份有限公司 一种烯草酮中间体的合成方法
US20240140962A1 (en) * 2021-02-08 2024-05-02 Medshine Discovery Inc. 5,6-dihydrothieno[3,4-h]quinazoline compound
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ319158A (en) * 1995-10-02 1999-10-28 Hoffmann La Roche Pyrimidine derivatives as 5ht2c-receptor antagonists
GEP20094664B (en) 2003-05-22 2009-04-10 Nerviano Medical Sciences Srl Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法

Also Published As

Publication number Publication date
CO6670575A2 (es) 2013-05-15
JP5991974B2 (ja) 2016-09-14
WO2012010704A1 (en) 2012-01-26
SG187548A1 (en) 2013-03-28
MA34389B1 (fr) 2013-07-03
UY33526A (es) 2012-02-29
CN103097388A (zh) 2013-05-08
TW201217380A (en) 2012-05-01
US20120238542A1 (en) 2012-09-20
BR112013000107A2 (pt) 2016-05-17
ECSP13012448A (es) 2013-03-28
JP2013532652A (ja) 2013-08-19
EP2595987B1 (en) 2018-04-18
AU2011281504A1 (en) 2013-01-10
AP2012006640A0 (en) 2012-12-31
CA2803467A1 (en) 2012-01-26
MX2013000821A (es) 2013-05-30
US8735386B2 (en) 2014-05-27
AR082850A1 (es) 2013-01-16
EP2595987A1 (en) 2013-05-29
EA201201661A1 (ru) 2013-07-30
KR20130132394A (ko) 2013-12-04
CL2012003745A1 (es) 2013-05-31
GEP20156289B (en) 2015-05-25

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