AR115007A1 - Derivados de triazolona o sales de los mismos y composiciones farmacéuticas que comprenden los mismos - Google Patents
Derivados de triazolona o sales de los mismos y composiciones farmacéuticas que comprenden los mismosInfo
- Publication number
- AR115007A1 AR115007A1 ARP190100713A ARP190100713A AR115007A1 AR 115007 A1 AR115007 A1 AR 115007A1 AR P190100713 A ARP190100713 A AR P190100713A AR P190100713 A ARP190100713 A AR P190100713A AR 115007 A1 AR115007 A1 AR 115007A1
- Authority
- AR
- Argentina
- Prior art keywords
- triazolone
- derivatives
- salts
- same
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Reivindicación 1: Un compuesto de fórmula (1), o un isómero del mismo, o una sal farmacéuticamente aceptable del mismo; donde n es 1 ó 2; A es un grupo heteroarilo; dicho grupo heteroarilo tiene 1 a 5 heteroátomos miembros del anillo elegidos entre O, N o S, y dicho grupo heteroarilo está opcionalmente sustituido con un sustituyente elegido entre alquilo C₁₋₃, halógeno, -R, -CH=CH-R, y CºCR; y R es un anillo cíclico sustituido o no sustituido, que contiene opcionalmente de 1 a 5 heteroátomos miembros del anillo elegidos entre O, N o S, y el anillo cíclico es aromático o no aromático.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180032548A KR20190110736A (ko) | 2018-03-21 | 2018-03-21 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115007A1 true AR115007A1 (es) | 2020-11-18 |
Family
ID=67986894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190100713A AR115007A1 (es) | 2018-03-21 | 2019-03-21 | Derivados de triazolona o sales de los mismos y composiciones farmacéuticas que comprenden los mismos |
Country Status (10)
Country | Link |
---|---|
US (2) | US10995086B2 (es) |
EP (1) | EP3768675A4 (es) |
JP (2) | JP7383627B2 (es) |
KR (2) | KR20190110736A (es) |
CN (1) | CN111886233B (es) |
AR (1) | AR115007A1 (es) |
AU (1) | AU2019237344B2 (es) |
CA (1) | CA3093057A1 (es) |
TW (1) | TWI803600B (es) |
WO (1) | WO2019180646A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
KR20190110736A (ko) * | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
KR20200004036A (ko) | 2018-07-03 | 2020-01-13 | 주식회사유한양행 | (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법 |
WO2020121261A1 (en) | 2018-12-14 | 2020-06-18 | Yuhan Corporation | 3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same |
TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
KR20220145981A (ko) * | 2021-04-22 | 2022-11-01 | 주식회사유한양행 | 트리아졸론, 테트라졸론, 및 이미다졸론, 또는 그의 염, 및 그를 포함하는 제약 조성물 |
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DE2725148A1 (de) | 1977-06-03 | 1978-12-14 | Hoechst Ag | 1-aryl-4-alkyl-1,2,4-triazol-5-one und verfahren zu ihrer herstellung |
JP2007501802A (ja) | 2003-08-08 | 2007-02-01 | ラ ホヤ ファーマシューティカル カンパニー | 疾患の処置に有用な、セミカルバジド感受性アミンオキシダーゼ(ssao)およびvap−1媒介性接着のインヒビター |
KR100572996B1 (ko) | 2003-08-12 | 2006-04-25 | 한국화학연구원 | 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법 |
JP2007523955A (ja) * | 2004-02-25 | 2007-08-23 | ラ ホヤ ファーマシューティカル カンパニー | 疾患の治療のためのアミンおよびアミド |
TW200726765A (en) | 2005-06-17 | 2007-07-16 | Bristol Myers Squibb Co | Triazolopyridine cannabinoid receptor 1 antagonists |
EP2004166A2 (en) | 2006-03-31 | 2008-12-24 | La Jolla Pharmaceutical Company | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases |
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CN101657433A (zh) * | 2007-03-29 | 2010-02-24 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
GB0722075D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
EP2222160B1 (en) | 2007-11-21 | 2015-03-18 | Pharmaxis Ltd. | Haloallylamine inhibitors of ssao/vap-1 and uses therefor |
WO2010096722A1 (en) | 2009-02-20 | 2010-08-26 | Takeda Pharmaceutical Company Limited | 3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors |
US9505728B2 (en) | 2012-03-09 | 2016-11-29 | Inception 2, Inc. | Triazolone compounds and uses thereof |
US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
DK2844637T5 (en) | 2012-05-02 | 2018-08-13 | Boehringer Ingelheim Int | SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS BY SSAO AND USES THEREOF |
AU2014258128A1 (en) * | 2013-04-25 | 2015-10-29 | Yuhan Corporation | Novel triazolone derivatives or salts thereof and pharmaceutical composition comprising the same |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
JP2017537946A (ja) * | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメイン阻害剤としての置換複素環 |
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KR20190110736A (ko) * | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
CN110938059A (zh) | 2018-09-25 | 2020-03-31 | 上海轶诺药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
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EP3856176A4 (en) | 2018-09-28 | 2022-05-04 | Acucela Inc. | VAP-1 INHIBITORS |
CN112789277B (zh) | 2018-10-22 | 2022-11-04 | 广东东阳光药业有限公司 | 胍类衍生物及其用途 |
EP3870162A4 (en) | 2018-10-24 | 2022-08-24 | Metacrine, Inc. | SSAO INHIBITORS AND USES THEREOF |
TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
WO2020121261A1 (en) | 2018-12-14 | 2020-06-18 | Yuhan Corporation | 3,3-difluoroallylamines or salts thereof and pharmaceutical compositions comprising the same |
PE20212155A1 (es) | 2019-01-11 | 2021-11-09 | Transthera Sciences Nanjing Inc | Compuestos de halo-alilamina y uso de los mismos |
-
2018
- 2018-03-21 KR KR1020180032548A patent/KR20190110736A/ko unknown
-
2019
- 2019-03-20 AU AU2019237344A patent/AU2019237344B2/en active Active
- 2019-03-20 JP JP2020550176A patent/JP7383627B2/ja active Active
- 2019-03-20 EP EP19772403.2A patent/EP3768675A4/en active Pending
- 2019-03-20 WO PCT/IB2019/052278 patent/WO2019180646A1/en active Application Filing
- 2019-03-20 US US16/359,985 patent/US10995086B2/en active Active
- 2019-03-20 CA CA3093057A patent/CA3093057A1/en active Pending
- 2019-03-20 KR KR1020207029750A patent/KR20200124759A/ko unknown
- 2019-03-20 CN CN201980020696.5A patent/CN111886233B/zh active Active
- 2019-03-21 TW TW108109864A patent/TWI803600B/zh active
- 2019-03-21 AR ARP190100713A patent/AR115007A1/es unknown
-
2021
- 2021-03-22 US US17/208,887 patent/US11780830B2/en active Active
-
2023
- 2023-08-07 JP JP2023128580A patent/JP2023145748A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2019237344A1 (en) | 2020-10-01 |
US20190322655A1 (en) | 2019-10-24 |
TWI803600B (zh) | 2023-06-01 |
US20210317110A1 (en) | 2021-10-14 |
TW202003508A (zh) | 2020-01-16 |
KR20190110736A (ko) | 2019-10-01 |
JP2023145748A (ja) | 2023-10-11 |
AU2019237344B2 (en) | 2023-07-06 |
US10995086B2 (en) | 2021-05-04 |
JP7383627B2 (ja) | 2023-11-20 |
CN111886233A (zh) | 2020-11-03 |
JP2021518384A (ja) | 2021-08-02 |
KR20200124759A (ko) | 2020-11-03 |
CN111886233B (zh) | 2024-01-02 |
US11780830B2 (en) | 2023-10-10 |
EP3768675A1 (en) | 2021-01-27 |
CA3093057A1 (en) | 2019-09-26 |
WO2019180646A1 (en) | 2019-09-26 |
EP3768675A4 (en) | 2021-12-22 |
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