AR110001A1 - Derivados heteroarilo bicíclicos - Google Patents

Derivados heteroarilo bicíclicos

Info

Publication number
AR110001A1
AR110001A1 ARP170103007A ARP170103007A AR110001A1 AR 110001 A1 AR110001 A1 AR 110001A1 AR P170103007 A ARP170103007 A AR P170103007A AR P170103007 A ARP170103007 A AR P170103007A AR 110001 A1 AR110001 A1 AR 110001A1
Authority
AR
Argentina
Prior art keywords
halogen
lower alkyl
hydrogen
lower alkoxy
compounds
Prior art date
Application number
ARP170103007A
Other languages
English (en)
Inventor
Greta Vastakaite
Jrme Charles Sarie
Michael Reutlinger
Hasane Ratni
Werner Neidhart
Anja Limberg
Roland Jakob-Roetne
Bjoern Bartels
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR110001A1 publication Critical patent/AR110001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se refiere a un compuesto de fórmula (1), (2) ó (3), en las que: R¹ es hidrógeno, alquilo inferior, alquilo inferior sustituido con halógeno, halógeno, alcoxi inferior o alcoxi inferior sustituido con halógeno, R¹ puede ser diferente en el caso de que n = 2 ó 3; n es 1, 2 ó 3; Ar es un grupo heteroarilo de seis elementos, seleccionado de entre los compuestos del grupo de fórmulas (4), en el que R² es hidrógeno, alquilo inferior, alquilo inferior sustituido con halógeno, halógeno o alcoxi inferior; R³ es hidrógeno o halógeno; o a una sal de adición de ácido farmacéuticamente aceptable de los mismos. Los compuestos pueden utilizarse para el tratamiento de la enfermedad de Alzheimer, la angiopatía amiloide cerebral, la hemorragia cerebral hereditaria con amiloidosis de tipo holandés (HCHWA-D), la demencia multiinfarto, la demencia pugilística o el síndrome de Down.
ARP170103007A 2016-11-01 2017-10-30 Derivados heteroarilo bicíclicos AR110001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16196720 2016-11-01

Publications (1)

Publication Number Publication Date
AR110001A1 true AR110001A1 (es) 2019-02-13

Family

ID=57218802

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103007A AR110001A1 (es) 2016-11-01 2017-10-30 Derivados heteroarilo bicíclicos

Country Status (7)

Country Link
US (1) US10941147B2 (es)
EP (1) EP3535266B1 (es)
JP (1) JP7111704B2 (es)
CN (1) CN109641912B (es)
AR (1) AR110001A1 (es)
TW (1) TWI761384B (es)
WO (1) WO2018083050A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018001918A1 (en) * 2016-06-27 2018-01-04 F. Hoffmann-La Roche Ag Triazolopyridines as gamma-secretase modulators
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
WO2019121434A1 (en) * 2017-12-18 2019-06-27 F. Hoffmann-La Roche Ag Triazolo-azepine derivatives
US11370802B2 (en) * 2018-01-22 2022-06-28 Hoffmann-La Roche, Inc. Triazolo-azepine derivatives
US12084461B2 (en) * 2018-09-03 2024-09-10 Hoffmann-La Roche Inc. Bicyclic heteroaryl derivatives
KR20210102900A (ko) * 2018-12-13 2021-08-20 에프. 호프만-라 로슈 아게 알츠하이머 병의 치료를 위한 감마-세크레타제 조절제로서 7-페녹시-N-(3-아자바이사이클로[3.2.1]옥탄-8-일)-6,7-다이하이드로-5H-피롤로[1,2-b][1,2,4]트라이아졸-2-아민 유도체 및 관련 화합물
CN114787163A (zh) 2019-11-29 2022-07-22 豪夫迈·罗氏有限公司 用于制备 (9S)-2-溴-9-(2,3,4-三氟苯基)-6,7,8,9-四氢-5H-[1,2,4]三唑并[1,5-a]氮杂䓬的方法
WO2022122864A1 (en) 2020-12-11 2022-06-16 F. Hoffmann-La Roche Ag Process for the preparation of (9s)-n-[3-(6-methylpyrimidin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl]-9-(2,3,4-trifluorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[1,5-a]azepin-2-amine and its solid form

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JPWO2011007756A1 (ja) 2009-07-13 2012-12-27 武田薬品工業株式会社 複素環化合物及びその用途
US8486967B2 (en) * 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US8703763B2 (en) * 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
WO2017042114A1 (en) * 2015-09-09 2017-03-16 F. Hoffmann-La Roche Ag Bridged piperidine derivatives
CN108137579B (zh) * 2015-12-10 2022-01-07 豪夫迈·罗氏有限公司 桥连哌啶衍生物
US11014912B2 (en) 2016-09-27 2021-05-25 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of USP30

Also Published As

Publication number Publication date
CN109641912A (zh) 2019-04-16
JP2019532972A (ja) 2019-11-14
US20190284191A1 (en) 2019-09-19
EP3535266A1 (en) 2019-09-11
WO2018083050A1 (en) 2018-05-11
CN109641912B (zh) 2021-10-29
EP3535266B1 (en) 2021-12-29
JP7111704B2 (ja) 2022-08-02
TWI761384B (zh) 2022-04-21
US10941147B2 (en) 2021-03-09
TW201821427A (zh) 2018-06-16

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