EA201201661A1 - Новые аминопиразолохиназолины - Google Patents

Новые аминопиразолохиназолины

Info

Publication number
EA201201661A1
EA201201661A1 EA201201661A EA201201661A EA201201661A1 EA 201201661 A1 EA201201661 A1 EA 201201661A1 EA 201201661 A EA201201661 A EA 201201661A EA 201201661 A EA201201661 A EA 201201661A EA 201201661 A1 EA201201661 A1 EA 201201661A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminopyrazolohinazolines
new
compounds
medicines
excessive
Prior art date
Application number
EA201201661A
Other languages
English (en)
Inventor
Маттиас Трой
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43037625&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201661(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201201661A1 publication Critical patent/EA201201661A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к соединениям общей формулы (I), в которой группы R-Rи X являются такими, как определено в п.1 формулы изобретения, которые являются подходящими для лечения заболеваний, характеризующихся чрезмерной или аномальной пролиферацией клеток, к фармацевтическим препаратам, которые содержат такие соединения, и к их применению в качестве лекарственных средств.
EA201201661A 2010-07-23 2011-07-22 Новые аминопиразолохиназолины EA201201661A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10170683 2010-07-23
PCT/EP2011/062683 WO2012010704A1 (en) 2010-07-23 2011-07-22 New aminopyrazoloquinazolines

Publications (1)

Publication Number Publication Date
EA201201661A1 true EA201201661A1 (ru) 2013-07-30

Family

ID=43037625

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201661A EA201201661A1 (ru) 2010-07-23 2011-07-22 Новые аминопиразолохиназолины

Country Status (22)

Country Link
US (1) US8735386B2 (ru)
EP (1) EP2595987B1 (ru)
JP (1) JP5991974B2 (ru)
KR (1) KR20130132394A (ru)
CN (1) CN103097388A (ru)
AP (1) AP2012006640A0 (ru)
AR (1) AR082850A1 (ru)
AU (1) AU2011281504A1 (ru)
BR (1) BR112013000107A2 (ru)
CA (1) CA2803467A1 (ru)
CL (1) CL2012003745A1 (ru)
CO (1) CO6670575A2 (ru)
EA (1) EA201201661A1 (ru)
EC (1) ECSP13012448A (ru)
GE (1) GEP20156289B (ru)
MA (1) MA34389B1 (ru)
MX (1) MX2013000821A (ru)
PE (1) PE20131143A1 (ru)
SG (1) SG187548A1 (ru)
TW (1) TW201217380A (ru)
UY (1) UY33526A (ru)
WO (1) WO2012010704A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6128133B2 (ja) * 2012-01-23 2017-05-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
ES2724331T3 (es) * 2013-11-15 2019-09-10 Oncoceutics Inc 7-Bencil-4-(2-metilbencil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1H)-ona, sales de la misma y procedimientos de uso
MA55402A (fr) 2015-01-30 2022-02-02 Oncoceutics Inc Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie
EP3294742B1 (en) * 2015-05-13 2020-01-08 Boehringer Ingelheim International GmbH New (5,8-dimethyl-9-phenyl-5,8-dihydro-6h-pyrazolo[3,4-h)quinazolin-2-yl)-(1h-pyrazol-5-yl)-amines and theri derivatives as igf-1r/1r inhibitors.
AU2017356569B2 (en) * 2016-11-11 2020-10-08 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
DK3632904T3 (da) * 2017-05-26 2022-07-25 Jiangsu Atom Bioscience And Pharmaceutical Co Ltd URAT1-inhibitorer til at fremme urinsyreudskillelse
CN107383019B (zh) * 2017-07-28 2019-10-15 江苏艾凡生物医药有限公司 吡唑并[4,3-h]喹唑啉类化合物及其用途
JP2021521282A (ja) * 2018-04-24 2021-08-26 上海海雁医薬科技有限公司Ｓｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． Ｃｄｋ４／６阻害剤、その薬学的に許容可能な塩と結晶多形体、及びその応用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CA3128200A1 (en) * 2019-01-30 2020-08-06 Yale University Compounds, compositions, and methods for treating fibrosis
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
CA3132229A1 (en) * 2019-03-07 2020-09-10 BioNTech SE Process for the preparation of a substituted imidazoquinoline
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
WO2020214889A1 (en) * 2019-04-19 2020-10-22 Fount Bio, Inc. Delivery and retention of active agents within the skin
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
EP4013750A1 (en) 2019-08-14 2022-06-22 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2021072232A1 (en) 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
US11345681B1 (en) 2020-06-05 2022-05-31 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
CN111960974A (zh) * 2020-08-28 2020-11-20 山东潍坊润丰化工股份有限公司 一种烯草酮中间体的合成方法
WO2022166725A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 5，6-二氢噻吩并[3，4-h]喹唑啉类化合物
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
WO1997012880A1 (en) * 1995-10-02 1997-04-10 F.Hoffmann-La Roche Ag Pyrimidine derivatives as 5ht2c-receptor antagonists
RS52899B (en) 2003-05-22 2014-02-28 Nerviano Medical Sciences S.R.L. PIRAZOLO-HINAZOLINE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法

Also Published As

Publication number Publication date
EP2595987A1 (en) 2013-05-29
UY33526A (es) 2012-02-29
CN103097388A (zh) 2013-05-08
WO2012010704A1 (en) 2012-01-26
CL2012003745A1 (es) 2013-05-31
GEP20156289B (en) 2015-05-25
CA2803467A1 (en) 2012-01-26
PE20131143A1 (es) 2013-10-23
US8735386B2 (en) 2014-05-27
AR082850A1 (es) 2013-01-16
JP2013532652A (ja) 2013-08-19
MX2013000821A (es) 2013-05-30
KR20130132394A (ko) 2013-12-04
AU2011281504A1 (en) 2013-01-10
BR112013000107A2 (pt) 2016-05-17
SG187548A1 (en) 2013-03-28
TW201217380A (en) 2012-05-01
AP2012006640A0 (en) 2012-12-31
JP5991974B2 (ja) 2016-09-14
MA34389B1 (fr) 2013-07-03
CO6670575A2 (es) 2013-05-15
EP2595987B1 (en) 2018-04-18
ECSP13012448A (es) 2013-03-28
US20120238542A1 (en) 2012-09-20

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