CR20230331A - Derivados de pirazolamida - Google Patents

Derivados de pirazolamida

Info

Publication number
CR20230331A
CR20230331A CR20230331A CR20230331A CR20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A
Authority
CR
Costa Rica
Prior art keywords
sup
pyrazoleamide
derivatives
formula
present
Prior art date
Application number
CR20230331A
Other languages
English (en)
Inventor
Anthony Richard Bradley
Luke Green
Andrew Simon Bell
Wolfgang Haap
Jérémy BESNARD
Andreas Kuglstatter
Xavier Lucas
Claus Riemer
Hoorn Willem Paul Van
Patrizio Mattei
Buelent Kocer
Dmitry Mazunin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20230331A publication Critical patent/CR20230331A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona compuestos de fórmula I o II: <img alt="" src="data:image/png;base64,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 (***)
CR20230331A 2021-01-29 2022-01-27 Derivados de pirazolamida CR20230331A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21154295 2021-01-29
PCT/EP2022/051823 WO2022162034A1 (en) 2021-01-29 2022-01-27 Pyrazoleamide derivatives

Publications (1)

Publication Number Publication Date
CR20230331A true CR20230331A (es) 2023-09-01

Family

ID=74418268

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230331A CR20230331A (es) 2021-01-29 2022-01-27 Derivados de pirazolamida

Country Status (17)

Country Link
US (1) US20230382911A1 (es)
EP (1) EP4284797A1 (es)
JP (1) JP2024504788A (es)
KR (1) KR20230141787A (es)
CN (1) CN116867782A (es)
AR (1) AR124720A1 (es)
AU (1) AU2022212487A1 (es)
CA (1) CA3209599A1 (es)
CL (1) CL2023002052A1 (es)
CO (1) CO2023010155A2 (es)
CR (1) CR20230331A (es)
IL (1) IL304189A (es)
MX (1) MX2023008562A (es)
PE (1) PE20231387A1 (es)
TW (1) TW202246259A (es)
WO (1) WO2022162034A1 (es)
ZA (1) ZA202306694B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014207213A1 (en) * 2013-06-28 2014-12-31 Medizinische Universität Innsbruck Novel inhibitors of protein kinase c epsilon signaling
JP6806342B2 (ja) 2015-04-10 2021-01-06 ベイジーン リミテッド インドールアミンとしての新規５又は８−置換イミダゾ［１，５−ａ］ピリジン類、及び／又はトリプトファン２，３−ジオキシゲナーゼ
CN106146493A (zh) 2015-04-21 2016-11-23 中国科学院上海药物研究所 吡唑并[3,4-b]吡啶类和吲唑类化合物的制备方法和用途

Also Published As

Publication number Publication date
WO2022162034A1 (en) 2022-08-04
PE20231387A1 (es) 2023-09-12
MX2023008562A (es) 2023-08-08
KR20230141787A (ko) 2023-10-10
JP2024504788A (ja) 2024-02-01
AR124720A1 (es) 2023-04-26
US20230382911A1 (en) 2023-11-30
CN116867782A (zh) 2023-10-10
ZA202306694B (en) 2024-03-27
TW202246259A (zh) 2022-12-01
CA3209599A1 (en) 2022-08-04
IL304189A (en) 2023-09-01
CL2023002052A1 (es) 2023-12-22
CO2023010155A2 (es) 2023-09-08
EP4284797A1 (en) 2023-12-06
AU2022212487A1 (en) 2023-07-13

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