SG11202011386QA - Polycyclic pyridone derivative - Google Patents
Polycyclic pyridone derivativeInfo
- Publication number
- SG11202011386QA SG11202011386QA SG11202011386QA SG11202011386QA SG11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA
- Authority
- SG
- Singapore
- Prior art keywords
- pyridone derivative
- polycyclic pyridone
- polycyclic
- derivative
- pyridone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018104160 | 2018-05-31 | ||
| PCT/JP2019/021445 WO2019230857A1 (en) | 2018-05-31 | 2019-05-30 | Polycyclic pyridone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202011386QA true SG11202011386QA (en) | 2020-12-30 |
Family
ID=68698906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202011386QA SG11202011386QA (en) | 2018-05-31 | 2019-05-30 | Polycyclic pyridone derivative |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11453669B2 (en) |
| EP (1) | EP3805221A4 (en) |
| JP (1) | JP7353707B2 (en) |
| KR (1) | KR20210018324A (en) |
| CN (1) | CN112533922B (en) |
| AU (1) | AU2019277547A1 (en) |
| BR (1) | BR112020024098A2 (en) |
| CA (1) | CA3101950A1 (en) |
| CL (1) | CL2020002987A1 (en) |
| CO (1) | CO2020014296A2 (en) |
| CR (1) | CR20200645A (en) |
| DO (1) | DOP2020000222A (en) |
| EA (1) | EA202092923A1 (en) |
| IL (1) | IL279050A (en) |
| MA (1) | MA52802A (en) |
| MX (1) | MX2020012185A (en) |
| PE (1) | PE20201414A1 (en) |
| PH (1) | PH12020551999A1 (en) |
| SG (1) | SG11202011386QA (en) |
| WO (1) | WO2019230857A1 (en) |
| ZA (1) | ZA202007568B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019230858A1 (en) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | Polycyclic carbamoylpyridone derivative |
| PL3938047T3 (en) | 2019-03-22 | 2022-11-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| US20230058677A1 (en) * | 2019-11-28 | 2023-02-23 | Shionogi & Co., Ltd. | Polycyclic pyridopyrazine derivative |
| WO2021107066A1 (en) * | 2019-11-28 | 2021-06-03 | 塩野義製薬株式会社 | Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent |
| AU2021225809B2 (en) | 2020-02-24 | 2023-08-24 | Gilead Sciences, Inc. | Tetracyclic compounds for treating HIV infection |
| CN115667270B (en) * | 2020-05-21 | 2024-06-04 | 辰欣药业股份有限公司 | Fused ring derivatives and their pharmaceutical use |
| FI4196479T3 (en) | 2021-01-19 | 2024-01-17 | Gilead Sciences Inc | Substituted pyridotriazine compounds and uses thereof |
| EP4384178A1 (en) * | 2021-08-11 | 2024-06-19 | Merck Sharp & Dohme LLC | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1549315A4 (en) | 2002-09-11 | 2007-05-23 | Merck & Co Inc | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| EP1578748B1 (en) | 2002-12-27 | 2010-09-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| WO2006088173A1 (en) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity |
| KR101504998B1 (en) | 2005-04-28 | 2015-03-23 | 비이브 헬쓰케어 컴퍼니 | Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity |
| KR20080064182A (en) | 2005-10-27 | 2008-07-08 | 시오노기세야쿠 가부시키가이샤 | Polycyclic carbamoylpyridone derivative having inhibitory activity on hiv integrase |
| SG183484A1 (en) | 2010-02-26 | 2012-09-27 | Japan Tobacco Inc | 1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| BR112014008896A2 (en) | 2011-10-12 | 2017-04-18 | Shionogi & Co | polycyclic pyridone derivative having integrase inhibitory activity |
| WO2014099586A1 (en) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
| SG11201504857SA (en) | 2012-12-21 | 2015-07-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| US20140221380A1 (en) | 2012-12-27 | 2014-08-07 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR |
| RS56701B1 (en) | 2013-05-17 | 2018-03-30 | Merck Sharp & Dohme | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| EP3008044B1 (en) * | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| WO2014200080A1 (en) | 2013-06-14 | 2014-12-18 | ヤンマー株式会社 | Prediction device, prediction method, and computer program |
| NO2865735T3 (en) | 2013-07-12 | 2018-07-21 | ||
| HUE037347T2 (en) | 2013-07-12 | 2018-08-28 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections |
| WO2015039348A1 (en) | 2013-09-23 | 2015-03-26 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
| KR101809392B1 (en) | 2013-09-27 | 2017-12-14 | 머크 샤프 앤드 돔 코포레이션 | Substituted quinolizine derivatives useful as hiv integrase inhibitors |
| WO2015089847A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2015199167A1 (en) | 2014-06-25 | 2015-12-30 | 日本たばこ産業株式会社 | METHOD FOR PRODUCING SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE, AND INTERMEDIATE |
| JPWO2016027879A1 (en) * | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | Polycyclic pyridone derivatives having integrase inhibitory activity |
| WO2016094198A1 (en) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
| WO2016090545A1 (en) * | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrate inhibitors |
| TWI695003B (en) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| EP3285582B1 (en) | 2015-03-26 | 2020-11-11 | Merck Sharp & Dohme Corp. | Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors |
| SI3466490T1 (en) | 2015-04-02 | 2020-12-31 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| WO2016187788A1 (en) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
| EP3377065B1 (en) | 2015-11-17 | 2022-05-18 | Merck Sharp & Dohme Corp. | Spirocyclic pyridotriazine derivatives useful as hiv integrase inhibitors |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
| WO2017113288A1 (en) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| JOP20190130A1 (en) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
| CN110062627A (en) | 2016-12-02 | 2019-07-26 | 默沙东公司 | It can be used as the tricyclic heterocyclic compounds of hiv integrase inhibitor |
| EP3752144B1 (en) | 2018-02-15 | 2022-12-28 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| CA3101180A1 (en) | 2018-04-27 | 2019-10-31 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| CN110526930B (en) | 2018-05-23 | 2022-06-03 | 莫云芬 | anti-HIV (human immunodeficiency virus) sulfur-containing polycyclic-hydroxypyridone formamide analogue and application thereof |
| EP3801543A4 (en) | 2018-06-05 | 2022-03-02 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| PL3938047T3 (en) | 2019-03-22 | 2022-11-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
-
2019
- 2019-05-30 MX MX2020012185A patent/MX2020012185A/en unknown
- 2019-05-30 MA MA052802A patent/MA52802A/en unknown
- 2019-05-30 PE PE2020001864A patent/PE20201414A1/en unknown
- 2019-05-30 AU AU2019277547A patent/AU2019277547A1/en active Pending
- 2019-05-30 BR BR112020024098-2A patent/BR112020024098A2/en unknown
- 2019-05-30 CR CR20200645A patent/CR20200645A/en unknown
- 2019-05-30 WO PCT/JP2019/021445 patent/WO2019230857A1/en active Application Filing
- 2019-05-30 SG SG11202011386QA patent/SG11202011386QA/en unknown
- 2019-05-30 EP EP19812190.7A patent/EP3805221A4/en active Pending
- 2019-05-30 KR KR1020207037581A patent/KR20210018324A/en not_active Application Discontinuation
- 2019-05-30 US US17/058,260 patent/US11453669B2/en active Active
- 2019-05-30 CN CN201980050400.4A patent/CN112533922B/en active Active
- 2019-05-30 JP JP2020522576A patent/JP7353707B2/en active Active
- 2019-05-30 EA EA202092923A patent/EA202092923A1/en unknown
- 2019-05-30 CA CA3101950A patent/CA3101950A1/en active Pending
-
2020
- 2020-11-17 CL CL2020002987A patent/CL2020002987A1/en unknown
- 2020-11-18 CO CONC2020/0014296A patent/CO2020014296A2/en unknown
- 2020-11-20 PH PH12020551999A patent/PH12020551999A1/en unknown
- 2020-11-27 DO DO2020000222A patent/DOP2020000222A/en unknown
- 2020-11-29 IL IL279050A patent/IL279050A/en unknown
- 2020-12-04 ZA ZA2020/07568A patent/ZA202007568B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20200645A (en) | 2021-02-05 |
| IL279050A (en) | 2021-01-31 |
| PH12020551999A1 (en) | 2021-09-27 |
| JP7353707B2 (en) | 2023-10-02 |
| US20210155622A1 (en) | 2021-05-27 |
| JPWO2019230857A1 (en) | 2021-06-24 |
| CL2020002987A1 (en) | 2021-04-16 |
| ZA202007568B (en) | 2022-04-28 |
| WO2019230857A1 (en) | 2019-12-05 |
| DOP2020000222A (en) | 2021-03-15 |
| BR112020024098A2 (en) | 2021-02-17 |
| CA3101950A1 (en) | 2019-12-05 |
| KR20210018324A (en) | 2021-02-17 |
| CO2020014296A2 (en) | 2020-12-21 |
| MX2020012185A (en) | 2021-01-29 |
| CN112533922A (en) | 2021-03-19 |
| PE20201414A1 (en) | 2020-12-07 |
| EP3805221A1 (en) | 2021-04-14 |
| EA202092923A1 (en) | 2021-04-09 |
| CN112533922B (en) | 2024-03-22 |
| US11453669B2 (en) | 2022-09-27 |
| MA52802A (en) | 2021-04-14 |
| AU2019277547A1 (en) | 2021-01-14 |
| EP3805221A4 (en) | 2022-01-05 |
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