AR111314A1 - Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue - Google Patents
Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengueInfo
- Publication number
- AR111314A1 AR111314A1 ARP180100776A ARP180100776A AR111314A1 AR 111314 A1 AR111314 A1 AR 111314A1 AR P180100776 A ARP180100776 A AR P180100776A AR P180100776 A ARP180100776 A AR P180100776A AR 111314 A1 AR111314 A1 AR 111314A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- dengue
- medicament
- indolina
- viric
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente solicitud se refiere a derivados de indolina sustituidos, a métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferentemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue. Además, se refiere a composiciones farmacéuticas o preparados combinados de los compuestos, a composiciones o preparados para su uso como un medicamento, más preferentemente para la prevención o el tratamiento de infecciones virales por dengue y a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto que tiene la fórmula (1), donde R¹ es cloro o fluoro; R² es -CH₂CH₂OH, o C₃₋₅ alquil-COOH; R³ es trifluorometilo, o trifluorometoxi; R⁴ es hidrógeno, fluoro o metoxi; y R⁵ es hidrógeno o metilo; o una sal, solvato o polimorfo farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17164048 | 2017-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111314A1 true AR111314A1 (es) | 2019-06-26 |
Family
ID=58464340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100776A AR111314A1 (es) | 2017-03-31 | 2018-03-28 | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US11083707B2 (es) |
| EP (1) | EP3601266B1 (es) |
| JP (1) | JP7203752B2 (es) |
| KR (1) | KR102530832B1 (es) |
| CN (1) | CN110461831B (es) |
| AR (1) | AR111314A1 (es) |
| AU (1) | AU2018246301B2 (es) |
| BR (1) | BR112019020175A2 (es) |
| CA (1) | CA3055867C (es) |
| CL (1) | CL2019002745A1 (es) |
| CO (1) | CO2019010295A2 (es) |
| CR (1) | CR20190446A (es) |
| DK (1) | DK3601266T3 (es) |
| EA (1) | EA039784B1 (es) |
| EC (1) | ECSP19070369A (es) |
| ES (1) | ES2884151T3 (es) |
| HR (1) | HRP20210942T1 (es) |
| HU (1) | HUE054678T2 (es) |
| IL (1) | IL269658B (es) |
| JO (1) | JOP20180025B1 (es) |
| LT (1) | LT3601266T (es) |
| MX (1) | MX2019011606A (es) |
| NI (1) | NI201900099A (es) |
| PE (1) | PE20191650A1 (es) |
| PH (1) | PH12019502201A1 (es) |
| SG (1) | SG11201908786VA (es) |
| SI (1) | SI3601266T1 (es) |
| TW (1) | TWI795393B (es) |
| UA (1) | UA126288C2 (es) |
| UY (1) | UY37645A (es) |
| WO (1) | WO2018178240A1 (es) |
| ZA (1) | ZA201906395B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| KR102625991B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
| CN112159325B (zh) * | 2020-10-10 | 2022-11-25 | 浙江工业大学 | 一种合成2-氨基-3-硝基甲苯的方法 |
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| JP2001520998A (ja) | 1997-10-27 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | インドールｓＰＬＡ２阻害剤のモルホリノ−Ｎ−エチルエステルプロドラッグ |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| US20050074457A1 (en) | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
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| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PL3370698T3 (pl) | 2015-11-03 | 2022-04-25 | Zoetis Services Llc | Kompozyty polimerowe zol-żel i ich zastosowania |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| MY194647A (en) | 2016-03-31 | 2022-12-09 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
| SG11201808411RA (en) | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
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| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625991B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2018
- 2018-03-26 JO JOP/2018/0025A patent/JOP20180025B1/ar active
- 2018-03-28 AR ARP180100776A patent/AR111314A1/es unknown
- 2018-03-29 KR KR1020197031207A patent/KR102530832B1/ko active IP Right Grant
- 2018-03-29 AU AU2018246301A patent/AU2018246301B2/en active Active
- 2018-03-29 CR CR20190446A patent/CR20190446A/es unknown
- 2018-03-29 UA UAA201910701A patent/UA126288C2/uk unknown
- 2018-03-29 US US16/493,768 patent/US11083707B2/en active Active
- 2018-03-29 DK DK18715612.0T patent/DK3601266T3/da active
- 2018-03-29 TW TW107110872A patent/TWI795393B/zh active
- 2018-03-29 LT LTEP18715612.0T patent/LT3601266T/lt unknown
- 2018-03-29 EP EP18715612.0A patent/EP3601266B1/en active Active
- 2018-03-29 SG SG11201908786V patent/SG11201908786VA/en unknown
- 2018-03-29 CN CN201880022017.3A patent/CN110461831B/zh active Active
- 2018-03-29 CA CA3055867A patent/CA3055867C/en active Active
- 2018-03-29 WO PCT/EP2018/058079 patent/WO2018178240A1/en active Application Filing
- 2018-03-29 MX MX2019011606A patent/MX2019011606A/es unknown
- 2018-03-29 HU HUE18715612A patent/HUE054678T2/hu unknown
- 2018-03-29 BR BR112019020175-0A patent/BR112019020175A2/pt unknown
- 2018-03-29 EA EA201992329A patent/EA039784B1/ru unknown
- 2018-03-29 SI SI201830307T patent/SI3601266T1/sl unknown
- 2018-03-29 JP JP2019553169A patent/JP7203752B2/ja active Active
- 2018-03-29 ES ES18715612T patent/ES2884151T3/es active Active
- 2018-03-29 PE PE2019001933A patent/PE20191650A1/es unknown
- 2018-04-02 UY UY0001037645A patent/UY37645A/es not_active Application Discontinuation
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2019
- 2019-09-24 CO CONC2019/0010295A patent/CO2019010295A2/es unknown
- 2019-09-24 PH PH12019502201A patent/PH12019502201A1/en unknown
- 2019-09-25 IL IL269658A patent/IL269658B/en unknown
- 2019-09-26 CL CL2019002745A patent/CL2019002745A1/es unknown
- 2019-09-27 EC ECSENADI201970369A patent/ECSP19070369A/es unknown
- 2019-09-27 ZA ZA2019/06395A patent/ZA201906395B/en unknown
- 2019-09-27 NI NI201900099A patent/NI201900099A/es unknown
-
2021
- 2021-06-11 HR HRP20210942TT patent/HRP20210942T1/hr unknown
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