AR107490A1 - Derivados de pirazol-piridina como inhibidores de eaat3 - Google Patents
Derivados de pirazol-piridina como inhibidores de eaat3Info
- Publication number
- AR107490A1 AR107490A1 ARP170100242A ARP170100242A AR107490A1 AR 107490 A1 AR107490 A1 AR 107490A1 AR P170100242 A ARP170100242 A AR P170100242A AR P170100242 A ARP170100242 A AR P170100242A AR 107490 A1 AR107490 A1 AR 107490A1
- Authority
- AR
- Argentina
- Prior art keywords
- cyclopropyl
- hydrogen
- cyano
- isopropyl
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Compuestos de la fórmula (1), en la que: R¹’ es CH₃; R¹ es CH₃, etilo, CF₃, CH₂OH, ciclopropilo o ciano o R¹’ y R¹ juntos pueden formar un anillo 1,1-dioxo-tetrahidro-tiofen-3-ilo; R² es hidrógeno, CH₃, etilo, isopropilo, tert-butilo, ciclopropilo, ciclopropil-metilo o hidroxi-metilo; R³ es hidrógeno, Cl, F, CF₃, CH₃, isopropilo, metoxi, ciano o ciclopropilo; R⁴ es hidrógeno, CH₃, F o Cl; o a una sal farmacéuticamente aceptable o una sal de adición de ácido, a una mezcla racémica, o a sus enantiómeros correspondientes y/o los isómeros ópticos y/o los estereoisómeros de los mismos. Los compuestos de la fórmula (1) pueden emplearse para el tratamiento de trastornos psiquiátricos, por ejemplo la esquizofrenia, el trastorno bipolar, el trastorno obsesivo-compulsivo o los trastornos del espectro autista.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16153741 | 2016-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107490A1 true AR107490A1 (es) | 2018-05-02 |
Family
ID=55275018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100242A AR107490A1 (es) | 2016-02-02 | 2017-01-31 | Derivados de pirazol-piridina como inhibidores de eaat3 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10457663B2 (es) |
| EP (1) | EP3411365B1 (es) |
| JP (1) | JP6905988B2 (es) |
| CN (1) | CN108473462B (es) |
| AR (1) | AR107490A1 (es) |
| HK (1) | HK1252767A1 (es) |
| TW (1) | TW201730176A (es) |
| WO (1) | WO2017133990A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107207449B (zh) | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| WO2017202896A1 (en) * | 2016-05-27 | 2017-11-30 | F. Hoffmann-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| WO2018069362A1 (en) | 2016-10-14 | 2018-04-19 | F. Hoffmann-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040191803A1 (en) * | 2002-11-22 | 2004-09-30 | Michela Gallagher | Target for therapy of cognitive impairment |
| JP2006151954A (ja) | 2004-10-27 | 2006-06-15 | Taisho Pharmaceut Co Ltd | アスパラギン酸誘導体 |
| US7939556B2 (en) | 2005-10-14 | 2011-05-10 | Neurosearch A/S | Imidazole derivatives and their use for modulating the GABAA receptor complex |
| EP2038264B1 (en) | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazole-substituted arylamides |
| CA2700841A1 (en) * | 2007-09-27 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| WO2009043780A1 (en) * | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Tetrazole-substituted aryl amide derivatives and uses thereof |
| PT2234976E (pt) | 2007-12-17 | 2013-07-11 | Hoffmann La Roche | Novas arilamidas substituídas por pirazol |
| WO2009077365A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel imidazole-substituted arylamides |
| BRPI0821266B8 (pt) | 2007-12-17 | 2023-02-07 | Hoffmann La Roche | Derivados de arilamida triazol-substituída e seu uso e composição farmacêutica |
| TW201006801A (en) | 2008-07-18 | 2010-02-16 | Lilly Co Eli | Imidazole carboxamides |
| CA2741666C (en) | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| RU2013132930A (ru) * | 2010-12-17 | 2015-01-27 | Тайсо Фармасьютикал Ко., Лтд. | Производное пиразола |
| CN107207449B (zh) | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| JP6877359B2 (ja) | 2015-06-04 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | イミダゾール誘導体 |
| WO2017009274A1 (en) * | 2015-07-14 | 2017-01-19 | F. Hoffmann-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
| WO2017025523A1 (en) | 2015-08-12 | 2017-02-16 | F. Hoffmann-La Roche Ag | Pyridine and pyrimidine derivatives |
| JP6849668B2 (ja) | 2015-10-28 | 2021-03-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピリジン又はピリミジン誘導体 |
-
2017
- 2017-01-30 CN CN201780007351.7A patent/CN108473462B/zh active Active
- 2017-01-30 JP JP2018540416A patent/JP6905988B2/ja active Active
- 2017-01-30 EP EP17702832.1A patent/EP3411365B1/en active Active
- 2017-01-30 WO PCT/EP2017/051873 patent/WO2017133990A1/en active Application Filing
- 2017-01-31 AR ARP170100242A patent/AR107490A1/es unknown
- 2017-02-02 TW TW106103514A patent/TW201730176A/zh unknown
-
2018
- 2018-07-30 US US16/049,469 patent/US10457663B2/en not_active Expired - Fee Related
- 2018-09-20 HK HK18112128.0A patent/HK1252767A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019509987A (ja) | 2019-04-11 |
| CN108473462A (zh) | 2018-08-31 |
| US10457663B2 (en) | 2019-10-29 |
| TW201730176A (zh) | 2017-09-01 |
| CN108473462B (zh) | 2021-06-22 |
| EP3411365A1 (en) | 2018-12-12 |
| JP6905988B2 (ja) | 2021-07-21 |
| HK1252767A1 (zh) | 2019-05-31 |
| US20180339975A1 (en) | 2018-11-29 |
| EP3411365B1 (en) | 2019-11-20 |
| WO2017133990A1 (en) | 2017-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |