SG11201702463YA - Mono- or di-substituted indole derivatives as dengue viral replication inhibitors - Google Patents
Mono- or di-substituted indole derivatives as dengue viral replication inhibitorsInfo
- Publication number
- SG11201702463YA SG11201702463YA SG11201702463YA SG11201702463YA SG11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA SG 11201702463Y A SG11201702463Y A SG 11201702463YA
- Authority
- SG
- Singapore
- Prior art keywords
- mono
- viral replication
- indole derivatives
- substituted indole
- replication inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14187374 | 2014-10-01 | ||
| EP15159164 | 2015-03-16 | ||
| PCT/EP2015/072551 WO2016050841A1 (en) | 2014-10-01 | 2015-09-30 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201702463YA true SG11201702463YA (en) | 2017-04-27 |
Family
ID=54199687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201702463YA SG11201702463YA (en) | 2014-10-01 | 2015-09-30 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9944598B2 (en) |
| EP (1) | EP3201176B1 (en) |
| JP (1) | JP6732736B2 (en) |
| KR (1) | KR102478311B1 (en) |
| CN (1) | CN107001264B (en) |
| AU (1) | AU2015326930B2 (en) |
| BR (1) | BR112017006299A2 (en) |
| CA (1) | CA2959573A1 (en) |
| CL (1) | CL2017000782A1 (en) |
| CY (1) | CY1121874T1 (en) |
| DK (1) | DK3201176T3 (en) |
| EA (1) | EA032546B1 (en) |
| ES (1) | ES2714074T3 (en) |
| HR (1) | HRP20190199T1 (en) |
| HU (1) | HUE041888T2 (en) |
| IL (1) | IL251396A0 (en) |
| LT (1) | LT3201176T (en) |
| MA (1) | MA40768B1 (en) |
| ME (1) | ME03360B (en) |
| MX (1) | MX2017004299A (en) |
| PH (1) | PH12017500571A1 (en) |
| PL (1) | PL3201176T3 (en) |
| PT (1) | PT3201176T (en) |
| RS (1) | RS58461B1 (en) |
| SG (1) | SG11201702463YA (en) |
| SI (1) | SI3201176T1 (en) |
| TW (1) | TWI681951B (en) |
| UA (1) | UA121119C2 (en) |
| UY (1) | UY36340A (en) |
| WO (1) | WO2016050841A1 (en) |
| ZA (1) | ZA201702301B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| SG11201702628XA (en) | 2014-10-01 | 2017-04-27 | Merck Patent Gmbh | Boronic acid derivatives |
| AU2015326920A1 (en) * | 2014-10-01 | 2017-03-02 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| JOP20160086B1 (en) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JO3633B1 (en) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| JOP20160198B1 (en) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| CR20180495A (en) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | INDOL DERIVATIVES REPLACED AS VIRAL REPLICATION INHIBITORS OF DENGUE |
| MA44498A (en) * | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | SUBSTITUTED INDOLINE DERIVATIVES USED AS DENGUE VIRUS REPLICATION INHIBITORS |
| WO2017167952A1 (en) * | 2016-04-01 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (en) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (en) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (en) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | Substituted indoline derivatives as dengue viral replication inhibitors |
| EP3630724B1 (en) * | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| BR112019024195A2 (en) * | 2017-05-22 | 2020-06-23 | Janssen Pharmaceuticals, Inc. | COMPOUND AND PHARMACEUTICAL COMPOSITION OF INDOLINE DERIVATIVES REPLACED AS INHIBITORS OF DENGUE VIRAL REPLICATION |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
-
2015
- 2015-09-30 TW TW104132008A patent/TWI681951B/en not_active IP Right Cessation
- 2015-09-30 CA CA2959573A patent/CA2959573A1/en not_active Abandoned
- 2015-09-30 CN CN201580053446.3A patent/CN107001264B/en active Active
- 2015-09-30 US US15/515,574 patent/US9944598B2/en active Active
- 2015-09-30 MX MX2017004299A patent/MX2017004299A/en unknown
- 2015-09-30 DK DK15771136.7T patent/DK3201176T3/en active
- 2015-09-30 JP JP2017513061A patent/JP6732736B2/en active Active
- 2015-09-30 EP EP15771136.7A patent/EP3201176B1/en active Active
- 2015-09-30 KR KR1020177011122A patent/KR102478311B1/en active IP Right Grant
- 2015-09-30 SI SI201530603T patent/SI3201176T1/en unknown
- 2015-09-30 MA MA40768A patent/MA40768B1/en unknown
- 2015-09-30 PL PL15771136T patent/PL3201176T3/en unknown
- 2015-09-30 ME MEP-2019-62A patent/ME03360B/en unknown
- 2015-09-30 BR BR112017006299-2A patent/BR112017006299A2/en not_active Application Discontinuation
- 2015-09-30 SG SG11201702463YA patent/SG11201702463YA/en unknown
- 2015-09-30 EA EA201790758A patent/EA032546B1/en not_active IP Right Cessation
- 2015-09-30 WO PCT/EP2015/072551 patent/WO2016050841A1/en active Application Filing
- 2015-09-30 RS RS20190206A patent/RS58461B1/en unknown
- 2015-09-30 PT PT15771136T patent/PT3201176T/en unknown
- 2015-09-30 UA UAA201704215A patent/UA121119C2/en unknown
- 2015-09-30 HU HUE15771136A patent/HUE041888T2/en unknown
- 2015-09-30 ES ES15771136T patent/ES2714074T3/en active Active
- 2015-09-30 AU AU2015326930A patent/AU2015326930B2/en not_active Expired - Fee Related
- 2015-09-30 LT LTEP15771136.7T patent/LT3201176T/en unknown
- 2015-10-01 UY UY0001036340A patent/UY36340A/en unknown
-
2017
- 2017-03-27 PH PH12017500571A patent/PH12017500571A1/en unknown
- 2017-03-27 IL IL251396A patent/IL251396A0/en unknown
- 2017-03-31 CL CL2017000782A patent/CL2017000782A1/en unknown
- 2017-03-31 ZA ZA2017/02301A patent/ZA201702301B/en unknown
-
2019
- 2019-01-30 HR HRP20190199TT patent/HRP20190199T1/en unknown
- 2019-03-01 CY CY20191100257T patent/CY1121874T1/en unknown
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