AR104331A1 - Derivados de tetrazol - Google Patents
Derivados de tetrazolInfo
- Publication number
- AR104331A1 AR104331A1 ARP160101090A ARP160101090A AR104331A1 AR 104331 A1 AR104331 A1 AR 104331A1 AR P160101090 A ARP160101090 A AR P160101090A AR P160101090 A ARP160101090 A AR P160101090A AR 104331 A1 AR104331 A1 AR 104331A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- cyclopropyl
- disorder
- schizophrenia
- stereoisomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente solicitud se refiere a compuestos inhibidores de EAAT3, sal farmacéuticamente aceptable, sal de adición de ácido, a una mezcla racémica o a enantiómeros correspondientes y/o isómeros ópticos y/o estereoisómeros de los mismos para el uso en el tratamiento de la esquizofrenia, el trastorno bipolar, el trastorno obsesivo-compulsivo o los trastornos del espectro autista. Reivindicación 1: Un compuesto de la fórmula (1), en la que: R¹ es CH₃; R¹ es metilo, etilo, CF₃, CH₂OH, ciclopropilo o ciano, o R¹ y R¹ juntos pueden formar un anillo 1,1-dioxo-tetrahidro-tiofen-3-ilo; R² es hidrógeno, metilo, etilo, isopropilo, tert-butilo, ciclopropilo o CF₃; R³ es Cl, F, CF₃, metilo, metoxi, isopropilo o ciclopropilo; R⁴ es hidrógeno, metilo, F o Cl; o una sal farmacéuticamente aceptable o una sal de adición de ácido, una mezcla racémica o los enantiómeros correspondientes y/o isómeros ópticos y/o estereoisómeros de los mismos para el uso en el tratamiento de la esquizofrenia, el trastorno bipolar, el trastorno obsesivo-compulsivo o los trastornos del espectro autista.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15164885 | 2015-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104331A1 true AR104331A1 (es) | 2017-07-12 |
Family
ID=53008328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101090A AR104331A1 (es) | 2015-04-23 | 2016-04-21 | Derivados de tetrazol |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10577332B2 (es) |
| EP (1) | EP3286182A1 (es) |
| JP (1) | JP6518789B2 (es) |
| CN (1) | CN107207449B (es) |
| AR (1) | AR104331A1 (es) |
| TW (1) | TW201711998A (es) |
| WO (1) | WO2016169902A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6518789B2 (ja) | 2015-04-23 | 2019-05-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 精神障害の処置において使用するためのテトラゾール誘導体 |
| CN107531642B (zh) * | 2015-06-04 | 2021-06-22 | 豪夫迈·罗氏有限公司 | 咪唑衍生物 |
| JP6831376B2 (ja) * | 2015-10-06 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾール誘導体 |
| EP3368522B1 (en) | 2015-10-28 | 2021-08-04 | F. Hoffmann-La Roche AG | Pyridine or pyrimidine derivatives |
| JP6905988B2 (ja) | 2016-02-02 | 2021-07-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｅａａｔ３阻害剤としてのピラゾール−ピリジン誘導体 |
| WO2017202896A1 (en) * | 2016-05-27 | 2017-11-30 | F. Hoffmann-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| WO2018069362A1 (en) | 2016-10-14 | 2018-04-19 | F. Hoffmann-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
| CN109096177A (zh) * | 2018-08-31 | 2018-12-28 | 中国药科大学 | 3－酰胺基苯甲酸衍生物、其制备方法及医药用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882926A (en) | 1993-10-20 | 1999-03-16 | Oregon Health Sciences University | Excitatory amino acid transporter gene and uses |
| JP2006151954A (ja) | 2004-10-27 | 2006-06-15 | Taisho Pharmaceut Co Ltd | アスパラギン酸誘導体 |
| EP1940822A1 (en) | 2005-10-14 | 2008-07-09 | NeuroSearch A/S | Imidazole derivatives and their use for modulating the gaba-a receptor complex |
| CA2654915C (en) * | 2006-06-29 | 2015-07-28 | F.Hoffmann-La Roche Ag | Tetrazole-substituted arylamides |
| KR101186704B1 (ko) | 2007-10-04 | 2012-09-27 | 에프. 호프만-라 로슈 아게 | 테트라졸-치환된 아릴 아마이드 유도체 및 이의 용도 |
| BR122018070508B8 (pt) | 2007-12-17 | 2021-07-27 | Hoffmann La Roche | derivados de arilamida triazol-substituída e seu uso |
| ES2570628T3 (es) | 2007-12-17 | 2016-05-19 | Hoffmann La Roche | Nuevas arilamidas con sustitución imidazol |
| EP2234976B1 (en) | 2007-12-17 | 2013-04-10 | F. Hoffmann-La Roche AG | Novel pyrazole-substituted arylamides |
| TW201006801A (en) | 2008-07-18 | 2010-02-16 | Lilly Co Eli | Imidazole carboxamides |
| US20110237578A1 (en) | 2008-09-18 | 2011-09-29 | Zhi-Liang Wei | Amide compounds, compositions and uses thereof |
| CA2741666C (en) | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| JP6518789B2 (ja) | 2015-04-23 | 2019-05-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 精神障害の処置において使用するためのテトラゾール誘導体 |
| CN107531642B (zh) | 2015-06-04 | 2021-06-22 | 豪夫迈·罗氏有限公司 | 咪唑衍生物 |
| CN107709311B (zh) | 2015-07-14 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 2-苯基-6-咪唑基-吡啶-4-甲酰胺衍生物及其作为eaat3抑制剂的用途 |
| WO2017025523A1 (en) | 2015-08-12 | 2017-02-16 | F. Hoffmann-La Roche Ag | Pyridine and pyrimidine derivatives |
| JP6831376B2 (ja) | 2015-10-06 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾール誘導体 |
| EP3368522B1 (en) | 2015-10-28 | 2021-08-04 | F. Hoffmann-La Roche AG | Pyridine or pyrimidine derivatives |
| JP6905988B2 (ja) | 2016-02-02 | 2021-07-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｅａａｔ３阻害剤としてのピラゾール−ピリジン誘導体 |
| WO2017202896A1 (en) | 2016-05-27 | 2017-11-30 | F. Hoffmann-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
-
2016
- 2016-04-19 JP JP2017555265A patent/JP6518789B2/ja not_active Expired - Fee Related
- 2016-04-19 EP EP16717143.8A patent/EP3286182A1/en not_active Withdrawn
- 2016-04-19 WO PCT/EP2016/058594 patent/WO2016169902A1/en active Application Filing
- 2016-04-19 CN CN201680007499.6A patent/CN107207449B/zh not_active Expired - Fee Related
- 2016-04-19 US US15/569,349 patent/US10577332B2/en not_active Expired - Fee Related
- 2016-04-21 AR ARP160101090A patent/AR104331A1/es unknown
- 2016-04-22 TW TW105112725A patent/TW201711998A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20180297961A1 (en) | 2018-10-18 |
| JP2018513866A (ja) | 2018-05-31 |
| CN107207449A (zh) | 2017-09-26 |
| CN107207449B (zh) | 2020-11-10 |
| EP3286182A1 (en) | 2018-02-28 |
| US10577332B2 (en) | 2020-03-03 |
| WO2016169902A1 (en) | 2016-10-27 |
| TW201711998A (zh) | 2017-04-01 |
| JP6518789B2 (ja) | 2019-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |