MX2022012898A - Ecomposición farmacéutica para administración oral que comprende derivado de aminopirimidina o sal, hidrato o solvato farmacéuticamente aceptable de esta. - Google Patents
Ecomposición farmacéutica para administración oral que comprende derivado de aminopirimidina o sal, hidrato o solvato farmacéuticamente aceptable de esta.Info
- Publication number
- MX2022012898A MX2022012898A MX2022012898A MX2022012898A MX2022012898A MX 2022012898 A MX2022012898 A MX 2022012898A MX 2022012898 A MX2022012898 A MX 2022012898A MX 2022012898 A MX2022012898 A MX 2022012898A MX 2022012898 A MX2022012898 A MX 2022012898A
- Authority
- MX
- Mexico
- Prior art keywords
- solvate
- hydrate
- pharmaceutically acceptable
- acceptable salt
- oral administration
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000012453 solvate Substances 0.000 title abstract 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción proporciona una composición farmacéutica para administración oral que comprende N-(5-(4-(4-((dimetilamino)m etil)-3-fenil-1H-pirazol-1-il)pirimidina-2-ilamino)-4-metoxi-2-mo rfolinofenil)acrilamida o una sal, hidrato o solvato farmacéuticamente aceptable de esta como un ingrediente activo; y una combinación de (i) un derivado de celulosa y (ii) un azúcar o poliol como diluyentes. Las composiciones descritas se caracterizan por una capacidad de fabricación mejorada, mientras se mantienen los beneficios farmacéuticos de minimizar el efecto de acuerdo con cambios en el entorno de pH en el estómago, poseen excelente estabilidad, y exhiben buena biodisponibilidad.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063009623P | 2020-04-14 | 2020-04-14 | |
US202063014277P | 2020-04-23 | 2020-04-23 | |
PCT/IB2021/053035 WO2021209893A1 (en) | 2020-04-14 | 2021-04-13 | Pharmaceutical composition for oral administration comprising amin op yrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022012898A true MX2022012898A (es) | 2023-01-24 |
Family
ID=75562794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022012898A MX2022012898A (es) | 2020-04-14 | 2021-04-13 | Ecomposición farmacéutica para administración oral que comprende derivado de aminopirimidina o sal, hidrato o solvato farmacéuticamente aceptable de esta. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210322323A1 (es) |
EP (1) | EP4135669A1 (es) |
JP (1) | JP2023522634A (es) |
KR (1) | KR20230002656A (es) |
CN (1) | CN115484937A (es) |
AU (1) | AU2021257662A1 (es) |
BR (1) | BR112022020609A2 (es) |
CA (1) | CA3180184A1 (es) |
IL (1) | IL297240A (es) |
MX (1) | MX2022012898A (es) |
TW (1) | TW202207940A (es) |
UY (1) | UY39171A (es) |
WO (1) | WO2021209893A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200043618A (ko) * | 2018-10-18 | 2020-04-28 | 주식회사유한양행 | 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물 |
EP4349835A1 (en) * | 2021-06-01 | 2024-04-10 | Hangzhou Solipharma Co., Ltd. | Hydrate crystal form of lazertinib methanesulfonate, preparation method therefor and use thereof |
WO2023138492A1 (zh) * | 2022-01-19 | 2023-07-27 | 南京明德新药研发有限公司 | 一种包含嘧啶基团的三并环类化合物的组合物及其制备方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6437006B1 (en) * | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
EP2076249A2 (en) * | 2006-10-27 | 2009-07-08 | FMC Corporation | Dry granulation binders, products, and use thereof |
EP2198857A1 (en) * | 2008-12-19 | 2010-06-23 | Ratiopharm GmbH | Oral dispersible tablet |
CA3182876A1 (en) | 2012-11-21 | 2014-05-30 | Janssen Biotech, Inc. | Bispecific egfr/c-met antibodies |
US9918989B2 (en) * | 2013-07-12 | 2018-03-20 | The Regents Of The University Of California | Combination therapies for malaria |
GB201402070D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
BR112017007769B1 (pt) | 2014-10-13 | 2023-10-10 | Yuhan Corporation | Compostos derivados de aminopirimidina, composição farmacêutica que compreende os ditos compostos e uso terapêutico dos mesmos |
EP3439653B1 (en) * | 2016-04-07 | 2021-01-20 | ChemoCentryx, Inc. | Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors |
AU2018210397B2 (en) * | 2017-01-20 | 2024-02-29 | Exelixis, Inc. | Combinations of cabozantinib and atezolizumab to treat cancer |
AR111469A1 (es) * | 2017-04-21 | 2019-07-17 | Yuhan Corp | Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma |
KR20200043618A (ko) * | 2018-10-18 | 2020-04-28 | 주식회사유한양행 | 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물 |
US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
-
2021
- 2021-04-12 TW TW110113031A patent/TW202207940A/zh unknown
- 2021-04-13 CA CA3180184A patent/CA3180184A1/en active Pending
- 2021-04-13 US US17/228,753 patent/US20210322323A1/en active Pending
- 2021-04-13 KR KR1020227039484A patent/KR20230002656A/ko active Search and Examination
- 2021-04-13 AU AU2021257662A patent/AU2021257662A1/en active Pending
- 2021-04-13 IL IL297240A patent/IL297240A/en unknown
- 2021-04-13 BR BR112022020609A patent/BR112022020609A2/pt unknown
- 2021-04-13 MX MX2022012898A patent/MX2022012898A/es unknown
- 2021-04-13 CN CN202180028642.0A patent/CN115484937A/zh active Pending
- 2021-04-13 EP EP21719733.4A patent/EP4135669A1/en active Pending
- 2021-04-13 UY UY0001039171A patent/UY39171A/es unknown
- 2021-04-13 WO PCT/IB2021/053035 patent/WO2021209893A1/en active Application Filing
- 2021-04-13 JP JP2022562451A patent/JP2023522634A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210322323A1 (en) | 2021-10-21 |
KR20230002656A (ko) | 2023-01-05 |
WO2021209893A8 (en) | 2022-10-13 |
TW202207940A (zh) | 2022-03-01 |
UY39171A (es) | 2021-10-29 |
EP4135669A1 (en) | 2023-02-22 |
IL297240A (en) | 2022-12-01 |
BR112022020609A2 (pt) | 2022-11-29 |
WO2021209893A1 (en) | 2021-10-21 |
CA3180184A1 (en) | 2021-10-21 |
CN115484937A (zh) | 2022-12-16 |
AU2021257662A1 (en) | 2022-12-15 |
JP2023522634A (ja) | 2023-05-31 |
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