CL2020002987A1 - Derivado policíclico de piridona - Google Patents

Derivado policíclico de piridona

Info

Publication number
CL2020002987A1
CL2020002987A1 CL2020002987A CL2020002987A CL2020002987A1 CL 2020002987 A1 CL2020002987 A1 CL 2020002987A1 CL 2020002987 A CL2020002987 A CL 2020002987A CL 2020002987 A CL2020002987 A CL 2020002987A CL 2020002987 A1 CL2020002987 A1 CL 2020002987A1
Authority
CL
Chile
Prior art keywords
substituted
pyridone
ring
polycyclic derivative
unsubstituted
Prior art date
Application number
CL2020002987A
Other languages
English (en)
Inventor
Yoshiyuki Taoda
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of CL2020002987A1 publication Critical patent/CL2020002987A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con un compuesto representado por la siguiente fórmula (I) (en la fórmula, el anillo A es un heterociclo no aromático sustituido o no sustituido; el anillo C es un anillo de benceno, etc.; Q es un heterociclo aromático de 5 miembros, etc.; R1 es independientemente halógeno, etc.; L es alquileno sustituido o no sustituido; R3 es alquilo sustituido o no sustituido, etc.; R4 es hidrógeno, etc.; y n es un número entero de 1 a 3.
CL2020002987A 2018-05-31 2020-11-17 Derivado policíclico de piridona CL2020002987A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018104160 2018-05-31

Publications (1)

Publication Number Publication Date
CL2020002987A1 true CL2020002987A1 (es) 2021-04-16

Family

ID=68698906

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002987A CL2020002987A1 (es) 2018-05-31 2020-11-17 Derivado policíclico de piridona

Country Status (21)

Country Link
US (1) US11453669B2 (es)
EP (1) EP3805221A4 (es)
JP (1) JP7353707B2 (es)
KR (1) KR20210018324A (es)
CN (1) CN112533922B (es)
AU (1) AU2019277547A1 (es)
BR (1) BR112020024098A2 (es)
CA (1) CA3101950A1 (es)
CL (1) CL2020002987A1 (es)
CO (1) CO2020014296A2 (es)
CR (1) CR20200645A (es)
DO (1) DOP2020000222A (es)
EA (1) EA202092923A1 (es)
IL (1) IL279050A (es)
MA (1) MA52802A (es)
MX (1) MX2020012185A (es)
PE (1) PE20201414A1 (es)
PH (1) PH12020551999A1 (es)
SG (1) SG11202011386QA (es)
WO (1) WO2019230857A1 (es)
ZA (1) ZA202007568B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20210477A1 (es) 2018-05-31 2021-03-11 Shionogi & Co Derivado policiclico de carbamoilpiridona
MX2021011394A (es) 2019-03-22 2021-10-13 Gilead Sciences Inc Compuestos de carbamoilpiridona triciclica puenteada y su uso farmaceutico.
TW202133858A (zh) * 2019-11-28 2021-09-16 日商鹽野義製藥股份有限公司 以組合整合酶阻礙劑及抗ｈｉｖ藥為特徵之ｈｉｖ感染症的預防及治療用醫藥
JPWO2021107065A1 (es) * 2019-11-28 2021-06-03
CN115151545A (zh) 2020-02-24 2022-10-04 吉利德科学公司 用于治疗hiv感染的四环化合物
JP7407976B2 (ja) 2020-05-21 2024-01-04 シーセン ファーマシューティカル カンパニー リミテッド 縮合環誘導体及びその薬学的用途
FI4196479T3 (fi) 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä
WO2023018913A1 (en) * 2021-08-11 2023-02-16 Merck Sharp & Dohme Llc Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza

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AU2003267098B2 (en) 2002-09-11 2008-11-20 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
MXPA05007010A (es) 2002-12-27 2005-08-18 Angeletti P Ist Richerche Bio Tetrahidro-4h-pirido[1,2-a]pirimidinas y compuestos relacionados utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana.
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
EP1852434B1 (en) 2005-02-21 2011-07-13 Shionogi Co., Ltd. Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity
DK3372281T3 (da) 2005-04-28 2021-09-27 Viiv Healthcare Co Polycyklisk carbamoylpyridon-derivat med HIV-integrase-hæmmende aktivitet
BRPI0617842A2 (pt) * 2005-10-27 2011-08-09 Shionogi & Co composto ou um sal farmaceuticamente aceitável ou um solvato do mesmo, e, composição farmacêutica
KR20120130185A (ko) 2010-02-26 2012-11-29 니뽄 다바코 산교 가부시키가이샤 １,３,４,８―테트라히드로―２Ｈ―피리도［１,２―ａ］피라진 유도체 및 그의 ＨＩＶ 인테그라제 저해제로서의 이용
WO2011129095A1 (ja) 2010-04-12 2011-10-20 塩野義製薬株式会社 インテグラーゼ阻害活性を有するピリドン誘導体
CA2851218A1 (en) 2011-10-12 2013-04-18 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
PT2822954E (pt) 2012-12-21 2016-06-16 Gilead Sciences Inc Compostos carbamoilpiridona policíclicos e seu uso farmacêutico
EP2940019B1 (en) 2012-12-27 2018-03-28 Japan Tobacco Inc. SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR
US9643982B2 (en) 2013-05-17 2017-05-09 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
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WO2014200080A1 (ja) 2013-06-14 2014-12-18 ヤンマー株式会社 予測装置、予測方法及びコンピュータプログラム
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MX2021011394A (es) 2019-03-22 2021-10-13 Gilead Sciences Inc Compuestos de carbamoilpiridona triciclica puenteada y su uso farmaceutico.

Also Published As

Publication number Publication date
CN112533922A (zh) 2021-03-19
CN112533922B (zh) 2024-03-22
JPWO2019230857A1 (ja) 2021-06-24
EP3805221A1 (en) 2021-04-14
PE20201414A1 (es) 2020-12-07
US11453669B2 (en) 2022-09-27
MX2020012185A (es) 2021-01-29
SG11202011386QA (en) 2020-12-30
JP7353707B2 (ja) 2023-10-02
CR20200645A (es) 2021-02-05
PH12020551999A1 (en) 2021-09-27
WO2019230857A1 (ja) 2019-12-05
US20210155622A1 (en) 2021-05-27
MA52802A (fr) 2021-04-14
EP3805221A4 (en) 2022-01-05
AU2019277547A1 (en) 2021-01-14
IL279050A (en) 2021-01-31
KR20210018324A (ko) 2021-02-17
CO2020014296A2 (es) 2020-12-21
EA202092923A1 (ru) 2021-04-09
BR112020024098A2 (pt) 2021-02-17
ZA202007568B (en) 2022-04-28
DOP2020000222A (es) 2021-03-15
CA3101950A1 (en) 2019-12-05

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