CL2020002987A1 - Derivado policíclico de piridona - Google Patents

Derivado policíclico de piridona

Info

Publication number
CL2020002987A1
CL2020002987A1 CL2020002987A CL2020002987A CL2020002987A1 CL 2020002987 A1 CL2020002987 A1 CL 2020002987A1 CL 2020002987 A CL2020002987 A CL 2020002987A CL 2020002987 A CL2020002987 A CL 2020002987A CL 2020002987 A1 CL2020002987 A1 CL 2020002987A1
Authority
CL
Chile
Prior art keywords
substituted
pyridone
ring
polycyclic derivative
unsubstituted
Prior art date
Application number
CL2020002987A
Other languages
English (en)
Inventor
Yoshiyuki Taoda
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of CL2020002987A1 publication Critical patent/CL2020002987A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con un compuesto representado por la siguiente fórmula (I) (en la fórmula, el anillo A es un heterociclo no aromático sustituido o no sustituido; el anillo C es un anillo de benceno, etc.; Q es un heterociclo aromático de 5 miembros, etc.; R1 es independientemente halógeno, etc.; L es alquileno sustituido o no sustituido; R3 es alquilo sustituido o no sustituido, etc.; R4 es hidrógeno, etc.; y n es un número entero de 1 a 3.
CL2020002987A 2018-05-31 2020-11-17 Derivado policíclico de piridona CL2020002987A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018104160 2018-05-31

Publications (1)

Publication Number Publication Date
CL2020002987A1 true CL2020002987A1 (es) 2021-04-16

Family

ID=68698906

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002987A CL2020002987A1 (es) 2018-05-31 2020-11-17 Derivado policíclico de piridona

Country Status (21)

Country Link
US (1) US11453669B2 (es)
EP (1) EP3805221A4 (es)
JP (1) JP7353707B2 (es)
KR (1) KR20210018324A (es)
CN (1) CN112533922B (es)
AU (1) AU2019277547A1 (es)
BR (1) BR112020024098A2 (es)
CA (1) CA3101950A1 (es)
CL (1) CL2020002987A1 (es)
CO (1) CO2020014296A2 (es)
CR (1) CR20200645A (es)
DO (1) DOP2020000222A (es)
EA (1) EA202092923A1 (es)
IL (1) IL279050A (es)
MA (1) MA52802A (es)
MX (1) MX2020012185A (es)
PE (1) PE20201414A1 (es)
PH (1) PH12020551999A1 (es)
SG (1) SG11202011386QA (es)
WO (1) WO2019230857A1 (es)
ZA (1) ZA202007568B (es)

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WO2019230858A1 (ja) 2018-05-31 2019-12-05 塩野義製薬株式会社 多環性カルバモイルピリドン誘導体
KR20210142711A (ko) 2019-03-22 2021-11-25 길리애드 사이언시즈, 인코포레이티드 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도
JPWO2021107066A1 (es) * 2019-11-28 2021-06-03
WO2021107065A1 (ja) * 2019-11-28 2021-06-03 塩野義製薬株式会社 多環性ピリドピラジン誘導体
US11697652B2 (en) 2020-02-24 2023-07-11 Gilead Sciences, Inc. Tetracyclic compounds and uses thereof
US20230212187A1 (en) * 2020-05-21 2023-07-06 Cisen Pharmaceutical Co., Ltd Fused ring derivatives and use thereof in pharmacy
SI4196479T1 (sl) 2021-01-19 2024-01-31 Gilead Sciences, Inc. Substituirane piridotriazinske spojine in njihove uporabe
WO2023018913A1 (en) * 2021-08-11 2023-02-16 Merck Sharp & Dohme Llc Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza

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EP1549315A4 (en) 2002-09-11 2007-05-23 Merck & Co Inc DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS
BR0317749A (pt) 2002-12-27 2005-11-22 Angeletti P Ist Richerche Bio Composto, composição farmacêutica, e, uso de um composto
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
JP5317257B2 (ja) 2005-02-21 2013-10-16 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
DK3187225T3 (da) * 2005-04-28 2022-02-28 Viiv Healthcare Co Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet
MX2008005137A (es) 2005-10-27 2008-09-29 Shionogi & Co Derivado de carbamoilpiridona policiclica que tiene actividad inhibidora en vih integrasa.
KR20120130185A (ko) 2010-02-26 2012-11-29 니뽄 다바코 산교 가부시키가이샤 １,３,４,８―테트라히드로―２Ｈ―피리도［１,２―ａ］피라진 유도체 및 그의 ＨＩＶ 인테그라제 저해제로서의 이용
WO2011129095A1 (ja) 2010-04-12 2011-10-20 塩野義製薬株式会社 インテグラーゼ阻害活性を有するピリドン誘導体
KR20140090197A (ko) 2011-10-12 2014-07-16 시오노기세야쿠 가부시키가이샤 인터그라아제 억제 활성을 갖는 폴리사이클릭 피리돈 유도체
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KR20210142711A (ko) 2019-03-22 2021-11-25 길리애드 사이언시즈, 인코포레이티드 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도

Also Published As

Publication number Publication date
CO2020014296A2 (es) 2020-12-21
SG11202011386QA (en) 2020-12-30
US11453669B2 (en) 2022-09-27
CN112533922B (zh) 2024-03-22
JP7353707B2 (ja) 2023-10-02
AU2019277547A1 (en) 2021-01-14
WO2019230857A1 (ja) 2019-12-05
MX2020012185A (es) 2021-01-29
US20210155622A1 (en) 2021-05-27
CA3101950A1 (en) 2019-12-05
PH12020551999A1 (en) 2021-09-27
MA52802A (fr) 2021-04-14
IL279050A (en) 2021-01-31
EA202092923A1 (ru) 2021-04-09
PE20201414A1 (es) 2020-12-07
EP3805221A4 (en) 2022-01-05
JPWO2019230857A1 (ja) 2021-06-24
CN112533922A (zh) 2021-03-19
CR20200645A (es) 2021-02-05
BR112020024098A2 (pt) 2021-02-17
DOP2020000222A (es) 2021-03-15
KR20210018324A (ko) 2021-02-17
EP3805221A1 (en) 2021-04-14
ZA202007568B (en) 2022-04-28

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