EA201992334A1 - Замещенные производные индолина в качестве ингибиторов репликации вирусов денге - Google Patents

Замещенные производные индолина в качестве ингибиторов репликации вирусов денге

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Publication number
EA201992334A1
EA201992334A1 EA201992334A EA201992334A EA201992334A1 EA 201992334 A1 EA201992334 A1 EA 201992334A1 EA 201992334 A EA201992334 A EA 201992334A EA 201992334 A EA201992334 A EA 201992334A EA 201992334 A1 EA201992334 A1 EA 201992334A1
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EA
Eurasian Patent Office
Prior art keywords
money
indoline derivatives
virus replication
compounds
substituted indoline
Prior art date
Application number
EA201992334A
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English (en)
Inventor
Дороте Алис Мари-Эв Бардио
Барт Рудольф Романи Кестелейн
Жан-Франсуа Бонфанти
Пьер Жан-Мари Бернар Рабуассон
Арно Дидье М Маршан
Original Assignee
Янссен Фармасьютикалз, Инк.
Католике Университейт Левен
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Янссен Фармасьютикалз, Инк., Католике Университейт Левен filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA201992334A1 publication Critical patent/EA201992334A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к замещенным производным индолина, способам предупреждения или лечения вирусных инфекций денге посредством применения указанных соединений, а также относится к указанным соединениям для применения в качестве лекарственного препарата, более предпочтительно для применения в качестве лекарственного препарата для лечения или предупреждения вирусных инфекций денге. Настоящее изобретение дополнительно относится к фармацевтическим композициям или комбинированным препаратам на основе соединений, к композициям или препаратам для применения в качестве лекарственного препарата, более предпочтительно для предупреждения или лечения вирусных инфекций денге. Настоящее изобретение также относится к способам получения соединений.
EA201992334A 2017-03-31 2018-03-29 Замещенные производные индолина в качестве ингибиторов репликации вирусов денге EA201992334A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17164045 2017-03-31
PCT/EP2018/058077 WO2018178238A1 (en) 2017-03-31 2018-03-29 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
EA201992334A1 true EA201992334A1 (ru) 2020-02-20

Family

ID=58464339

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992334A EA201992334A1 (ru) 2017-03-31 2018-03-29 Замещенные производные индолина в качестве ингибиторов репликации вирусов денге

Country Status (31)

Country Link
US (1) US11179368B2 (ru)
EP (1) EP3601225B1 (ru)
JP (1) JP7038733B2 (ru)
KR (1) KR102556222B1 (ru)
CN (1) CN110612284B (ru)
AR (1) AR111315A1 (ru)
AU (1) AU2018246299A1 (ru)
BR (1) BR112019019928A2 (ru)
CA (1) CA3055260A1 (ru)
CL (1) CL2019002744A1 (ru)
CO (1) CO2019010292A2 (ru)
CR (1) CR20190447A (ru)
DK (1) DK3601225T3 (ru)
EA (1) EA201992334A1 (ru)
EC (1) ECSP19070413A (ru)
ES (1) ES2887673T3 (ru)
HR (1) HRP20211102T1 (ru)
HU (1) HUE055576T2 (ru)
IL (1) IL269657A (ru)
JO (1) JOP20180026A1 (ru)
LT (1) LT3601225T (ru)
MA (1) MA48987A (ru)
MX (1) MX2019011608A (ru)
NI (1) NI201900098A (ru)
PE (1) PE20191652A1 (ru)
PH (1) PH12019502095A1 (ru)
SG (1) SG11201908465QA (ru)
SI (1) SI3601225T1 (ru)
TW (1) TW201900610A (ru)
UY (1) UY37646A (ru)
WO (1) WO2018178238A1 (ru)

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CA3055260A1 (en) 2018-10-04
TW201900610A (zh) 2019-01-01
US11179368B2 (en) 2021-11-23
JP7038733B2 (ja) 2022-03-18
ECSP19070413A (es) 2019-10-31
MX2019011608A (es) 2019-11-08
NI201900098A (es) 2020-03-11
SG11201908465QA (en) 2019-10-30
KR20190135496A (ko) 2019-12-06
CN110612284B (zh) 2023-10-31
UY37646A (es) 2018-09-28
AU2018246299A1 (en) 2019-09-19
MA48987A (fr) 2020-02-05
CO2019010292A2 (es) 2019-10-09
EP3601225A1 (en) 2020-02-05
KR102556222B1 (ko) 2023-07-14
IL269657A (en) 2019-11-28
CL2019002744A1 (es) 2019-12-27
JP2020512374A (ja) 2020-04-23
CN110612284A (zh) 2019-12-24
HUE055576T2 (hu) 2021-12-28
BR112019019928A2 (pt) 2020-04-22
PE20191652A1 (es) 2019-11-07
ES2887673T3 (es) 2021-12-27
LT3601225T (lt) 2021-08-10
SI3601225T1 (sl) 2021-09-30
JOP20180026A1 (ar) 2019-01-30
WO2018178238A1 (en) 2018-10-04
PH12019502095A1 (en) 2020-03-09
US20200054606A1 (en) 2020-02-20
HRP20211102T1 (hr) 2021-10-29
DK3601225T3 (da) 2021-08-16
AR111315A1 (es) 2019-06-26
EP3601225B1 (en) 2021-06-02
CR20190447A (es) 2019-11-13

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