HRP20210942T1 - Supstituirani derivati indolina kao inhibitori replikacije denga virusa - Google Patents
Supstituirani derivati indolina kao inhibitori replikacije denga virusa Download PDFInfo
- Publication number
- HRP20210942T1 HRP20210942T1 HRP20210942TT HRP20210942T HRP20210942T1 HR P20210942 T1 HRP20210942 T1 HR P20210942T1 HR P20210942T T HRP20210942T T HR P20210942TT HR P20210942 T HRP20210942 T HR P20210942T HR P20210942 T1 HRP20210942 T1 HR P20210942T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- compound
- denv
- formula
- infection
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title claims 4
- 206010012310 Dengue fever Diseases 0.000 title claims 4
- 208000025729 dengue disease Diseases 0.000 title claims 4
- 229940123627 Viral replication inhibitor Drugs 0.000 title 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 208000015181 infectious disease Diseases 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052731 fluorine Chemical group 0.000 claims 1
- 239000011737 fluorine Chemical group 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (10)
1. Spoj koji ima formulu (I)
[image]
naznačen time što
R1 je klor ili fluor,
R2 je -CH2CH2OH, ili C3-5alkilCOOH;
R3 je trifluormetil, ili trifluormetoksi;
R4 je vodik, fluor, ili metoksi; i
R5 je vodik ili metil;
ili njegova farmaceutski prihvatljiva sol, solvat ili polimorf.
2. Spoj ili njegov stereoizomerni oblik, njegova farmaceutski prihvatljiva sol, solvat ili polimorf prema patentnom zahtjevu 1, naznačen time što je navedeni spoj odabran iz skupine koja sadrži
[image]
[image]
[image]
[image]
[image]
[image]
3. Spoj prema patentnom zahtjevu 1, naznačen time što navedeni spoj ima (+) specifičnu rotaciju.
4. Spoj prema patentnom zahtjevu 1, naznačen time što je navedeni spoj odabran od:
[image]
[image]
[image]
[image]
[image]
ili
[image]
5. Farmaceutski pripravak naznačen time što sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 4, zajedno s jednom ili više farmaceutski prihvatljivih pomoćnih tvari, razrjeđivača ili nosača.
6. Farmaceutski pripravak prema patentnom zahtjevu 5, naznačen time što sadrži drugi ili daljnji aktivni sastojak.
7. Farmaceutski pripravak prema patentnom zahtjevu 6, naznačen time što je drugi ili daljnji aktivni sastojak antivirusno sredstvo.
8. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time što se koristi kao lijek.
9. Spoj formule (I) prema bilo kojem od zahtjeva 1 do 4, naznačen time što se koristi u liječenju infekcije denga groznicom i za prevenciju ili liječenje bolesti povezane s infekcijom denga groznicom.
10. Spoj formule (I) za uporabu prema patentnom zahtjevu 9, naznačen time što je infekcija denga groznicom infekcija s virusima soja DENV-1, DENV-2, DENV-3 ili DENV-4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17164048 | 2017-03-31 | ||
EP18715612.0A EP3601266B1 (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
PCT/EP2018/058079 WO2018178240A1 (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210942T1 true HRP20210942T1 (hr) | 2021-10-15 |
Family
ID=58464340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210942TT HRP20210942T1 (hr) | 2017-03-31 | 2021-06-11 | Supstituirani derivati indolina kao inhibitori replikacije denga virusa |
Country Status (32)
Country | Link |
---|---|
US (1) | US11083707B2 (hr) |
EP (1) | EP3601266B1 (hr) |
JP (1) | JP7203752B2 (hr) |
KR (1) | KR102530832B1 (hr) |
CN (1) | CN110461831B (hr) |
AR (1) | AR111314A1 (hr) |
AU (1) | AU2018246301B2 (hr) |
BR (1) | BR112019020175A2 (hr) |
CA (1) | CA3055867C (hr) |
CL (1) | CL2019002745A1 (hr) |
CO (1) | CO2019010295A2 (hr) |
CR (1) | CR20190446A (hr) |
DK (1) | DK3601266T3 (hr) |
EA (1) | EA039784B1 (hr) |
EC (1) | ECSP19070369A (hr) |
ES (1) | ES2884151T3 (hr) |
HR (1) | HRP20210942T1 (hr) |
HU (1) | HUE054678T2 (hr) |
IL (1) | IL269658B (hr) |
JO (1) | JOP20180025B1 (hr) |
LT (1) | LT3601266T (hr) |
MX (1) | MX2019011606A (hr) |
NI (1) | NI201900099A (hr) |
PE (1) | PE20191650A1 (hr) |
PH (1) | PH12019502201A1 (hr) |
SG (1) | SG11201908786VA (hr) |
SI (1) | SI3601266T1 (hr) |
TW (1) | TWI795393B (hr) |
UA (1) | UA126288C2 (hr) |
UY (1) | UY37645A (hr) |
WO (1) | WO2018178240A1 (hr) |
ZA (1) | ZA201906395B (hr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
BR112018068956A2 (pt) | 2016-04-01 | 2019-01-22 | Janssen Pharmaceuticals Inc | derivados do composto indol substituídos como inibidores da replicação viral da dengue |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
CN112159325B (zh) * | 2020-10-10 | 2022-11-25 | 浙江工业大学 | 一种合成2-氨基-3-硝基甲苯的方法 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2308443A1 (en) | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
WO2003050295A2 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
WO2005113516A1 (en) | 2004-05-14 | 2005-12-01 | Neurocrine Biosciences, Inc. | Uracil-type gonadotropin-releasing hormone receptor antagonists and methods related thereto |
JP2008526980A (ja) | 2005-01-14 | 2008-07-24 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染症を治療するためのインドール誘導体 |
US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
CA2726985A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
US7948798B1 (en) | 2009-07-22 | 2011-05-24 | Marvell International Ltd. | Mixed multi-level cell and single level cell storage device |
PT2523951E (pt) | 2010-01-15 | 2015-09-14 | Gilead Sciences Inc | Inibidores de vírus flaviviridae |
EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
GB201305376D0 (en) * | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
JP6464176B2 (ja) | 2014-01-31 | 2019-02-06 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 芳香族p2’基を有する第xia因子阻害剤としてのマクロ環 |
NO2721243T3 (hr) | 2014-10-01 | 2018-10-20 | ||
ME03344B (me) | 2014-10-01 | 2019-10-20 | Janssen Pharmaceuticals Inc | Mono- ili di-supstituisani indoli kao inнibitori replikacije denga virusa |
SG11201702463YA (en) | 2014-10-01 | 2017-04-27 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
JOP20150335B1 (ar) | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JO3633B1 (ar) * | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
EP3370698B1 (en) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Sol-gel polymer composites and uses thereof |
MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
BR112018068538B1 (pt) | 2016-03-31 | 2023-12-12 | Takeda Pharmaceutical Company Limited | Composto, medicamento, e, uso de um composto |
WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
TW202313671A (zh) | 2016-04-01 | 2023-04-01 | 美商凱特製藥公司 | 嵌合抗原和t細胞受體及使用方法 |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
IL296966A (en) | 2016-04-01 | 2022-12-01 | Amgen Inc | Chimeric flt-3 receptors and methods of using them |
EA039392B1 (ru) | 2016-04-01 | 2022-01-21 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способ лечения рака с применением замещенного аминопуринового соединения |
CN113150170A (zh) | 2016-04-01 | 2021-07-23 | 凯德药业股份有限公司 | 嵌合受体及其方法和用途 |
BR112018068956A2 (pt) | 2016-04-01 | 2019-01-22 | Janssen Pharmaceuticals Inc | derivados do composto indol substituídos como inibidores da replicação viral da dengue |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
-
2018
- 2018-03-26 JO JOP/2018/0025A patent/JOP20180025B1/ar active
- 2018-03-28 AR ARP180100776A patent/AR111314A1/es unknown
- 2018-03-29 SG SG11201908786V patent/SG11201908786VA/en unknown
- 2018-03-29 KR KR1020197031207A patent/KR102530832B1/ko active IP Right Grant
- 2018-03-29 ES ES18715612T patent/ES2884151T3/es active Active
- 2018-03-29 JP JP2019553169A patent/JP7203752B2/ja active Active
- 2018-03-29 WO PCT/EP2018/058079 patent/WO2018178240A1/en active Application Filing
- 2018-03-29 US US16/493,768 patent/US11083707B2/en active Active
- 2018-03-29 CR CR20190446A patent/CR20190446A/es unknown
- 2018-03-29 EA EA201992329A patent/EA039784B1/ru unknown
- 2018-03-29 SI SI201830307T patent/SI3601266T1/sl unknown
- 2018-03-29 EP EP18715612.0A patent/EP3601266B1/en active Active
- 2018-03-29 TW TW107110872A patent/TWI795393B/zh active
- 2018-03-29 DK DK18715612.0T patent/DK3601266T3/da active
- 2018-03-29 LT LTEP18715612.0T patent/LT3601266T/lt unknown
- 2018-03-29 PE PE2019001933A patent/PE20191650A1/es unknown
- 2018-03-29 CA CA3055867A patent/CA3055867C/en active Active
- 2018-03-29 BR BR112019020175-0A patent/BR112019020175A2/pt unknown
- 2018-03-29 UA UAA201910701A patent/UA126288C2/uk unknown
- 2018-03-29 HU HUE18715612A patent/HUE054678T2/hu unknown
- 2018-03-29 AU AU2018246301A patent/AU2018246301B2/en active Active
- 2018-03-29 MX MX2019011606A patent/MX2019011606A/es unknown
- 2018-03-29 CN CN201880022017.3A patent/CN110461831B/zh active Active
- 2018-04-02 UY UY0001037645A patent/UY37645A/es not_active Application Discontinuation
-
2019
- 2019-09-24 CO CONC2019/0010295A patent/CO2019010295A2/es unknown
- 2019-09-24 PH PH12019502201A patent/PH12019502201A1/en unknown
- 2019-09-25 IL IL269658A patent/IL269658B/en unknown
- 2019-09-26 CL CL2019002745A patent/CL2019002745A1/es unknown
- 2019-09-27 ZA ZA2019/06395A patent/ZA201906395B/en unknown
- 2019-09-27 NI NI201900099A patent/NI201900099A/es unknown
- 2019-09-27 EC ECSENADI201970369A patent/ECSP19070369A/es unknown
-
2021
- 2021-06-11 HR HRP20210942TT patent/HRP20210942T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20210942T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
HRP20211102T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
HRP20210724T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
HRP20200408T1 (hr) | Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa | |
HRP20211278T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
HRP20211224T1 (hr) | Derivati pirimidina za liječenje virusnih infekcija | |
HRP20210847T1 (hr) | Supstituirani derivati indola kao inhibitori replikacije denga virusa | |
HRP20211223T1 (hr) | Heterociklički indoli za upotrebu kod infekcije virusom influence | |
HRP20201023T1 (hr) | Dioksilan analozi uridina za liječenje raka | |
HRP20170654T1 (hr) | Makrociklički deaza-purinoni za liječenje virusnih infekcija | |
HRP20210241T1 (hr) | Derivat policikličkog piridona protiv gripe i njegov predlijek | |
HRP20171512T1 (hr) | Derivati betulina | |
MX2022010520A (es) | Macrociclos peptidicos contra acinetobacter baumannii. | |
HRP20230274T1 (hr) | Kemijski spojevi | |
ZA202006378B (en) | N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof | |
CR20200488A (es) | Péptidos macrocíclicos contra actinetobacter baumannii | |
HRP20210038T1 (hr) | Pirolopirimidini za uporabu u infekciji virusom gripe | |
HRP20161125T1 (hr) | Makrociklički purini za liječenje virusnih infekcija | |
PH12020551264A1 (en) | Pyridone Derivative, Composition And Use As Antiviral Drug Thereof | |
PH12021551257A1 (en) | Cyclic pantetheine derivatives and uses thereof | |
MX368504B (es) | Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos. | |
EA201791872A1 (ru) | Полициклические карбамоилпиридоновые соединения и их фармацевтическое применение | |
UY29085A1 (es) | Derivados de pirimidina 4-sulfonamido sustituidos, compuestos intermedios para su preparación, procedimientos de preparación, composiciones medicinales conteniéndolos y aplicaci0nes | |
HRP20211749T1 (hr) | Pentanske kiseline supstituirane pirolo-[2-3,b]pirimidin-piridinima za liječenje virusnih infekcija influencom | |
CO2018001700A2 (es) | Derivados de n-[1h-bencimidazol-2-il] metil-pirazin-2-il-carboxamida, composiciones y procedimientos de preparación de los mismos |