CR20200488A - Péptidos macrocíclicos contra actinetobacter baumannii - Google Patents
Péptidos macrocíclicos contra actinetobacter baumanniiInfo
- Publication number
- CR20200488A CR20200488A CR20200488A CR20200488A CR20200488A CR 20200488 A CR20200488 A CR 20200488A CR 20200488 A CR20200488 A CR 20200488A CR 20200488 A CR20200488 A CR 20200488A CR 20200488 A CR20200488 A CR 20200488A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sup
- acinetobacter baumannii
- against acinetobacter
- peptide macrocycles
- macrocycles against
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
Abstract
<p>La presente invención proporciona compuestos de fórmula (I):en la que X<sup>1</sup>, X<sup>2</sup>, R<sup>1</sup> a R<sup>6</sup> y A son tal como se indica en la presente memoria, así como sales farmacéuticamente aceptables de los mismos. Además, la presente invención se refiere a la preparación de los compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y a su utilización como medicamentos destinados al tratamiento de enfermedades e infecciones causadas por bacterias.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNPCT/CN2018/084131 | 2018-04-23 | ||
PCT/EP2019/060272 WO2019206853A1 (en) | 2018-04-23 | 2019-04-23 | Peptide macrocycles against acinetobacter baumannii |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20200488A true CR20200488A (es) | 2021-02-26 |
Family
ID=66290410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20200488A CR20200488A (es) | 2018-04-23 | 2019-04-23 | Péptidos macrocíclicos contra actinetobacter baumannii |
Country Status (19)
Country | Link |
---|---|
US (2) | US11819532B2 (es) |
EP (1) | EP3784262A1 (es) |
JP (2) | JP7460541B2 (es) |
KR (1) | KR20210005574A (es) |
CN (1) | CN111886020B (es) |
AR (1) | AR114290A1 (es) |
AU (1) | AU2019260124A1 (es) |
BR (1) | BR112020021729A2 (es) |
CA (1) | CA3089688A1 (es) |
CL (1) | CL2020002695A1 (es) |
CR (1) | CR20200488A (es) |
IL (2) | IL278053B1 (es) |
MA (1) | MA52352A (es) |
MX (1) | MX2020007633A (es) |
PE (1) | PE20210855A1 (es) |
PH (1) | PH12020551762A1 (es) |
SG (1) | SG11202007219PA (es) |
UA (1) | UA126943C2 (es) |
WO (1) | WO2019206853A1 (es) |
Families Citing this family (20)
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KR20180063138A (ko) | 2015-10-27 | 2018-06-11 | 에프. 호프만-라 로슈 아게 | 아시네토박터 바우만니이에 대항하는 펩티드 거대고리 |
US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
US11819532B2 (en) * | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
EA202092248A1 (ru) | 2018-04-23 | 2021-02-04 | Селджин Корпорейшн | Замещенные соединения 4-аминоизоиндолин-1,3-диона, их композиции и способы лечения ими |
CN113613722A (zh) | 2019-03-08 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 新型咪唑-吡唑衍生物 |
WO2021148420A1 (en) | 2020-01-22 | 2021-07-29 | F. Hoffmann-La Roche Ag | Novel heterocyclic compounds |
CN115485279A (zh) | 2020-04-29 | 2022-12-16 | 豪夫迈·罗氏有限公司 | 抗菌8-苯基氨基-3-(吡唑-4-基)咪唑并[1,2-a]吡嗪衍生物 |
JP2023527479A (ja) | 2020-06-01 | 2023-06-28 | エフ. ホフマン-ラ ロシュ アーゲー | 新規イミダゾピラジン誘導体 |
EP4161930A1 (en) | 2020-06-08 | 2023-04-12 | F. Hoffmann-La Roche AG | Novel imidazo-pyrazine derivatives |
JP2023529866A (ja) | 2020-06-09 | 2023-07-12 | エフ. ホフマン-ラ ロシュ アーゲー | 新規イミダゾピラジン誘導体 |
JP2023538969A (ja) | 2020-08-31 | 2023-09-12 | エフ. ホフマン-ラ ロシュ アーゲー | 抗菌薬としてのイミダゾール-ピラゾール誘導体 |
EP4208454A1 (en) | 2020-09-01 | 2023-07-12 | F. Hoffmann-La Roche AG | Imidazole-pyrazole derivatives with anti-bacterial properties |
WO2022049272A1 (en) | 2020-09-07 | 2022-03-10 | F. Hoffmann-La Roche Ag | Novel heterocyclic antibiotics |
EP4288424A1 (en) | 2021-02-07 | 2023-12-13 | F. Hoffmann-La Roche AG | Novel heteroaryl-substituted imidazole derivatives |
CN117715892A (zh) | 2021-07-06 | 2024-03-15 | 豪夫迈·罗氏有限公司 | 用于治疗细菌感染的季铵阳离子取代化合物 |
WO2023285497A1 (en) | 2021-07-15 | 2023-01-19 | F. Hoffmann-La Roche Ag | Imidazole derivatives and their use as antibiotics |
WO2023152347A1 (en) * | 2022-02-14 | 2023-08-17 | F. Hoffmann-La Roche Ag | Process for manufacturing macrocyclic peptides |
WO2023161316A1 (en) | 2022-02-25 | 2023-08-31 | F. Hoffmann-La Roche Ag | Zwitterionic antibacterial compounds |
WO2023194418A1 (en) | 2022-04-07 | 2023-10-12 | F. Hoffmann-La Roche Ag | Crystalline forms of a macrocyclic peptide antibiotic |
WO2024033278A1 (en) | 2022-08-09 | 2024-02-15 | F. Hoffmann-La Roche Ag | Process for manufacturing an antibiotic macrocyclic peptide |
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US6660832B1 (en) | 1999-08-20 | 2003-12-09 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds and preparation methods thereof |
DE10226921A1 (de) | 2002-06-17 | 2003-12-24 | Bayer Ag | Antibakterielle Amid-Makrozyklen |
DE10234422A1 (de) | 2002-07-29 | 2004-02-12 | Bayer Ag | Antibakterielle Ester-Makrozyklen |
MXPA05002113A (es) | 2002-08-23 | 2005-06-03 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios para ellas, analogos y usos de los mismos. |
WO2004111077A1 (en) | 2003-06-18 | 2004-12-23 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
US7491695B2 (en) | 2003-06-18 | 2009-02-17 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
EP1498422A1 (de) | 2003-07-17 | 2005-01-19 | Jerini AG | C5a-Rezeptor-Antagonisten |
DK1648922T3 (da) | 2003-07-31 | 2011-03-14 | Tranzyme Pharma Inc | Rumligt definerede makrocykliske forbindelser, der er anvendelige til opdagelse af lægemidler |
WO2005012332A1 (en) | 2003-07-31 | 2005-02-10 | Tranzyme Pharma | Spatially-defined macrocycles incorporating peptide bond surrogates |
WO2005033129A1 (de) | 2003-10-01 | 2005-04-14 | Bayer Healthcare Ag | Antibakterielle amid-makrozyklen |
EP1737884B1 (en) | 2004-03-19 | 2016-10-19 | The University Of Queensland | Alpha helical mimics, their uses and methods for their production |
DE102004025731A1 (de) | 2004-05-26 | 2005-12-15 | Bayer Healthcare Ag | Antibakterielle Amid-Makrozyklen III |
US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
CN101107264A (zh) | 2005-01-17 | 2008-01-16 | 捷瑞尼股份公司 | C5a受体拮抗剂 |
DE102005014245A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Antibakterielle Amid-Makrozyklen V |
GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
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EP2350031A2 (en) | 2008-08-20 | 2011-08-03 | Ensemble Therapeutics Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
WO2011050270A2 (en) | 2009-10-23 | 2011-04-28 | Tranzyme Pharma, Inc. | Macrocyclic inhibitors of serine protease enzymes |
CA2778990A1 (en) | 2009-10-30 | 2011-05-05 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same |
CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
US20130123196A1 (en) | 2011-08-31 | 2013-05-16 | New York University | Thioether-, ether-, and alkylamine-linked hydrogen bond surrogate peptidomimetics |
CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
CN103387601B (zh) | 2012-05-11 | 2017-01-11 | 南开大学 | 抗登革热病毒(denv)杂环肽类化合物及其制备方法和用途 |
WO2014048976A1 (en) * | 2012-09-25 | 2014-04-03 | Vaxdyn Sl | Anti-acinetobacter baumannii immunogens |
BR112015011697A2 (pt) | 2012-11-21 | 2017-07-11 | Rqx Pharmaceuticals Inc | antibióticos macrocíclicos de amplo espectro |
US9493510B2 (en) | 2013-01-10 | 2016-11-15 | Noliva Therapeutics Llc | Peptidomimetic compounds |
EP2942389A1 (en) * | 2014-05-05 | 2015-11-11 | Servicio Andaluz De Salud | Vaccine against Acinetobacter baumannii based on lipopolysaccharide-deficient cellular components |
WO2016016291A1 (en) | 2014-07-30 | 2016-02-04 | Ferrer Internacional, S.A. | Arylhydrazides containing a 2-pyridone moiety as selective antibacterial agents |
KR20180063138A (ko) | 2015-10-27 | 2018-06-11 | 에프. 호프만-라 로슈 아게 | 아시네토박터 바우만니이에 대항하는 펩티드 거대고리 |
EP3388444A1 (en) | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Anti-bacterial peptide macrocycles and use thereof |
US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
US11819532B2 (en) * | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
-
2019
- 2019-04-19 US US16/389,292 patent/US11819532B2/en active Active
- 2019-04-23 PE PE2020000996A patent/PE20210855A1/es unknown
- 2019-04-23 IL IL278053A patent/IL278053B1/en unknown
- 2019-04-23 MX MX2020007633A patent/MX2020007633A/es unknown
- 2019-04-23 CN CN201980020627.4A patent/CN111886020B/zh active Active
- 2019-04-23 KR KR1020207029322A patent/KR20210005574A/ko unknown
- 2019-04-23 AU AU2019260124A patent/AU2019260124A1/en active Pending
- 2019-04-23 CA CA3089688A patent/CA3089688A1/en active Pending
- 2019-04-23 IL IL309537A patent/IL309537A/en unknown
- 2019-04-23 SG SG11202007219PA patent/SG11202007219PA/en unknown
- 2019-04-23 BR BR112020021729-8A patent/BR112020021729A2/pt unknown
- 2019-04-23 EP EP19719814.6A patent/EP3784262A1/en active Pending
- 2019-04-23 WO PCT/EP2019/060272 patent/WO2019206853A1/en unknown
- 2019-04-23 AR ARP190101064A patent/AR114290A1/es unknown
- 2019-04-23 CR CR20200488A patent/CR20200488A/es unknown
- 2019-04-23 UA UAA202007319A patent/UA126943C2/uk unknown
- 2019-04-23 MA MA052352A patent/MA52352A/fr unknown
- 2019-04-23 JP JP2020558432A patent/JP7460541B2/ja active Active
-
2020
- 2020-10-16 CL CL2020002695A patent/CL2020002695A1/es unknown
- 2020-10-23 PH PH12020551762A patent/PH12020551762A1/en unknown
-
2023
- 2023-10-12 US US18/379,626 patent/US20240050516A1/en active Pending
-
2024
- 2024-01-26 JP JP2024010026A patent/JP2024050700A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20190321440A1 (en) | 2019-10-24 |
AR114290A1 (es) | 2020-08-12 |
IL278053A (en) | 2020-11-30 |
PE20210855A1 (es) | 2021-05-18 |
UA126943C2 (uk) | 2023-02-22 |
CN111886020B (zh) | 2024-04-05 |
CA3089688A1 (en) | 2019-10-31 |
JP2024050700A (ja) | 2024-04-10 |
CN111886020A (zh) | 2020-11-03 |
MX2020007633A (es) | 2020-09-14 |
TW201945386A (zh) | 2019-12-01 |
JP7460541B2 (ja) | 2024-04-02 |
MA52352A (fr) | 2021-03-03 |
AU2019260124A1 (en) | 2020-08-06 |
US11819532B2 (en) | 2023-11-21 |
EP3784262A1 (en) | 2021-03-03 |
IL278053B1 (en) | 2024-01-01 |
JP2021522210A (ja) | 2021-08-30 |
PH12020551762A1 (en) | 2021-06-14 |
SG11202007219PA (en) | 2020-08-28 |
IL309537A (en) | 2024-02-01 |
KR20210005574A (ko) | 2021-01-14 |
US20240050516A1 (en) | 2024-02-15 |
CL2020002695A1 (es) | 2021-02-19 |
BR112020021729A2 (pt) | 2021-01-26 |
WO2019206853A1 (en) | 2019-10-31 |
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