DOP2020000222A - Derivado policiclico de piridona - Google Patents
Derivado policiclico de piridonaInfo
- Publication number
- DOP2020000222A DOP2020000222A DO2020000222A DO2020000222A DOP2020000222A DO P2020000222 A DOP2020000222 A DO P2020000222A DO 2020000222 A DO2020000222 A DO 2020000222A DO 2020000222 A DO2020000222 A DO 2020000222A DO P2020000222 A DOP2020000222 A DO P2020000222A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- substituted
- polycyclical
- piridone
- derivative
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se relaciona con un compuesto representado por la siguiente fórmula (I) (en la fórmula, el anillo A es un heterociclo no aromático sustituido o no sustituido; el anillo C es un anillo de benceno, etc.; Q es un heterociclo aromático de 5 miembros, etc.; R1 es independientemente halógeno, etc.; L es alquileno sustituido o no sustituido; R3 es alquilo sustituido o no sustituido, etc.; R4 es hidrógeno, etc.; y n es un número entero de 1 a 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018104160 | 2018-05-31 | ||
| PCT/JP2019/021445 WO2019230857A1 (ja) | 2018-05-31 | 2019-05-30 | 多環性ピリドン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2020000222A true DOP2020000222A (es) | 2021-03-15 |
Family
ID=68698906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2020000222A DOP2020000222A (es) | 2018-05-31 | 2020-11-27 | Derivado policiclico de piridona |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11453669B2 (es) |
| EP (1) | EP3805221A4 (es) |
| JP (1) | JP7353707B2 (es) |
| KR (1) | KR20210018324A (es) |
| CN (1) | CN112533922B (es) |
| AU (1) | AU2019277547A1 (es) |
| BR (1) | BR112020024098A2 (es) |
| CA (1) | CA3101950A1 (es) |
| CL (1) | CL2020002987A1 (es) |
| CO (1) | CO2020014296A2 (es) |
| CR (1) | CR20200645A (es) |
| DO (1) | DOP2020000222A (es) |
| EA (1) | EA202092923A1 (es) |
| IL (1) | IL279050A (es) |
| MA (1) | MA52802A (es) |
| MX (1) | MX2020012185A (es) |
| PE (1) | PE20201414A1 (es) |
| PH (1) | PH12020551999A1 (es) |
| SG (1) | SG11202011386QA (es) |
| WO (1) | WO2019230857A1 (es) |
| ZA (1) | ZA202007568B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20230571A (es) | 2018-05-31 | 2024-01-22 | Shionogi & Co | DERIVADO POLICÍCLICO DE CARBAMOILPIRIDONA (divisional 2020-0644) |
| EP4122537A1 (en) | 2019-03-22 | 2023-01-25 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| US20230059640A1 (en) * | 2019-11-28 | 2023-02-23 | Shionogi & Co., Ltd. | Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent |
| JPWO2021107065A1 (es) * | 2019-11-28 | 2021-06-03 | ||
| US11697652B2 (en) | 2020-02-24 | 2023-07-11 | Gilead Sciences, Inc. | Tetracyclic compounds and uses thereof |
| WO2021233302A1 (zh) * | 2020-05-21 | 2021-11-25 | 南京明德新药研发有限公司 | 稠环衍生物及其在药学上的应用 |
| WO2022159387A1 (en) | 2021-01-19 | 2022-07-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| EP4384178A1 (en) * | 2021-08-11 | 2024-06-19 | Merck Sharp & Dohme LLC | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003267098B2 (en) | 2002-09-11 | 2008-11-20 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors |
| EP1578748B1 (en) | 2002-12-27 | 2010-09-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| EP1852434B1 (en) | 2005-02-21 | 2011-07-13 | Shionogi Co., Ltd. | Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity |
| WO2006116764A1 (en) | 2005-04-28 | 2006-11-02 | Smithkline Beecham Corporation | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
| CA2626956A1 (en) * | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
| WO2011105590A1 (ja) | 2010-02-26 | 2011-09-01 | 日本たばこ産業株式会社 | １，３，４，８－テトラヒドロ－２Ｈ－ピリド［１，２－ａ］ピラジン誘導体及びそのＨＩＶインテグラーゼ阻害剤としての利用 |
| JP5766690B2 (ja) | 2010-04-12 | 2015-08-19 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| US9200009B2 (en) | 2011-10-12 | 2015-12-01 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase inhibitory activity |
| WO2014099586A1 (en) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| KR102527797B1 (ko) | 2012-12-21 | 2023-05-03 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
| US20140221380A1 (en) | 2012-12-27 | 2014-08-07 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR |
| ME02977B (me) | 2013-05-17 | 2018-10-20 | Merck Sharp & Dohme | Fuzionisana triciklicna heterociklicna jedinjenja као inhibiтori hiv integraze |
| EP3008044B1 (en) * | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| WO2014200080A1 (ja) | 2013-06-14 | 2014-12-18 | ヤンマー株式会社 | 予測装置、予測方法及びコンピュータプログラム |
| CA2916993C (en) | 2013-07-12 | 2019-01-15 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| NO2865735T3 (es) | 2013-07-12 | 2018-07-21 | ||
| WO2015039348A1 (en) | 2013-09-23 | 2015-03-26 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
| EA030695B1 (ru) | 2013-09-27 | 2018-09-28 | Мерк Шарп И Доум Корп. | Замещенные производные хинолизина, которые можно использовать как ингибиторы интегразы вич |
| WO2015089847A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2015199167A1 (ja) | 2014-06-25 | 2015-12-30 | 日本たばこ産業株式会社 | 置換されたスピロピリド［１，２－ａ］ピラジン誘導体の製造方法および中間体 |
| EP3196201B1 (en) | 2014-08-22 | 2021-04-28 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| EP3229804B1 (en) | 2014-12-09 | 2020-05-06 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2016090545A1 (en) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrate inhibitors |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| EP3285582B1 (en) | 2015-03-26 | 2020-11-11 | Merck Sharp & Dohme Corp. | Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors |
| AU2016244035B2 (en) | 2015-04-02 | 2018-11-01 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| WO2017087257A1 (en) | 2015-11-17 | 2017-05-26 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors |
| US10624912B2 (en) | 2015-11-17 | 2020-04-21 | Merck Sharp & Dohme Corp. | Spirocyclic Pyridotriazine Derivatives useful as HIV integrase inhibitors |
| WO2017106071A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| JP2020500866A (ja) | 2016-12-02 | 2020-01-16 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｈｉｖインテグラーゼ阻害剤として有用な三環式複素環化合物 |
| WO2019160783A1 (en) | 2018-02-15 | 2019-08-22 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2019209667A1 (en) | 2018-04-27 | 2019-10-31 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| CN110526930B (zh) | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
| WO2019236396A1 (en) | 2018-06-05 | 2019-12-12 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| EP4122537A1 (en) | 2019-03-22 | 2023-01-25 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
-
2019
- 2019-05-30 WO PCT/JP2019/021445 patent/WO2019230857A1/ja active Application Filing
- 2019-05-30 KR KR1020207037581A patent/KR20210018324A/ko not_active Application Discontinuation
- 2019-05-30 MX MX2020012185A patent/MX2020012185A/es unknown
- 2019-05-30 SG SG11202011386QA patent/SG11202011386QA/en unknown
- 2019-05-30 JP JP2020522576A patent/JP7353707B2/ja active Active
- 2019-05-30 BR BR112020024098-2A patent/BR112020024098A2/pt unknown
- 2019-05-30 EP EP19812190.7A patent/EP3805221A4/en active Pending
- 2019-05-30 CR CR20200645A patent/CR20200645A/es unknown
- 2019-05-30 AU AU2019277547A patent/AU2019277547A1/en active Pending
- 2019-05-30 MA MA052802A patent/MA52802A/fr unknown
- 2019-05-30 CN CN201980050400.4A patent/CN112533922B/zh active Active
- 2019-05-30 CA CA3101950A patent/CA3101950A1/en active Pending
- 2019-05-30 PE PE2020001864A patent/PE20201414A1/es unknown
- 2019-05-30 EA EA202092923A patent/EA202092923A1/ru unknown
- 2019-05-30 US US17/058,260 patent/US11453669B2/en active Active
-
2020
- 2020-11-17 CL CL2020002987A patent/CL2020002987A1/es unknown
- 2020-11-18 CO CONC2020/0014296A patent/CO2020014296A2/es unknown
- 2020-11-20 PH PH12020551999A patent/PH12020551999A1/en unknown
- 2020-11-27 DO DO2020000222A patent/DOP2020000222A/es unknown
- 2020-11-29 IL IL279050A patent/IL279050A/en unknown
- 2020-12-04 ZA ZA2020/07568A patent/ZA202007568B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2020012185A (es) | 2021-01-29 |
| CR20200645A (es) | 2021-02-05 |
| JP7353707B2 (ja) | 2023-10-02 |
| US20210155622A1 (en) | 2021-05-27 |
| MA52802A (fr) | 2021-04-14 |
| ZA202007568B (en) | 2022-04-28 |
| KR20210018324A (ko) | 2021-02-17 |
| CA3101950A1 (en) | 2019-12-05 |
| SG11202011386QA (en) | 2020-12-30 |
| CN112533922B (zh) | 2024-03-22 |
| PE20201414A1 (es) | 2020-12-07 |
| EA202092923A1 (ru) | 2021-04-09 |
| EP3805221A1 (en) | 2021-04-14 |
| CO2020014296A2 (es) | 2020-12-21 |
| JPWO2019230857A1 (ja) | 2021-06-24 |
| EP3805221A4 (en) | 2022-01-05 |
| WO2019230857A1 (ja) | 2019-12-05 |
| AU2019277547A1 (en) | 2021-01-14 |
| US11453669B2 (en) | 2022-09-27 |
| CL2020002987A1 (es) | 2021-04-16 |
| IL279050A (en) | 2021-01-31 |
| PH12020551999A1 (en) | 2021-09-27 |
| CN112533922A (zh) | 2021-03-19 |
| BR112020024098A2 (pt) | 2021-02-17 |
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