HRP20211102T1 - Supstituirani derivati indolina kao inhibitori replikacije denga virusa - Google Patents
Supstituirani derivati indolina kao inhibitori replikacije denga virusa Download PDFInfo
- Publication number
- HRP20211102T1 HRP20211102T1 HRP20211102TT HRP20211102T HRP20211102T1 HR P20211102 T1 HRP20211102 T1 HR P20211102T1 HR P20211102T T HRP20211102T T HR P20211102TT HR P20211102 T HRP20211102 T HR P20211102T HR P20211102 T1 HRP20211102 T1 HR P20211102T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- image
- ch2ch2oh
- trifluoromethyl
- chlorine
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title claims 4
- 206010012310 Dengue fever Diseases 0.000 title claims 4
- 208000025729 dengue disease Diseases 0.000 title claims 4
- 229940123627 Viral replication inhibitor Drugs 0.000 title 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (10)
1. Spoj formule (I), uključujući bilo koji njihov stereokemijski izomerni oblik,
[image]
naznačen time što
R1 je fluor, R2 je -CH2CH2OH, R3 je trifluormetil, i R4 je vodik, ili
R1 je fluor, R2 je -CH2CH2OH, R3 je trifluormetil, i R4 je metoksi, ili
R1 je fluor, R2 je -CH2CH2OH, R3 je trifluormetoksi, i R4 je vodik, ili
R1 je klor, R2 je -CH2CH2OH, R3 je trifluormetil, i R4 je vodik, ili
R1 je klor, R2 je -CH2CH2OH, R3 je trifluormetil, i R4 je metoksi, ili
R1 je klor, R2 je -CH2CH2OH, R3 je trifluormetoksi, i R4 je vodik, ili
R1 je klor, R2 je -(CH2)3COOH, R3 je trifluormetil, i R4 je vodik, ili
R1 je klor, R2 je -(CH2)3COOH, R3 je trifluormetil, i R4 je metoksi, ili
R1 je klor, R2 je -(CH2)3COOH, R3 je trifluormetoksi, i R4 je vodik;
ili njegova farmaceutski prihvatljiva sol, solvat ili polimorf.
2. Spoj prema patentnom zahtjevu 1 naznačen time što je navedeni spoj odabran od
[image]
[image]
[image]
3. Spoj prema patentnom zahtjevu 1 naznačen time što navedeni spoj ima (+) specifičnu rotaciju.
4. Spoj prema patentnom zahtjevu 1 naznačen time što je navedeni spoj odabran od:
[image]
[image]
[image]
[image]
ili
[image]
5. Farmaceutski pripravak naznačen time što sadrži spoj prema bilo kojem od zahtjeva 1 do 4 zajedno s jednom ili više farmaceutski prihvatljivih pomoćnih tvari, razrjeđivača ili nosača.
6. Farmaceutski pripravak prema patentnom zahtjevu 5 naznačen time što sadrži drugi ili daljnji aktivni sastojak.
7. Farmaceutski pripravak prema patentnom zahtjevu 6 naznačen time što je drugi ili daljnji aktivni sastojak antivirusno sredstvo.
8. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 4 naznačen time što se koristi kao lijek.
9. Spoj formule (I) prema bilo kojem od patentnih zahtjeva 1 do 4 naznačen time što se koristi u liječenju infekcije denga groznicom i za prevenciju ili liječenje bolesti povezane s infekcijom denga groznicom.
10. Spoj formule (I) za uporabu u skladu s patentnim zahtjevom 9 naznačen time što je infekcija denga groznicom infekcija virusima soja DENV-1, DENV-2, DENV-3 ili DENV-4.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17164045 | 2017-03-31 | ||
| PCT/EP2018/058077 WO2018178238A1 (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
| EP18715611.2A EP3601225B1 (en) | 2017-03-31 | 2018-03-29 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20211102T1 true HRP20211102T1 (hr) | 2021-10-29 |
Family
ID=58464339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211102TT HRP20211102T1 (hr) | 2017-03-31 | 2021-07-12 | Supstituirani derivati indolina kao inhibitori replikacije denga virusa |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US11179368B2 (hr) |
| EP (1) | EP3601225B1 (hr) |
| JP (1) | JP7038733B2 (hr) |
| KR (1) | KR102556222B1 (hr) |
| CN (1) | CN110612284B (hr) |
| AR (1) | AR111315A1 (hr) |
| AU (1) | AU2018246299A1 (hr) |
| BR (1) | BR112019019928A2 (hr) |
| CA (1) | CA3055260A1 (hr) |
| CL (1) | CL2019002744A1 (hr) |
| CO (1) | CO2019010292A2 (hr) |
| CR (1) | CR20190447A (hr) |
| DK (1) | DK3601225T3 (hr) |
| EA (1) | EA201992334A1 (hr) |
| EC (1) | ECSP19070413A (hr) |
| ES (1) | ES2887673T3 (hr) |
| HR (1) | HRP20211102T1 (hr) |
| HU (1) | HUE055576T2 (hr) |
| IL (1) | IL269657A (hr) |
| JO (1) | JOP20180026A1 (hr) |
| LT (1) | LT3601225T (hr) |
| MA (1) | MA48987A (hr) |
| MX (1) | MX2019011608A (hr) |
| NI (1) | NI201900098A (hr) |
| PE (1) | PE20191652A1 (hr) |
| PH (1) | PH12019502095A1 (hr) |
| SG (1) | SG11201908465QA (hr) |
| SI (1) | SI3601225T1 (hr) |
| TW (1) | TW201900610A (hr) |
| UY (1) | UY37646A (hr) |
| WO (1) | WO2018178238A1 (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625991B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001520998A (ja) | 1997-10-27 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | インドールｓＰＬＡ２阻害剤のモルホリノ−Ｎ−エチルエステルプロドラッグ |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| US20050074457A1 (en) | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| CA2593450A1 (en) | 2005-01-14 | 2006-07-20 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| CA2597213A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| JP5559174B2 (ja) | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| US7948798B1 (en) | 2009-07-22 | 2011-05-24 | Marvell International Ltd. | Mixed multi-level cell and single level cell storage device |
| SG182478A1 (en) | 2010-01-15 | 2012-08-30 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| AP2016009122A0 (en) | 2013-10-23 | 2016-03-31 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| HUE040226T2 (hu) | 2014-01-31 | 2019-02-28 | Bristol Myers Squibb Co | Makrociklusok heterociklusos P2' csoportokkal XIA faktor inhibitorokként |
| NO2721243T3 (hr) | 2014-10-01 | 2018-10-20 | ||
| CN107001265B (zh) | 2014-10-01 | 2021-06-15 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经单取代的或二取代的吲哚 |
| PL3201176T3 (pl) | 2014-10-01 | 2019-06-28 | Janssen Pharmaceuticals, Inc. | Mono- lub di-podstawione pochodne indolowe jako inhibitory replikacji wirusa dengi |
| JOP20150335B1 (ar) * | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PL3370698T3 (pl) | 2015-11-03 | 2022-04-25 | Zoetis Services Llc | Kompozyty polimerowe zol-żel i ich zastosowania |
| MY194647A (en) | 2016-03-31 | 2022-12-09 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| TN2018000337A1 (en) | 2016-04-01 | 2020-01-16 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
| SG11201808411RA (en) | 2016-04-01 | 2018-10-30 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JP7014731B2 (ja) | 2016-04-01 | 2022-02-01 | シグナル ファーマシューティカルズ，エルエルシー | 置換アミノプリン化合物、その組成物、及びそれらを用いた治療方法 |
| WO2017173384A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Chimeric receptors and methods of use thereof |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR102625991B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2017
- 2017-03-31 JO JOP/2018/0026A patent/JOP20180026A1/ar unknown
-
2018
- 2018-03-28 AR ARP180100777A patent/AR111315A1/es unknown
- 2018-03-29 PE PE2019001919A patent/PE20191652A1/es unknown
- 2018-03-29 MA MA048987A patent/MA48987A/fr unknown
- 2018-03-29 KR KR1020197031206A patent/KR102556222B1/ko active IP Right Grant
- 2018-03-29 US US16/492,667 patent/US11179368B2/en active Active
- 2018-03-29 ES ES18715611T patent/ES2887673T3/es active Active
- 2018-03-29 CR CR20190447A patent/CR20190447A/es unknown
- 2018-03-29 SI SI201830334T patent/SI3601225T1/sl unknown
- 2018-03-29 LT LTEPPCT/EP2018/058077T patent/LT3601225T/lt unknown
- 2018-03-29 MX MX2019011608A patent/MX2019011608A/es unknown
- 2018-03-29 CA CA3055260A patent/CA3055260A1/en not_active Abandoned
- 2018-03-29 BR BR112019019928A patent/BR112019019928A2/pt not_active IP Right Cessation
- 2018-03-29 EA EA201992334A patent/EA201992334A1/ru unknown
- 2018-03-29 TW TW107110873A patent/TW201900610A/zh unknown
- 2018-03-29 EP EP18715611.2A patent/EP3601225B1/en active Active
- 2018-03-29 DK DK18715611.2T patent/DK3601225T3/da active
- 2018-03-29 WO PCT/EP2018/058077 patent/WO2018178238A1/en active Application Filing
- 2018-03-29 HU HUE18715611A patent/HUE055576T2/hu unknown
- 2018-03-29 CN CN201880022012.0A patent/CN110612284B/zh active Active
- 2018-03-29 AU AU2018246299A patent/AU2018246299A1/en not_active Abandoned
- 2018-03-29 SG SG11201908465Q patent/SG11201908465QA/en unknown
- 2018-03-29 JP JP2019553485A patent/JP7038733B2/ja active Active
- 2018-04-02 UY UY0001037646A patent/UY37646A/es unknown
-
2019
- 2019-09-13 PH PH12019502095A patent/PH12019502095A1/en unknown
- 2019-09-24 CO CONC2019/0010292A patent/CO2019010292A2/es unknown
- 2019-09-25 IL IL26965719A patent/IL269657A/en unknown
- 2019-09-26 CL CL2019002744A patent/CL2019002744A1/es unknown
- 2019-09-27 NI NI201900098A patent/NI201900098A/es unknown
- 2019-09-27 EC ECSENADI201970413A patent/ECSP19070413A/es unknown
-
2021
- 2021-07-12 HR HRP20211102TT patent/HRP20211102T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20211102T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
| HRP20210942T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
| HRP20210724T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
| HRP20211278T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
| HRP20200408T1 (hr) | Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa | |
| HRP20210241T1 (hr) | Derivat policikličkog piridona protiv gripe i njegov predlijek | |
| HRP20211223T1 (hr) | Heterociklički indoli za upotrebu kod infekcije virusom influence | |
| HRP20200648T1 (hr) | Derivati sulfamoilpirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b | |
| MX2022010520A (es) | Macrociclos peptidicos contra acinetobacter baumannii. | |
| HRP20231018T1 (hr) | Terapeutski spojevi korisni za profilaktičko ili terapijsko liječenje hiv virusne infekcije | |
| CR20200488A (es) | Péptidos macrocíclicos contra actinetobacter baumannii | |
| CY1123260T1 (el) | Ενα αλας νατριου του ν-((1,2,3,5,6,7-eξaϋδpo-s-inδaken-4-υλ)καρβαμοϋλ)-1-ισοπροπυλ-1η-πυραζολο-3-σουλφοναμιδιου | |
| PH12020551264A1 (en) | Pyridone Derivative, Composition And Use As Antiviral Drug Thereof | |
| HRP20171648T1 (hr) | Supstituirani piperidil-etil-pirimidin kao inhibitor grelin-o-acil-transferaze | |
| PH12021551257A1 (en) | Cyclic pantetheine derivatives and uses thereof | |
| MX368504B (es) | Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos. | |
| HRP20220781T1 (hr) | Derivati 2,4-diaminokinazolina i njihova upotreba u liječenju virusnih infekcija, raka ili alergija | |
| EA201791872A1 (ru) | Полициклические карбамоилпиридоновые соединения и их фармацевтическое применение | |
| NO20074781L (no) | 4-Oksokinazolin-3-ylbenzamidderivater for behandling av cytokinsykdommer | |
| MY154683A (en) | Pharmaceutical composition for a hepatitis c viral protease inhibitor | |
| MA32633B1 (fr) | Formes cristallines d'un derive 2-thiazolyl-4-quinolinyl-oxy, un inhibiteur puissant du vhc | |
| AR111878A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| BR112015011179A8 (pt) | composições farmacêuticas aquosas estáveis compreendendo insulina humana ou um análogo ou derivado das mesmas, seu uso e processos para sua preparação | |
| HRP20211749T1 (hr) | Pentanske kiseline supstituirane pirolo-[2-3,b]pirimidin-piridinima za liječenje virusnih infekcija influencom | |
| EA201071039A1 (ru) | Новые производные 1-бензил-3-гидроксиметилиндазола и их применение для лечения заболеваний, основанных на экспрессии mcp-1, cx3cr1 и p40 |