NI201900099A - Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue - Google Patents

Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue

Info

Publication number
NI201900099A
NI201900099A NI201900099A NI201900099A NI201900099A NI 201900099 A NI201900099 A NI 201900099A NI 201900099 A NI201900099 A NI 201900099A NI 201900099 A NI201900099 A NI 201900099A NI 201900099 A NI201900099 A NI 201900099A
Authority
NI
Nicaragua
Prior art keywords
dengue viral
inhibitors
compounds
indoline derivatives
viral replication
Prior art date
Application number
NI201900099A
Other languages
English (en)
Inventor
Rudolf Romanie Kesteleyn Bart
Bonfanti Jean-François
Coesemans Erwin
Jean-Marie Bernard Raboisson Pierre
Didier M Marchand Arnaud
Alice Marie-Eve Bardiot Dorothée
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of NI201900099A publication Critical patent/NI201900099A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a derivados de indolina sustituidos, a métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferiblemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue. La presente invención se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferiblemente para la prevención o el tratamiento de infecciones virales por dengue. La invención también se refiere a procesos para la preparación de los compuestos.
NI201900099A 2017-03-31 2019-09-27 Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue NI201900099A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164048 2017-03-31

Publications (1)

Publication Number Publication Date
NI201900099A true NI201900099A (es) 2020-03-11

Family

ID=58464340

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201900099A NI201900099A (es) 2017-03-31 2019-09-27 Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue

Country Status (32)

Country Link
US (1) US11083707B2 (es)
EP (1) EP3601266B1 (es)
JP (1) JP7203752B2 (es)
KR (1) KR102530832B1 (es)
CN (1) CN110461831B (es)
AR (1) AR111314A1 (es)
AU (1) AU2018246301B2 (es)
BR (1) BR112019020175A2 (es)
CA (1) CA3055867C (es)
CL (1) CL2019002745A1 (es)
CO (1) CO2019010295A2 (es)
CR (1) CR20190446A (es)
DK (1) DK3601266T3 (es)
EA (1) EA039784B1 (es)
EC (1) ECSP19070369A (es)
ES (1) ES2884151T3 (es)
HR (1) HRP20210942T1 (es)
HU (1) HUE054678T2 (es)
IL (1) IL269658B (es)
JO (1) JOP20180025B1 (es)
LT (1) LT3601266T (es)
MX (1) MX2019011606A (es)
NI (1) NI201900099A (es)
PE (1) PE20191650A1 (es)
PH (1) PH12019502201A1 (es)
SG (1) SG11201908786VA (es)
SI (1) SI3601266T1 (es)
TW (1) TWI795393B (es)
UA (1) UA126288C2 (es)
UY (1) UY37645A (es)
WO (1) WO2018178240A1 (es)
ZA (1) ZA201906395B (es)

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Also Published As

Publication number Publication date
IL269658A (en) 2019-11-28
US20200121647A1 (en) 2020-04-23
PH12019502201A1 (en) 2020-09-28
CN110461831A (zh) 2019-11-15
KR20190137108A (ko) 2019-12-10
CO2019010295A2 (es) 2019-10-09
ZA201906395B (en) 2021-05-26
UA126288C2 (uk) 2022-09-14
AU2018246301B2 (en) 2021-08-19
EA039784B1 (ru) 2022-03-14
CR20190446A (es) 2019-11-29
UY37645A (es) 2018-09-28
SI3601266T1 (sl) 2021-08-31
IL269658B (en) 2022-01-01
KR102530832B1 (ko) 2023-05-09
EA201992329A1 (ru) 2020-02-20
EP3601266B1 (en) 2021-04-28
SG11201908786VA (en) 2019-10-30
TWI795393B (zh) 2023-03-11
BR112019020175A2 (pt) 2020-06-02
JP2020512355A (ja) 2020-04-23
TW201900635A (zh) 2019-01-01
PE20191650A1 (es) 2019-11-07
CL2019002745A1 (es) 2019-12-27
HRP20210942T1 (hr) 2021-10-15
CA3055867C (en) 2024-01-02
AU2018246301A1 (en) 2019-09-19
HUE054678T2 (hu) 2021-09-28
US11083707B2 (en) 2021-08-10
LT3601266T (lt) 2021-07-12
WO2018178240A1 (en) 2018-10-04
EP3601266A1 (en) 2020-02-05
JOP20180025B1 (ar) 2021-08-17
DK3601266T3 (da) 2021-07-19
CA3055867A1 (en) 2018-10-04
JP7203752B2 (ja) 2023-01-13
JOP20180025A1 (ar) 2019-01-30
ES2884151T3 (es) 2021-12-10
CN110461831B (zh) 2022-11-01
AR111314A1 (es) 2019-06-26
MX2019011606A (es) 2019-11-08
ECSP19070369A (es) 2019-10-31

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