AR105662A1 - Derivados de piridina y de pirimidina como inhibidores del eaat3 - Google Patents

Derivados de piridina y de pirimidina como inhibidores del eaat3

Info

Publication number
AR105662A1
AR105662A1 ARP160102450A ARP160102450A AR105662A1 AR 105662 A1 AR105662 A1 AR 105662A1 AR P160102450 A ARP160102450 A AR P160102450A AR P160102450 A ARP160102450 A AR P160102450A AR 105662 A1 AR105662 A1 AR 105662A1
Authority
AR
Argentina
Prior art keywords
methyl
cyclopropyl
cyano
ethyl
eaat3
Prior art date
Application number
ARP160102450A
Other languages
English (en)
Inventor
Wichmann Juergen
Hoener Marius
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR105662A1 publication Critical patent/AR105662A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de la fórmula (1), en la que: R¹ es CH₃; R¹ es metilo, etilo, CF₃, CH₂OH, ciclopropilo o ciano, o R¹ y R¹ juntos pueden formar un anillo de 1,1-dioxo-tetra-hidro-tiofen-3-ilo; R² es hidrógeno, metilo, etilo, isopropilo, tert-butilo o ciclopropilo; R³ es Cl, F, CF₃, ciano, metilo, metoxi o ciclopropilo; R⁴ es hidrógeno, metilo o F; X es N o CH; Y es N o CH; con la condición de que X e Y no sean simultáneamente CH; o a una sal farmacéuticamente aceptable o una sal de adición de ácido, a una mezcla racémica o a los enantiómeros correspondientes y/o isómeros ópticos y/o estereoisómeros de los mismos. Los compuestos de la fórmula (1) pueden utilizarse para el tratamiento de trastornos psiquiátricos, tales como la esquizofrenia, el trastorno bipolar, el trastorno obsesivo-compulsivo o los trastornos del espectro autista.
ARP160102450A 2015-08-12 2016-08-10 Derivados de piridina y de pirimidina como inhibidores del eaat3 AR105662A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15180759 2015-08-12

Publications (1)

Publication Number Publication Date
AR105662A1 true AR105662A1 (es) 2017-10-25

Family

ID=53835950

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102450A AR105662A1 (es) 2015-08-12 2016-08-10 Derivados de piridina y de pirimidina como inhibidores del eaat3

Country Status (8)

Country Link
US (1) US10005736B1 (es)
EP (1) EP3334727B1 (es)
JP (1) JP6754828B2 (es)
CN (1) CN107922391B (es)
AR (1) AR105662A1 (es)
HK (1) HK1251226A1 (es)
TW (1) TW201718499A (es)
WO (1) WO2017025523A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016169902A1 (en) 2015-04-23 2016-10-27 F. Hoffmann-La Roche Ag Tetrazole derivatives for use in the treatment of psychiatric disorders
WO2017060202A1 (en) 2015-10-06 2017-04-13 F. Hoffmann-La Roche Ag Triazole derivatives
CN107922381B (zh) * 2015-10-28 2020-10-13 豪夫迈·罗氏有限公司 吡啶或嘧啶衍生物
JP6905988B2 (ja) 2016-02-02 2021-07-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｅａａｔ３阻害剤としてのピラゾール−ピリジン誘導体
CN109071451B (zh) 2016-05-27 2022-07-15 豪夫迈·罗氏有限公司 作为eaat3抑制剂的吡唑化合物
EP3526201B1 (en) 2016-10-14 2020-11-18 H. Hoffnabb-La Roche Ag Imidazole compounds as eaat3 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2658362A1 (en) * 2006-06-29 2008-01-03 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors
JP5608655B2 (ja) * 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
MX2011004570A (es) * 2008-10-31 2011-06-17 Merck Sharp & Dohme Antagonistas del receptor p2x3 para el tratamiento del dolor.

Also Published As

Publication number Publication date
EP3334727B1 (en) 2019-05-15
US20180162824A1 (en) 2018-06-14
CN107922391A (zh) 2018-04-17
HK1251226A1 (zh) 2019-01-25
JP2018522916A (ja) 2018-08-16
EP3334727A1 (en) 2018-06-20
CN107922391B (zh) 2020-09-25
WO2017025523A1 (en) 2017-02-16
US10005736B1 (en) 2018-06-26
JP6754828B2 (ja) 2020-09-16
TW201718499A (zh) 2017-06-01

Similar Documents

Publication Publication Date Title
AR105662A1 (es) Derivados de piridina y de pirimidina como inhibidores del eaat3
AR104331A1 (es) Derivados de tetrazol
DOP2017000149A (es) Compuestos de triazolopirimidina y usos de los mismos
CR20170237A (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
CL2018000036A1 (es) Derivados etinilo
CO2019000932A2 (es) Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica.
PE20191496A1 (es) 2-heteroaril-3-oxo-2,3-dihidropiridazin-4-carboxamidas
EA201691302A1 (ru) Новые гетероциклические соединения
UY37774A (es) Compuestos 5-cianoindol sustituidos y usos de los mismos
AR099177A1 (es) Determinadas (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1
AR104863A1 (es) Derivados imidazol
ECSP18024565A (es) Benzamidas sustituidas con isoxazolinas y análalogos como insecticidas
EA201492170A1 (ru) Новые замещенные в цикле n-пиридиниламиды в качестве ингибиторов киназ
EA201590438A1 (ru) 2-оксо-2,3-дигидроиндолы для лечения расстройств центральной нервной системы
AR098522A1 (es) Compuesto de triazolo-piridina
UY37466A (es) N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa
AR101359A1 (es) Derivados de 2-oxa-5-azabiciclo[2.2.1]heptan-3-ilo
AR099047A1 (es) Derivados etinilo
UY36416A (es) 1-[2-(aminometil)bencil]-2-tioxo-1,2,3,5-tetrahidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inhibidores de la mieloperoxidasa
AR105327A1 (es) Derivados de imidazol
CL2020002588A1 (es) Compuestos derivados de indol, composiciones que los contienen, útiles en el tratamiento de infestación por helmintos, preferentemente trematodos, en mamíferos. (divisional de solicitud n° 03258-2016)
CO2020010306A2 (es) Compuestos de sulfonimidoilpurinona 7-sustituida y derivados para el tratamiento y profilaxis de cáncer de hígado.
AR107490A1 (es) Derivados de pirazol-piridina como inhibidores de eaat3
AR106475A1 (es) Derivados de piridina o de pirimidina
CO6801735A2 (es) Derivados de pirazolidin-3-ona

Legal Events

Date Code Title Description
FB Suspension of granting procedure