EA201300874A1 - Новые азаиндолилфенилсульфонамиды в качестве ингибиторов серин/треонинкиназы - Google Patents

Новые азаиндолилфенилсульфонамиды в качестве ингибиторов серин/треонинкиназы

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Publication number
EA201300874A1
EA201300874A1 EA201300874A EA201300874A EA201300874A1 EA 201300874 A1 EA201300874 A1 EA 201300874A1 EA 201300874 A EA201300874 A EA 201300874A EA 201300874 A EA201300874 A EA 201300874A EA 201300874 A1 EA201300874 A1 EA 201300874A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treoninkinase
azaindolylphenyl
serin
sulphonamides
inhibitors
Prior art date
Application number
EA201300874A
Other languages
English (en)
Inventor
Хайнц Штадтмюллер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201300874A1 publication Critical patent/EA201300874A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В заявке описаны соединения общей формулы (I)в которой группы R-R, А, X, Y и m являются такими, как определено в п.1 формулы изобретения, которые являются подходящими для лечения заболеваний, характеризующихся чрезмерной или аномальной пролиферацией клеток, фармацевтические препараты, которые содержат соединения такого типа, и их применение в качестве лекарственных средств.
EA201300874A 2011-02-02 2012-02-02 Новые азаиндолилфенилсульфонамиды в качестве ингибиторов серин/треонинкиназы EA201300874A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11153087 2011-02-02
EP11181258 2011-09-14
PCT/EP2012/051796 WO2012104388A1 (en) 2011-02-02 2012-02-02 New azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors

Publications (1)

Publication Number Publication Date
EA201300874A1 true EA201300874A1 (ru) 2014-02-28

Family

ID=45558742

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300874A EA201300874A1 (ru) 2011-02-02 2012-02-02 Новые азаиндолилфенилсульфонамиды в качестве ингибиторов серин/треонинкиназы

Country Status (14)

Country Link
US (1) US8889684B2 (ru)
EP (1) EP2670749B1 (ru)
JP (1) JP5850952B2 (ru)
KR (1) KR20140014149A (ru)
CN (1) CN103476773A (ru)
AU (1) AU2012213390A1 (ru)
BR (1) BR112013019714A2 (ru)
CA (1) CA2825279A1 (ru)
CL (1) CL2013002063A1 (ru)
EA (1) EA201300874A1 (ru)
IL (1) IL227399A0 (ru)
MX (1) MX2013008868A (ru)
UY (1) UY33890A (ru)
WO (1) WO2012104388A1 (ru)

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Also Published As

Publication number Publication date
CN103476773A (zh) 2013-12-25
WO2012104388A1 (en) 2012-08-09
CA2825279A1 (en) 2012-08-09
IL227399A0 (en) 2013-09-30
EP2670749A1 (en) 2013-12-11
US8889684B2 (en) 2014-11-18
US20130029993A1 (en) 2013-01-31
KR20140014149A (ko) 2014-02-05
AU2012213390A1 (en) 2013-08-01
EP2670749B1 (en) 2016-01-27
CL2013002063A1 (es) 2013-12-27
JP5850952B2 (ja) 2016-02-03
MX2013008868A (es) 2013-08-14
JP2014504622A (ja) 2014-02-24
BR112013019714A2 (pt) 2016-10-18
UY33890A (es) 2012-08-31

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