LT3601266T - Pakeisti indolino dariniai, kaip dengės viruso replikacijos inhibitoriai - Google Patents

Pakeisti indolino dariniai, kaip dengės viruso replikacijos inhibitoriai

Info

Publication number
LT3601266T
LT3601266T LTEP18715612.0T LT18715612T LT3601266T LT 3601266 T LT3601266 T LT 3601266T LT 18715612 T LT18715612 T LT 18715612T LT 3601266 T LT3601266 T LT 3601266T
Authority
LT
Lithuania
Prior art keywords
viral replication
replication inhibitors
indoline derivatives
dengue viral
substituted indoline
Prior art date
Application number
LTEP18715612.0T
Other languages
English (en)
Inventor
Bart Rudolf Romanie Kesteleyn
Jean-François BONFANTI
Erwin Coesemans
Pierre Jean-Marie Bernard Raboisson
Arnaud Didier M Marchand
Dorothée Alice Marie-Eve Bardiot
Original Assignee
Janssen Pharmaceuticals, Inc.
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven filed Critical Janssen Pharmaceuticals, Inc.
Publication of LT3601266T publication Critical patent/LT3601266T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEP18715612.0T 2017-03-31 2018-03-29 Pakeisti indolino dariniai, kaip dengės viruso replikacijos inhibitoriai LT3601266T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17164048 2017-03-31
PCT/EP2018/058079 WO2018178240A1 (en) 2017-03-31 2018-03-29 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
LT3601266T true LT3601266T (lt) 2021-07-12

Family

ID=58464340

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP18715612.0T LT3601266T (lt) 2017-03-31 2018-03-29 Pakeisti indolino dariniai, kaip dengės viruso replikacijos inhibitoriai

Country Status (32)

Country Link
US (1) US11083707B2 (lt)
EP (1) EP3601266B1 (lt)
JP (1) JP7203752B2 (lt)
KR (1) KR102530832B1 (lt)
CN (1) CN110461831B (lt)
AR (1) AR111314A1 (lt)
AU (1) AU2018246301B2 (lt)
BR (1) BR112019020175A2 (lt)
CA (1) CA3055867C (lt)
CL (1) CL2019002745A1 (lt)
CO (1) CO2019010295A2 (lt)
CR (1) CR20190446A (lt)
DK (1) DK3601266T3 (lt)
EA (1) EA039784B1 (lt)
EC (1) ECSP19070369A (lt)
ES (1) ES2884151T3 (lt)
HR (1) HRP20210942T1 (lt)
HU (1) HUE054678T2 (lt)
IL (1) IL269658B (lt)
JO (1) JOP20180025B1 (lt)
LT (1) LT3601266T (lt)
MX (1) MX2019011606A (lt)
NI (1) NI201900099A (lt)
PE (1) PE20191650A1 (lt)
PH (1) PH12019502201A1 (lt)
SG (1) SG11201908786VA (lt)
SI (1) SI3601266T1 (lt)
TW (1) TWI795393B (lt)
UA (1) UA126288C2 (lt)
UY (1) UY37645A (lt)
WO (1) WO2018178240A1 (lt)
ZA (1) ZA201906395B (lt)

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JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
LT3436435T (lt) 2016-03-31 2021-08-25 Janssen Pharmaceuticals, Inc. Pakeistieji indolo dariniai kaip dangės viruso replikacijos inhibitoriai
SG11201808237UA (en) 2016-04-01 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole compound derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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JP7203764B2 (ja) 2017-05-22 2023-01-13 ヤンセン ファーマシューティカルズ,インコーポレーテッド デングウイルス複製阻害剤としての置換インドリン誘導体
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CN112159325B (zh) * 2020-10-10 2022-11-25 浙江工业大学 一种合成2-氨基-3-硝基甲苯的方法

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JP7203764B2 (ja) 2017-05-22 2023-01-13 ヤンセン ファーマシューティカルズ,インコーポレーテッド デングウイルス複製阻害剤としての置換インドリン誘導体
BR112019024311A2 (pt) 2017-05-22 2020-07-28 Janssen Pharmaceuticals, Inc. derivados de indolina substituídos como inibidores da replicação viral do dengue

Also Published As

Publication number Publication date
EA201992329A1 (ru) 2020-02-20
AU2018246301B2 (en) 2021-08-19
AR111314A1 (es) 2019-06-26
TW201900635A (zh) 2019-01-01
ECSP19070369A (es) 2019-10-31
EP3601266A1 (en) 2020-02-05
US11083707B2 (en) 2021-08-10
NI201900099A (es) 2020-03-11
HUE054678T2 (hu) 2021-09-28
US20200121647A1 (en) 2020-04-23
KR102530832B1 (ko) 2023-05-09
EP3601266B1 (en) 2021-04-28
CA3055867A1 (en) 2018-10-04
CN110461831A (zh) 2019-11-15
BR112019020175A2 (pt) 2020-06-02
JP7203752B2 (ja) 2023-01-13
KR20190137108A (ko) 2019-12-10
IL269658A (en) 2019-11-28
PH12019502201A1 (en) 2020-09-28
DK3601266T3 (da) 2021-07-19
JOP20180025A1 (ar) 2019-01-30
ES2884151T3 (es) 2021-12-10
CO2019010295A2 (es) 2019-10-09
JOP20180025B1 (ar) 2021-08-17
MX2019011606A (es) 2019-11-08
PE20191650A1 (es) 2019-11-07
IL269658B (en) 2022-01-01
UY37645A (es) 2018-09-28
EA039784B1 (ru) 2022-03-14
SI3601266T1 (sl) 2021-08-31
SG11201908786VA (en) 2019-10-30
CA3055867C (en) 2024-01-02
UA126288C2 (uk) 2022-09-14
CR20190446A (es) 2019-11-29
HRP20210942T1 (hr) 2021-10-15
CL2019002745A1 (es) 2019-12-27
WO2018178240A1 (en) 2018-10-04
CN110461831B (zh) 2022-11-01
TWI795393B (zh) 2023-03-11
ZA201906395B (en) 2021-05-26
AU2018246301A1 (en) 2019-09-19
JP2020512355A (ja) 2020-04-23

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