AR110122A1 - Fenoxitriazoles - Google Patents
FenoxitriazolesInfo
- Publication number
- AR110122A1 AR110122A1 ARP170103067A ARP170103067A AR110122A1 AR 110122 A1 AR110122 A1 AR 110122A1 AR P170103067 A ARP170103067 A AR P170103067A AR P170103067 A ARP170103067 A AR P170103067A AR 110122 A1 AR110122 A1 AR 110122A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- substituted
- unsubstituted
- heterocycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto de fórmula (1), en el que HetAr es un grupo heteroarilo de cinco o seis miembros, seleccionado de entre los compuestos del grupo de fórmulas (2); en el que R¹ es hidrógeno, alquilo inferior, alcoxi inferior o alquilo inferior sustituido por halógeno y puede ser el mismo o diferente, si aparecen dos R¹; R² es alquilo inferior o un derivado mono o polideuterado del mismo, alquilo inferior sustituido por halógeno o alcoxi inferior, alquenilo inferior sustituido o no sustituido por halógeno cicloalquilo o CH₂-cicloalquilo sustituido o no sustituido por halógeno, heterocicloalquilo o CH₂-heterocicloalquilo sustituido o no sustituido por alquilo inferior; R³ es halógeno, alquilo inferior, alquilo inferior sustituido por halógeno, alcoxi inferior sustituido por halógeno o S(O)₂-alquilo inferior; n es 1, 2 ó 3; si n es > 1, entonces R³ puede ser el mismo o diferente; o una sal de adición ácida del mismo activa a nivel farmacéutico, una mezcla racémica o su correspondiente enantiómero, y/o un isómero óptico y/o estereoisómero del mismo. Los compuestos pueden utilizarse para el tratamiento de la enfermedad de Alzheimer, angiopatía amiloide cerebral, hemorragia cerebral hereditaria con amiloidosis de tipo holandés (HCHWA-D), demencia por múltiples infartos, demencia pugilística o síndrome de Down.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16197660 | 2016-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110122A1 true AR110122A1 (es) | 2019-02-27 |
Family
ID=57249738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103067A AR110122A1 (es) | 2016-11-08 | 2017-11-06 | Fenoxitriazoles |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11319314B2 (es) |
| EP (1) | EP3538516B1 (es) |
| JP (1) | JP7132218B2 (es) |
| CN (1) | CN109790149B (es) |
| AR (1) | AR110122A1 (es) |
| TW (1) | TWI757360B (es) |
| WO (1) | WO2018087018A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| US20220056036A1 (en) * | 2018-12-13 | 2022-02-24 | Hoffmann-La Roche Inc. | 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease |
| CN114340611A (zh) | 2019-04-08 | 2022-04-12 | 频率医疗公司 | 用于治疗听力损失的chir99021和丙戊酸的组合 |
| WO2020229398A1 (de) | 2019-05-14 | 2020-11-19 | Bayer Aktiengesellschaft | (1-alkenyl)-substituierte pyrazole und triazole als schädlingsbekämpfungsmittel |
| CN111233751B (zh) * | 2020-03-25 | 2021-02-02 | 丽水绿氟科技有限公司 | 一种3,3-二氟-4-氨基哌啶类化合物及其衍生物的制备方法 |
| EP3974414A1 (de) | 2020-09-25 | 2022-03-30 | Bayer AG | 5-amino substituierte pyrazole und triazole als schädlingsbekämpfungsmittel |
| EP4036083A1 (de) | 2021-02-02 | 2022-08-03 | Bayer Aktiengesellschaft | 5-oxy substituierte hetereozyklen, als schädlingsbekämpfungsmittel |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432985B2 (en) | 2000-04-25 | 2002-08-13 | Hoffmann-La Roche Inc. | Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| EP2454239B1 (en) * | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
| BR112012017310A2 (pt) * | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
| US8703763B2 (en) | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
-
2017
- 2017-11-06 WO PCT/EP2017/078260 patent/WO2018087018A1/en unknown
- 2017-11-06 TW TW106138234A patent/TWI757360B/zh active
- 2017-11-06 CN CN201780060341.XA patent/CN109790149B/zh active Active
- 2017-11-06 US US16/348,322 patent/US11319314B2/en active Active
- 2017-11-06 EP EP17797302.1A patent/EP3538516B1/en active Active
- 2017-11-06 JP JP2019523709A patent/JP7132218B2/ja active Active
- 2017-11-06 AR ARP170103067A patent/AR110122A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3538516A1 (en) | 2019-09-18 |
| JP7132218B2 (ja) | 2022-09-06 |
| US20210309653A1 (en) | 2021-10-07 |
| WO2018087018A1 (en) | 2018-05-17 |
| US11319314B2 (en) | 2022-05-03 |
| JP2019534295A (ja) | 2019-11-28 |
| EP3538516B1 (en) | 2021-06-16 |
| CN109790149B (zh) | 2022-05-17 |
| TW201821417A (zh) | 2018-06-16 |
| TWI757360B (zh) | 2022-03-11 |
| CN109790149A (zh) | 2019-05-21 |
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